Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3

Journal of Biological Chemistry

Volumn 290, Issue 8, 2015, Pages 4663-4676

  Lu, Ling ^a,d   Sirish, Padmini ^a   Zhang, Zheng ^a   Woltz, Ryan L ^a   Li, Ning ^a   Timofeyev, Valeriy ^a   Knowlton, Anne A ^a,b   Zhang, Xiao Dong ^a   Yamoah, Ebenezer N ^c   Chiamvimonvat, Nipavan ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^d NANJING NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM;

GENE TRANSCRIPTIONS; L-TYPE CALCIUM CHANNELS;

TRANSCRIPTION;

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL L TYPE CAV1.3; MYOSIN LIGHT CHAIN 2; UNCLASSIFIED DRUG; ALPHA1D (CAV1.3) L-TYPE CALCIUM CHANNEL, HUMAN; CACNA1D PROTEIN, MOUSE; CARDIAC MYOSIN; MYOSIN LIGHT CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATRIAL FIBRILLATION; BIOASSAY; CARBOXY TERMINAL SEQUENCE; CELL FRACTIONATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE SILENCING; GENE TRANSFER; GENETIC TRANSCRIPTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; MOLECULAR CLONING; MOLECULAR INTERACTION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION; VIRAL GENE DELIVERY SYSTEM; WHOLE CELL PATCH CLAMP; ACTIVE TRANSPORT; ANIMAL; BIOSYNTHESIS; CARDIAC MUSCLE CELL; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEART ATRIUM; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CARDIAC MYOSINS; CELL NUCLEUS; GENE EXPRESSION REGULATION; HEART ATRIA; HUMANS; MICE; MICE, KNOCKOUT; MYOCYTES, CARDIAC; MYOSIN LIGHT CHAINS; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION, GENETIC;

EID: 84929008602     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.586883     Document Type: Article

References (58)

1. v1.3 (α1D) calcium channels in atria: insights gained from gene-targeted null mutant mice. Circulation 112, 1936-1944
2. v1.3 (α1D) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ. Res. 90, 981-987
3. + Channel in atrioventricular node automaticity. J. Mol. Cell. Cardiol. 50, 194-202
4. + channels. Cell 102, 89-97
5. + channels in cardiac pacemaker activity. Proc. Natl. Acad. Sci. U.S.A. 100, 5543-5548
6. v1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness. Nat. Neurosci. 14, 77-84
7. Cunha, S. R., Hund, T. J., Hashemi, S., Voigt, N., Li, N., Wright, P., Koval, O., Li, J., Gudmundsson, H., Gumina, R. J., Karck, M., Schott, J. J., Probst, V., Le Marec, H., Anderson, M. E., Dobrev, D., Wehrens, X. H., and Mohler, P. J. (2011) Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation 124, 1212-1222
8. + channel in human and mouse hearts. J. Biol. Chem. 278, 49085-49094
9. + channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 289, H2714-H2723
10. + channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels. Circ. Res. 107, 851-859
11. + channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J. Physiol. 587, 1087-1100
12. + channel in atrioventricular nodes. Circ. Res. 102, 465-471
13. Ozgen, N., Dun, W., Sosunov, E. A., Anyukhovsky, E. P., Hirose, M., Duffy, H. S., Boyden, P. A., and Rosen, M. R. (2007) Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites. Cardiovasc. Res. 75, 758-769
14. + channels terminates and protects against atrial fibrillation. Circ. Arrhythm Electrophysiol. 3, 380-390
15. Chua, S. K., Chang, P. C., Maruyama, M., Turker, I., Shinohara, T., Shen, M. J., Chen, Z., Shen, C., Rubart-von der Lohe, M., Lopshire, J. C., Ogawa, M., Weiss, J. N., Lin, S. F., Ai, T., and Chen, P. S. (2011) Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles. Circ. Res. 108, 971-979
16. Ellinor, P. T., Lunetta, K. L., Glazer, N. L., Pfeufer, A., Alonso, A., Chung, M. K., Sinner, M. F., de Bakker, P. I., Mueller, M., Lubitz, S. A., Fox, E., Darbar, D., Smith, N. L., Smith, J. D., Schnabel, R. B., Soliman, E. Z., Rice, K. M., Van Wagoner, D. R., Beckmann, B. M., van Noord, C., Wang, K., Ehret, G. B., Rotter, J. I., Hazen, S. L., Steinbeck, G., Smith, A. V., Launer, L. J., Harris, T. B., Makino, S., Nelis, M., Milan, D. J., Perz, S., Esko, T., Köttgen, A., Moebus, S., Newton-Cheh, C., Li, M., Möhlenkamp, S., Wang, T. J., Kao, W. H., Vasan, R. S., Nöthen, M. M., MacRae, C. A., Stricker, B. H., Hofman, A., Uitterlinden, A. G., Levy, D., Boerwinkle, E., Metspalu, A., Topol, E. J., Chakravarti, A., Gudnason, V., Psaty, B. M., Roden, D. M., Meitinger, T., Wichmann, H. E., Witteman, J. C., Barnard, J., Arking, D. E., Benjamin, E. J., Heckbert, S. R., and Kaab, S. (2010) Common variants in KCNN3 are associated with lone atrial fibrillation. Nat. Genet. 42, 240-244
17. + channels via β-actinin2. Circ. Res. 100, 112-120
18. + channel (SK2 channel). Proc. Natl. Acad. Sci. U.S.A. 106, 18402-18407
19. + channel α(1D) subunit in postnatal pancreatic beta cell generation. J. Clin. Invest. 108, 1015-1022
20. + channel expression and activity: novel insights from genetically altered mice. J. Physiol. 562, 745-758
21. +-activated potassium channels. J. Neurosci. 19, 8830-8838
22. Sirish, P., López, J. E., Li, N., Wong, A., Timofeyev, V., Young, J. N., Majdi, M., Li, R. A., Chen, H. S., and Chiamvimonvat, N. (2012) MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts. J. Mol. Cell Cardiol. 52, 264-272
23. Kikuchi, K., McDonald, A. D., Sasano, T., and Donahue, J. K. (2005) Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer. Circulation 111, 264-270
24. Hamill, O. P., Marty, A., Neher, E., Sakmann, B., and Sigworth, F. J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391, 85-100
25. V1.2 encodes a transcription factor. Cell 127, 591-606
26. Gomez-Ospina, N., Panagiotakos, G., Portmann, T., Pasca, S. P., Rabah, D., Budzillo, A., Kinet, J. P., and Dolmetsch, R. E. (2013) A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT. PLoS One 8, e60526
27. + (SK2) channel. Proc. Natl. Acad. Sci. U.S.A. 111, 9989-9994
28. + channels: role in channel function. Trends Neurosci. 21, 148-154
29. Ertel, E. A., Campbell, K. P., Harpold, M. M., Hofmann, F., Mori, Y., Perez-Reyes, E., Schwartz, A., Snutch, T. P., Tanabe, T., Birnbaumer, L., Tsien, R. W., and Catterall, W. A. (2000) Nomenclature of voltage-gated calcium channels. Neuron 25, 533-535
30. Ellinor, P. T., Zhang, J. F., Randall, A. D., Zhou, M., Schwarz, T. L., Tsien, R. W., and Horne, W. A. (1993) Functional expression of a rapidly inactivating neuronal calcium channel. Nature 363, 455-458
31. Fox, A. P., Nowycky, M. C., and Tsien, R. W. (1987) Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J. Physiol. 394, 149-172
32. Usowicz, M. M., Sugimori, M., Cherksey, B., and Llinás, R. (1992) P-type calcium channels in the somata and dendrites of adult cerebellar Purkinje cells. Neuron 9, 1185-1199
33. + channels. J. Biol. Chem. 267, 1403-1406
34. + channel mRNAs. J. Mol. Cell. Cardiol. 29, 3035-3042
35. + channels activating at negative voltages. J. Biol. Chem. 276, 22100-22106
36. Lipscombe, D., Helton, T. D., and Xu, W. (2004) L-type calcium channels: the low down. J. Neurophysiol. 92, 2633-2641
37. + channels is dependent on a Shank-binding domain. J. Neurosci. 25, 1050-1062
38. Dolmetsch, R. (2003) Excitation-transcription coupling: signaling by ion channels to the nucleus. Sci STKE 2003, PE4
39. Dolmetsch, R. E., Pajvani, U., Fife, K., Spotts, J. M., and Greenberg, M. E. (2001) Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science 294, 333-339
40. West, A. E., Chen, W. G., Dalva, M. B., Dolmetsch, R. E., Kornhauser, J. M., Shaywitz, A. J., Takasu, M. A., Tao, X., and Greenberg, M. E. (2001) Calcium regulation of neuronal gene expression. Proc. Natl. Acad. Sci. U.S.A. 98, 11024-11031
41. Graef, I. A., Mermelstein, P. G., Stankunas, K., Neilson, J. R., Deisseroth, K., Tsien, R. W., and Crabtree, G. R. (1999) L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature 401, 703-708
42. Mao, Z., Bonni, A., Xia, F., Nadal-Vicens, M., and Greenberg, M. E. (1999) Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science 286, 785-790
43. Sheng, M., McFadden, G., and Greenberg, M. E. (1990) Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron 4, 571-582
44. Hardingham, G. E., Arnold, F. J., and Bading, H. (2001) Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat. Neurosci. 4, 261-267
45. Schroder, E., Byse, M., and Satin, J. (2009) L-type calcium channel C terminus autoregulates transcription. Circ. Res. 104, 1373-1381
46. V1.1 channels in skeletal muscle. Proc. Natl. Acad. Sci. U.S.A. 102, 5274-5279
47. V1.2 channel by its proteolytically processed distal C-terminal domain. J. Physiol. 576, 87-102
48. Hell, J. W., Westenbroek, R. E., Warner, C., Ahlijanian, M. K., Prystay, W., Gilbert, M. M., Snutch, T. P., and Catterall, W. A. (1993) Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel α1 subunits. J. Cell Biol. 123, 949-962
49. Kubodera, T., Yokota, T., Ohwada, K., Ishikawa, K., Miura, H., Matsuoka, T., and Mizusawa, H. (2003) Proteolytic cleavage and cellular toxicity of the human α1A calcium channel in spinocerebellar ataxia type 6. Neurosci. Lett. 341, 74-78
50. Westenbroek, R. E., Hell, J. W., Warner, C., Dubel, S. J., Snutch, T. P., and Catterall, W. A. (1992) Biochemical properties and subcellular distribution of an N-type calcium channel α1 subunit. Neuron 9, 1099-1115
51. + channel α1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity. Hum. Mol. Genet. 15, 1587-1599
52. Köhler, M., Hirschberg, B., Bond, C. T., Kinzie, J. M., Marrion, N. V., Maylie, J., and Adelman, J. P. (1996) Small-conductance, calcium-activated potassium channels from mammalian brain. Science 273, 1709-1714
53. Shmukler, B. E., Bond, C. T., Wilhelm, S., Bruening-Wright, A., Maylie, J., Adelman, J. P., and Alper, S. L. (2001) Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Biochim. Biophys. Acta 1518, 36-46
54. + channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system. Mol. Cell. Neurosci. 15, 476-493
55. Vergara, C., Latorre, R., Marrion, N. V., and Adelman, J. P. (1998) Calcium-activated potassium channels. Curr. Opin. Neurobiol. 8, 321-329
56. Rimini, R., Rimland, J. M., and Terstappen, G. C. (2000) Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain. Brain Res. Mol. Brain Res. 85, 218-220
57. Ishii, T. M., Maylie, J., and Adelman, J. P. (1997) Determinants of apamin and D-tubocurarine block in SK potassium channels. J. Biol. Chem. 272, 23195-23200
58. + channels stably expressed in HEK 293 cells. Br. J. Pharmacol. 129, 991-999