In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11

PLoS Genetics

Volumn 11, Issue 8, 2015, Pages

  Varga, Rita Eva ^a   Khundadze, Mukhran ^a   Damme, Markus ^b   Nietzsche, Sandor ^a   Hoffmann, Birgit ^a   Stauber, Tobias ^c,e   Koch, Nicole ^a   Hennings, J Christopher ^a   Franzka, Patricia ^a   Huebner, Antje K ^a   Kessels, Michael M ^a   Biskup, Christoph ^a   Jentsch, Thomas J ^c   Qualmann, Britta ^a   Braulke, Thomas ^d   Kurth, Ingo ^a   Beetz, Christian ^a   Hübner, Christian A ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN D; CELL PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROTEIN P62; SPATACSIN; UNCLASSIFIED DRUG; PROTEIN; SPG11 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; BRAIN CELL; CELL COUNT; CELL DEPLETION; CELL PH; CELL SELECTION; CONTROLLED STUDY; EMBRYO; GENE; GENE FUNCTION; GENE LOCUS; GENE MUTATION; HEREDITARY MOTOR SENSORY NEUROPATHY; IN VIVO STUDY; KNOCKOUT MOUSE; LYSOSOME; MOUSE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PROTEIN DEGRADATION; PURKINJE CELL; SPG11 GENE; ANIMAL; C57BL MOUSE; CELL CULTURE; CEREBELLUM; FEMALE; GENETICS; MALE; MOTOR CORTEX; PATHOLOGY; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; CELLS, CULTURED; CEREBELLUM; FEMALE; LYSOSOMES; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR CORTEX; PROTEINS; PURKINJE CELLS; SPASTIC PARAPLEGIA, HEREDITARY;

EID: 84940782253     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005454     Document Type: Article

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