GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 309, Issue 5, 2015, Pages G400-G407

  Johansson, Maja ^a,b   Agusti, Ana ^c   Llansola, Marta ^d   Montoliu, Carmina ^c   Strömberg, Jessica ^b   Malinina, Evgenya ^b   Ragagnin, Gianna ^b   Doverskog, Magnus ^a   Bäckström, Torbjörn ^b   Felipo, Vicente ^d  

^a Umecrine Cognition AB   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c Instituto Universitario IVI INCLIVA   (Spain)

^d CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

GABAA receptors; Hepatic encephalopathy; Hyperammonemia; Neurosteroids

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA,21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; GR 3027; UNCLASSIFIED DRUG; DEOXYCORTICOSTERONE; ELTANOLONE; HYDROXYSTEROID; TETRAHYDRODEOXYCORTICOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; HEPATIC ENCEPHALOPATHY; HUMAN; HUMAN CELL; HYPERAMMONEMIA; MALE; MORRIS WATER MAZE TEST; MOTOR COORDINATION; NONHUMAN; PORTOCAVAL SHUNT; PRIORITY JOURNAL; RAT; SPATIAL LEARNING; SPATIAL MEMORY; ANALOGS AND DERIVATIVES; ANIMAL; DRUG ANTAGONISM; HEK293 CELL LINE; LOCOMOTION; MAZE TEST; METABOLISM; WISTAR RAT;

ANIMALS; CIRCADIAN RHYTHM; DESOXYCORTICOSTERONE; DRUG ANTAGONISM; HEK293 CELLS; HEPATIC ENCEPHALOPATHY; HUMANS; HYDROXYSTEROIDS; HYPERAMMONEMIA; LOCOMOTION; MALE; MAZE LEARNING; PREGNANOLONE; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 84940738195     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00073.2015.     Document Type: Article

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