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Volumn 55, Issue 6, 2014, Pages 367-379

The dark side of 5α-reductase inhibitors' therapy: Sexual dysfunction, high gleason grade prostate cancer and depression

Author keywords

5a reductase inhibitors; Depression; Physiological sexual dysfunction; Prostate neoplasms

Indexed keywords

ALFAXALONE; ANDROSTANOLONE; DUTASTERIDE; FINASTERIDE; STEROID 5ALPHA REDUCTASE; STREPTAVIDIN;

EID: 84902592198     PISSN: 20056737     EISSN: 20056745     Source Type: Journal    
DOI: 10.4111/kju.2014.55.6.367     Document Type: Review
Times cited : (71)

References (100)
  • 1
    • 84871382108 scopus 로고    scopus 로고
    • 5α-reductases in human physiology: An unfolding story
    • Traish AM. 5α-reductases in human physiology: an unfolding story. Endocr Pract 2012;18:965-75.
    • (2012) Endocr Pract , vol.18 , pp. 965-975
    • Traish, A.M.1
  • 2
    • 79951991163 scopus 로고    scopus 로고
    • Adverse side effects of 5α-reductase inhibitors therapy: Persistent diminished libido and erectile dysfunction and depression in a subset of patients
    • Traish AM, Hassani J, Guay AT, Zitzmann M, Hansen ML. Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients. J Sex Med 2011;8:872-84.
    • (2011) J Sex Med , vol.8 , pp. 872-884
    • Traish, A.M.1    Hassani, J.2    Guay, A.T.3    Zitzmann, M.4    Hansen, M.L.5
  • 3
    • 77955057089 scopus 로고    scopus 로고
    • SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder
    • Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, et al. SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 2010;142:203-17.
    • (2010) Cell , vol.142 , pp. 203-217
    • Cantagrel, V.1    Lefeber, D.J.2    Ng, B.G.3    Guan, Z.4    Silhavy, J.L.5    Bielas, S.L.6
  • 4
    • 77955036295 scopus 로고    scopus 로고
    • SRD5A3: A surprising role in glycosylation
    • Stiles AR, Russell DW. SRD5A3: a surprising role in glycosylation. Cell 2010;142:196-8.
    • (2010) Cell , vol.142 , pp. 196-198
    • Stiles, A.R.1    Russell, D.W.2
  • 5
    • 57649176913 scopus 로고    scopus 로고
    • Shifting the paradigm of testosterone and prostate cancer: The saturation model and the limits of androgen-dependent growth
    • Morgentaler A, Traish AM. Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth. Eur Urol 2009;55:310-20.
    • (2009) Eur Urol , vol.55 , pp. 310-320
    • Morgentaler, A.1    Traish, A.M.2
  • 6
    • 71649097081 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: A potential molecular switch for tumour growth
    • Traish AM, Morgentaler A. Epidermal growth factor receptor expression escapes androgen regulation in prostate cancer: a potential molecular switch for tumour growth. Br J Cancer 2009;101:1949-56.
    • (2009) Br J Cancer , vol.101 , pp. 1949-1956
    • Traish, A.M.1    Morgentaler, A.2
  • 7
    • 0023640882 scopus 로고
    • Prostatic epidermal growth factor receptors and their regulation by androgens
    • Traish AM, Wotiz HH. Prostatic epidermal growth factor receptors and their regulation by androgens. Endocrinology 1987;121:1461-7.
    • (1987) Endocrinology , vol.121 , pp. 1461-1467
    • Traish, A.M.1    Wotiz, H.H.2
  • 8
    • 84902547279 scopus 로고    scopus 로고
    • Personalized medicine for the management of benign prostatic hyperplasia
    • Feb 25 [Epub]
    • Bechis SK, Otsetov AG, Ge R, Olumi AF. Personalized medicine for the management of benign prostatic hyperplasia. J Urol 2014 Feb 25 [Epub]. http://dx.doi.org/10.1016/j.juro.2014.01.114.
    • (2014) J Urol
    • Bechis, S.K.1    Otsetov, A.G.2    Ge, R.3    Olumi, A.F.4
  • 9
    • 57449107265 scopus 로고    scopus 로고
    • 5-alpha reductase inhibitors and erectile dysfunction: The connection
    • Erdemir F, Harbin A, Hellstrom WJ. 5-alpha reductase inhibitors and erectile dysfunction: the connection. J Sex Med 2008;5:2917-24.
    • (2008) J Sex Med , vol.5 , pp. 2917-2924
    • Erdemir, F.1    Harbin, A.2    Hellstrom, W.J.3
  • 10
    • 84871488147 scopus 로고    scopus 로고
    • Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation
    • Gur S, Kadowitz PJ, Hellstrom WJ. Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation. Expert Opin Drug Saf 2013;12:81-90.
    • (2013) Expert Opin Drug Saf , vol.12 , pp. 81-90
    • Gur, S.1    Kadowitz, P.J.2    Hellstrom, W.J.3
  • 11
    • 79957924605 scopus 로고    scopus 로고
    • Persistent sexual side effects of finasteride for male pattern hair loss
    • Irwig MS, Kolukula S. Persistent sexual side effects of finasteride for male pattern hair loss. J Sex Med 2011;8:1747-53.
    • (2011) J Sex Med , vol.8 , pp. 1747-1753
    • Irwig, M.S.1    Kolukula, S.2
  • 12
    • 78649787861 scopus 로고    scopus 로고
    • Finasteride-induced depression: New insights into possible pathomechanisms
    • Romer B, Gass P. Finasteride-induced depression: new insights into possible pathomechanisms. J Cosmet Dermatol 2010;9: 331-2.
    • (2010) J Cosmet Dermatol , vol.9 , pp. 331-332
    • Romer, B.1    Gass, P.2
  • 16
    • 84902573470 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. 2010 Meeting Materials, Oncologic Drugs Advisory Committee [Internet]. Silver Spring: U.S. Food and Drug Administration; [c2014] [cited 2010 Dec 1]. Available from
    • U.S. Food and Drug Administration. 2010 Meeting Materials, Oncologic Drugs Advisory Committee [Internet]. Silver Spring: U.S. Food and Drug Administration; [c2014] [cited 2010 Dec 1]. Available from: http://www.fda.gov/advisorycommittees/committeesmeetingmaterials/drugs/oncologicdrugsadvisorycommittee/ucm195226.htm.
  • 18
    • 84868213002 scopus 로고    scopus 로고
    • Persistent sexual side effects of finasteride: Could they be permanent?
    • Irwig MS. Persistent sexual side effects of finasteride: could they be permanent? J Sex Med 2012;9:2927-32.
    • (2012) J Sex Med , vol.9 , pp. 2927-2932
    • Irwig, M.S.1
  • 19
    • 0346666783 scopus 로고    scopus 로고
    • Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia
    • Wessells H, Roy J, Bannow J, Grayhack J, Matsumoto AM, Tenover L, et al. Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia. Urology 2003;61:579-84.
    • (2003) Urology , vol.61 , pp. 579-584
    • Wessells, H.1    Roy, J.2    Bannow, J.3    Grayhack, J.4    Matsumoto, A.M.5    Tenover, L.6
  • 20
    • 38049098261 scopus 로고    scopus 로고
    • Molecular characterization of 6 unrelated Italian patients with 5alpha-reductase type 2 deficiency
    • Baldinotti F, Majore S, Fogli A, Marrocco G, Ghirri P, Vuerich M, et al. Molecular characterization of 6 unrelated Italian patients with 5alpha-reductase type 2 deficiency. J Androl 2008; 29:20-8.
    • (2008) J Androl , vol.29 , pp. 20-28
    • Baldinotti, F.1    Majore, S.2    Fogli, A.3    Marrocco, G.4    Ghirri, P.5    Vuerich, M.6
  • 21
    • 0346502851 scopus 로고    scopus 로고
    • Sex determination and differentiation
    • MacLaughlin DT, Donahoe PK. Sex determination and differentiation. N Engl J Med 2004;350:367-78.
    • (2004) N Engl J Med , vol.350 , pp. 367-378
    • Maclaughlin, D.T.1    Donahoe, P.K.2
  • 22
    • 0017445819 scopus 로고
    • The mechanism of action of androgens
    • Mainwaring WI. The mechanism of action of androgens. Monogr Endocrinol 1977;10:1-178.
    • (1977) Monogr Endocrinol , vol.10 , pp. 1-178
    • Mainwaring, W.I.1
  • 23
    • 0019490089 scopus 로고
    • Attenuation by a 5 alpha-reductase inhibitor of the activational effect of testosterone propionate on penile erections in castrated male rats
    • Bradshaw WG, Baum MJ, Awh CC. Attenuation by a 5 alpha-reductase inhibitor of the activational effect of testosterone propionate on penile erections in castrated male rats. Endocrinology 1981;109:1047-51.
    • (1981) Endocrinology , vol.109 , pp. 1047-1051
    • Bradshaw, W.G.1    Baum, M.J.2    Awh, C.C.3
  • 24
    • 0019222474 scopus 로고
    • Hormonal regulation of penile erection in castrated male rats
    • Gray GD, Smith ER, Davidson JM. Hormonal regulation of penile erection in castrated male rats. Physiol Behav 1980;24:463-8.
    • (1980) Physiol Behav , vol.24 , pp. 463-468
    • Gray, G.D.1    Smith, E.R.2    Davidson, J.M.3
  • 25
    • 0016188373 scopus 로고
    • Effects of testosterone propionate and dihydrotestosterone on penile morphology and sexual reflexes of spinal male rats
    • Hart BL. Effects of testosterone propionate and dihydrotestosterone on penile morphology and sexual reflexes of spinal male rats. Horm Behav 1973;4:239-46.
    • (1973) Horm Behav , vol.4 , pp. 239-246
    • Hart, B.L.1
  • 26
    • 0018717912 scopus 로고
    • Activation of sexual reflexes of male rats by dihydrotestosterone but not estrogen
    • Hart BL. Activation of sexual reflexes of male rats by dihydrotestosterone but not estrogen. Physiol Behav 1979;23:107-9.
    • (1979) Physiol Behav , vol.23 , pp. 107-109
    • Hart, B.L.1
  • 27
    • 0029012207 scopus 로고
    • Contribution of dihydrotestosterone to male sexual behaviour
    • Mantzoros CS, Georgiadis EI, Trichopoulos D. Contribution of dihydrotestosterone to male sexual behaviour. BMJ 1995;310: 1289-91.
    • (1995) BMJ , vol.310 , pp. 1289-1291
    • Mantzoros, C.S.1    Georgiadis, E.I.2    Trichopoulos, D.3
  • 28
    • 0017158377 scopus 로고
    • The inhibition of the conversion of testosterone into 5alpha-dihydrotestosterone in the reproductive organs of the male rat
    • Saksena SK, Lau IF, Chang MC. The inhibition of the conversion of testosterone into 5alpha-dihydrotestosterone in the reproductive organs of the male rat. Steroids 1976;27:751-7.
    • (1976) Steroids , vol.27 , pp. 751-757
    • Saksena, S.K.1    Lau, I.F.2    Chang, M.C.3
  • 29
    • 0018565975 scopus 로고
    • A comparison of the effects of methyltrienolone (R 1881) and 5 alpha-dihydrotestosterone on sexual behavior of castrated male rats
    • Baum MJ. A comparison of the effects of methyltrienolone (R 1881) and 5 alpha-dihydrotestosterone on sexual behavior of castrated male rats. Horm Behav 1979;13:165-74.
    • (1979) Horm Behav , vol.13 , pp. 165-174
    • Baum, M.J.1
  • 30
    • 0028904997 scopus 로고
    • Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat
    • Lugg JA, Rajfer J, Gonzalez-Cadavid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology 1995;136: 1495-501.
    • (1995) Endocrinology , vol.136 , pp. 1495-1501
    • Lugg, J.A.1    Rajfer, J.2    Gonzalez-Cadavid, N.F.3
  • 31
    • 0030795430 scopus 로고    scopus 로고
    • Adrenal control of erectile function and nitric oxide synthase in the rat penis
    • Penson DF, Ng C, Rajfer J, Gonzalez-Cadavid NF. Adrenal control of erectile function and nitric oxide synthase in the rat penis. Endocrinology 1997;138:3925-32.
    • (1997) Endocrinology , vol.138 , pp. 3925-3932
    • Penson, D.F.1    Ng, C.2    Rajfer, J.3    Gonzalez-Cadavid, N.F.4
  • 32
    • 0028880076 scopus 로고
    • Restoration of normal adult penile erectile response in aged rats by long-term treatment with androgens
    • Garban H, Marquez D, Cai L, Rajfer J, Gonzalez-Cadavid NF. Restoration of normal adult penile erectile response in aged rats by long-term treatment with androgens. Biol Reprod 1995;53:1365-72.
    • (1995) Biol Reprod , vol.53 , pp. 1365-1372
    • Garban, H.1    Marquez, D.2    Cai, L.3    Rajfer, J.4    Gonzalez-Cadavid, N.F.5
  • 33
    • 0041682860 scopus 로고    scopus 로고
    • Effects of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernosum
    • Park KH, Kim SW, Kim KD, Paick JS. Effects of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernosum. BJU Int 1999;83:327-33.
    • (1999) BJU Int , vol.83 , pp. 327-333
    • Park, K.H.1    Kim, S.W.2    Kim, K.D.3    Paick, J.S.4
  • 34
    • 0036451778 scopus 로고    scopus 로고
    • Androgen implants in medial amygdala briefly maintain noncontact erection in castrated male rats
    • Bialy M, Sachs BD. Androgen implants in medial amygdala briefly maintain noncontact erection in castrated male rats. Horm Behav 2002;42:345-55.
    • (2002) Horm Behav , vol.42 , pp. 345-355
    • Bialy, M.1    Sachs, B.D.2
  • 36
    • 0029024952 scopus 로고
    • Placing erection in context: The reflexogenic-psychogenic dichotomy reconsidered
    • Sachs BD. Placing erection in context: the reflexogenic-psychogenic dichotomy reconsidered. Neurosci Biobehav Rev 1995;19: 211-24.
    • (1995) Neurosci Biobehav Rev , vol.19 , pp. 211-224
    • Sachs, B.D.1
  • 37
    • 0033302395 scopus 로고    scopus 로고
    • The effects of androgen on penile reflex, erectile response to electrical stimulation and penile NOS activity in the rat
    • Seo SI, Kim SW, Paick JS. The effects of androgen on penile reflex, erectile response to electrical stimulation and penile NOS activity in the rat. Asian J Androl 1999;1:169-74.
    • (1999) Asian J Androl , vol.1 , pp. 169-174
    • Seo, S.I.1    Kim, S.W.2    Paick, J.S.3
  • 38
    • 84863531474 scopus 로고    scopus 로고
    • Incomplete recovery of erectile function in rat after discontinuation of dual 5-alpha reductase inhibitor therapy
    • Oztekin CV, Gur S, Abdulkadir NA, Lokman U, Akdemir AO, Cetinkaya M, et al. Incomplete recovery of erectile function in rat after discontinuation of dual 5-alpha reductase inhibitor therapy. J Sex Med 2012;9:1773-81.
    • (2012) J Sex Med , vol.9 , pp. 1773-1781
    • Oztekin, C.V.1    Gur, S.2    Abdulkadir, N.A.3    Lokman, U.4    Akdemir, A.O.5    Cetinkaya, M.6
  • 39
    • 80255127536 scopus 로고    scopus 로고
    • The effects of chronic 5-alpha-reductase inhibitor (dutasteride) treatment on rat erectile function
    • Pinsky MR, Gur S, Tracey AJ, Harbin A, Hellstrom WJ. The effects of chronic 5-alpha-reductase inhibitor (dutasteride) treatment on rat erectile function. J Sex Med 2011;8:3066-74.
    • (2011) J Sex Med , vol.8 , pp. 3066-3074
    • Pinsky, M.R.1    Gur, S.2    Tracey, A.J.3    Harbin, A.4    Hellstrom, W.J.5
  • 40
    • 84883240058 scopus 로고    scopus 로고
    • Long-term oral administration of 5α-reductase inhibitor attenuates erectile function by inhibiting autophagy and promoting apoptosis of smooth muscle cells in corpus cavernosum of aged rats
    • Zhang MG, Wang XJ, Shen ZJ, Gao PJ. Long-term oral administration of 5α-reductase inhibitor attenuates erectile function by inhibiting autophagy and promoting apoptosis of smooth muscle cells in corpus cavernosum of aged rats. Urology 2013;82:743.e9-15.
    • (2013) Urology , vol.82 , Issue.743 , pp. 9-15
    • Zhang, M.G.1    Wang, X.J.2    Shen, Z.J.3    Gao, P.J.4
  • 41
    • 0032981996 scopus 로고    scopus 로고
    • Effects of castration and androgen replacement on erectile function in a rabbit model
    • Traish AM, Park K, Dhir V, Kim NN, Moreland RB, Goldstein I. Effects of castration and androgen replacement on erectile function in a rabbit model. Endocrinology 1999;140:1861-8.
    • (1999) Endocrinology , vol.140 , pp. 1861-1868
    • Traish, A.M.1    Park, K.2    Dhir, V.3    Kim, N.N.4    Moreland, R.B.5    Goldstein, I.6
  • 42
    • 0029827421 scopus 로고    scopus 로고
    • Efficacy and safety of finasteride therapy for benign prostatic hyperplasia: Results of a 2-year randomized controlled trial (the PROSPECT study). PROscar Safety Plus Efficacy Canadian Two year Study
    • Nickel JC, Fradet Y, Boake RC, Pommerville PJ, Perreault JP, Afridi SK, et al. Efficacy and safety of finasteride therapy for benign prostatic hyperplasia: results of a 2-year randomized controlled trial (the PROSPECT study). PROscar Safety Plus Efficacy Canadian Two year Study. CMAJ 1996;155:1251-9.
    • (1996) CMAJ , vol.155 , pp. 1251-1259
    • Nickel, J.C.1    Fradet, Y.2    Boake, R.C.3    Pommerville, P.J.4    Perreault, J.P.5    Afridi, S.K.6
  • 43
    • 0030916980 scopus 로고    scopus 로고
    • Efficacy and tolerability of finasteride in symptomatic benign prostatic hyperplasia: A primary care study. Primary Care Investigator Study Group
    • Tenover JL, Pagano GA, Morton AS, Liss CL, Byrnes CA. Efficacy and tolerability of finasteride in symptomatic benign prostatic hyperplasia: a primary care study. Primary Care Investigator Study Group. Clin Ther 1997;19:243-58.
    • (1997) Clin Ther , vol.19 , pp. 243-258
    • Tenover, J.L.1    Pagano, G.A.2    Morton, A.S.3    Liss, C.L.4    Byrnes, C.A.5
  • 44
    • 0005309240 scopus 로고    scopus 로고
    • Efficacy of finasteride is maintained in patients with benign prostatic hyperplasia treated for 5 years. The North American Finasteride Study Group
    • Hudson PB, Boake R, Trachtenberg J, Romas NA, Rosenblatt S, Narayan P, et al. Efficacy of finasteride is maintained in patients with benign prostatic hyperplasia treated for 5 years. The North American Finasteride Study Group. Urology 1999;53:690-5.
    • (1999) Urology , vol.53 , pp. 690-695
    • Hudson, P.B.1    Boake, R.2    Trachtenberg, J.3    Romas, N.A.4    Rosenblatt, S.5    Narayan, P.6
  • 45
    • 0032856647 scopus 로고    scopus 로고
    • Effect of finasteride on bother and other health-related quality of life aspects associated with benign prostatic hyperplasia. PLESS Study Group. Proscar Long-term Efficacy and Safety Study
    • Bruskewitz R, Girman CJ, Fowler J, Rigby OF, Sullivan M, Bracken RB, et al. Effect of finasteride on bother and other health-related quality of life aspects associated with benign prostatic hyperplasia. PLESS Study Group. Proscar Long-term Efficacy and Safety Study. Urology 1999;54:670-8.
    • (1999) Urology , vol.54 , pp. 670-678
    • Bruskewitz, R.1    Girman, C.J.2    Fowler, J.3    Rigby, O.F.4    Sullivan, M.5    Bracken, R.B.6
  • 46
    • 0030423280 scopus 로고    scopus 로고
    • The safety of finasteride used in benign prostatic hypertrophy: A non-interventional observational cohort study in 14,772 patients
    • Wilton L, Pearce G, Edet E, Freemantle S, Stephens MD, Mann RD. The safety of finasteride used in benign prostatic hypertrophy: a non-interventional observational cohort study in 14,772 patients. Br J Urol 1996;78:379-84.
    • (1996) Br J Urol , vol.78 , pp. 379-384
    • Wilton, L.1    Pearce, G.2    Edet, E.3    Freemantle, S.4    Stephens, M.D.5    Mann, R.D.6
  • 47
    • 0038672692 scopus 로고    scopus 로고
    • AUA guideline on management of benign prostatic hyperplasia (2003). Chapter 1: Diagnosis and treatment recommendations
    • AUA Practice Guidelines Committee
    • AUA Practice Guidelines Committee. AUA guideline on management of benign prostatic hyperplasia (2003). Chapter 1: Diagnosis and treatment recommendations. J Urol 2003;170(2 Pt 1):530-47.
    • (2003) J Urol , vol.170 , Issue.2 PART 1 , pp. 530-547
  • 48
    • 3343024319 scopus 로고    scopus 로고
    • Finasteride in the treatment of clinical benign prostatic hyperplasia: A systematic review of randomised trials
    • Edwards JE, Moore RA. Finasteride in the treatment of clinical benign prostatic hyperplasia: a systematic review of randomised trials. BMC Urol 2002;2:14.
    • (2002) BMC Urol , vol.2 , pp. 14
    • Edwards, J.E.1    Moore, R.A.2
  • 49
    • 38849201263 scopus 로고    scopus 로고
    • The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT study
    • Roehrborn CG, Siami P, Barkin J, Damiao R, Major-Walker K, Morrill B, et al. The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT study. J Urol 2008;179:616-21.
    • (2008) J Urol , vol.179 , pp. 616-621
    • Roehrborn, C.G.1    Siami, P.2    Barkin, J.3    Damiao, R.4    Major-Walker, K.5    Morrill, B.6
  • 50
    • 34848860581 scopus 로고    scopus 로고
    • Combination therapy with dutasteride and tamsulosin in men with moderate-to-severe benign prostatic hyperplasia and prostate enlargement: The CombAT (Combination of Avodart and Tamsulosin) trial rationale and study design
    • Siami P, Roehrborn CG, Barkin J, Damiao R, Wyczolkowski M, Duggan A, et al. Combination therapy with dutasteride and tamsulosin in men with moderate-to-severe benign prostatic hyperplasia and prostate enlargement: the CombAT (Combination of Avodart and Tamsulosin) trial rationale and study design. Contemp Clin Trials 2007;28:770-9.
    • (2007) Contemp Clin Trials , vol.28 , pp. 770-779
    • Siami, P.1    Roehrborn, C.G.2    Barkin, J.3    Damiao, R.4    Wyczolkowski, M.5    Duggan, A.6
  • 51
    • 33745061712 scopus 로고    scopus 로고
    • Effect of dutasteride on the symptoms of benign prostatic hyperplasia, and patient quality of life and discomfort, in clinical practice
    • Desgrandchamps F, Droupy S, Irani J, Saussine C, Comenducci A. Effect of dutasteride on the symptoms of benign prostatic hyperplasia, and patient quality of life and discomfort, in clinical practice. BJU Int 2006;98:83-8.
    • (2006) BJU Int , vol.98 , pp. 83-88
    • Desgrandchamps, F.1    Droupy, S.2    Irani, J.3    Saussine, C.4    Comenducci, A.5
  • 52
    • 52949152825 scopus 로고    scopus 로고
    • The effect of 5 alpha-reductase inhibitors on erectile function
    • Canguven O, Burnett AL. The effect of 5 alpha-reductase inhibitors on erectile function. J Androl 2008;29:514-23.
    • (2008) J Androl , vol.29 , pp. 514-523
    • Canguven, O.1    Burnett, A.L.2
  • 53
    • 84867526448 scopus 로고    scopus 로고
    • A 5-year retrospective analysis of 5α-reductase inhibitors in men with benign prostatic hyperplasia: Finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasteride
    • Kaplan SA, Chung DE, Lee RK, Scofield S, Te AE. A 5-year retrospective analysis of 5α-reductase inhibitors in men with benign prostatic hyperplasia: finasteride has comparable urinary symptom efficacy and prostate volume reduction, but less sexual side effects and breast complications than dutasteride. Int J Clin Pract 2012;66:1052-5.
    • (2012) Int J Clin Pract , vol.66 , pp. 1052-1055
    • Kaplan, S.A.1    Chung, D.E.2    Lee, R.K.3    Scofield, S.4    Te, A.E.5
  • 54
    • 84930483933 scopus 로고    scopus 로고
    • Changes in sexual function in benign prostatic hyperplasia patients taking dutasteride: 1-year follow-up results
    • Chi BH, Kim SC. Changes in sexual function in benign prostatic hyperplasia patients taking dutasteride: 1-year follow-up results. Korean J Urol 2011;52:632-6.
    • (2011) Korean J Urol , vol.52 , pp. 632-636
    • Chi, B.H.1    Kim, S.C.2
  • 55
    • 84900426701 scopus 로고    scopus 로고
    • Change in sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia associated with long-term treatment with doxazosin, finasteride and combined therapy
    • Dec 14 [Epub], 2013.12.014
    • Fwu CW, Eggers PW, Kirkali Z, McVary KT, Burrows PK, Kusek JW. Change in sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia associated with long-term treatment with doxazosin, finasteride and combined therapy. J Urol 2013 Dec 14 [Epub]. http://dx.doi.org/10.1016/j.juro.2013.12.014.
    • (2013) J Urol
    • Fwu, C.W.1    Eggers, P.W.2    Kirkali, Z.3    McVary, K.T.4    Burrows, P.K.5    Kusek, J.W.6
  • 56
    • 0009829895 scopus 로고    scopus 로고
    • Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941
    • Huggins C, Hodges CV. Studies on prostatic cancer. I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941. J Urol 2002;167(2 Pt 2):948-51.
    • (2002) J Urol , vol.167 , Issue.2 PART 2 , pp. 948-951
    • Huggins, C.1    Hodges, C.V.2
  • 57
    • 79955624272 scopus 로고    scopus 로고
    • Correlation between circulatory, local prostatic, and intra-prostatic androgen levels
    • Olsson M, Ekstrom L, Guillemette C, Belanger A, Rane A, Gustafsson O. Correlation between circulatory, local prostatic, and intra-prostatic androgen levels. Prostate 2011;71:909-14.
    • (2011) Prostate , vol.71 , pp. 909-914
    • Olsson, M.1    Ekstrom, L.2    Guillemette, C.3    Belanger, A.4    Rane, A.5    Gustafsson, O.6
  • 58
    • 84867077468 scopus 로고    scopus 로고
    • Goodbye androgen hypothesis, hello saturation model
    • Morgentaler A. Goodbye androgen hypothesis, hello saturation model. Eur Urol 2012;62:765-7.
    • (2012) Eur Urol , vol.62 , pp. 765-767
    • Morgentaler, A.1
  • 59
    • 84867052045 scopus 로고    scopus 로고
    • Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trial
    • Muller RL, Gerber L, Moreira DM, Andriole G, Castro- Santamaria R, Freedland SJ. Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trial. Eur Urol 2012;62:757-64.
    • (2012) Eur Urol , vol.62 , pp. 757-764
    • Muller, R.L.1    Gerber, L.2    Moreira, D.M.3    Andriole, G.4    Castro-Santamaria, R.5    Freedland, S.J.6
  • 61
    • 84857068554 scopus 로고    scopus 로고
    • What's wrong with chemoprevention of prostate cancer?
    • Justman S. What's wrong with chemoprevention of prostate cancer? Am J Bioeth 2011;11:21-5.
    • (2011) Am J Bioeth , vol.11 , pp. 21-25
    • Justman, S.1
  • 62
    • 70249126559 scopus 로고    scopus 로고
    • Three considerations before advising 5-alpha-reductase inhibitors for chemoprevention
    • author reply e23
    • Walsh PC. Three considerations before advising 5-alpha-reductase inhibitors for chemoprevention. J Clin Oncol 2009;27:e22; author reply e23.
    • (2009) J Clin Oncol , vol.27 , pp. 22
    • Walsh, P.C.1
  • 63
    • 77950510825 scopus 로고    scopus 로고
    • Chemoprevention of prostate cancer
    • Walsh PC. Chemoprevention of prostate cancer. N Engl J Med 2010;362:1237-8.
    • (2010) N Engl J Med , vol.362 , pp. 1237-1238
    • Walsh, P.C.1
  • 64
    • 84876039466 scopus 로고    scopus 로고
    • 5-alpha Reductase inhibitors in prostate cancer: From clinical trials to clinical practice
    • Ehdaie B, Touijer KA. 5-alpha Reductase inhibitors in prostate cancer: from clinical trials to clinical practice. Eur Urol 2013;63:788-9.
    • (2013) Eur Urol , vol.63 , pp. 788-789
    • Ehdaie, B.1    Touijer, K.A.2
  • 65
    • 80051548428 scopus 로고    scopus 로고
    • Battling prostate cancer with 5-alpha-reductase inhibitors: A pyrrhic victory?
    • Hoffman RM, Roberts RG, Barry MJ. Battling prostate cancer with 5-alpha-reductase inhibitors: a pyrrhic victory? J Gen Intern Med 2011;26:798-801.
    • (2011) J Gen Intern Med , vol.26 , pp. 798-801
    • Hoffman, R.M.1    Roberts, R.G.2    Barry, M.J.3
  • 66
    • 0038311875 scopus 로고    scopus 로고
    • Safety and tolerability of the dual 5alpha-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasia
    • Andriole GL, Kirby R. Safety and tolerability of the dual 5alpha-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasia. Eur Urol 2003;44:82-8.
    • (2003) Eur Urol , vol.44 , pp. 82-88
    • Andriole, G.L.1    Kirby, R.2
  • 67
    • 78650684271 scopus 로고    scopus 로고
    • Effect of dutasteride on prostate biopsy rates and the diagnosis of prostate cancer in men with lower urinary tract symptoms and enlarged prostates in the Combination of Avodart and Tamsulosin trial
    • Roehrborn CG, Andriole GL, Wilson TH, Castro R, Rittmaster RS. Effect of dutasteride on prostate biopsy rates and the diagnosis of prostate cancer in men with lower urinary tract symptoms and enlarged prostates in the Combination of Avodart and Tamsulosin trial. Eur Urol 2011;59:244-9.
    • (2011) Eur Urol , vol.59 , pp. 244-249
    • Roehrborn, C.G.1    Andriole, G.L.2    Wilson, T.H.3    Castro, R.4    Rittmaster, R.S.5
  • 68
    • 0029859580 scopus 로고    scopus 로고
    • Human prostate tumor growth in athymic mice: Inhibition by androgens and stimulation by finasteride
    • Umekita Y, Hiipakka RA, Kokontis JM, Liao S. Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride. Proc Natl Acad Sci U S A 1996;93: 11802-7.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11802-11807
    • Umekita, Y.1    Hiipakka, R.A.2    Kokontis, J.M.3    Liao, S.4
  • 69
    • 84888840943 scopus 로고    scopus 로고
    • A new era of testosterone and prostate cancer: From physiology to clinical implications
    • Khera M, Crawford D, Morales A, Salonia A, Morgentaler A. A new era of testosterone and prostate cancer: from physiology to clinical implications. Eur Urol 2014;65:115-23.
    • (2014) Eur Urol , vol.65 , pp. 115-123
    • Khera, M.1    Crawford, D.2    Morales, A.3    Salonia, A.4    Morgentaler, A.5
  • 70
    • 79955826230 scopus 로고    scopus 로고
    • Finasteride upregulates expression of androgen receptor in hyperplastic prostate and LNCaP cells: Implications for chemoprevention of prostate cancer
    • Hsieh JT, Chen SC, Yu HJ, Chang HC. Finasteride upregulates expression of androgen receptor in hyperplastic prostate and LNCaP cells: implications for chemoprevention of prostate cancer. Prostate 2011;71:1115-21.
    • (2011) Prostate , vol.71 , pp. 1115-1121
    • Hsieh, J.T.1    Chen, S.C.2    Yu, H.J.3    Chang, H.C.4
  • 71
    • 84873370170 scopus 로고    scopus 로고
    • Finasteride increases the expression of hemoxygenase-1 (HO-1) and NF-E2-related factor-2 (Nrf2) proteins in PC-3 cells: Implication of finasteride-mediated high-grade prostate tumor occurrence
    • Yun DK, Lee J, Keum YS. Finasteride increases the expression of hemoxygenase-1 (HO-1) and NF-E2-related factor-2 (Nrf2) proteins in PC-3 cells: implication of finasteride-mediated high-grade prostate tumor occurrence. Biomol Ther (Seoul) 2013;21:49-53.
    • (2013) Biomol Ther (Seoul) , vol.21 , pp. 49-53
    • Yun, D.K.1    Lee, J.2    Keum, Y.S.3
  • 72
    • 0032956181 scopus 로고    scopus 로고
    • Neurosteroids: Expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system
    • Mensah-Nyagan AG, Do-Rego JL, Beaujean D, Luu-The V, Pelletier G, Vaudry H. Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system. Pharmacol Rev 1999;51:63-81.
    • (1999) Pharmacol Rev , vol.51 , pp. 63-81
    • Mensah-Nyagan, A.G.1    Do-Rego, J.L.2    Beaujean, D.3    Luu-The, V.4    Pelletier, G.5    Vaudry, H.6
  • 74
    • 84861554984 scopus 로고    scopus 로고
    • Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy
    • Reddy DS. Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy. Front Endocrinol (Lausanne) 2011;2:38.
    • (2011) Front Endocrinol (Lausanne) , vol.2 , pp. 38
    • Reddy, D.S.1
  • 75
  • 76
    • 84885926631 scopus 로고    scopus 로고
    • Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology
    • Melcangi RC, Caruso D, Abbiati F, Giatti S, Calabrese D, Piazza F, et al. Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology. J Sex Med 2013;10:2598-603.
    • (2013) J Sex Med , vol.10 , pp. 2598-2603
    • Melcangi, R.C.1    Caruso, D.2    Abbiati, F.3    Giatti, S.4    Calabrese, D.5    Piazza, F.6
  • 77
    • 4544282704 scopus 로고    scopus 로고
    • Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury
    • He J, Evans CO, Hoffman SW, Oyesiku NM, Stein DG. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp Neurol 2004;189:404-12.
    • (2004) Exp Neurol , vol.189 , pp. 404-412
    • He, J.1    Evans, C.O.2    Hoffman, S.W.3    Oyesiku, N.M.4    Stein, D.G.5
  • 79
    • 77957780905 scopus 로고    scopus 로고
    • Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases
    • Ishrat T, Sayeed I, Atif F, Hua F, Stein DG. Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases. Exp Neurol 2010;226:183-90.
    • (2010) Exp Neurol , vol.226 , pp. 183-190
    • Ishrat, T.1    Sayeed, I.2    Atif, F.3    Hua, F.4    Stein, D.G.5
  • 80
    • 84858164763 scopus 로고    scopus 로고
    • Cytoarchitectural characteristics of hippocampal CA1 pyramidal neurons of rats, four months after global cerebral ischemia and progesterone treatment
    • Moralí G, Montes P, Gonzalez-Burgos I, Velazquez-Zamora DA, Cervantes M. Cytoarchitectural characteristics of hippocampal CA1 pyramidal neurons of rats, four months after global cerebral ischemia and progesterone treatment. Restor Neurol Neurosci 2012;30:1-8.
    • (2012) Restor Neurol Neurosci , vol.30 , pp. 1-8
    • Moralí, G.1    Montes, P.2    Gonzalez-Burgos, I.3    Velazquez-Zamora, D.A.4    Cervantes, M.5
  • 81
    • 33645002699 scopus 로고    scopus 로고
    • Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion
    • Sayeed I, Guo Q, Hoffman SW, Stein DG. Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion. Ann Emerg Med 2006;47:381-9.
    • (2006) Ann Emerg Med , vol.47 , pp. 381-389
    • Sayeed, I.1    Guo, Q.2    Hoffman, S.W.3    Stein, D.G.4
  • 82
    • 34249018018 scopus 로고    scopus 로고
    • Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep
    • Yawno T, Yan EB, Walker DW, Hirst JJ. Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep. Neuroscience 2007;146:1726-33.
    • (2007) Neuroscience , vol.146 , pp. 1726-1733
    • Yawno, T.1    Yan, E.B.2    Walker, D.W.3    Hirst, J.J.4
  • 83
    • 84874906143 scopus 로고    scopus 로고
    • Allopregnanolone- mediated protective effects of progesterone on tributyltin- induced neuronal injury in rat hippocampal slices
    • Ishihara Y, Kawami T, Ishida A, Yamazaki T. Allopregnanolone- mediated protective effects of progesterone on tributyltin- induced neuronal injury in rat hippocampal slices. J Steroid Biochem Mol Biol 2013;135:1-6.
    • (2013) J Steroid Biochem Mol Biol , vol.135 , pp. 1-6
    • Ishihara, Y.1    Kawami, T.2    Ishida, A.3    Yamazaki, T.4
  • 85
    • 34548563903 scopus 로고    scopus 로고
    • Neurosteroid regulation of central nervous system development
    • Mellon SH. Neurosteroid regulation of central nervous system development. Pharmacol Ther 2007;116:107-24.
    • (2007) Pharmacol Ther , vol.116 , pp. 107-124
    • Mellon, S.H.1
  • 86
    • 77953240724 scopus 로고    scopus 로고
    • Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects
    • Naylor JC, Kilts JD, Hulette CM, Steffens DC, Blazer DG, Ervin JF, et al. Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects. Biochim Biophys Acta 2010;1801:951-9.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 951-959
    • Naylor, J.C.1    Kilts, J.D.2    Hulette, C.M.3    Steffens, D.C.4    Blazer, D.G.5    Ervin, J.F.6
  • 87
    • 79959534299 scopus 로고    scopus 로고
    • Finasteride-associated cataract and intraoperative floppy-iris syndrome
    • Wong AC, Mak ST. Finasteride-associated cataract and intraoperative floppy-iris syndrome. J Cataract Refract Surg 2011;37:1351-4.
    • (2011) J Cataract Refract Surg , vol.37 , pp. 1351-1354
    • Wong, A.C.1    Mak, S.T.2
  • 88
    • 71849101222 scopus 로고    scopus 로고
    • Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice
    • Singh S, Hota D, Prakash A, Khanduja KL, Arora SK, Chakrabarti A. Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice. Pharmacol Biochem Behav 2010;94:416-22.
    • (2010) Pharmacol Biochem Behav , vol.94 , pp. 416-422
    • Singh, S.1    Hota, D.2    Prakash, A.3    Khanduja, K.L.4    Arora, S.K.5    Chakrabarti, A.6
  • 89
    • 0032590065 scopus 로고    scopus 로고
    • Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice
    • Kokate TG, Banks MK, Magee T, Yamaguchi S, Rogawski MA. Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. J Pharmacol Exp Ther 1999;288:679-84.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 679-684
    • Kokate, T.G.1    Banks, M.K.2    Magee, T.3    Yamaguchi, S.4    Rogawski, M.A.5
  • 90
    • 0347994966 scopus 로고    scopus 로고
    • The anticonvulsant effects of progesterone and 5alpha-dihydroprogesterone on amygdala-kindled seizures in rats
    • Lonsdale D, Burnham WM. The anticonvulsant effects of progesterone and 5alpha-dihydroprogesterone on amygdala-kindled seizures in rats. Epilepsia 2003;44:1494-9.
    • (2003) Epilepsia , vol.44 , pp. 1494-1499
    • Lonsdale, D.1    Burnham, W.M.2
  • 91
    • 3042552746 scopus 로고    scopus 로고
    • Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice
    • Reddy DS, Castaneda DC, O'Malley BW, Rogawski MA. Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J Pharmacol Exp Ther 2004;310:230-9.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 230-239
    • Reddy, D.S.1    Castaneda, D.C.2    O'Malley, B.W.3    Rogawski, M.A.4
  • 92
    • 0030913442 scopus 로고    scopus 로고
    • Pharmacological options in the treatment of benign prostatic hyperplasia
    • Kenny B, Ballard S, Blagg J, Fox D. Pharmacological options in the treatment of benign prostatic hyperplasia. J Med Chem 1997;40:1293-315.
    • (1997) J Med Chem , vol.40 , pp. 1293-1315
    • Kenny, B.1    Ballard, S.2    Blagg, J.3    Fox, D.4
  • 93
    • 0033672097 scopus 로고    scopus 로고
    • Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test
    • Khisti RT, Chopde CT, Jain SP. Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test. Pharmacol Biochem Behav 2000;67:137-43.
    • (2000) Pharmacol Biochem Behav , vol.67 , pp. 137-143
    • Khisti, R.T.1    Chopde, C.T.2    Jain, S.P.3
  • 94
    • 0028916048 scopus 로고
    • Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABAA receptors
    • Bitran D, Shiekh M, McLeod M. Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABAA receptors. J Neuroendocrinol 1995;7:171-7.
    • (1995) J Neuroendocrinol , vol.7 , pp. 171-177
    • Bitran, D.1    Shiekh, M.2    McLeod, M.3
  • 95
    • 0032539862 scopus 로고    scopus 로고
    • Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine
    • Uzunova V, Sheline Y, Davis JM, Rasmusson A, Uzunov DP, Costa E, et al. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc Natl Acad Sci U S A 1998;95:3239-44.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3239-3244
    • Uzunova, V.1    Sheline, Y.2    Davis, J.M.3    Rasmusson, A.4    Uzunov, D.P.5    Costa, E.6
  • 96
    • 4444325500 scopus 로고    scopus 로고
    • Role of progesterone and other neuroactive steroids in anxiety disorders
    • Le Melledo JM, Baker G. Role of progesterone and other neuroactive steroids in anxiety disorders. Expert Rev Neurother 2004;4:851-60.
    • (2004) Expert Rev Neurother , vol.4 , pp. 851-860
    • Le Melledo, J.M.1    Baker, G.2
  • 97
    • 84866508901 scopus 로고    scopus 로고
    • Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects
    • Irwig MS. Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects. J Clin Psychiatry 2012;73:1220-3.
    • (2012) J Clin Psychiatry , vol.73 , pp. 1220-1223
    • Irwig, M.S.1
  • 99
    • 84894075744 scopus 로고    scopus 로고
    • A randomized, active- and placebo- controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia
    • Gubelin Harcha W, Barboza Martinez J, Tsai TF, Katsuoka K, Kawashima M, Tsuboi R, et al. A randomized, active- and placebo- controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. J Am Acad Dermatol 2014;70:489-498.e3.
    • (2014) J Am Acad Dermatol , vol.70 , pp. 489-498
    • Gubelin Harcha, W.1    Barboza Martinez, J.2    Tsai, T.F.3    Katsuoka, K.4    Kawashima, M.5    Tsuboi, R.6
  • 100
    • 84979821568 scopus 로고    scopus 로고
    • Persistent sexual and nonsexual adverse effects of finasteride in younger men
    • Irwig MS. Persistent sexual and nonsexual adverse effects of finasteride in younger men. Sex Med Rev 2014;2:24-35.
    • (2014) Sex Med Rev , vol.2 , pp. 24-35
    • Irwig, M.S.1


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