Benzyl isothiocyanate (BITC) induces apoptosis of GBM 8401 human brain glioblastoma multiforms cells via activation of caspase-8/Bid and the reactive oxygen species-dependent mitochondrial pathway

Environmental Toxicology

Volumn 31, Issue 12, 2016, Pages 1751-1760

  Shang, Hung Sheng ^a   Shih, Yung Luen ^b,c,d   Lu, Tai Jung ^e   Lee, Ching Hsiao ^e   Hsueh, Shu Ching ^f   Chou, Yu Cheng ^g,h   Lu, Hsu Feng ^b,f   Liao, Nien Chieh ^f   Chung, Jing Gung ^i,j  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e JEN TEH JUNIOR COLLEGE OF MEDICINE   (Taiwan)

^f CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^g TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^h TZU CHI UNIVERSITY   (Taiwan)

ⁱ CHINA MEDICAL UNIVERSITY   (Taiwan)

^j ASIA UNIVERSITY   (Taiwan)

more..

Author keywords

apoptosis; BITC; GBM 8401 human brain glioblastoma multiforms cells; mitochondria

Indexed keywords

BRAIN; CELL DEATH; CELL MEMBRANES; CELLS; CYTOLOGY; DISEASES; MITOCHONDRIA; PROTEINS;

BENZYL ISOTHIOCYANATE; BITC; DOSE-DEPENDENT MANNER; GLIOBLASTOMAS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PATHWAYS; MITOCHONDRIAL SIGNALING PATHWAYS; REACTIVE OXYGEN SPECIES;

CELL SIGNALING;

BENZYL ISOTHIOCYANATE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; CALPAIN 1; CALPAIN 2; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN BID; REACTIVE OXYGEN METABOLITE; X BOX BINDING PROTEIN 1; ANTINEOPLASTIC AGENT; CASPASE INHIBITOR; ISOTHIOCYANIC ACID DERIVATIVE;

APOPTOSIS; BRAIN; CANCER; CELLS AND CELL COMPONENTS; CYTOCHROME; INHIBITION; MORPHOLOGY; ORGANIC COMPOUND; PROTEIN; REACTIVE OXYGEN SPECIES; SENSORY SYSTEM;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL GROWTH; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BRAIN NEOPLASMS; DRUG EFFECTS; G1 PHASE CELL CYCLE CHECKPOINT; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BRAIN NEOPLASMS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITORS; CELL LINE, TUMOR; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINTS; GLIOBLASTOMA; HUMANS; ISOTHIOCYANATES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84940921070     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.22177     Document Type: Article

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