An interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: A potential role of mesenchymal cells in the disease

Haematologica

Volumn 96, Issue 7, 2011, Pages 1015-1023

  Giannoni, Paolo ^a   Scaglione, Silvia ^b   Quarto, Rodolfo ^a,c   Narcisi, Roberto ^c   Parodi, Manuela ^a   Balleari, Enrico ^b   Barbieri, Federica ^c   Pattarozzi, Alessandra ^c   Florio, Tullio ^c   Ferrini, Silvano ^b   Corte, Giorgio ^b   de Totero, Daniela ^b  

^a ADVANCED BIOTECHNOLOGY CENTER   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Chronic lymphocytic leukemia; Growth factors; Mesenchymal stem cells; Survival

Indexed keywords

SCATTER FACTOR; SCATTER FACTOR RECEPTOR; STAT3 PROTEIN; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CANCER CELL CULTURE; CARTILAGE CELL; CELL SURVIVAL; CELL VIABILITY; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBROBLAST; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LEUKEMIA CELL; MESENCHYME CELL; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; STROMA CELL; TRABECULAR BONE;

APOPTOSIS; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CXCL12; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; HEPATOCYTE GROWTH FACTOR; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MESENCHYMAL STEM CELLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MET; RECEPTORS, CXCR4; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR;

EID: 79960002693     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.029736     Document Type: Article

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