Participation of WNT and β -catenin in physiological and pathological endometrial changes: Association with angiogenesis

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Kiewisz, Jolanta ^a   Wasniewski, Tomasz ^a   Kmiec, Zbigniew ^a  

^a UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; WNT PROTEIN; WNT10A PROTEIN; WNT10B PROTEIN; WNT11 PROTEIN; WNT2 PROTEIN; WNT4 PROTEIN; WNT5A PROTEIN; WNT5B PROTEIN; WNT6 PROTEIN; WNT7B PROTEIN;

ANGIOGENESIS; BLOOD VESSEL; CARCINOGENESIS; DROSOPHILA MELANOGASTER; ENDOMETRIUM; ENDOMETRIUM CANCER; FEMALE GENITAL SYSTEM; GENE EXPRESSION; HORMONAL REGULATION; HUMAN; NONHUMAN; REVIEW; WNT SIGNALING PATHWAY; CELL DIFFERENTIATION; FEMALE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY;

BETA CATENIN; CELL DIFFERENTIATION; ENDOMETRIUM; FEMALE; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; WNT PROTEINS;

EID: 84940827158     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/854056     Document Type: Review

References (93)

1. K. M. Cadigan and R. Nusse, "Wnt signaling: a common theme in animal development," Genes and Development, vol. 11, no. 24, pp. 3286-3305, 1997.
2. A. Kikuchi, H. Yamamoto, and S. Kishida, "Multiplicity of the interactions of Wnt proteins and their receptors," Cellular Signalling, vol. 19, no. 4, pp. 659-671, 2007.
3. http://web.stanford.edu/group/nusselab/cgi-bin/wnt/
4. M. A. Torres, J. A. Yang-Snyder, S. M. Purcell, A. A. DeMarais, L. L. McGrew, and R. T. Moon, "Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development," The Journal of Cell Biology, vol. 133, no. 5, pp. 1123-1137, 1996.
5. D. Strutt, "Frizzledsignalling and cell polarisation inDrosophila and vertebrates," Development, vol. 130, no. 19, pp. 4501-4513, 2003.
6. C. Miller and D. A. Sassoon, "Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract," Development, vol. 125, no. 16, pp. 3201-3211, 1998.
7. M. Mericskay, J. Kitajewski, and D. Sassoon, "Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus," Development, vol. 131, no. 9, pp. 2061-2072, 2004.
8. O. A. Mohamed, M. Jonnaert, C. Labelle-Dumais, K. Kuroda, H. J. Clarke, and D. Dufort, "UterineWnt/beta-catenin signaling is required for implantation," Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 24, pp. 8579-8584, 2005.
9. F. F. Bartol, A. A. Wiley, and C. A. Bagnell, "Uterine development and endometrial programming," Society of Reproduction and Fertility supplement, vol. 62, pp. 113-130, 2006.
10. J. C. Chen, A. A. Wiley, T.-Y. Ho et al., "Transient estrogen exposure frombirth affects uterine expression of developmental markers in neonatal gilts with lasting consequences in pregnant adults," Reproduction, vol. 139, no. 3, pp. 623-630, 2010.
11. S. Tulac, N. R. Nayak, L. C. Kao et al., "Identification, characterization, and regulation of the canonicalWnt signaling pathway in human endometrium," Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 8, pp. 3860-3866, 2003.
12. T. D. Bui, L. Zhang, M. C. P. Rees, R. Bicknell, and A. L. Harris, "Expression and hormone regulation of Wnt2, 3, 4, 5a, 7a, 7b and 10b in normal human endometriumand endometrial carcinoma," British Journal ofCancer, vol. 75, no. 8, pp. 1131-1136, 1997.
13. K. Hayashi, R. C. Burghardt, F. W. Bazer, and T. E. Spencer, "WNTs in the ovine uterus: potential regulation of periimplantation ovine conceptus development," Endocrinology, vol. 148, no. 7, pp. 3496-3506, 2007.
14. M. O. Atli, A. Guzeloglu, and D. A. Dinc, "Expression of wingless type (WNT) genes and their antagonists at mRNA levels in equine endometrium during the estrous cycle and early pregnancy," Animal Reproduction Science, vol. 125, no. 1-4, pp. 94-102, 2011.
15. J. Kiewisz, M. M. Kaczmarek, A. Andronowska, A. Blitek, and A. J. Ziecik, "Gene expression of WNTs, β-catenin and Ecadherin during the periimplantation period of pregnancy in pigs-involvement of steroid hormones," Theriogenology, vol. 76, no. 4, pp. 687-699, 2011.
16. J. Kiewisz, M. M. Kaczmarek, E. Morawska, A. Blitek, W. Kapelanski, and A. J. Ziecik, "Estrus synchronization affects WNTsignaling in the porcine reproductive tract and embryos," Theriogenology, vol. 76, no. 9, pp. 1684-1694, 2011.
17. K. Stark, S. Vainio, G. Vassileva, and A. P. McMahon, "Epithelial transformation metanephric mesenchyme in the developing kidney regulated byWnt-4," Nature, vol. 372, no. 6507, pp. 679-683, 1994.
18. S. Vainio, M. Heikkila, A. Kispert, N. Chin, and A. P. McMahon, "Female development in mammals is regulated by Wnt-4 signalling," Nature, vol. 397, no. 6718, pp. 405-409, 1999.
19. X. Hou, Y. Tan, M. Li, S. K. Dey, and S. K. Das, "Canonical Wnt signaling is critical to estrogen-mediated uterine growth," Molecular Endocrinology, vol. 18, no. 12, pp. 3035-3049, 2004.
20. T. P. Yamaguchi, A. Bradley, A. P. McMahon, and S. Jones, "A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo," Development, vol. 126, no. 6, pp. 1211-1223, 1999.
21. M. Heikkil, H. Peltoketo, and S. Vainio, "Wnts and the female reproductive system," Journal of Experimental Zoology, vol. 290, no. 6, pp. 616-623, 2001.
22. A. Pavlova, E. Boutin, G. Cunha, and D. Sassoon, "Msx1 (Hox-7. 1) in the adult mouse uterus: cellular interactions underlying regulation of expression," Development, vol. 120, no. 2, pp. 335-345, 1994.
23. C. Miller, A. Pavlova, and D. A. Sassoon, "Differential expression patterns of Wnt genes in the murine female reproductive tract during development and the estrous cycle," Mechanisms of Development, vol. 76, no. 1-2, pp. 91-99, 1998.
24. K. Hayashi, D. W. Erikson, S. A. Tilford et al., "Wnt genes in the mouse uterus: potential regulation of implantation," Biology of Reproduction, vol. 80, no. 5, pp. 989-1000, 2009.
25. M. C. Satterfield, G. Song, K. Hayashi, F. W. Bazer, and T. E. Spencer, "Progesterone regulation of the endometrial WNT system in the ovine uterus," Reproduction, Fertility and Development, vol. 20, no. 8, pp. 935-946, 2008.
26. X. Fan, S. Krieg, J. Y. Hwang et al., "Dynamic regulation of Wnt7a expression in the primate endometrium: Implications for postmenstrual regeneration and secretory transformation," Endocrinology, vol. 153, no. 3, pp. 1063-1069, 2012.
27. R. Gaetje, U. Holtrich, T. Karn et al., "Characterization of WNT7Aexpression in human endometriumand endometriotic lesions," Fertility and Sterility, vol. 88, no. 6, pp. 1534-1540, 2007.
28. C. Peng, X. Zhang, Y. Wang, L. Li, Q. Wang, and J. Zheng, "Expression and prognostic significance of Wnt7a in human endometrial carcinoma," Obstetrics and Gynecology International, vol. 2012, Article ID 134962, 8 pages, 2012.
29. Y. Wang, P. Hanifi-Moghaddam, E. E. Hanekamp et al., "Progesterone inhibition of Wnt/β-catenin signaling in normal endometrium and endometrial cancer," Clinical Cancer Research, vol. 15, no. 18, pp. 5784-5793, 2009.
30. M. K. Oehler, I. Z. MacKenzie, D. Wallwiener, R. Bicknell, and M. C. Rees, "Wnt-7a is upregulated by norethisterone in human endometrial epithelial cells: a possible mechanism by which progestogens reduce the risk of estrogen-induced endometrial neoplasia," Cancer Letters, vol. 186, no. 1, pp. 75-81, 2002.
31. H. Aberle, S. Butz, J. Stappert, H. Weissig, R. Kemler, and H. Hoschuetzky, "Assembly of the cadherin-catenin complex in vitrowith recombinant proteins," Journal of Cell Science, vol. 107, no. 12, pp. 3655-3663, 1994.
32. J.-W. Jeong, H. S. Lee, H. L. Franco et al., "Beta-cateninmediates glandular formation and dysregulation of beta-catenin induces hyperplasia formation in the murine uterus," Oncogene, vol. 28, no. 1, pp. 31-40, 2009.
33. S. Tabibzadeh, A. Babaknia, Q. F. Kong et al., "Menstruation is associated with disordered expression of desmoplakin I/II and cadherin/catenins and conversion of F-to G-actin in endometrial epithelium," Human Reproduction, vol. 10, no. 4, pp. 776-784, 1995.
34. J. Fujimoto, S. Ichigo, M. Hori, and T. Tamaya, "Alteration of E-cadherin, alpha-and beta-catenin mRNA expression in human uterine endometrium during the menstrual cycle," Gynecological Endocrinology, vol. 10, no. 3, pp. 187-191, 1996.
35. G. T. C. Chen, S. Getsios, and C. D. MacCalman, "Progesterone regulates β-catenin mRNA levels in human endometrial stromal cells in vitro," Endocrine, vol. 9, no. 3, pp. 263-267, 1998.
36. H. Nei, T. Saito, H. Yamasaki, H. Mizumoto, E. Ito, and R. Kudo, "Nuclear localization of β-catenin in normal and carcinogenic endometrium,"Molecular Carcinogenesis, vol. 25, no. 3, pp. 207-218, 1999.
37. A. G. Gunin, V. U. Emelianov, I. U. Mironkin, M. P. Morozov, and A. S. Tolmachev, "Lithium treatment enhances estradiolinduced proliferation and hyperplasia formation in the uterus of mice," The European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 114, no. 1, pp. 83-91, 2004.
38. A. J. Polotsky, L. Zhu, N. Santoro, and J. W. Pollard, "Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium," Human Reproduction, vol. 24, no. 8, pp. 1960-1967, 2009.
39. D.-H. Yang, J.-Y. Yoon, S.-H. Lee et al., "Wnt5a is required for endothelial differentiation of embryonic stem cells and vascularization via pathways involving both Wnt/β-Catenin and protein kinase Cα," Circulation Research, vol. 104, no. 3, pp. 372-379, 2009.
40. A. Jemal, R. Siegel, and T. Murray, "Cancer statistics, 2011," CA: A Cancer Journal for Clinicians, vol. 61, no. 4, pp. 212-236, 2011.
41. G. DAndrilli, A. Bovicelli, M. G. Paggi, and A. Giordano, "New insights in endometrial carcinogenesis," Journal of Cellular Physiology, vol. 227, no. 7, pp. 2842-2846, 2012.
42. A. J. Ryan, B. Susil, T. W. Jobling, and M. K. Oehler, "Endometrial cancer," Cell and Tissue Research, vol. 322, no. 1, pp. 53-61, 2005.
43. J. Prat, A. Gallardo, M. Cuatrecasas, and L. Catasus, "Endometrial carcinoma: pathology and genetics," Pathology, vol. 39, no. 1, pp. 72-87, 2007.
44. W. T. Creasman, F. Odicino, P. Mausinneuve, M. A. Quinn, U. Beller, and J. L. Benedet, "Carcinoma of the corpus uteri. FIGO Annual Report," International Journal of Gynaecology and Obstetrics, vol. 26, no. 95, supplement 1, pp. 105-143, 2006.
45. E. Hiroki, J.-I. Akahira, F. Suzuki et al., "Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas," Cancer Science, vol. 101, no. 1, pp. 241-249, 2010.
46. Y. Liu, F. Meng, Y. Xu et al., "Overexpression of Wnt7a is associated with tumor progression and unfavorable prognosis in endometrial cancer," International Journal of Gynecological Cancer, vol. 23, no. 2, pp. 304-311, 2013.
47. J. Wagner and L. Lehmann, "Estrogens modulate the gene expression ofWnt-7a in cultured endometrial adenocarcinoma cells," Molecular Nutrition and Food Research, vol. 50, no. 4-5, pp. 368-372, 2006.
48. H. Newill, R. Loske, J. Wagner, C. Johannes, R. L. Lorenz, and L. Lehmann, "Oxidation products of stigmasterol interfere with the action of the female sex hormone 17beta-estradiol in cultured human breast and endometrium cell lines," Molecular Nutrition and Food Research, vol. 51, no. 7, pp. 888-898, 2007.
49. H. Chen, Y. Wang, and F. Xue, "Expression and the clinical significance of Wnt10a and Wnt10b in endometrial cancer are associated with theWnt/β-catenin pathway," Oncology Reports, vol. 29, no. 2, pp. 507-514, 2013.
50. Y. Wang, M. van der Zee, R. Fodde, and L. J. Blok, "Wnt/B-catenin and sex hormone signaling in endometrial homeostasis and cancer," Oncotarget, vol. 1, no. 7, pp. 674-684, 2010.
51. T. H. Dellinger, K. Planutis, K. S. Tewari, and R. F. Holcombe, "Role of canonical Wnt signaling in endometrial carcinogenesis," Expert ReviewofAnticancerTherapy, vol. 12, no. 1, pp. 51-62, 2012.
52. T. Fukuchi, M. Sakamoto, H. Tsuda, K. Maruyama, S. Nozawa, and S. Hirohashi, "β-catenin mutation in carcinoma of the uterine endometrium," Cancer Research, vol. 58, no. 16, pp. 3526-3528, 1998.
53. T. Ikeda, K. Yoshinaga, S. Semba, E. Kondo, H. Ohmori, and A. Horii, "Mutational analysis of the CTNNB1 (β-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation," Oncology Reports, vol. 7, no. 2, pp. 323-326, 2000.
54. H. Yano, A. Hara, J. Shinoda et al., "Immunohistochemical analysis of β-catenin in N-ethyl-N-nitrosourea-induced rat gliomas: implications in regulation of angiogenesis," Neurological Research, vol. 22, no. 5, pp. 527-532, 2000.
55. H. Yano, A. Hara, K. Takenaka et al., "Differential expression of β-catenin in human glioblastomamultiforme and normal brain tissue," Neurological Research, vol. 22, no. 7, pp. 650-656, 2000.
56. C. G. Eberhart, T. Tihan, and P. C. Burger, "Nuclear localization and mutation of beta-catenin in medulloblastomas," Journal of Neuropathology and Experimental Neurology, vol. 59, no. 4, pp. 333-337, 2000.
57. M. Saegusa, M. Hashimura, T. Yoshida, and I. Okayasu, "β-catenin mutations and aberrant nuclear expression during endometrial tumorigenesis," British Journal of Cancer, vol. 84, no. 2, pp. 209-217, 2001.
58. P. W. Schlosshauer, E. C. Pirog, R. L. Levine, and L. H. Ellenson, "Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma," Modern Pathology, vol. 13, no. 10, pp. 1066-1071, 2000.
59. G. Moreno-Bueno, D. Hardisson, C. Sanchez et al., "Abnormalities of the APC/beta-catenin pathway in endometrial cancer," Oncogene, vol. 21, no. 52, pp. 7981-7990, 2002.
60. Q. Li, A. Kannan, W. Wang et al., "Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human,"The Journal of Biological Chemistry, vol. 282, no. 43, pp. 31725-31732, 2007.
61. P. S. Tanwar, H.-J. Lee, L. Zhang et al., "Constitutive activation of beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice," Biology of Reproduction, vol. 81, no. 3, pp. 545-552, 2009.
62. M. van der Zee, Y. Jia, Y. Wang et al., "Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression," The Journal of Pathology, vol. 230, no. 1, pp. 48-58, 2013.
63. N. Yi, Q.-P. Liao, T. Li, and Y. Xiong, "Novel expression profiles and invasiveness-related biology function of DKK1 in endometrial carcinoma," Oncology Reports, vol. 21, no. 6, pp. 1421-1427, 2009.
64. Y. Kubota, "Tumor angiogenesis and anti-angiogenic therapy," The Keio Journal of Medicine, vol. 61, no. 2, pp. 47-56, 2012.
65. E. Dejana, "The role of wnt signaling in physiological and pathological angiogenesis," Circulation Research, vol. 107, no. 8, pp. 943-952, 2010.
66. R. Demir, A. Yaba, and B. Huppertz, "Vasculogenesis and angiogenesis in the endometrium during menstrual cycle and implantation," Acta Histochemica, vol. 112, no. 3, pp. 203-214, 2010.
67. R. D. Koos, "Minireview: putting physiology back into estrogens mechanism of action," Endocrinology, vol. 152, no. 12, pp. 4481-4488, 2011.
68. C. E. Gargett and P. A. W. Rogers, "Human endometrial angiogenesis," Reproduction, vol. 121, no. 2, pp. 181-186, 2001.
69. H. O. D. Critchley, J. Osei, T. A. Henderson et al., "Hypoxiainducible factor-1 expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2)," Endocrinology, vol. 147, no. 2, pp. 744-753, 2006.
70. L. G. Nardo, "Vascular endothelial growth factor expression in the endometrium during the menstrual cycle, implantation window and early pregnancy," Current Opinion in Obstetrics and Gynecology, vol. 17, no. 4, pp. 419-423, 2005.
71. P. Carmeliet, L. Moons, and D. Collen, "Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis," Cardiovascular Research, vol. 39, no. 1, pp. 8-33, 1998.
72. T. N. H. Masckauchan, C. J. Shawber, Y. Funahashi, C.-M. Li, and J. Kitajewski, "Wnt/β-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells," Angiogenesis, vol. 8, no. 1, pp. 43-51, 2005.
73. M. M. Bakre, A. Hoi, J. C. Y. Mong, Y. Y. Koh, K. Y. Wong, and L. W. Stanton, "Generation of multipotential mesendodermal progenitors from mouse embryonic stem cells via sustained Wnt pathway activation," The Journal of Biological Chemistry, vol. 282, no. 43, pp. 31703-31712, 2007.
74. P. S. Woll, J. K. Morris, M. S. Painschab et al., "Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells," Blood, vol. 111, no. 1, pp. 122-131, 2008.
75. A. M. Goodwin, J. Kitajewski, and P. A. DAmore, "Wnt1 and Wnt5a affect endothelial proliferation and capillary length; Wnt2 does not," Growth Factors, vol. 25, no. 1, pp. 25-32, 2007.
76. C.-W. Cheng, S. K. Smith, and D. S. Charnock-Jones, "Wnt-1 signaling inhibits human umbilical vein endothelial cell proliferation and alters cell morphology," Experimental Cell Research, vol. 291, no. 2, pp. 415-425, 2003.
77. S. J. Monkley, S. J. Delaney, D. J. Pennisi, J. H. Christiansen, and B. J. Wainwright, "Targeted disruption of theWnt2 gene results in placentation defects," Development, vol. 122, no. 11, pp. 3343-3353, 1996.
78. X. Ye, Y. Wang, H. Cahill et al., "Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization," Cell, vol. 139, no. 2, pp. 285-298, 2009.
79. T.-O. Ishikawa, Y. Tamai, A. M. Zorn et al., "MouseWnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis," Development, vol. 128, no. 1, pp. 25-33, 2001.
80. I. Samarzija, P. Sini, T. Schlange, G. MacDonald, and N. E. Hynes, "Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways," Biochemical and Biophysical Research Communications, vol. 386, no. 3, pp. 449-454, 2009.
81. C.-W. Cheng, J.-C. Yeh, T.-P. Fan, S. K. Smith, and D. S. Charnock-Jones, "Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration," Biochemical and Biophysical Research Communications, vol. 365, no. 2, pp. 285-290, 2008.
82. R. Daneman, D. Agalliu, L. Zhou, F. Kuhnert, C. J. Kuo, and B. A. Barres, "Wnt/β-catenin signaling is required forCNS, but not non-CNS, angiogenesis," Proceedings of theNationalAcademy of Sciences of the United States of America, vol. 106, no. 2, pp. 641-646, 2009.
83. W. Shu, Y. Q. Jiang, M. M. Lu, and E. E. Morrisey, "Wnt7b regulatesmesenchymal proliferation and vascular development in the lung," Development, vol. 129, no. 20, pp. 4831-4842, 2002.
84. A. Cattelino, S. Liebner, R. Gallini et al., "The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility,"The Journal of Cell Biology, vol. 162, no. 6, pp. 1111-1122, 2003.
85. H. Madjar, H. J. Prompeler, W. Sauerbrei, R. Wolfarth, and A. Pfleiderer, "Color Doppler flow criteria of breast lesions," Ultrasound in Medicine and Biology, vol. 20, no. 9, pp. 849-858, 1994.
86. M. Perrot-Applanat, M. T. Groyer-Picard, E. Garcia, F. Lorenzo, and E. Milgrom, "Immunocytochemical demonstration of estrogen and progesterone receptors in muscle cells of uterine arteries in rabbits and humans," Endocrinology, vol. 123, no. 3, pp. 1511-1519, 1988.
87. G. Krikun, F. Schatz, and C. J. Lockwood, "Endometrial angiogenesis: from physiology to pathology," Annals of the New York Academy of Sciences, vol. 1034, pp. 27-35, 2004.
88. K. Y. Lee, J.-W. Jeong, J. Wang et al., "Bmp2 is critical for the murine uterine decidual response," Molecular and Cellular Biology, vol. 27, no. 15, pp. 5468-5478, 2007.
89. K. A. Dunlap, J. Filant, K. Hayashi et al., "Postnatal deletion of Wnt7a inhibits uterine gland morphogenesis and compromises adult fertility in mice," Biology of Reproduction, vol. 85, no. 2, pp. 386-396, 2011.
90. G. L. Mutter, M.-C. Lin, J. T. Fitzgerald et al., "Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers," The Journal of the National Cancer Institute, vol. 92, no. 11, pp. 924-931, 2000.
91. P. W. Schlosshauer, L. H. Ellenson, and R. A. Soslow, "Betacatenin and E-cadherin expression patterns in high-grade endometrial carcinoma are associated with histological subtype," Modern Pathology, vol. 15, no. 10, pp. 1032-1037, 2002.
92. S. Erkanli, F. Eren, S. Pekin, and T. Bagis, "BCL-2 and P53 expression in endometrial carcinoma," Journal of Experimental and Clinical Cancer Research, vol. 23, no. 1, pp. 97-103, 2004.
93. S. F. Lax, B. Kendall, H. Tashiro, R. J. C. Slebos, and L. H. Ellenson, "The frequency of p53, k-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma," Cancer, vol. 88, no. 4, pp. 814-824, 2000.