Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway

PLoS Pathogens

Volumn 11, Issue 8, 2015, Pages

  Joubert, Pierre Emmanuel ^a,b   Stapleford, Kenneth ^a   Guivel Benhassine, Florence ^a   Vignuzzi, Marco ^a   Schwartz, Olivier ^a   Albert, Matthew L ^a,b  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL) IMIDAZOLE; ALPHA INTERFERON; BETA INTERFERON; CHIKUNGUNYA PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; MAMMALIAN TARGET OF RAPAMYCIN C1 INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TACROLIMUS; TEMSIROLIMUS; UNCLASSIFIED DRUG; VIRUS PROTEIN; EIF4E PROTEIN, MOUSE; INITIATION FACTOR 4E; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; VIRAL PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; AUTOPHAGY; CHIKUNGUNYA; CHIKUNGUNYA VIRUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TRANSLATION; VIRUS LOAD; VIRUS REPLICATION; VIRUS TITRATION; VIRUS TRANSCRIPTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; GENE INACTIVATION; HOST PARASITE INTERACTION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CHIKUNGUNYA FEVER; CHIKUNGUNYA VIRUS; DISEASE MODELS, ANIMAL; EUKARYOTIC INITIATION FACTOR-4E; FLOW CYTOMETRY; GENE KNOCKOUT TECHNIQUES; HOST-PARASITE INTERACTIONS; MICE; MULTIPROTEIN COMPLEXES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN BIOSYNTHESIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSFECTION; VIRAL PROTEINS;

EID: 84940767191     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005091     Document Type: Article

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