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Volumn 20, Issue 9, 2015, Pages 1127-1134

Reorienting the immune system in the treatment of cancer by using anti-PD-1 and anti-PD-L1 antibodies

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; ANTINEOPLASTIC AGENT; AVELUMAB; BMS 936559; DURVALUMAB; IPILIMUMAB; MEDI 0860; MPDL 3280A; NIVOLUMAB; PEMBROLIZUMAB; PIDILIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH 1 RECEPTOR; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN;

EID: 84941025887     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.07.003     Document Type: Review
Times cited : (33)

References (84)
  • 2
    • 84855940380 scopus 로고    scopus 로고
    • A new therapeutic strategy for malaria: Targeting T cell exhaustion
    • G.J. Freeman, and A.H. Sharpe A new therapeutic strategy for malaria: targeting T cell exhaustion Nat. Immunol. 13 2012 113 115
    • (2012) Nat. Immunol. , vol.13 , pp. 113-115
    • Freeman, G.J.1    Sharpe, A.H.2
  • 3
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • D.R. Leach, and et al. Enhancement of antitumor immunity by CTLA-4 blockade Science 271 1996 1734 1736
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1
  • 4
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • F. Hodi, and S. O'Day Improved survival with ipilimumab in patients with metastatic melanoma N. Engl. J. Med. 363 2010 711 723
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.1    O'Day, S.2
  • 5
    • 84928917822 scopus 로고    scopus 로고
    • Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
    • D. Schadendorf, and et al. Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma J. Clin. Oncol. 2015 10.1200/JCO.2014.56.2736
    • (2015) J. Clin. Oncol.
    • Schadendorf, D.1
  • 6
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Y. Ishida, and et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death EMBO J. 1 1992 3887 3895
    • (1992) EMBO J. , vol.1 , pp. 3887-3895
    • Ishida, Y.1
  • 7
    • 12144290320 scopus 로고    scopus 로고
    • Structural and functional analysis of the costimulatory receptor programmed death-1
    • X. Zhang, and et al. Structural and functional analysis of the costimulatory receptor programmed death-1 Immunity 20 2004 337 347
    • (2004) Immunity , vol.20 , pp. 337-347
    • Zhang, X.1
  • 8
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
    • Y. Agata, and et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes Int. Immunol. 8 1996 765 772
    • (1996) Int. Immunol. , vol.8 , pp. 765-772
    • Agata, Y.1
  • 9
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • E.J. Wherry T cell exhaustion Nat. Immunol. 131 2011 492 499
    • (2011) Nat. Immunol. , vol.131 , pp. 492-499
    • Wherry, E.J.1
  • 10
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • H. Dong, and et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion Nat. Med. 5 1999 1365 1369
    • (1999) Nat. Med. , vol.5 , pp. 1365-1369
    • Dong, H.1
  • 11
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Y. Latchman, and et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation Nat. Immunol. 2 2001 261 268
    • (2001) Nat. Immunol. , vol.2 , pp. 261-268
    • Latchman, Y.1
  • 12
    • 0037477605 scopus 로고    scopus 로고
    • The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    • M.J.I. Ansari, and et al. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice J. Exp. Med. 198 2003 63 69
    • (2003) J. Exp. Med. , vol.198 , pp. 63-69
    • Ansari, M.J.I.1
  • 13
    • 84872348271 scopus 로고    scopus 로고
    • Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice
    • H. Frebel, and et al. Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice J. Exp. Med. 209 2012 2485 2499
    • (2012) J. Exp. Med. , vol.209 , pp. 2485-2499
    • Frebel, H.1
  • 14
    • 36749010774 scopus 로고    scopus 로고
    • Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
    • T. Pentcheva-Hoang, and et al. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability Proc. Natl. Acad. Sci. U. S. A. 104 2007 17765 17770
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 17765-17770
    • Pentcheva-Hoang, T.1
  • 15
    • 27144496045 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    • R.V. Parry, and et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms Mol. Cell. Biol. 25 2005 9543 9553
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 9543-9553
    • Parry, R.V.1
  • 16
    • 0037438490 scopus 로고    scopus 로고
    • Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: Attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses
    • F. Bennett, and et al. Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses J. Immunol. 170 2003 711 718
    • (2003) J. Immunol. , vol.170 , pp. 711-718
    • Bennett, F.1
  • 17
    • 15444377924 scopus 로고    scopus 로고
    • Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA
    • M. Tsuda, and et al. Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA Biochem. Biophys. Res. Commun. 330 2005 263 270
    • (2005) Biochem. Biophys. Res. Commun. , vol.330 , pp. 263-270
    • Tsuda, M.1
  • 18
    • 0242559053 scopus 로고    scopus 로고
    • Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis
    • N. Rodig, and et al. Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis Eur. J. Immunol. 33 2003 3117 3126
    • (2003) Eur. J. Immunol. , vol.33 , pp. 3117-3126
    • Rodig, N.1
  • 19
    • 84908647853 scopus 로고    scopus 로고
    • Attenuation of IFN-γ-induced B7-H1 expression by 15-deoxy-delta(12,14)-prostaglandin J2 via downregulation of the Jak/STAT/IRF-1 signaling pathway
    • S-K. Seo, and et al. Attenuation of IFN-γ-induced B7-H1 expression by 15-deoxy-delta(12,14)-prostaglandin J2 via downregulation of the Jak/STAT/IRF-1 signaling pathway Life Sci. 112 2014 82 89
    • (2014) Life Sci. , vol.112 , pp. 82-89
    • Seo, S.-K.1
  • 20
    • 33645846313 scopus 로고    scopus 로고
    • Tissue expression of PD-L1 mediates peripheral T cell tolerance
    • M.E. Keir, and et al. Tissue expression of PD-L1 mediates peripheral T cell tolerance J. Exp. Med. 203 2006 883 895
    • (2006) J. Exp. Med. , vol.203 , pp. 883-895
    • Keir, M.E.1
  • 21
    • 84920398319 scopus 로고    scopus 로고
    • B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease
    • R. Deng, and et al. B7H1/CD80 interaction augments PD-1-dependent T cell apoptosis and ameliorates graft-versus-host disease J. Immunol. 194 2014 560 574
    • (2014) J. Immunol. , vol.194 , pp. 560-574
    • Deng, R.1
  • 22
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • L.M. Francisco, and et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells J. Exp. Med. 206 2009 3015 3029
    • (2009) J. Exp. Med. , vol.206 , pp. 3015-3029
    • Francisco, L.M.1
  • 23
    • 0035794314 scopus 로고    scopus 로고
    • B7-Dc, a new dendritic cell molecule with potent costimulatory properties for T cells
    • S-Y. Tseng, and et al. B7-Dc, a new dendritic cell molecule with potent costimulatory properties for T cells J. Exp. Med. 193 2001 839 846
    • (2001) J. Exp. Med. , vol.193 , pp. 839-846
    • Tseng, S.-Y.1
  • 24
    • 0037111483 scopus 로고    scopus 로고
    • Expression of programmed death 1 ligands by murine T cells and APC
    • T. Yamazaki, and et al. Expression of programmed death 1 ligands by murine T cells and APC J. Immunol. 169 2002 5538 5545
    • (2002) J. Immunol. , vol.169 , pp. 5538-5545
    • Yamazaki, T.1
  • 25
    • 0038302927 scopus 로고    scopus 로고
    • PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
    • P. Loke, and J.P. Allison PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells Proc. Natl. Acad. Sci. U. S. A. 100 2003 5336 5341
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 5336-5341
    • Loke, P.1    Allison, J.P.2
  • 26
    • 84899758346 scopus 로고    scopus 로고
    • RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
    • Y. Xiao, and et al. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance J. Exp. Med. 211 2014 943 959
    • (2014) J. Exp. Med. , vol.211 , pp. 943-959
    • Xiao, Y.1
  • 27
    • 79953059789 scopus 로고    scopus 로고
    • Natural innate and adaptive immunity to cancer
    • M.D. Vesely, and et al. Natural innate and adaptive immunity to cancer Annu. Rev. Immunol. 29 2011 235 271
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 235-271
    • Vesely, M.D.1
  • 28
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • R.S. Herbst, and et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients Nature 515 2014 563 567
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1
  • 29
    • 0141953992 scopus 로고    scopus 로고
    • B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma
    • S. Strome, and et al. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma Cancer Res. 63 2003 6501 6505
    • (2003) Cancer Res. , vol.63 , pp. 6501-6505
    • Strome, S.1
  • 30
    • 10344220548 scopus 로고    scopus 로고
    • Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
    • R.H. Thompson, and et al. Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target Proc. Natl. Acad. Sci. U. S. A. 101 2004 17174 17179
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 17174-17179
    • Thompson, R.H.1
  • 31
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • J. Hamanishi, and et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer Proc. Natl. Acad. Sci. U. S. A. 104 2007 3360 3365
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 3360-3365
    • Hamanishi, J.1
  • 32
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    • T. Nomi, and et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer Clin. Cancer Res. 13 2007 2151 2157
    • (2007) Clin. Cancer Res. , vol.13 , pp. 2151-2157
    • Nomi, T.1
  • 33
    • 84896488675 scopus 로고    scopus 로고
    • PD-1(+) immune cell infiltration inversely correlates with survival of operable breast cancer patients
    • S. Sun, and et al. PD-1(+) immune cell infiltration inversely correlates with survival of operable breast cancer patients Cancer Immunol. Immunother. 63 2014 395 406
    • (2014) Cancer Immunol. Immunother. , vol.63 , pp. 395-406
    • Sun, S.1
  • 34
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    • J. Matsuzaki, and et al. Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer Proc. Natl. Acad. Sci. U. S. A. 107 2010 7875 7880
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 7875-7880
    • Matsuzaki, J.1
  • 35
    • 84867544962 scopus 로고    scopus 로고
    • PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines
    • W. Peng, and et al. PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines Cancer Res. 72 2012 5209 5218
    • (2012) Cancer Res. , vol.72 , pp. 5209-5218
    • Peng, W.1
  • 36
    • 33745197352 scopus 로고    scopus 로고
    • Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro
    • C. Blank, and et al. Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro Int. J. Cancer 119 2006 317 327
    • (2006) Int. J. Cancer , vol.119 , pp. 317-327
    • Blank, C.1
  • 37
    • 84865416551 scopus 로고    scopus 로고
    • B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets
    • M. Mkrtichyan, and et al. B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets J. Immunol. 189 2012 2338 2347
    • (2012) J. Immunol. , vol.189 , pp. 2338-2347
    • Mkrtichyan, M.1
  • 38
    • 84875442610 scopus 로고    scopus 로고
    • HLA-restricted CTL that are specific for the immune checkpoint ligand PD-L1 occur with high frequency in cancer patients
    • S. Munir, and et al. HLA-restricted CTL that are specific for the immune checkpoint ligand PD-L1 occur with high frequency in cancer patients Cancer Res. 73 2013 1764 1776
    • (2013) Cancer Res. , vol.73 , pp. 1764-1776
    • Munir, S.1
  • 39
    • 84887316694 scopus 로고    scopus 로고
    • Cutaneous T cell lymphoma cells are targets for immune checkpoint ligand PD-L1-specific, cytotoxic T cells
    • S. Munir, and et al. Cutaneous T cell lymphoma cells are targets for immune checkpoint ligand PD-L1-specific, cytotoxic T cells Leukemia 27 2013 2251 2253
    • (2013) Leukemia , vol.27 , pp. 2251-2253
    • Munir, S.1
  • 40
    • 84891840810 scopus 로고    scopus 로고
    • Harnessing PD-L1-specific cytotoxic T cells for anti-leukemia immunotherapy to defeat mechanisms of immune escape mediated by the PD-1 pathway
    • S.M. Ahmad, and et al. Harnessing PD-L1-specific cytotoxic T cells for anti-leukemia immunotherapy to defeat mechanisms of immune escape mediated by the PD-1 pathway Leukemia 28 2014 236 238
    • (2014) Leukemia , vol.28 , pp. 236-238
    • Ahmad, S.M.1
  • 41
    • 84905375431 scopus 로고    scopus 로고
    • The stimulation of PD-L1-specific cytotoxic T lymphocytes can both directly and indirectly enhance antileukemic immunity
    • S.M. Ahmad, and et al. The stimulation of PD-L1-specific cytotoxic T lymphocytes can both directly and indirectly enhance antileukemic immunity Blood Cancer J. 4 2014 e230
    • (2014) Blood Cancer J. , vol.4 , pp. e230
    • Ahmad, S.M.1
  • 42
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • O. Hamid, and et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma N. Engl. J. Med. 369 2013 134 144
    • (2013) N. Engl. J. Med. , vol.369 , pp. 134-144
    • Hamid, O.1
  • 43
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
    • C. Robert, and et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial Lancet 6736 2014 1 9
    • (2014) Lancet , vol.6736 , pp. 1-9
    • Robert, C.1
  • 44
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • C. Robert, and et al. Pembrolizumab versus ipilimumab in advanced melanoma N. Engl. J. Med. 372 2015 2521 2532
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2521-2532
    • Robert, C.1
  • 45
    • 84928637112 scopus 로고    scopus 로고
    • A phase 1b study of pembrolizumab (Pembro; MK-3475) in patients (Pts) with advanced gastric cancer
    • K. Muro, and et al. A phase 1b study of pembrolizumab (Pembro; MK-3475) in patients (Pts) with advanced gastric cancer Ann. Oncol. 25 Suppl 4 2014 LBA15
    • (2014) Ann. Oncol. , vol.25 , pp. LBA15
    • Muro, K.1
  • 46
    • 84928637112 scopus 로고    scopus 로고
    • A phase 1b study of pembrolizumab (Pembro; MK-3475) in patients (Pts) with advanced urothelial tract cancer
    • E. Plimack, and et al. A phase 1b study of pembrolizumab (Pembro; MK-3475) in patients (Pts) with advanced urothelial tract cancer Ann. Oncol. 25 Suppl 4 2014 LBA23
    • (2014) Ann. Oncol. , vol.25 , pp. LBA23
    • Plimack, E.1
  • 47
    • 84920993558 scopus 로고    scopus 로고
    • A phase Ib study of pembrolizumab (Pembro; MK-3475) in patients (pts) with human papilloma virus (HPV)-positive and negative head and neck cancer (HNC)
    • L.Q.M. Chow, and et al. A phase Ib study of pembrolizumab (Pembro; MK-3475) in patients (pts) with human papilloma virus (HPV)-positive and negative head and neck cancer (HNC) Ann. Oncol. 25 Suppl 4 2014 LBA31
    • (2014) Ann. Oncol. , vol.25 , pp. LBA31
    • Chow, L.Q.M.1
  • 48
    • 84924907300 scopus 로고    scopus 로고
    • Antitumor activity of pembrolizumab (Pembro; MK-3475) and correlation with programmed death ligand 1 (PD-L1 expression in a pooled analysis of patients (pts) with advanced non-small cell lung carcinoma (NSCLC)
    • E. Garon, and et al. Antitumor activity of pembrolizumab (Pembro; MK-3475) and correlation with programmed death ligand 1 (PD-L1 expression in a pooled analysis of patients (pts) with advanced non-small cell lung carcinoma (NSCLC) Ann. Oncol. 25 Suppl. 4 2014 LBA43
    • (2014) Ann. Oncol. , vol.25 , pp. LBA43
    • Garon, E.1
  • 49
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • J.R. Brahmer, and et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates J. Clin. Oncol. 28 2010 3167 3175
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1
  • 50
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • S.L. Topalian, and et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N. Engl. J. Med. 366 2012 2443 2454
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2443-2454
    • Topalian, S.L.1
  • 51
    • 84892866206 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma
    • J.S. Weber, and et al. Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma J. Clin. Oncol. 31 2013 4311 4318
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4311-4318
    • Weber, J.S.1
  • 52
    • 84925221855 scopus 로고    scopus 로고
    • PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • S.M. Ansell, and et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma N. Engl. J. Med. 372 2015 311 319
    • (2015) N. Engl. J. Med. , vol.372 , pp. 311-319
    • Ansell, S.M.1
  • 53
    • 84929572937 scopus 로고    scopus 로고
    • Nivolumab for metastatic renal cell carcinoma: Results of a randomized phase II trial
    • R.J. Motzer, and et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial J. Clin. Oncol. 2014 10.1200/JCO.2014.59.0703
    • (2014) J. Clin. Oncol.
    • Motzer, R.J.1
  • 54
    • 84925622262 scopus 로고    scopus 로고
    • A phase 3 randomized, open-label study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus investigator's choice chemotherapy (ICC) in patients with advanced melanoma after prior anti-CTLA-4 therapy
    • J.S. Weber, and et al. A phase 3 randomized, open-label study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus investigator's choice chemotherapy (ICC) in patients with advanced melanoma after prior anti-CTLA-4 therapy Ann. Oncol. 25 Suppl 4 2014 LBA3
    • (2014) Ann. Oncol. , vol.25 , pp. LBA3
    • Weber, J.S.1
  • 55
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • C. Robert, and et al. Nivolumab in previously untreated melanoma without BRAF mutation N. Engl. J. Med. 372 2015 320 330
    • (2015) N. Engl. J. Med. , vol.372 , pp. 320-330
    • Robert, C.1
  • 56
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • J. Brahmer, and et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer N. Engl. J. Med. 2015 10.1056/NEJMoa1504627
    • (2015) N. Engl. J. Med.
    • Brahmer, J.1
  • 57
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • M.a. Curran, and et al. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors Proc. Natl. Acad. Sci. U. S. A. 107 2010 4275 4280
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 4275-4280
    • Curran, M.A.1
  • 58
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • J.D. Wolchok, and et al. Nivolumab plus ipilimumab in advanced melanoma N. Engl. J. Med. 369 2013 122 133
    • (2013) N. Engl. J. Med. , vol.369 , pp. 122-133
    • Wolchok, J.D.1
  • 59
    • 84907498833 scopus 로고    scopus 로고
    • Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in advanced melanoma (MEL)
    • M. Sznol, and et al. Survival, response duration, and activity by BRAF mutation (MT) status of nivolumab (NIVO, anti-PD-1, BMS-936558, ONO-4538) and ipilimumab (IPI) concurrent therapy in advanced melanoma (MEL) J. Clin. Oncol. 32 2014 LBA9003
    • (2014) J. Clin. Oncol. , vol.32 , pp. LBA9003
    • Sznol, M.1
  • 60
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • J. Larkin, and et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma N. Engl. J. Med. 373 2015 23 34
    • (2015) N. Engl. J. Med. , vol.373 , pp. 23-34
    • Larkin, J.1
  • 61
    • 84914148032 scopus 로고    scopus 로고
    • Phase i study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
    • H-J. Hammers, and et al. Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC) J. Clin. Oncol. 32 2014 4504
    • (2014) J. Clin. Oncol. , vol.32 , pp. 4504
    • Hammers, H.-J.1
  • 62
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase i results
    • S.J. Antonia, and et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results J. Clin. Oncol. 32 2014 8023
    • (2014) J. Clin. Oncol. , vol.32 , pp. 8023
    • Antonia, S.J.1
  • 63
    • 49649114804 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • R. Berger, and et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies Clin. Cancer Res. 14 2008 3044 3051
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3044-3051
    • Berger, R.1
  • 64
    • 84890096527 scopus 로고    scopus 로고
    • Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: Results of an international phase II trial
    • P. Armand, and et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial J. Clin. Oncol. 31 2013 4199 4206
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4199-4206
    • Armand, P.1
  • 65
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial
    • J.R. Westin, and et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial Lancet Oncol. 15 2014 69 77
    • (2014) Lancet Oncol. , vol.15 , pp. 69-77
    • Westin, J.R.1
  • 66
    • 84907613231 scopus 로고    scopus 로고
    • Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma
    • M. Atkins, and et al. Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma J. Clin. Oncol. 32 2014 9001
    • (2014) J. Clin. Oncol. , vol.32 , pp. 9001
    • Atkins, M.1
  • 67
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • J.R. Brahmer, and et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer N. Engl. J. Med. 366 2012 2455 2465
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1
  • 68
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • T. Powles, and et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer Nature 515 2014 558 562
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1
  • 69
    • 84937759727 scopus 로고    scopus 로고
    • The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma
    • K.M. Mahoney, and et al. The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma Clin. Ther. 37 2015 764 782
    • (2015) Clin. Ther. , vol.37 , pp. 764-782
    • Mahoney, K.M.1
  • 70
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • D.T. Le, and et al. PD-1 blockade in tumors with mismatch-repair deficiency N. Engl. J. Med. 372 2015 2509 2520
    • (2015) N. Engl. J. Med. , vol.372 , pp. 2509-2520
    • Le, D.T.1
  • 71
    • 84991030732 scopus 로고    scopus 로고
    • Rational combinations of immunotherapeutics that target discrete pathways
    • S. Spranger, and T. Gajewski Rational combinations of immunotherapeutics that target discrete pathways J. Immunother. Cancer 1 2013 16
    • (2013) J. Immunother. Cancer , vol.1 , pp. 16
    • Spranger, S.1    Gajewski, T.2
  • 72
    • 84977091096 scopus 로고    scopus 로고
    • Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy
    • S.J. Mandl, and et al. Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy J. Immunother. Cancer 2 2014 34
    • (2014) J. Immunother. Cancer , vol.2 , pp. 34
    • Mandl, S.J.1
  • 73
    • 79951820132 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators
    • R.B. Sørensen, and et al. Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators Blood 117 2011 2200 2210
    • (2011) Blood , vol.117 , pp. 2200-2210
    • Sørensen, R.B.1
  • 74
    • 84901598853 scopus 로고    scopus 로고
    • Accumulation of memory precursor CD8 T cells in regressing tumors following combination therapy with vaccine and anti-PD-1 antibody
    • L. Karyampudi, and et al. Accumulation of memory precursor CD8 T cells in regressing tumors following combination therapy with vaccine and anti-PD-1 antibody Cancer Res. 74 2015 2974 2985
    • (2015) Cancer Res. , vol.74 , pp. 2974-2985
    • Karyampudi, L.1
  • 75
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • S. Rosenberg, and et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy Clin. Cancer Res. 17 2011 4550 4557
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4550-4557
    • Rosenberg, S.1
  • 76
    • 84928587963 scopus 로고    scopus 로고
    • Achievements and challenges of adoptive T cell therapy with tumor-infiltrating or blood-derived lymphocytes for metastatic melanoma: What is needed to achieve standard of care?
    • I.M. Svane, and E.M. Verdegaal Achievements and challenges of adoptive T cell therapy with tumor-infiltrating or blood-derived lymphocytes for metastatic melanoma: what is needed to achieve standard of care? Cancer Immunol. Immunother. 63 2014 1081 1091
    • (2014) Cancer Immunol. Immunother. , vol.63 , pp. 1081-1091
    • Svane, I.M.1    Verdegaal, E.M.2
  • 77
    • 84899748384 scopus 로고    scopus 로고
    • PD-1 identifies the patient-specific infiltrating human tumors
    • A. Gros, and et al. PD-1 identifies the patient-specific infiltrating human tumors J. Clin. Invest. 124 2014 2246 2259
    • (2014) J. Clin. Invest. , vol.124 , pp. 2246-2259
    • Gros, A.1
  • 78
    • 84857789296 scopus 로고    scopus 로고
    • The secret ally: Immunostimulation by anticancer drugs
    • L. Galluzzi, and et al. The secret ally: immunostimulation by anticancer drugs Nat. Rev. Drug Discov. 11 2012 215 233
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 215-233
    • Galluzzi, L.1
  • 79
    • 84919475564 scopus 로고    scopus 로고
    • Combination of radiotherapy and immune checkpoint inhibitors
    • K.A. Pilones, and et al. Combination of radiotherapy and immune checkpoint inhibitors Semin. Radiat. Oncol. 25 2015 28 33
    • (2015) Semin. Radiat. Oncol. , vol.25 , pp. 28-33
    • Pilones, K.A.1
  • 80
    • 84877051042 scopus 로고    scopus 로고
    • Combining cancer immunotherapy and targeted therapy
    • A. Ribas, and J.D. Wolchok Combining cancer immunotherapy and targeted therapy Curr. Opin. Immunol. 25 2013 291 296
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 291-296
    • Ribas, A.1    Wolchok, J.D.2
  • 81
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of ipilimumab and vemurafenib
    • A. Ribas, and et al. Hepatotoxicity with combination of ipilimumab and vemurafenib N. Engl. J. Med. 368 2013 1365 1366
    • (2013) N. Engl. J. Med. , vol.368 , pp. 1365-1366
    • Ribas, A.1
  • 82
    • 84887862839 scopus 로고    scopus 로고
    • A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application
    • T. Okazaki, and et al. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application Nat. Immunol. 14 2013 1212 1218
    • (2013) Nat. Immunol. , vol.14 , pp. 1212-1218
    • Okazaki, T.1
  • 83
    • 84907532904 scopus 로고    scopus 로고
    • A phase 1 study of MEDI4736, an anti-PD-L1 antibody, in patients with advanced solid tumors
    • 2014 ASCO Annu. Meet. Abstr. 32, Abstract 3001
    • J. Lutzky, and S. Antonia A phase 1 study of MEDI4736, an anti-PD-L1 antibody, in patients with advanced solid tumors J. Clin. Oncol. 2014 2014 ASCO Annu. Meet. Abstr. 32, Abstract 3001
    • (2014) J. Clin. Oncol.
    • Lutzky, J.1    Antonia, S.2
  • 84
    • 84912134974 scopus 로고    scopus 로고
    • Phase i open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies
    • 2014 ASCO Annu. Meet. Abstr. 32, Abstract 3064
    • C. Heery, and et al. Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies J. Clin. Oncol. 2014 2014 ASCO Annu. Meet. Abstr. 32, Abstract 3064
    • (2014) J. Clin. Oncol.
    • Heery, C.1


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