The Battle over mTOR: An Emerging Theatre in Host-Pathogen Immunity

PLoS Pathogens

Volumn 8, Issue 9, 2012, Pages

  Martin, Sunil ^a   Saha, Bhaskar ^b   Riley, James L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN;

ARTICLE; CELL METABOLISM; DRUG TARGETING; HOST PATHOGEN INTERACTION; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; NONHUMAN;

BACTERIA; HOST-PATHOGEN INTERACTIONS; HUMANS; INFECTION; MACROPHAGES; MOLECULAR TARGETED THERAPY; T-LYMPHOCYTES; TOR SERINE-THREONINE KINASES; VIRUSES;

EID: 84866918092     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002894     Document Type: Article

References (46)

1. Delgoffe GM, Powell JD, (2009) mTOR: taking cues from the immune microenvironment. Immunology 127: 459-465.
2. Bhavsar AP, Guttman JA, Finlay BB, (2007) Manipulation of host-cell pathways by bacterial pathogens. Nature 449: 827-834.
3. Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, et al. (2002) The CD28 signaling pathway regulates glucose metabolism. Immunity 16: 769-777.
4. Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, et al. (2001) Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 21: 5899-5912.
5. Wada HG, Indelicato SR, Meyer L, Kitamura T, Miyajima A, et al. (1993) GM-CSF triggers a rapid, glucose dependent extracellular acidification by TF-1 cells: evidence for sodium/proton antiporter and PKC mediated activation of acid production. J Cell Physiol 154: 129-138.
6. Fox CJ, Hammerman PS, Thompson CB, (2005) Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol 5: 844-852.
7. Winer S, Winer DA, (2012) The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance. Immunol Cell Biol.
8. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI, (2011) Human nutrition, the gut microbiome and the immune system. Nature 474: 327-336.
9. June CH, Blazar BR, Riley JL, (2009) Engineering lymphocyte subsets: tools, trials and tribulations. Nat Rev Immunol 9: 704-716.
10. Zhang Y, Satterlee A, Huang L, (2012) In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles[quest]. Mol Ther 20: 1298-1304.
11. Zoncu R, Efeyan A, Sabatini DM, (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35.
12. Powell JD, Pollizzi KN, Heikamp EB, Horton MR, (2012) Regulation of Immune Responses by mTOR. Annu Rev Immunol 30: 39-68.
13. van Dam TJ, Zwartkruis FJ, Bos JL, Snel B, (2011) Evolution of the TOR pathway. J Mol Evol 73: 209-220.
14. Gougeon ML, Melki MT, Saidi H, (2012) HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells. Cell Death Differ 19: 96-106.
15. Blanchet FP, Moris A, Nikolic DS, Lehmann M, Cardinaud S, et al. (2010) Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity 32: 654-669.
16. Chuluunbaatar U, Roller R, Feldman ME, Brown S, Shokat KM, et al. (2010) Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. Genes Dev 24: 2627-2639.
17. Nepomuceno RR, Balatoni CE, Natkunam Y, Snow AL, Krams SM, et al. (2003) Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas. Cancer Res 63: 4472-4480.
18. Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, et al. (2008) The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29: 565-577.
19. Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, et al. (2011) The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 12: 295-303.
20. Wang Y, Weiss LM, Orlofsky A, (2010) Coordinate control of host centrosome position, organelle distribution, and migratory response by Toxoplasma gondii via host mTORC2. J Biol Chem 285: 15611-15618.
21. Jaramillo M, Gomez MA, Larsson O, Shio MT, Topisirovic I, et al. (2011) Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host Microbe 9: 331-341.
22. Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B, Saha B, (2004) Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat Med 10: 540-544.
23. Alain T, Lun X, Martineau Y, Sean P, Pulendran B, et al. (2010) Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proc Natl Acad Sci U S A 107: 1576-1581.
24. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, et al. (2011) mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146: 408-420.
25. Rub A, Dey R, Jadhav M, Kamat R, Chakkaramakkil S, et al. (2009) Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nat Immunol 10: 273-280.
26. Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, et al. (2009) mTOR regulates memory CD8 T-cell differentiation. Nature 460: 108-112.
27. Li Q, Rao RR, Araki K, Pollizzi K, Odunsi K, et al. (2011) A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity. Immunity 34: 541-553.
28. Weichhart T, Saemann MD, (2009) The multiple facets of mTOR in immunity. Trends Immunol 30: 218-226.
29. Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, et al. (2010) T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med 16: 406-412.
30. Meili R, Cron P, Hemmings BA, Ballmer-Hofer K, (1998) Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism. Oncogene 16: 903-907.
31. Fothergill T, McMillan NA, (2006) Papillomavirus virus-like particles activate the PI3-kinase pathway via alpha-6 beta-4 integrin upon binding. Virology 352: 319-328.
32. Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B, (2007) Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci U S A 104: 19011-19016.
33. Pipas JM, Levine AJ, (2001) Role of T antigen interactions with p53 in tumorigenesis. Semin Cancer Biol 11: 23-30.
34. Pim D, Massimi P, Dilworth SM, Banks L, (2005) Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A. Oncogene 24: 7830-7838.
35. Wang G, Barrett JW, Stanford M, Werden SJ, Johnston JB, et al. (2006) Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor. Proc Natl Acad Sci U S A 103: 4640-4645.
36. Stanford MM, Barrett JW, Nazarian SH, Werden S, McFadden G, (2007) Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells. J Virol 81: 1251-1260.
37. Clippinger AJ, Maguire TG, Alwine JC, (2011) The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. J Virol 85: 3930-3939.
38. Kudchodkar SB, Del Prete GQ, Maguire TG, Alwine JC, (2007) AMPK-mediated inhibition of mTOR kiase is circumvented during immediate-early times of human cytomegalovirus infection. J Virol 81: 3649-3651.
39. Lu Z, Hu X, Li Y, Zheng L, Zhou Y, et al. (2004) Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin. J Biol Chem 279: 35664-35670.
40. Clippinger AJ, Maguire TG, Alwine JC, (2011) Human Cytomegalovirus Infection Maintains mTOR Activity and Its Perinuclear Localization during Amino Acid Deprivation. J Virol 85: 9369-9376.
41. Yu Y, Kudchodkar SB, Alwine JC, (2005) Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection. J Virol 79: 6882-6889.
42. O'Shea C, Klupsch K, Choi S, Bagus B, Soria C, et al. (2005) Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO J 24: 1211-1221.
43. Walsh D, Mohr I, (2004) Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. Genes Dev 18: 660-672.
44. Walsh D, Arias C, Perez C, Halladin D, Escandon M, et al. (2008) Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells. Mol Cell Biol 28: 2648-2658.
45. Walsh D, Perez C, Notary J, Mohr I, (2005) Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells. J Virol 79: 8057-8064.
46. McMahon R, Zaborowska I, Walsh D, (2011) Noncytotoxic inhibition of viral infection through eIF4F-independent suppression of translation by 4EGi-1. J Virol 85: 853-864.