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Volumn 8, Issue 2, 2015, Pages 110-122

Pharmacology of L-type calcium channels: Novel drugs for old targets?

Author keywords

Calcium homeostasis; Drug discovery L type channels; Neuropsychiatric disorders; Pharmacology; Voltage gated calcium channels

Indexed keywords

CALCIUM CHANNEL L TYPE; ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL BLOCKING AGENT; ISOPROTEIN; PROTEIN SUBUNIT;

EID: 84940998956     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467208666150507105845     Document Type: Review
Times cited : (101)

References (117)
  • 1
    • 29844439240 scopus 로고    scopus 로고
    • International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels
    • Catterall, W. A.; Perez-Reyes, E.; Snutch, T. P.; Striessnig, J. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol. Rev., 2005, 57(4), 411-425.
    • (2005) Pharmacol. Rev , vol.57 , Issue.4 , pp. 411-425
    • Catterall, W.A.1    Perez-Reyes, E.2    Snutch, T.P.3    Striessnig, J.4
  • 3
    • 84897470727 scopus 로고    scopus 로고
    • Neuronal voltage-gated calcium channels: Structure, function, and dysfunction
    • Simms, B. A.; Zamponi, G. W. Neuronal voltage-gated calcium channels: structure, function, and dysfunction. Neuron, 2014, 82(1), 24-45.
    • (2014) Neuron , vol.82 , Issue.1 , pp. 24-45
    • Simms, B.A.1    Zamponi, G.W.2
  • 4
    • 84862128440 scopus 로고    scopus 로고
    • Ca2+-dependent modulation of voltage-gated Ca2+ channels
    • Christel, C.; Lee, A. Ca2+-dependent modulation of voltage-gated Ca2+ channels. Biochim. Biophys. Acta, 2012, 1820(8), 1243-1252.
    • (2012) Biochim. Biophys. Acta , vol.1820 , Issue.8 , pp. 1243-1252
    • Christel, C.1    Lee, A.2
  • 5
    • 84876945146 scopus 로고    scopus 로고
    • The alpha2delta subunits of voltage-gated calcium channels
    • Dolphin, A. C. The alpha2delta subunits of voltage-gated calcium channels. Biochim. Biophys. Acta, 2013, 1828(7), 1541-1549.
    • (2013) Biochim. Biophys. Acta , vol.1828 , Issue.7 , pp. 1541-1549
    • Dolphin, A.C.1
  • 7
    • 58849166243 scopus 로고    scopus 로고
    • A Cav1. 1 Ca2+ channel splice variant with high conductance and voltage-sensitivity alters EC coupling in developing skeletal muscle
    • Tuluc, P.; Molenda, N.; Schlick, B.; Obermair, G. J.; Flucher, B. E.; Jurkat-Rott, K. A Cav1. 1 Ca2+ channel splice variant with high conductance and voltage-sensitivity alters EC coupling in developing skeletal muscle. Biophys J, 2009, 96(1), 35-44.
    • (2009) Biophys J , vol.96 , Issue.1 , pp. 35-44
    • Tuluc, P.1    Molenda, N.2    Schlick, B.3    Obermair, G.J.4    Flucher, B.E.5    Jurkat-Rott, K.6
  • 8
    • 55749094173 scopus 로고    scopus 로고
    • Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene knockout models
    • Striessnig, J.; Koschak, A. Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene knockout models. Channels(Austin), 2008, 2(4), 233-251.
    • (2008) Channels(Austin) , vol.2 , Issue.4 , pp. 233-251
    • Striessnig, J.1    Koschak, A.2
  • 10
    • 0035933830 scopus 로고    scopus 로고
    • EE1D (Cav1. 3) subunits can form L-type calcium channels activating at negative voltages
    • Koschak, A.; Reimer, D.; Huber, I.; Grabner, M.; Glossmann, H.; Engel, J.; Striessnig, J. EE1D (Cav1. 3) subunits can form L-type calcium channels activating at negative voltages. J. Biol. Chem., 2001, 276(25), 22100-22106.
    • (2001) J. Biol. Chem , vol.276 , Issue.25 , pp. 22100-22106
    • Koschak, A.1    Reimer, D.2    Huber, I.3    Grabner, M.4    Glossmann, H.5    Engel, J.6    Striessnig, J.7
  • 12
    • 50349096521 scopus 로고    scopus 로고
    • Genesis and regulation of the heart automaticity
    • Mangoni, M. E.; Nargeot, J. Genesis and regulation of the heart automaticity. Physiol. Rev., 2008, 88(3), 919-982.
    • (2008) Physiol. Rev , vol.88 , Issue.3 , pp. 919-982
    • Mangoni, M.E.1    Nargeot, J.2
  • 14
    • 84876935425 scopus 로고    scopus 로고
    • Cav1. 3 and Cav1. 2 channels of adrenal chromaffin cells: Emerging views on cAMP/cGMP-mediated phosphorylation and role in pacemaking
    • Vandael, D. H.; Mahapatra, S.; Calorio, C.; Marcantoni, A.; Carbone, E. Cav1. 3 and Cav1. 2 channels of adrenal chromaffin cells: Emerging views on cAMP/cGMP-mediated phosphorylation and role in pacemaking. Biochim. Biophys. Acta, 2013, 1828(7), 1608-1618.
    • (2013) Biochim. Biophys. Acta , vol.1828 , Issue.7 , pp. 1608-1618
    • Vandael, D.H.1    Mahapatra, S.2    Calorio, C.3    Marcantoni, A.4    Carbone, E.5
  • 15
    • 67650523964 scopus 로고    scopus 로고
    • Structural model for dihydropyridine binding to L-type calcium channels
    • Tikhonov, D. B.; Zhorov, B. S. Structural model for dihydropyridine binding to L-type calcium channels. J. Biol. Chem., 2009, 284(28), 19006-19017.
    • (2009) J. Biol. Chem , vol.284 , Issue.28 , pp. 19006-19017
    • Tikhonov, D.B.1    Zhorov, B.S.2
  • 17
    • 85007472048 scopus 로고    scopus 로고
    • The molecular basis of calcium antagonist drug action-recent developments
    • Zamponi, G.W., Ed.; Landes Biosciences
    • Striessnig, J.; Hoda, J. C.; Wappl, E.; Koschak, A. The molecular basis of calcium antagonist drug action-recent developments. In: Voltage-gated calciumm channels, Zamponi, G. W., Ed.; Landes Biosciences; 2005.
    • (2005) Voltage-gated calciumm channels
    • Striessnig, J.1    Hoda, J.C.2    Wappl, E.3    Koschak, A.4
  • 18
    • 0022551124 scopus 로고
    • Calcium channels in muscle cells isolated from rat mesenteric arteries: Modulation by dihydropyridine drugs
    • Bean, B. P.; Sturek, M.; Puga, A.; Hermsmeyer, K. Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs. Circ. Res., 1986, 59(2), 229-235.
    • (1986) Circ. Res , vol.59 , Issue.2 , pp. 229-235
    • Bean, B.P.1    Sturek, M.2    Puga, A.3    Hermsmeyer, K.4
  • 19
    • 0034892731 scopus 로고    scopus 로고
    • Voltage-dependent acceleration of Cav1. 2 channel current decay by (+)-and (-)-isradipine
    • Berjukow, S.; Hering, S. Voltage-dependent acceleration of Cav1. 2 channel current decay by (+)-and (-)-isradipine. Br. J. Pharmacol., 2001, 133(7), 959-966.
    • (2001) Br. J. Pharmacol , vol.133 , Issue.7 , pp. 959-966
    • Berjukow, S.1    Hering, S.2
  • 20
    • 0023119223 scopus 로고
    • A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes
    • Hamilton, S. L.; Yatani, A.; Brush, K.; Schwartz, A.; Brown, A. M. A comparison between the binding and electrophysiological effects of dihydropyridines on cardiac membranes. Mol. Pharmacol., 1987, 31(3), 221-231.
    • (1987) Mol. Pharmacol , vol.31 , Issue.3 , pp. 221-231
    • Hamilton, S.L.1    Yatani, A.2    Brush, K.3    Schwartz, A.4    Brown, A.M.5
  • 21
    • 33947532545 scopus 로고    scopus 로고
    • Probing the architecture of an L-type calcium channel with a charged phenylalkylamine: Evidence for a widely open pore and drug trapping
    • Beyl, S.; Timin, E. N.; Hohaus, A.; Stary, A.; Kudrnac, M.; Guy, R. H.; Hering, S. Probing the architecture of an L-type calcium channel with a charged phenylalkylamine: evidence for a widely open pore and drug trapping. J. Biol. Chem., 2007, 282(6), 3864-3870.
    • (2007) J. Biol. Chem , vol.282 , Issue.6 , pp. 3864-3870
    • Beyl, S.1    Timin, E.N.2    Hohaus, A.3    Stary, A.4    Kudrnac, M.5    Guy, R.H.6    Hering, S.7
  • 22
    • 0030725008 scopus 로고    scopus 로고
    • Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation
    • Hering, S.; Aczel, S.; Kraus, R. L.; Berjukow, S.; Striessnig, J.; Timin, E. N. Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation. Proc. Natl. Acad. Sci. USA, 1997, 94(24), 13323-13328.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , Issue.24 , pp. 13323-13328
    • Hering, S.1    Aczel, S.2    Kraus, R.L.3    Berjukow, S.4    Striessnig, J.5    Timin, E.N.6
  • 24
    • 0028032853 scopus 로고
    • Voltage window for sustained elevation of cytosolic calcium in smooth muscle cells
    • Fleischmann, B. K.; Murray, R. K.; Kotlikoff, M. I. Voltage window for sustained elevation of cytosolic calcium in smooth muscle cells. Proc. Natl. Acad. Sci. USA, 1994, 91(25), 11914-11918.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , Issue.25 , pp. 11914-11918
    • Fleischmann, B.K.1    Murray, R.K.2    Kotlikoff, M.I.3
  • 25
    • 74949101892 scopus 로고    scopus 로고
    • Loss of Cav1. 3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells
    • Marcantoni, A.; Vandael, D. H.; Mahapatra, S.; Carabelli, V.; Sinnegger-Brauns, M. J.; Striessnig, J.; Carbone, E. Loss of Cav1. 3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cells. J. Neurosci., 2010, 30(2), 491-504.
    • (2010) J. Neurosci , vol.30 , Issue.2 , pp. 491-504
    • Marcantoni, A.1    Vandael, D.H.2    Mahapatra, S.3    Carabelli, V.4    Sinnegger-Brauns, M.J.5    Striessnig, J.6    Carbone, E.7
  • 27
    • 84897400905 scopus 로고    scopus 로고
    • C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1. 3 Ltype calcium channels
    • Lieb, A.; Ortner, N.; Striessnig, J. C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1. 3 Ltype calcium channels. Biophys. J., 2014, 106(7), 1467-1475.
    • (2014) Biophys. J , vol.106 , Issue.7 , pp. 1467-1475
    • Lieb, A.1    Ortner, N.2    Striessnig, J.3
  • 28
    • 0035882358 scopus 로고    scopus 로고
    • Neuronal Cav1. 3111 L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines
    • Xu, W.; Lipscombe, D. Neuronal Cav1. 3111 L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J. Neurosci., 2001, 21(16), 5944-5951.
    • (2001) J. Neurosci , vol.21 , Issue.16 , pp. 5944-5951
    • Xu, W.1    Lipscombe, D.2
  • 29
    • 0027449168 scopus 로고
    • Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity
    • Welling, A.; Kwan, Y. W.; Bosse, E.; Flockerzi, V.; Hofmann, F.; Kass, R. S. Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity. Circ. Res., 1993, 73(5), 974-980.
    • (1993) Circ. Res , vol.73 , Issue.5 , pp. 974-980
    • Welling, A.1    Kwan, Y.W.2    Bosse, E.3    Flockerzi, V.4    Hofmann, F.5    Kass, R.S.6
  • 32
    • 0037444439 scopus 로고    scopus 로고
    • Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels
    • Oliver, D.; Knipper, M.; Derst, C.; Fakler, B.; Liberman, M. C.; Gao, J.; He, D. Z.; Wu, X.; Jia, S.; Zuo, J. Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels. J. Neurosci., 2003, 23(6), 2141-2149.
    • (2003) J. Neurosci , vol.23 , Issue.6 , pp. 2141-2149
    • Oliver, D.1    Knipper, M.2    Derst, C.3    Fakler, B.4    Liberman, M.C.5    Gao, J.6    He, D.Z.7    Wu, X.8    Jia, S.9    Zuo, J.10
  • 34
    • 0034616911 scopus 로고    scopus 로고
    • Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type calcium channels
    • Platzer, J.; Engel, J.; Schrott-Fischer, A.; Stephan, K.; Bova, S.; Chen, H.; Zheng, H.; Striessnig, J. Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type calcium channels. Cell, 2000, 102(1), 89-97.
    • (2000) Cell , vol.102 , Issue.1 , pp. 89-97
    • Platzer, J.1    Engel, J.2    Schrott-Fischer, A.3    Stephan, K.4    Bova, S.5    Chen, H.6    Zheng, H.7    Striessnig, J.8
  • 37
    • 82755176667 scopus 로고    scopus 로고
    • Functional characterization of alternative splicing in the C terminus of L-type CaV1. 3 channels
    • Tan, B. Z.; Jiang, F.; Tan, M. Y.; Yu, D.; Huang, H.; Shen, Y.; Soong, T. W. Functional characterization of alternative splicing in the C terminus of L-type CaV1. 3 channels. J. Biol. Chem., 2011, 286(49), 42725-42735.
    • (2011) J. Biol. Chem , vol.286 , Issue.49 , pp. 42725-42735
    • Tan, B.Z.1    Jiang, F.2    Tan, M.Y.3    Yu, D.4    Huang, H.5    Shen, Y.6    Soong, T.W.7
  • 39
    • 58149378251 scopus 로고    scopus 로고
    • Stable membrane expression of postsynaptic Cav1. 2 calcium channel clusters is independent of interactions with AKAP79/150 and PDZ proteins
    • Di Biase, V.; Obermair, G. J.; Szabo, Z.; Altier, C.; Sanguesa, J.; Bourinet, E.; Flucher, B. E. Stable membrane expression of postsynaptic Cav1. 2 calcium channel clusters is independent of interactions with AKAP79/150 and PDZ proteins. J. Neurosci., 2008, 28(51), 13845-13855.
    • (2008) J. Neurosci , vol.28 , Issue.51 , pp. 13845-13855
    • Di Biase, V.1    Obermair, G.J.2    Szabo, Z.3    Altier, C.4    Sanguesa, J.5    Bourinet, E.6    Flucher, B.E.7
  • 40
    • 77950974013 scopus 로고    scopus 로고
    • Ca2+-dependent facilitation of Cav1. 3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II
    • Jenkins, M. A.; Christel, C. J.; Jiao, Y.; Abiria, S.; Kim, K. Y.; Usachev, Y. M.; Obermair, G. J.; Colbran, R. J.; Lee, A. Ca2+-dependent facilitation of Cav1. 3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. J. Neurosci., 2010, 30(15), 5125-5135.
    • (2010) J. Neurosci , vol.30 , Issue.15 , pp. 5125-5135
    • Jenkins, M.A.1    Christel, C.J.2    Jiao, Y.3    Abiria, S.4    Kim, K.Y.5    Usachev, Y.M.6    Obermair, G.J.7    Colbran, R.J.8    Lee, A.9
  • 42
    • 38649118171 scopus 로고    scopus 로고
    • Conditional forebrain deletion of the L-type calcium channel Cav1. 2 disrupts remote spatial memories in mice
    • White, J. A.; McKinney, B. C.; John, M. C.; Powers, P. A.; Kamp, T. J.; Murphy, G. G. Conditional forebrain deletion of the L-type calcium channel Cav1. 2 disrupts remote spatial memories in mice. Learn. Mem., 2008, 15(1), 1-5.
    • (2008) Learn. Mem , vol.15 , Issue.1 , pp. 1-5
    • White, J.A.1    McKinney, B.C.2    John, M.C.3    Powers, P.A.4    Kamp, T.J.5    Murphy, G.G.6
  • 43
    • 33749368862 scopus 로고    scopus 로고
    • The L-Type voltage-gated calcium channel Cav1. 3 mediates consolidation, but not extinction, of contextually conditioned fear in mice
    • McKinney, B. C.; Murphy, G. G. The L-Type voltage-gated calcium channel Cav1. 3 mediates consolidation, but not extinction, of contextually conditioned fear in mice. Learn. Mem., 2006, 13(5), 584-589.
    • (2006) Learn. Mem , vol.13 , Issue.5 , pp. 584-589
    • McKinney, B.C.1    Murphy, G.G.2
  • 45
    • 69949090356 scopus 로고    scopus 로고
    • Impaired longterm potentiation and enhanced neuronal excitability in the amygdala of Cav1. 3 knockout mice
    • McKinney, B. C.; Sze, W.; Lee, B.; Murphy, G. G. Impaired longterm potentiation and enhanced neuronal excitability in the amygdala of Cav1. 3 knockout mice. Neurobiol. Learn. Mem., 2009, 92(4), 519-528.
    • (2009) Neurobiol. Learn. Mem , vol.92 , Issue.4 , pp. 519-528
    • McKinney, B.C.1    Sze, W.2    Lee, B.3    Murphy, G.G.4
  • 46
    • 77954117096 scopus 로고    scopus 로고
    • Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1. 2 calcium channels
    • Langwieser, N.; Christel, C. J.; Kleppisch, T.; Hofmann, F.; Wotjak, C. T.; Moosmang, S. Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1. 2 calcium channels. J. Neurosci., 2010, 30(25), 8367-8375.
    • (2010) J. Neurosci , vol.30 , Issue.25 , pp. 8367-8375
    • Langwieser, N.1    Christel, C.J.2    Kleppisch, T.3    Hofmann, F.4    Wotjak, C.T.5    Moosmang, S.6
  • 47
    • 77950188817 scopus 로고    scopus 로고
    • Observational fear learning involves affective pain system and Cav1. 2 Ca2+ channels in ACC
    • Jeon, D.; Kim, S.; Chetana, M.; Jo, D.; Ruley, H. E.; Lin, S. Y.; Rabah, D.; Kinet, J. P.; Shin, H. S. Observational fear learning involves affective pain system and Cav1. 2 Ca2+ channels in ACC. Nat. Neurosci., 2010, 13(4), 482-488.
    • (2010) Nat. Neurosci , vol.13 , Issue.4 , pp. 482-488
    • Jeon, D.1    Kim, S.2    Chetana, M.3    Jo, D.4    Ruley, H.E.5    Lin, S.Y.6    Rabah, D.7    Kinet, J.P.8    Shin, H.S.9
  • 51
    • 33646485933 scopus 로고    scopus 로고
    • Brain activation pattern induced by stimulation of L-type Ca2+-channels: Contribution of Cav1. 3 and Cav1. 2 isoforms
    • Hetzenauer, A.; Sinnegger-Brauns, M. J.; Striessnig, J.; Singewald, N. Brain activation pattern induced by stimulation of L-type Ca2+-channels: contribution of Cav1. 3 and Cav1. 2 isoforms. Neuroscience, 2006, 139(3), 1005-1015.
    • (2006) Neuroscience , vol.139 , Issue.3 , pp. 1005-1015
    • Hetzenauer, A.1    Sinnegger-Brauns, M.J.2    Striessnig, J.3    Singewald, N.4
  • 52
    • 78650325317 scopus 로고    scopus 로고
    • Molecular switch from L-type Cav1. 3 to Cav1. 2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity
    • Giordano, T. P.; Tropea, T. F.; Satpute, S. S.; Sinnegger-Brauns, M. J.; Striessnig, J.; Kosofsky, B. E.; Rajadhyaksha, A. M. Molecular switch from L-type Cav1. 3 to Cav1. 2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity. J. Neurosci., 2010, 30(50), 17051-17062.
    • (2010) J. Neurosci , vol.30 , Issue.50 , pp. 17051-17062
    • Giordano, T.P.1    Tropea, T.F.2    Satpute, S.S.3    Sinnegger-Brauns, M.J.4    Striessnig, J.5    Kosofsky, B.E.6    Rajadhyaksha, A.M.7
  • 54
    • 49449099337 scopus 로고    scopus 로고
    • Individual dopamine midbrain neurons: Functional diversity and flexibility in health and disease
    • Liss, B.; Roeper, J. Individual dopamine midbrain neurons: functional diversity and flexibility in health and disease. Brain Res. Rev., 2008, 58(2), 314-321.
    • (2008) Brain Res. Rev , vol.58 , Issue.2 , pp. 314-321
    • Liss, B.1    Roeper, J.2
  • 56
    • 79958204001 scopus 로고    scopus 로고
    • The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease
    • Ilijic, E.; Guzman, J. N.; Surmeier, D. J. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol. Dis., 2011, 43(2), 364-371.
    • (2011) Neurobiol. Dis , vol.43 , Issue.2 , pp. 364-371
    • Ilijic, E.1    Guzman, J.N.2    Surmeier, D.J.3
  • 58
    • 0030601952 scopus 로고    scopus 로고
    • 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridineinduced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level
    • Kupsch, A.; Sautter, J.; Schwarz, J.; Riederer, P.; Gerlach, M.; Oertel, W. H. 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridineinduced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level. Brain Res., 1996, 741(1-2), 185-196.
    • (1996) Brain Res , vol.741 , Issue.1-2 , pp. 185-196
    • Kupsch, A.1    Sautter, J.2    Schwarz, J.3    Riederer, P.4    Gerlach, M.5    Oertel, W.H.6
  • 59
    • 79952406815 scopus 로고    scopus 로고
    • The origins of oxidant stress in Parkinson's disease and therapeutic strategies
    • Surmeier, D. J.; Guzman, J. N.; Sanchez-Padilla, J.; Goldberg, J. A. The origins of oxidant stress in Parkinson's disease and therapeutic strategies. Antioxid. Redox. Signal., 2011, 14(7), 1289-1301.
    • (2011) Antioxid. Redox. Signal , vol.14 , Issue.7 , pp. 1289-1301
    • Surmeier, D.J.1    Guzman, J.N.2    Sanchez-Padilla, J.3    Goldberg, J.A.4
  • 60
    • 69749095203 scopus 로고    scopus 로고
    • Robust pacemaking in substantia nigra dopaminergic neurons
    • Guzman, J. N.; Sanchez-Padilla, J.; Chan, C. S.; Surmeier, D. J. Robust pacemaking in substantia nigra dopaminergic neurons. J. Neurosci., 2009, 29(35), 11011-11019.
    • (2009) J. Neurosci , vol.29 , Issue.35 , pp. 11011-11019
    • Guzman, J.N.1    Sanchez-Padilla, J.2    Chan, C.S.3    Surmeier, D.J.4
  • 61
    • 84911440425 scopus 로고    scopus 로고
    • Dopamine midbrain neurons in health and Parkinson's disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels
    • Dragicevic, E.; Schiemann, J.; Liss, B. Dopamine midbrain neurons in health and Parkinson's disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience, 2015, 284C, 798-814.
    • (2015) Neuroscience , vol.284 C , pp. 798-814
    • Dragicevic, E.1    Schiemann, J.2    Liss, B.3
  • 62
    • 71849099262 scopus 로고    scopus 로고
    • Cav1. 3 channel voltage dependence, not Ca2+ selectivity, drives pacemaker activity and amplifies bursts in nigral dopamine neurons
    • Putzier, I.; Kullmann, P. H.; Horn, J. P.; Levitan, E. S. Cav1. 3 channel voltage dependence, not Ca2+ selectivity, drives pacemaker activity and amplifies bursts in nigral dopamine neurons. J. Neurosci., 2009, 29(49), 15414-15419.
    • (2009) J. Neurosci , vol.29 , Issue.49 , pp. 15414-15419
    • Putzier, I.1    Kullmann, P.H.2    Horn, J.P.3    Levitan, E.S.4
  • 65
    • 84867616336 scopus 로고    scopus 로고
    • Synaptic refinement of an inhibitory topographic map in the auditory brainstem requires functional Cav1. 3 calcium channels
    • Hirtz, J. J.; Braun, N.; Griesemer, D.; Hannes, C.; Janz, K.; Lohrke, S.; Muller, B.; Friauf, E. Synaptic refinement of an inhibitory topographic map in the auditory brainstem requires functional Cav1. 3 calcium channels. J. Neurosci., 2012, 32(42), 14602-14616.
    • (2012) J. Neurosci , vol.32 , Issue.42 , pp. 14602-14616
    • Hirtz, J.J.1    Braun, N.2    Griesemer, D.3    Hannes, C.4    Janz, K.5    Lohrke, S.6    Muller, B.7    Friauf, E.8
  • 70
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet, 2013, 381(9875), 1371-1379.
    • (2013) Lancet , vol.381 , Issue.9875 , pp. 1371-1379
  • 75
    • 84891509120 scopus 로고    scopus 로고
    • L-Type CaV1. 2 Calcium Channels: From In vitro Findings to In vivo Function
    • Hofmann, F.; Flockerzi, V.; Kahl, S.; Wegener, J. W. L-Type CaV1. 2 Calcium Channels: From In vitro Findings to In vivo Function. Physiol. Rev., 2014, 94(1), 303-326.
    • (2014) Physiol. Rev , vol.94 , Issue.1 , pp. 303-326
    • Hofmann, F.1    Flockerzi, V.2    Kahl, S.3    Wegener, J.W.4
  • 76
    • 48249083049 scopus 로고    scopus 로고
    • Voltage-gated ion channels in human pancreatic beta-cells: Electrophysiological characterization and role in insulin secretion
    • Braun, M.; Ramracheya, R.; Bengtsson, M.; Zhang, Q.; Karanauskaite, J.; Partridge, C.; Johnson, P. R.; Rorsman, P. Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes, 2008, 57(6), 1618-1628.
    • (2008) Diabetes , vol.57 , Issue.6 , pp. 1618-1628
    • Braun, M.1    Ramracheya, R.2    Bengtsson, M.3    Zhang, Q.4    Karanauskaite, J.5    Partridge, C.6    Johnson, P.R.7    Rorsman, P.8
  • 77
    • 34548210908 scopus 로고    scopus 로고
    • Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil
    • Levine, M.; Boyer, E. W.; Pozner, C. N.; Geib, A. J.; Thomsen, T.; Mick, N.; Thomas, S. H. Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil. Crit. Care Med., 2007, 35(9), 2071-2075.
    • (2007) Crit. Care Med , vol.35 , Issue.9 , pp. 2071-2075
    • Levine, M.1    Boyer, E.W.2    Pozner, C.N.3    Geib, A.J.4    Thomsen, T.5    Mick, N.6    Thomas, S.H.7
  • 78
    • 84869032631 scopus 로고    scopus 로고
    • Cav1. 3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells
    • Vandael, D. H.; Zuccotti, A.; Striessnig, J.; Carbone, E. Cav1. 3-driven SK channel activation regulates pacemaking and spike frequency adaptation in mouse chromaffin cells. J. Neurosci., 2012, 32(46), 16345-16359.
    • (2012) J. Neurosci , vol.32 , Issue.46 , pp. 16345-16359
    • Vandael, D.H.1    Zuccotti, A.2    Striessnig, J.3    Carbone, E.4
  • 80
    • 84861799719 scopus 로고    scopus 로고
    • Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators
    • Hu, C.; Rusin, C. G.; Tan, Z.; Guagliardo, N. A.; Barrett, P. Q. Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators. J. Clin. Invest., 2012, 122(6), 2046-2053.
    • (2012) J. Clin. Invest , vol.122 , Issue.6 , pp. 2046-2053
    • Hu, C.1    Rusin, C.G.2    Tan, Z.3    Guagliardo, N.A.4    Barrett, P.Q.5
  • 81
    • 0345305811 scopus 로고    scopus 로고
    • Dominant role of smooth muscle L-type calcium channel Cav1. 2 for blood pressure regulation
    • Moosmang, S.; Schulla, V.; Welling, A.; Feil, R.; Feil, S.; Wegener, J. W.; Hofmann, F.; Klugbauer, N. Dominant role of smooth muscle L-type calcium channel Cav1. 2 for blood pressure regulation. EMBO J., 2003, 22(22), 6027-6034.
    • (2003) EMBO J , vol.22 , Issue.22 , pp. 6027-6034
    • Moosmang, S.1    Schulla, V.2    Welling, A.3    Feil, R.4    Feil, S.5    Wegener, J.W.6    Hofmann, F.7    Klugbauer, N.8
  • 84
    • 36849031680 scopus 로고    scopus 로고
    • A smooth muscle Cav1. 2 calcium channel splice variant underlies hyperpolarized window current and enhanced statedependent inhibition by nifedipine
    • Liao, P.; Yu, D.; Li, G.; Yong, T. F.; Soon, J. L.; Chua, Y. L.; Soong, T. W. A smooth muscle Cav1. 2 calcium channel splice variant underlies hyperpolarized window current and enhanced statedependent inhibition by nifedipine. J. Biol. Chem., 2007, 282(48), 35133-35142.
    • (2007) J. Biol. Chem , vol.282 , Issue.48 , pp. 35133-35142
    • Liao, P.1    Yu, D.2    Li, G.3    Yong, T.F.4    Soon, J.L.5    Chua, Y.L.6    Soong, T.W.7
  • 85
    • 84884686125 scopus 로고    scopus 로고
    • C-Terminal alternative splicing of CaV1. 3 channels distinctively modulates their dihydropyridine sensitivity
    • Huang, H.; Yu, D.; Soong, T. W. C-Terminal alternative splicing of CaV1. 3 channels distinctively modulates their dihydropyridine sensitivity. Mol. Pharmacol., 2013, 84(4), 643-653.
    • (2013) Mol. Pharmacol , vol.84 , Issue.4 , pp. 643-653
    • Huang, H.1    Yu, D.2    Soong, T.W.3
  • 86
    • 0030709297 scopus 로고    scopus 로고
    • Brain pharmacokinetics and in vivo receptor binding of 1, 4-dihydropyridine calcium channel antagonists
    • Uchida, S.; Yamada, S.; Nagai, K.; Deguchi, Y.; Kimura, R. Brain pharmacokinetics and in vivo receptor binding of 1, 4-dihydropyridine calcium channel antagonists. Life Sci., 1997, 61(21), 2083-2090.
    • (1997) Life Sci , vol.61 , Issue.21 , pp. 2083-2090
    • Uchida, S.1    Yamada, S.2    Nagai, K.3    Deguchi, Y.4    Kimura, R.5
  • 88
    • 27744563691 scopus 로고    scopus 로고
    • Neuronal L-type calcium channels open quickly and are inhibited slowly
    • Helton, T. D.; Xu, W.; Lipscombe, D. Neuronal L-type calcium channels open quickly and are inhibited slowly. J. Neurosci., 2005, 25(44), 10247-10251.
    • (2005) J. Neurosci , vol.25 , Issue.44 , pp. 10247-10251
    • Helton, T.D.1    Xu, W.2    Lipscombe, D.3
  • 89
    • 77951857283 scopus 로고    scopus 로고
    • Ltype voltage-gated calcium channels: A single molecular switch for long-term potentiation/long-term depression-like plasticity and activity-dependent metaplasticity in humans
    • Wankerl, K.; Weise, D.; Gentner, R.; Rumpf, J. J.; Classen, J. Ltype voltage-gated calcium channels: a single molecular switch for long-term potentiation/long-term depression-like plasticity and activity-dependent metaplasticity in humans. J. Neurosci., 2010, 30(18), 6197-6204.
    • (2010) J. Neurosci , vol.30 , Issue.18 , pp. 6197-6204
    • Wankerl, K.1    Weise, D.2    Gentner, R.3    Rumpf, J.J.4    Classen, J.5
  • 90
    • 43049090484 scopus 로고    scopus 로고
    • Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response
    • Waltereit, R.; Mannhardt, S.; Nescholta, S.; Maser-Gluth, C.; Bartsch, D. Selective and protracted effect of nifedipine on fear memory extinction correlates with induced stress response. Learn. Mem., 2008, 15(5), 348-356.
    • (2008) Learn. Mem , vol.15 , Issue.5 , pp. 348-356
    • Waltereit, R.1    Mannhardt, S.2    Nescholta, S.3    Maser-Gluth, C.4    Bartsch, D.5
  • 91
    • 43049138816 scopus 로고    scopus 로고
    • L-type voltage-gated calcium channels in conditioned fear: A genetic and pharmacological analysis
    • McKinney, B. C.; Sze, W.; White, J. A.; Murphy, G. G. L-type voltage-gated calcium channels in conditioned fear: a genetic and pharmacological analysis. Learn. Mem., 2008, 15(5), 326-334.
    • (2008) Learn. Mem , vol.15 , Issue.5 , pp. 326-334
    • McKinney, B.C.1    Sze, W.2    White, J.A.3    Murphy, G.G.4
  • 92
    • 84887625913 scopus 로고    scopus 로고
    • Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson's disease (STEADY-PD)
    • Group, P. S. Phase II safety, tolerability, and dose selection study of isradipine as a potential disease-modifying intervention in early Parkinson's disease (STEADY-PD). Mov. Disord., 2013, 28(13), 1823-1831.
    • (2013) Mov. Disord , vol.28 , Issue.13 , pp. 1823-1831
    • Group, P.S.1
  • 93
    • 77951735527 scopus 로고    scopus 로고
    • L-type calcium channel blockers and Parkinson disease in Denmark
    • Ritz, B.; Rhodes, S. L.; Qian, L.; Schernhammer, E.; Olsen, J. H.; Friis, S. L-type calcium channel blockers and Parkinson disease in Denmark. Ann Neurol, 2010, 67(5), 600-606.
    • (2010) Ann Neurol , vol.67 , Issue.5 , pp. 600-606
    • Ritz, B.1    Rhodes, S.L.2    Qian, L.3    Schernhammer, E.4    Olsen, J.H.5    Friis, S.6
  • 94
    • 42049114453 scopus 로고    scopus 로고
    • Use of antihypertensives and the risk of Parkinson disease
    • Becker, C.; Jick, S. S.; Meier, C. R. Use of antihypertensives and the risk of Parkinson disease. Neurology, 2008, 70(16 Pt. 2), 1438-1444.
    • (2008) Neurology , vol.70 , Issue.16 , pp. 1438-1444
    • Becker, C.1    Jick, S.S.2    Meier, C.R.3
  • 98
    • 84872742484 scopus 로고    scopus 로고
    • Exploring the dominant role of Cav1 channels in signalling to the nucleus
    • Ma, H.; Cohen, S.; Li, B.; Tsien, R. W. Exploring the dominant role of Cav1 channels in signalling to the nucleus. Biosci. Rep., 2013, 33(1), 97-101.
    • (2013) Biosci. Rep , vol.33 , Issue.1 , pp. 97-101
    • Ma, H.1    Cohen, S.2    Li, B.3    Tsien, R.W.4
  • 101
    • 0032758961 scopus 로고    scopus 로고
    • Calcium channel blockers in psychiatric disorders: A review of the literature
    • Hollister, L. E.; Trevino, E. S. Calcium channel blockers in psychiatric disorders: a review of the literature. Can. J. Psychiatry, 1999, 44(7), 658-664.
    • (1999) Can. J. Psychiatry , vol.44 , Issue.7 , pp. 658-664
    • Hollister, L.E.1    Trevino, E.S.2
  • 102
    • 84878876322 scopus 로고    scopus 로고
    • Temperature-sensitive Cav1. 2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures
    • Radzicki, D.; Yau, H. J.; Pollema-Mays, S. L.; Mlsna, L.; Cho, K.; Koh, S.; Martina, M. Temperature-sensitive Cav1. 2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures. J. Neurosci., 2013, 33(24), 9920-9931.
    • (2013) J. Neurosci , vol.33 , Issue.24 , pp. 9920-9931
    • Radzicki, D.1    Yau, H.J.2    Pollema-Mays, S.L.3    Mlsna, L.4    Cho, K.5    Koh, S.6    Martina, M.7
  • 103
    • 0021884844 scopus 로고
    • Human red-blood-cell calcium-antagonist binding sites
    • Striessnig, J.; Zernig, G.; Glossmann, H. Human red-blood-cell calcium-antagonist binding sites. Eur. J. Biochem., 1985, 150, 67-77.
    • (1985) Eur. J. Biochem , vol.150 , pp. 67-77
    • Striessnig, J.1    Zernig, G.2    Glossmann, H.3
  • 104
    • 77956618692 scopus 로고    scopus 로고
    • Heart rate as a risk factor in chronic heart failure (SHIFT): The association between heart rate and outcomes in a randomised placebo-controlled trial
    • Bohm, M.; Swedberg, K.; Komajda, M.; Borer, J. S.; Ford, I.; Dubost-Brama, A.; Lerebours, G.; Tavazzi, L.; Investigators, S. Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial. Lancet, 2010, 376(9744), 886-894.
    • (2010) Lancet , vol.376 , Issue.9744 , pp. 886-894
    • Bohm, M.1    Swedberg, K.2    Komajda, M.3    Borer, J.S.4    Ford, I.5    Dubost-Brama, A.6    Lerebours, G.7    Tavazzi, L.8    Investigators, S.9
  • 105
    • 0037123934 scopus 로고    scopus 로고
    • Functional Roles of Cav1. 3 (alpha1D) calcium channel in sinoatrial nodes: Insight gained using gene-targeted null mutant mice
    • Zhang, Z.; Xu, Y.; Song, H.; Rodriguez, J.; Tuteja, D.; Namkung, Y.; Shin, H. S.; Chiamvimonvat, N. Functional Roles of Cav1. 3 (alpha1D) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ. Res., 2002, 90(9), 981-987.
    • (2002) Circ. Res , vol.90 , Issue.9 , pp. 981-987
    • Zhang, Z.1    Xu, Y.2    Song, H.3    Rodriguez, J.4    Tuteja, D.5    Namkung, Y.6    Shin, H.S.7    Chiamvimonvat, N.8
  • 106
    • 84907030784 scopus 로고    scopus 로고
    • Atrial fibrillation associated with ivabradine treatment: Meta-analysis of randomised controlled trials
    • Martin, R. I.; Pogoryelova, O.; Koref, M. S.; Bourke, J. P.; Teare, M. D.; Keavney, B. D. Atrial fibrillation associated with ivabradine treatment: meta-analysis of randomised controlled trials. Heart, 2014, 100(19), 1506-1510.
    • (2014) Heart , vol.100 , Issue.19 , pp. 1506-1510
    • Martin, R.I.1    Pogoryelova, O.2    Koref, M.S.3    Bourke, J.P.4    Teare, M.D.5    Keavney, B.D.6
  • 108
    • 47649124455 scopus 로고    scopus 로고
    • Verapamil-sustained release-based treatment strategy is equivalent to atenolol-based treatment strategy at reducing cardiovascular events in patients with prior myocardial infarction: An INternational VErapamil SR-Trandolapril (INVEST) substudy
    • Bangalore, S.; Messerli, F. H.; Cohen, J. D.; Bacher, P. H.; Sleight, P.; Mancia, G.; Kowey, P.; Zhou, Q.; Champion, A.; Pepine, C. J.; Investigators, I. Verapamil-sustained release-based treatment strategy is equivalent to atenolol-based treatment strategy at reducing cardiovascular events in patients with prior myocardial infarction: an INternational VErapamil SR-Trandolapril (INVEST) substudy. Am. Heart J., 2008, 156(2), 241-247.
    • (2008) Am. Heart J , vol.156 , Issue.2 , pp. 241-247
    • Bangalore, S.1    Messerli, F.H.2    Cohen, J.D.3    Bacher, P.H.4    Sleight, P.5    Mancia, G.6    Kowey, P.7    Zhou, Q.8    Champion, A.9    Pepine, C.J.10    Investigators, I.11
  • 110
    • 0030792754 scopus 로고    scopus 로고
    • Alternatively spliced IS6 segments of the alpha 1C gene determine the tissue-specific dihydropyridine sensitivity of cardiac and vascular smooth muscle L-type Calcium channels
    • Welling, A.; Ludwig, A.; Zimmer, S.; Klugbauer, N.; Flockerzi, V.; Hofmann, F. Alternatively spliced IS6 segments of the alpha 1C gene determine the tissue-specific dihydropyridine sensitivity of cardiac and vascular smooth muscle L-type Calcium channels. Circ. Res., 1997, 81(4), 526-532.
    • (1997) Circ. Res , vol.81 , Issue.4 , pp. 526-532
    • Welling, A.1    Ludwig, A.2    Zimmer, S.3    Klugbauer, N.4    Flockerzi, V.5    Hofmann, F.6
  • 111
    • 84869409550 scopus 로고    scopus 로고
    • CaV1. 3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease
    • Kang, S.; Cooper, G.; Dunne, S. F.; Dusel, B.; Luan, C. H.; Surmeier, D. J.; Silverman, R. B. CaV1. 3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nat. Commun., 2012, 3, 1146.
    • (2012) Nat. Commun , vol.3 , pp. 1146
    • Kang, S.1    Cooper, G.2    Dunne, S.F.3    Dusel, B.4    Luan, C.H.5    Surmeier, D.J.6    Silverman, R.B.7
  • 112
    • 84879049515 scopus 로고    scopus 로고
    • Structure-activity relationship of N, N'-disubstituted pyrimidinetriones as Ca(V)1. 3 calcium channelselective antagonists for Parkinson's disease
    • Kang, S.; Cooper, G.; Dunne, S. F.; Luan, C. H.; Surmeier, D. J.; Silverman, R. B. Structure-activity relationship of N, N'-disubstituted pyrimidinetriones as Ca(V)1. 3 calcium channelselective antagonists for Parkinson's disease. J. Med. Chem., 2013, 56(11), 4786-4797.
    • (2013) J. Med. Chem , vol.56 , Issue.11 , pp. 4786-4797
    • Kang, S.1    Cooper, G.2    Dunne, S.F.3    Luan, C.H.4    Surmeier, D.J.5    Silverman, R.B.6
  • 113
    • 84905053934 scopus 로고    scopus 로고
    • Modest Cav1. 342-selective inhibition by compound 8 is betasubunit dependent
    • Huang, H.; Ng, C. Y.; Yu, D.; Zhai, J.; Lam, Y.; Soong, T. W. Modest Cav1. 342-selective inhibition by compound 8 is betasubunit dependent. Nat. Commun., 2014, 5, 4481.
    • (2014) Nat. Commun , vol.5 , pp. 4481
    • Huang, H.1    Ng, C.Y.2    Yu, D.3    Zhai, J.4    Lam, Y.5    Soong, T.W.6
  • 115
    • 57449121882 scopus 로고    scopus 로고
    • Getting into the brain: Approaches to enhance brain drug delivery
    • Patel, M. M.; Goyal, B. R.; Bhadada, S. V.; Bhatt, J. S.; Amin, A. F. Getting into the brain: approaches to enhance brain drug delivery. CNS Drugs, 2009, 23(1), 35-58.
    • (2009) CNS Drugs , vol.23 , Issue.1 , pp. 35-58
    • Patel, M.M.1    Goyal, B.R.2    Bhadada, S.V.3    Bhatt, J.S.4    Amin, A.F.5
  • 116
    • 84900411054 scopus 로고    scopus 로고
    • Current approaches to enhance CNS delivery of drugs across the brain barriers
    • Lu, C. T.; Zhao, Y. Z.; Wong, H. L.; Cai, J.; Peng, L.; Tian, X. Q. Current approaches to enhance CNS delivery of drugs across the brain barriers. Int. J. Nanomedicine, 2014, 9, 2241-2257.
    • (2014) Int. J. Nanomedicine , vol.9 , pp. 2241-2257
    • Lu, C.T.1    Zhao, Y.Z.2    Wong, H.L.3    Cai, J.4    Peng, L.5    Tian, X.Q.6
  • 117
    • 0029801112 scopus 로고    scopus 로고
    • Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system
    • Yiu, S.; Knaus, E. E. Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J. Med. Chem., 1996, 39(23), 4576-4582.
    • (1996) J. Med. Chem , vol.39 , Issue.23 , pp. 4576-4582
    • Yiu, S.1    Knaus, E.E.2


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