Interaction of diltiazem with an intracellularly accessible binding site on Ca V1.2

British Journal of Pharmacology

Volumn 162, Issue 5, 2011, Pages 1074-1082

  Shabbir, W ^a   Beyl, S ^a   Timin, E N ^a   Schellmann, D ^a   Erker, T ^a   Hohaus, A ^a   Hockerman, G H ^b   Hering, S ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b PURDUE UNIVERSITY   (United States)

Author keywords

binding pocket; calcium antagonists; calcium channels; quaternary diltiazem; use dependent block

Indexed keywords

BARIUM; CALCIUM CHANNEL; CALCIUM CHANNEL CAV1.2; DILTIAZEM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN; CELL STRAIN TSA 201; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG SENSITIVITY; DRUG SYNTHESIS; EXTRACELLULAR SPACE; GENE; GENE MUTATION; HUMAN; HUMAN CELL; IIIS6 GENE; IVS6 GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHOLE CELL;

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL LINE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DILTIAZEM; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ION CHANNEL GATING; KINETICS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; RECOMBINANT PROTEINS;

EID: 79551504501     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01091.x     Document Type: Article

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