The E2-E166K substitution restores Chikungunya virus growth in OAS3 expressing cells by acting on viral entry

Virology

Volumn 434, Issue 1, 2012, Pages 27-37

  Henrik Gad, Hans ^a   Paulous, Sylvie ^a   Belarbi, Essia ^a   Diancourt, Laure ^a   Drosten, Christian ^b   Kümmerer, Beate M ^b   Plate, Aileen E ^a   Caro, Valérie ^a   Desprès, Philippe ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

2',5' oligoadenylate synthetase; Chikungunya virus; Envelope glycoprotein; Innate immunity; Molecular clone; Myoblasts; Viral diversity; Viral evasion

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE 3; GLUTAMIC ACID; GLYCOPROTEIN E2; LUCIFERASE; LYSINE; PROTEIN KINASE R; SYNTHETASE; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRUS RNA;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CHIKUNGUNYA ALPHAVIRUS; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOLECULAR CLONING; MYOBLAST; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENILLA; REPORTER GENE; VIROGENESIS; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS VIRULENCE;

2',5'-OLIGOADENYLATE SYNTHETASE; ANIMALS; APOPTOSIS; ARTIFICIAL GENE FUSION; CHIKUNGUNYA VIRUS; GENES, REPORTER; HELA CELLS; HUMANS; LUCIFERASES; MUTANT PROTEINS; MYOBLASTS; RENILLA; VIRAL PROTEINS; VIRUS INTERNALIZATION;

CHIKUNGUNYA VIRUS; RENILLA LUCIFERASE;

EID: 84868089299     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2012.07.019     Document Type: Article

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