L-type voltage-gated calcium channels in conditioned fear: A genetic and pharmacological analysis

Learning and Memory

Volumn 15, Issue 5, 2008, Pages 326-334

  McKinney, Brandon C ^a,b   Sze, Wilson ^c   White, Jessica A ^c   Murphy, Geoffrey G ^b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; NIFEDIPINE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVERSIVE BEHAVIOR; CONDITIONING; CONTROLLED STUDY; FEAR; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; LOCOMOTION; MALE; MEMORY CONSOLIDATION; MOLECULAR GENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMYGDALA; ANIMALS; ASSOCIATION LEARNING; AVOIDANCE LEARNING; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CONDITIONING, CLASSICAL; EXTINCTION, PSYCHOLOGICAL; FEAR; GENOTYPE; IMMUNOBLOTTING; LOCOMOTION; MICE; MICE, KNOCKOUT; NIFEDIPINE; RETENTION (PSYCHOLOGY); TASTE;

EID: 43049138816     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.893808     Document Type: Article

References (22)

1. Bauer, E.P., Schafe, G.E., and LeDoux, J.E. 2002. NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. J. Neurosci. 22: 5239-5249.
2. Cain, C.K., Blouin, A.M., and Barad, M. 2002. L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice. J. Neurosci. 22: 9113-9121.
3. Cain, C.K., Godsil, B.P., Jami, S., and Barad, M. 2005. The L-type calcium channel blocker nifedipine impairs extinction, but not reduced contingency effects, in mice. Learn. Mem. 12: 277-284.
4. Chen, A.P., Ohno, M., Giese, K.P., Kühn, R., Chen, R.L., and Silva, A.J. 2006. Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J. Neurosci. Res. 83: 28-38.
5. Delgado, M.R., Olsson, A., and Phelps, E.A. 2006. Extending animal models of fear conditioning to humans. Biol. Psychol. 73: 39-48.
6. Fanselow, M.S. and Poulos, A.M. 2005. The neuroscience of mammalian associative learning. Annu. Rev. Psychol. 56: 207-234.
7. Hell, J., Westenbroek, R., Warner, C., Ahlijanian, M., Prystay, W., Gilbert, M., Snutch, T., and Catterall, W. 1993. Identification and differential subcellular localization of the neuronal class C and class D L-type calcium channel 1 subunits. J. Cell Biol. 123: 949-962.
8. Helton, T.D., Xu, W., and Lipscombe, D. 2005. Neuronal L-type calcium channels open quickly and are inhibited slowly. J. Neurosci. 25: 10247-10251.
9. Hofmann, S.G. 2007. Cognitive processes during fear acquisition and extinction in animals and humans: Implications for exposure therapy of anxiety disorders. Clin. Psychol. Rev. 28: 200-211.
10. Josselyn, S.A., Kida, S., and Silva, A.J. 2004. Inducible repression of CREB function disrupts amygdala-dependent memory. Neurobiol. Learn. Mem. 82: 159-163.
11. Kelly, P.T. 1991. Calmodulin-dependent protein kinase II. Multifunctional roles in neuronal differentiation and synaptic plasticity. Mol. Neurobiol. 5: 153-177.
12. Maren, S. 2001. Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci. 24: 897-931.
13. V1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice. Learn. Mem. 13: 584-589.
14. McKinney, B.C., Schneider, J.S., Schafer, G.L., Lowing, J.L., Mohan, S., Zhao, M.X., Heng, M.Y., Albin, R.L., Seasholtz, A.F., Akil, H., et al. 2008. Decreased locomotor activity in mice expressing tTA under control of the CaMKIIα promoter. Genes Brain Behav. 7: 203-213.
15. McNally, G. and Akil, H. 2001. Effects of contextual or olfactory cues previously paired with morphine withdrawal on behavior and pain sensitivity in the rat. Psychopharmacology 156: 381-387.
16. Myers, K.M. and Davis, M. 2006. Mechanisms of fear extinction. Mol. Psychiatry 12: 120-150.
17. V1.2 L-type calcium channels in the rat basolateral amygdala. Brain Res. 1064: 52-55.
18. Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21: 70-71.
19. Suzuki, A., Josselyn, S.A., Frankland, P.W., Masushige, S., Silva, A.J., and Kida, S. 2004. Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J. Neurosci. 24: 4787-4795.
20. van Abeelen, J.H. 1989. Genetic control of hippocampal cholinergic and dynorphinergic mechanisms regulating novelty-induced exploratory behavior in house mice. Experientia 45: 839-845.
21. v1.2 disrupts remote spatial memories in mice. Learn. Mem. 15: 1-5.
22. 1 L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J. Neurosci. 21: 5944-5951.