메뉴 건너뛰기




Volumn 606, Issue , 2015, Pages 140-144

Role of orexin A signaling in dietary palmitic acid-activated microglial cells

Author keywords

Cytokine; Hypocretin; Immunomodulation; Neurodegeneration; Neuroinflammation; Palmitic acid

Indexed keywords

ARGINASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; OREXIN 1 RECEPTOR; OREXIN A; PALMITIC ACID; TUMOR NECROSIS FACTOR ALPHA; ARG1 PROTEIN, MOUSE; ARGINASE; CONDITIONED MEDIUM; CYTOKINE; FAT INTAKE; OREXIN; TUMOR NECROSIS FACTOR;

EID: 84941078394     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.08.033     Document Type: Article
Times cited : (57)

References (42)
  • 1
    • 0008390266 scopus 로고    scopus 로고
    • The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
    • de Lecea L., et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(1):322-327.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , Issue.1 , pp. 322-327
    • de Lecea, L.1
  • 2
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai T., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92(4):573-585.
    • (1998) Cell , vol.92 , Issue.4 , pp. 573-585
    • Sakurai, T.1
  • 3
    • 84888143202 scopus 로고    scopus 로고
    • Orexin: pathways to obesity resistance?
    • Butterick T.A., et al. Orexin: pathways to obesity resistance?. Rev. Endocr. Metab. Disord. 2013, 14(4):357-364.
    • (2013) Rev. Endocr. Metab. Disord. , vol.14 , Issue.4 , pp. 357-364
    • Butterick, T.A.1
  • 4
    • 84864857152 scopus 로고    scopus 로고
    • Brain orexin promotes obesity resistance
    • Kotz C., et al. Brain orexin promotes obesity resistance. Ann. N.Y Acad. Sci. 2012, 1264:72-86.
    • (2012) Ann. N.Y Acad. Sci. , vol.1264 , pp. 72-86
    • Kotz, C.1
  • 5
    • 84864627330 scopus 로고    scopus 로고
    • Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model
    • Butterick T.A., et al. Orexin A decreases lipid peroxidation and apoptosis in a novel hypothalamic cell model. Neurosci. Lett. 2012, 524(1):30-34.
    • (2012) Neurosci. Lett. , vol.524 , Issue.1 , pp. 30-34
    • Butterick, T.A.1
  • 6
    • 84895075249 scopus 로고    scopus 로고
    • Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling
    • Sokolowska P., et al. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J. Mol. Neurosci. 2014, 52(1):48-55.
    • (2014) J. Mol. Neurosci. , vol.52 , Issue.1 , pp. 48-55
    • Sokolowska, P.1
  • 7
    • 84655167918 scopus 로고    scopus 로고
    • Orexins promote survival of rat cortical neurons
    • Sokolowska P., et al. Orexins promote survival of rat cortical neurons. Neurosci. Lett. 2012, 506(2):303-306.
    • (2012) Neurosci. Lett. , vol.506 , Issue.2 , pp. 303-306
    • Sokolowska, P.1
  • 8
    • 84876298227 scopus 로고    scopus 로고
    • Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation
    • Xiong X., et al. Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation. Stroke 2013, 44(3):764-770.
    • (2013) Stroke , vol.44 , Issue.3 , pp. 764-770
    • Xiong, X.1
  • 9
    • 84868209611 scopus 로고    scopus 로고
    • Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    • Hu X., et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 2012, 43(11):3063-3070.
    • (2012) Stroke , vol.43 , Issue.11 , pp. 3063-3070
    • Hu, X.1
  • 10
    • 84897976299 scopus 로고    scopus 로고
    • Microglial priming in neurodegenerative disease
    • Perry V.H., Holmes C. Microglial priming in neurodegenerative disease. Nat. Rev. Neurol. 2014, 10(4):217-224.
    • (2014) Nat. Rev. Neurol. , vol.10 , Issue.4 , pp. 217-224
    • Perry, V.H.1    Holmes, C.2
  • 11
    • 45749151055 scopus 로고    scopus 로고
    • Brain foods: the effects of nutrients on brain function
    • Gomez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat. Rev. Neurosci. 2008, 9(7):568-578.
    • (2008) Nat. Rev. Neurosci. , vol.9 , Issue.7 , pp. 568-578
    • Gomez-Pinilla, F.1
  • 12
    • 84871650203 scopus 로고    scopus 로고
    • Neuroinflammation and neurodegeneration in overnutrition-induced diseases
    • Cai D. Neuroinflammation and neurodegeneration in overnutrition-induced diseases. Trends Endocrinol. Metab. 2013, 24(1):40-47.
    • (2013) Trends Endocrinol. Metab. , vol.24 , Issue.1 , pp. 40-47
    • Cai, D.1
  • 13
    • 84855459760 scopus 로고    scopus 로고
    • Obesity is associated with hypothalamic injury in rodents and humans
    • Thaler J.P., et al. Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 2012, 122(1):153-162.
    • (2012) J. Clin. Invest. , vol.122 , Issue.1 , pp. 153-162
    • Thaler, J.P.1
  • 14
    • 84862928989 scopus 로고    scopus 로고
    • Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling
    • Wang Z., et al. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling. Br. J. Nutr. 2012, 107(2):229-241.
    • (2012) Br. J. Nutr. , vol.107 , Issue.2 , pp. 229-241
    • Wang, Z.1
  • 15
    • 84919847348 scopus 로고    scopus 로고
    • Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function
    • Valdearcos M., et al. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014, 9:2124-2138.
    • (2014) Cell Rep. , vol.9 , pp. 2124-2138
    • Valdearcos, M.1
  • 16
    • 0025233694 scopus 로고
    • Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus
    • Blasi E., et al. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J. Neuroimmunol. 1990, 27(2-3):229-237.
    • (1990) J. Neuroimmunol. , vol.27 , Issue.2-3 , pp. 229-237
    • Blasi, E.1
  • 17
    • 72749091486 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons
    • Belsham D.D., et al. Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons. FASEB J. 2009, 23(12):4256-4265.
    • (2009) FASEB J. , vol.23 , Issue.12 , pp. 4256-4265
    • Belsham, D.D.1
  • 18
    • 84864312233 scopus 로고    scopus 로고
    • OX2R activation induces PKC-mediated ERK and CREB phosphorylation
    • Guo Y., Feng P. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp. Cell Res. 2012, 318(16):2004-2013.
    • (2012) Exp. Cell Res. , vol.318 , Issue.16 , pp. 2004-2013
    • Guo, Y.1    Feng, P.2
  • 19
    • 79955601028 scopus 로고    scopus 로고
    • Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
    • Pike L.S., et al. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim. Biophys. Acta 2011, 1807(6):726-734.
    • (2011) Biochim. Biophys. Acta , vol.1807 , Issue.6 , pp. 726-734
    • Pike, L.S.1
  • 20
    • 78651300299 scopus 로고    scopus 로고
    • TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules
    • Matsunaga N., et al. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Mol. Pharmacol. 2011, 79(1):34-41.
    • (2011) Mol. Pharmacol. , vol.79 , Issue.1 , pp. 34-41
    • Matsunaga, N.1
  • 21
    • 70350304545 scopus 로고    scopus 로고
    • Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model
    • Takashima K., et al. Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. Br. J. Pharmacol. 2009, 157(7):1250-1262.
    • (2009) Br. J. Pharmacol. , vol.157 , Issue.7 , pp. 1250-1262
    • Takashima, K.1
  • 22
    • 0027169767 scopus 로고
    • A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples
    • 536-537
    • Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 1993, 15(3):532-534. 536-537.
    • (1993) Biotechniques , vol.15 , Issue.3 , pp. 532-534
    • Chomczynski, P.1
  • 23
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 24
    • 0032513269 scopus 로고    scopus 로고
    • Palmitic acid is associated with halorhodopsin as a free fatty acid. Radiolabeling of halorhodopsin with 3H-palmitic acid and chemical analysis of the reaction products of purified halorhodopsin with thiols and NaBH4
    • Colella M., et al. Palmitic acid is associated with halorhodopsin as a free fatty acid. Radiolabeling of halorhodopsin with 3H-palmitic acid and chemical analysis of the reaction products of purified halorhodopsin with thiols and NaBH4. Biochim. Biophys. Acta 1998, 1370(2):273-279.
    • (1998) Biochim. Biophys. Acta , vol.1370 , Issue.2 , pp. 273-279
    • Colella, M.1
  • 25
    • 15244350494 scopus 로고    scopus 로고
    • Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand
    • Taylor D.L., et al. Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. J. Neurosci. 2005, 25(11):2952-2964.
    • (2005) J. Neurosci. , vol.25 , Issue.11 , pp. 2952-2964
    • Taylor, D.L.1
  • 26
    • 54949148770 scopus 로고    scopus 로고
    • Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway
    • Pais T.F., et al. Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. J. Neuroinflammation 2008, 5:43.
    • (2008) J. Neuroinflammation , vol.5 , pp. 43
    • Pais, T.F.1
  • 27
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay M.E., Lowery R.L., Majewska A.K. Microglial interactions with synapses are modulated by visual experience. PLoS Biol. 2010, 8(11):e1000527.
    • (2010) PLoS Biol. , vol.8 , Issue.11 , pp. e1000527
    • Tremblay, M.E.1    Lowery, R.L.2    Majewska, A.K.3
  • 28
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake H., et al. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci. 2009, 29(13):3974-3980.
    • (2009) J. Neurosci. , vol.29 , Issue.13 , pp. 3974-3980
    • Wake, H.1
  • 29
    • 84908651577 scopus 로고    scopus 로고
    • Obesity and neuroinflammation: a pathway to cognitive impairment
    • Miller A.A., Spencer S.J. Obesity and neuroinflammation: a pathway to cognitive impairment. Brain Behav. Immun. 2014, 42:10-21.
    • (2014) Brain Behav. Immun. , vol.42 , pp. 10-21
    • Miller, A.A.1    Spencer, S.J.2
  • 30
    • 84924295797 scopus 로고    scopus 로고
    • Hypothalamic microinflammation: a common basis of metabolic syndrome and aging
    • Tang Y., Purkayastha S., Cai D. Hypothalamic microinflammation: a common basis of metabolic syndrome and aging. Trends Neurosci. 2015, 38(1):36-44.
    • (2015) Trends Neurosci. , vol.38 , Issue.1 , pp. 36-44
    • Tang, Y.1    Purkayastha, S.2    Cai, D.3
  • 31
    • 84907904248 scopus 로고    scopus 로고
    • High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice
    • Nobunaga M., et al. High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice. Neurochem. Int. 2014, 78:61-66.
    • (2014) Neurochem. Int. , vol.78 , pp. 61-66
    • Nobunaga, M.1
  • 32
    • 84899697738 scopus 로고    scopus 로고
    • 2+-dependent PKCalpha and ERK1/2 signals
    • 2+-dependent PKCalpha and ERK1/2 signals. PLoS One 2014, 9(4):e95259.
    • (2014) PLoS One , vol.9 , Issue.4 , pp. e95259
    • Shu, Q.1
  • 33
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos D., et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 2005, 8(6):752-758.
    • (2005) Nat. Neurosci. , vol.8 , Issue.6 , pp. 752-758
    • Davalos, D.1
  • 34
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308(5726):1314-1318.
    • (2005) Science , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 35
    • 84875243183 scopus 로고    scopus 로고
    • Parkinson's disease in the nuclear age of neuroinflammation
    • Nolan Y.M., Sullivan A.M., Toulouse A. Parkinson's disease in the nuclear age of neuroinflammation. Trends Mol. Med. 2013, 19(3):187-196.
    • (2013) Trends Mol. Med. , vol.19 , Issue.3 , pp. 187-196
    • Nolan, Y.M.1    Sullivan, A.M.2    Toulouse, A.3
  • 36
    • 8544280702 scopus 로고    scopus 로고
    • Characterization of cellular and neurological damage following unilateral hypoxia/ischemia
    • Olson E.E., McKeon R.J. Characterization of cellular and neurological damage following unilateral hypoxia/ischemia. J. Neurol. Sci. 2004, 227(1):7-19.
    • (2004) J. Neurol. Sci. , vol.227 , Issue.1 , pp. 7-19
    • Olson, E.E.1    McKeon, R.J.2
  • 37
    • 84858861533 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice
    • Guerrero A.R., et al. Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice. J. Neuroinflammation 2012, 9:40.
    • (2012) J. Neuroinflammation , vol.9 , pp. 40
    • Guerrero, A.R.1
  • 38
    • 84889095882 scopus 로고    scopus 로고
    • IL-10 deficiency exacerbates the brain inflammatory response to permanent ischemia without preventing resolution of the lesion
    • Perez-de Puig I., et al. IL-10 deficiency exacerbates the brain inflammatory response to permanent ischemia without preventing resolution of the lesion. J. Cereb. Blood Flow Metab. 2013, 33(12):1955-1966.
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , Issue.12 , pp. 1955-1966
    • Perez-de Puig, I.1
  • 39
    • 84891373720 scopus 로고    scopus 로고
    • Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
    • Chhor V., et al. Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro. Brain Behav. Immunol. 2013, 32:70-85.
    • (2013) Brain Behav. Immunol. , vol.32 , pp. 70-85
    • Chhor, V.1
  • 41
    • 84901340197 scopus 로고    scopus 로고
    • Fractalkine regulation of microglial physiology and consequences on the brain and behavior
    • Paolicelli R.C., Bisht K., Tremblay M.E. Fractalkine regulation of microglial physiology and consequences on the brain and behavior. Front. Cell. Neurosci. 2014, 8:129.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 129
    • Paolicelli, R.C.1    Bisht, K.2    Tremblay, M.E.3
  • 42
    • 84896846872 scopus 로고    scopus 로고
    • Neuroinflammatory phenotypes and their roles in Alzheimer's disease
    • Wilcock D.M. Neuroinflammatory phenotypes and their roles in Alzheimer's disease. Neuro-degener. Dis. 2013, 13:183-185.
    • (2013) Neuro-degener. Dis. , vol.13 , pp. 183-185
    • Wilcock, D.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.