Denatured globular protein and bile salt-coated nanoparticles for poorly water-soluble drugs: Penetration across the intestinal epithelial barrier into the circulation system and enhanced oral bioavailability

International Journal of Pharmaceutics

Volumn 495, Issue 1, 2015, Pages 9-18

  He, Wei ^a   Yang, Ke ^a   Fan, Lifang ^a,b   Lv, Yaqi ^a   Jin, Zhu ^a   Zhu, Shumin ^a   Qin, Chao ^a   Wang, Yiao ^a   Yin, Lifang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Aosaikang Pharmaceutical Co Ltd   (China)

Author keywords

Absorption mechanism; Globular protein; Insoluble drug; Nanoemulsions; Pharmacokinetics; Solidification

Indexed keywords

BILE SALT; FENOFIBRATE; FENOFIBRIC ACID; GLOBULAR PROTEIN; NANOPARTICLE; SOYBEAN PROTEIN; BILE ACID; DRUG CARRIER; EMULSION; SUSPENSION; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; INTESTINE EPITHELIUM CELL; INTESTINE PERFUSION; MAXIMUM PLASMA CONCENTRATION; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN ISOLATION; RAT; SCANNING ELECTRON MICROSCOPY; SOLUBILIZATION; SYSTEMIC CIRCULATION; TRANSMISSION ELECTRON MICROSCOPY; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANIMAL; BIOAVAILABILITY; BLOOD; CACO-2 CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; EMULSION; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PROTEIN DENATURATION; SOLUBILITY; SUSPENSION; TISSUE DISTRIBUTION; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EMULSIONS; FENOFIBRATE; HUMANS; INTESTINAL ABSORPTION; NANOPARTICLES; PARTICLE SIZE; PROTEIN DENATURATION; RATS; SOLUBILITY; SOYBEAN PROTEINS; SUSPENSIONS; TISSUE DISTRIBUTION; WATER;

EID: 84940754659     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.08.086     Document Type: Article

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