AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

PLoS Pathogens

Volumn 11, Issue 8, 2015, Pages

  Fuchs, Sebastian P ^a,b   Martinez Navio, José M ^a   Piatak, Michael ^c   Lifson, Jeffrey D ^c   Gao, Guangping ^d   Desrosiers, Ronald C ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 41; NEUTRALIZING ANTIBODY; PARVOVIRUS VECTOR; ANTIIDIOTYPIC ANTIBODY; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY RESPONSE; ARTICLE; BINDING ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMORAL IMMUNITY; NONHUMAN; PROTECTION; PROTEIN PURIFICATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHESUS MONKEY; SEQUENCE ALIGNMENT; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS LOAD; ANIMAL; BLOOD; DEPENDOPARVOVIRUS; GENE VECTOR; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; INTRAMUSCULAR DRUG ADMINISTRATION; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; DEPENDOVIRUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC VECTORS; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; MACACA MULATTA; SAIDS VACCINES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; TRANSFECTION;

EID: 84940767753     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005090     Document Type: Article

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