Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia

Blood

Volumn 123, Issue 17, 2014, Pages 2663-2672

  Jitschin, Regina ^a   Hofmann, Andreas D ^a   Bruns, Heiko ^a   Gießl, Andreas ^a   Bricks, Juliane ^a   Berger, Jana ^a   Saul, Domenica ^a   Eckart, Michael J ^b   Mackensen, Andreas ^a   Mougiakakos, Dimitrios ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Onkologische Schwerpunktpraxis und Tagesklinik   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ADENOSINE TRIPHOSPHATE; GAMMA INTERFERON; GLUTATHIONE; HEME OXYGENASE 1; MALONALDEHYDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ADENOSINE TRIPHOSPHATASE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CYTOKINE; HMOX1 PROTEIN, HUMAN; ISOQUINOLINE DERIVATIVE;

ADAPTATION; AEROBIC METABOLISM; ANTIOXIDANT ACTIVITY; ARTICLE; BIOENERGY; CELL DEATH; CELL STRESS; CHRONIC LYMPHATIC LEUKEMIA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; FEEDBACK SYSTEM; GLYCOLYSIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MAJOR CLINICAL STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION; AGED; CELL SEPARATION; CELL TRANSFORMATION; ENERGY METABOLISM; FEMALE; FLOW CYTOMETRY; MALE; METABOLISM; MIDDLE AGED; MITOCHONDRION; MONONUCLEAR CELL; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; TRANSMISSION ELECTRON MICROSCOPY; VERY ELDERLY;

ADENOSINE TRIPHOSPHATASES; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL SEPARATION; CELL TRANSFORMATION, NEOPLASTIC; CYTOKINES; ENERGY METABOLISM; FEMALE; FLOW CYTOMETRY; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; ISOQUINOLINES; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKOCYTES, MONONUCLEAR; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES;

EID: 84899634480     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-10-532200     Document Type: Article

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