Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells

Oncotarget

Volumn 6, Issue 25, 2015, Pages 21074-21084

  Mak, Joyce P Y ^a   Man, Wing Yu ^a   Chow, Jeremy P H ^a   Ma, Hoi Tang ^a   Poon, Randy Y C ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

DNA damage checkpoint; Mitosis; Mitotic catastrophe; Nasopharyngeal carcinoma; WEE1

Indexed keywords

2 ALLYL 1 [6 (1 HYDROXY 1 METHYLETHYL) 2 PYRIDINYL] 6 [4 (4 METHYL 1 PIPERAZINYL)ANILINO] 1H PYRAZOLO[3,4 D]PYRIMIDIN 3(2H) ONE; 5 (3 FLUOROPHENYL) N (3 PIPERIDINYL) 3 UREIDO 2 THIOPHENECARBOXAMIDE; ATR PROTEIN; CHECKPOINT KINASE 1; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; WEE1 PROTEIN; 3-(CARBAMOYLAMINO)-5-(3-FLUOROPHENYL)-N-(3-PIPERIDYL)THIOPHENE-2-CARBOXAMIDE; ATM PROTEIN; ATR PROTEIN, HUMAN; CELL CYCLE PROTEIN; CHEK1 PROTEIN, HUMAN; CHEK1 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; NUCLEAR PROTEIN; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; THIOPHENE DERIVATIVE; UREA; WEE1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOMA CELL; CARCINOMA CELL LINE; CELL IMMORTALIZATION; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INACTIVATION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IONIZING RADIATION; MITOSIS; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PROTEIN EXPRESSION; RADIOSENSITIZATION; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CHEMISTRY; DNA DAMAGE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HELA CELL LINE; METABOLISM; NASOPHARYNX TUMOR; PHOSPHORYLATION; RNA INTERFERENCE; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CHECKPOINT KINASE 1; DNA DAMAGE; FLOW CYTOMETRY; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; MITOSIS; NASOPHARYNGEAL NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-TYROSINE KINASES; PYRAZOLES; PYRIMIDINES; RNA INTERFERENCE; THIOPHENES; UREA;

EID: 84940739834     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4020     Document Type: Article

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