Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression

Journal of Pathology

Volumn 230, Issue 1, 2013, Pages 48-58

  Van Der Zee, Marten ^a   Jia, Yundan ^a   Wang, Yongyi ^a   Heijmans Antonissen, Claudia ^a   Ewing, Patricia C ^a   Franken, Patrick ^a   Demayo, Francesco J ^b   Lydon, John P ^b   Burger, Curt W ^a   Fodde, Riccardo ^a   Blok, Leen J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

cancer; endometrium; molecular signalling; rate limiting; squamous cell metaplasia

Indexed keywords

APC PROTEIN; BETA CATENIN; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; WNT PROTEIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL NUCLEUS; CYTOPLASM; ENDOMETRIUM; ENDOMETRIUM CANCER; FEMALE; GENE DELETION; GENE FUNCTION; GENE INDUCTION; GENE LOSS; HETEROZYGOSITY LOSS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SQUAMOUS CELL METAPLASIA; WILD TYPE;

ANIMALS; BETA CATENIN; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; ENDOMETRIAL NEOPLASMS; FEMALE; GENE DELETION; GENE SILENCING; GENES, APC; LOSS OF HETEROZYGOSITY; MALE; MICE; MICE, KNOCKOUT; PTEN PHOSPHOHYDROLASE; RECEPTORS, PROGESTERONE; UTERUS; WNT SIGNALING PATHWAY;

EID: 84876131381     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4160     Document Type: Article

References (39)

1. Pijnenborg JM, Kisters N, van Engeland M, et al,. APC, β-catenin, and E-cadherin and the development of recurrent endometrial carcinoma. Int J Gynecol Cancer 2004; 14: 947-956.
2. Blumenthal GM, Dennis PA,. Germline PTEN mutations as a cause of early-onset endometrial cancer. J Clin Oncol 2008; 26: 2234; author reply, 2234.
3. Risinger JI, Dent GA, Ignar-Trowbridge D, et al., p53 gene mutations in human endometrial carcinoma. Mol Carcinog 1992; 5: 250-253.
4. Moreno-Bueno G, Hardisson D, Sanchez C, et al,. Abnormalities of the APC/β-catenin pathway in endometrial cancer. Oncogene 2002; 21: 7981-7990.
5. Zysman M, Saka A, Millar A, et al,. Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype. Cancer Res 2002; 62: 3663-3666.
6. Clevers H., Wnt/β-catenin signaling in development and disease. Cell 2006; 127: 469-480.
7. Wang Y, Hanifi-Moghaddam P, Hanekamp EE, et al,. Progesterone inhibition of Wnt/β-catenin signaling in normal endometrium and endometrial cancer. Clin Cancer Res 2009; 15: 5784-5793.
8. Logan CY, Nusse R,. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004; 20: 781-810.
9. Wang Y, Van der Zee M, Fodde R, et al,. Wnt/β-catenin signaling and sex hormone signaling in endometrial homeostasis and cancer. Oncotarget 2010; 1: 674-684.
10. Hou X, Tan Y, Li M, et al,. Canonical Wnt signaling is critical to estrogen-mediated uterine growth. Mol Endocrinol 2004; 18: 3035-3049.
11. Amant F, Moerman P, Neven P, et al,. Endometrial cancer. Lancet 2005; 366: 491-505.
12. Nei H, Saito T, Yamasaki H, et al,. Nuclear localization of β-catenin in normal and carcinogenic endometrium. Mol Carcinog 1999; 25: 207-218.
13. Carracedo A, Pandolfi PP,. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 2008; 27: 5527-5541.
14. Di Cristofano A, Pandolfi PP,. The multiple roles of PTEN in tumor suppression. Cell 2000; 100: 387-390.
15. Subauste MC, Nalbant P, Adamson ED, et al,. Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein β-catenin with the scaffolding protein MAGI-2. J Biol Chem 2005; 280: 5676-5681.
16. Daikoku T, Dey SK,. Two faces of PTEN. Nat Med 2008; 14: 1192-1193.
17. Soyal SM, Mukherjee A, Lee KY, et al,. Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis 2005; 41: 58-66.
18. Lesche R, Groszer M, Gao J, et al,. Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis 2002; 32: 148-149.
19. Robanus-Maandag EC, Koelink PJ, Breukel C, et al,. A new conditional Apc-mutant mouse model for colorectal cancer. Carcinogenesis 2010; 31: 946-952.
20. van der Zee M, Dik WA, Kap YS, et al,. Synthetic human chorionic gonadotropin-related oligopeptides impair early innate immune responses to Listeria monocytogenes in mice. J Infect Dis 2010; 201: 1072-1080.
21. Wang Y, Jia Y, Franken P, et al,. Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice. Mol Cell Endocrinol 2011; 341: 48-54.
22. Smits R, Kartheuser A, Jagmohan-Changur S, et al,. Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis. Carcinogenesis 1997; 18: 321-327.
23. van den Berg HR, Khan NA, van der Zee M,. Synthetic oligopeptides related to the β-subunit of human chorionic gonadotropin attenuate inflammation and liver damage after (trauma) hemorrhagic shock and resuscitation. Shock 2009; 31: 285-291.
24. Lague MN, Paquet M, Fan HY, et al,. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis 2008; 29: 2062-2072.
25. Wu R, Hendrix-Lucas N, Kuick R, et al,. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/β-catenin and PI3K/Pten signaling pathways. Cancer Cell 2007; 11: 321-333.
26. Kaghad M, Bonnet H, Yang A, et al,. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 1997; 90: 809-819.
27. Yang A, Kaghad M, Wang Y, et al,. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell 1998; 2: 305-316.
28. Harnden P, Southgate J,. Cytokeratin 14 as a marker of squamous differentiation in transitional cell carcinomas. J Clin Pathol 1997; 50: 1032-1033.
29. Koster MI, Roop DR,. Mechanisms regulating epithelial stratification. Annu Rev Cell Dev Biol 2007; 23: 93-113.
30. Patel L, Pass I, Coxon P, et al,. Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN. Curr Biol 2001; 11: 764-768.
31. Jansson EA, Are A, Greicius G, et al,. The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells. Proc Natl Acad Sci USA 2005; 102: 1460-1465.
32. Gaspar C, Fodde R,. APC dosage effects in tumorigenesis and stem cell differentiation. Int J Dev Biol 2004; 48: 377-386.
33. Wang H, Douglas W, Lia M, et al,. DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice. Am J Pathol 2002; 160: 1481-1486.
34. Risinger JI, Berchuck A, Kohler MF, et al,. Genetic instability of microsatellites in endometrial carcinoma. Cancer Res 1993; 53: 5100-5103.
35. Kobayashi K, Sagae S, Nishioka Y, et al,. Mutations of the β-catenin gene in endometrial carcinomas. Jpn J Cancer Res 1999; 90: 55-59.
36. Dikovskaya D, Newton IP, Nathke IS,. The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts. Mol Biol Cell 2004; 15: 2978-2991.
37. Dikovskaya D, Schiffmann D, Newton IP, et al,. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol 2007; 176: 183-195.
38. Radulescu S, Ridgway RA, Appleton P, et al,. Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol. Oncogene 2010; 29: 6418-6427.
39. Alberici P, Fodde R,. The role of the APC tumor suppressor in chromosomal instability. Genome Dyn 2006; 1: 149-170.