Reduced brain levels of DHEAS in hepatic coma patients: Significance for increased GABAergic tone in hepatic encephalopathy

Neurochemistry International

Volumn 61, Issue 1, 2012, Pages 48-53

  Ahboucha, Samir ^a,b   Talani, Giuseppe ^c   Fanutza, Tomas ^c   Sanna, Enrico ^c,d   Biggio, Giovanni ^c,d   Gamrani, Halima ^b   Butterworth, Roger F ^e  

^a HASSAN 1ST UNIVERSITY   (Morocco)

^b FACULTÉ DES SCIENCES SEMLALIA   (Morocco)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d CNR   (Italy)

^e UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Allopregnanolone; DHEAS; Hepatic encephalopathy; Increased GABAergic tone; Neurosteroids

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; PRASTERONE SULFATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BRAIN LEVEL; BRAIN SLICE; CONTROLLED STUDY; GABAERGIC SYSTEM; HEPATIC COMA; HEPATIC ENCEPHALOPATHY; HUMAN; NERVE CELL; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; COMA; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; GAMMA-AMINOBUTYRIC ACID; HEPATIC ENCEPHALOPATHY; HUMANS; MALE; MIDDLE AGED; PATCH-CLAMP TECHNIQUES; PREFRONTAL CORTEX; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84861370972     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.03.020     Document Type: Article

References (28)

1. S. Ahboucha, and R.F. Butterworth The neurosteroid system: implication in the pathophysiology of hepatic encephalopathy Neurochem. Int. 52 2008 575 587
2. S. Ahboucha, W. Jiang, N. Chatauret, O. Mamer, G.B. Baker, and R.F. Butterworth Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis Neurogastroenterol. Motil. 20 2008 949 957
3. S. Ahboucha, G.P. Layrargues, O. Mamer, and R.F. Butterworth Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy Ann. Neurol. 58 2005 169 170
4. S. Ahboucha, G. Pomier-Layrargues, C. Vincent, Z. Hassoun, R. Tamaz, B.G. Baker, and R.F. Butterworth Reduced plasma dehydroepiandrosterone sulfate levels are significantly correlated with fatigue severity in patients with primary biliary cirrhosis Neurochem. Int. 52 2008 569 574
5. H. Asaba, K. Hosoya, H. Takanaga, S. Ohtsuki, E. Tamura, T. Takizawa, and T. Terasaki Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2 J. Neurochem. 75 2000 1907 1916
6. P. Bannister, P. Sheridan, and M.S. Losowsky Plasma concentrations of sex hormones in postmenopausal women in non-alcoholic cirrhosis Clin. Endocrinol. 23 1985 335 340
7. U. Becker, T. Almdal, E. Christensen, C. Gluud, S. Farholt, P. Bennett, B. Svenstrup, and F. Hardt Sex hormones in postmenopausal women with primary biliary cirrhosis Hepatology 13 1991 865 869
8. A receptors: form, pharmacology, and function J. Neurosci. 29 2009 12757 12763
9. R.F. Butterworth, R. Lalonde, C. Power, G.B. Baker, H. Gamrani, and S. Ahboucha Dehydroepiandrosterone sulfate improves cholestasis-associated fatigue in bile duct ligated rats Neurogastroenterol. Motil. 21 2009 1319 1325
10. I. Charalampopoulos, E. Dermitzaki, L. Vardouli, C. Tsatsanis, C. Stournaras, A.N. Margioris, and A. Gravanis Dehydroepiandrosterone sulfate and ALLO directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization Endocrinology 146 2005 3309 3318
11. M. Charlton, P. Angulo, N. Chalasani, R. Merriman, K. Viker, P. Charatcharoenwitthaya, S. Sanderson, S. Gawrieh, A. Krishnan, and K. Lindor Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease Hepatology 47 2008 484 492
12. A receptor Neuroscience 45 1991 127 135
13. J.L. Do Rego, J.Y. Seong, D. Burel, J. Leprince, V. Luu-The, K. Tsutsui, M.C. Tonon, G. Pelletier, and H. Vaudry Neurosteroid biosynthesis: enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides Front. Neuroendocrinol. 30 2009 259 301
14. C. Franz, D. Watson, and C. Longcope Estrone sulfate and dehydroepiandrosterone sulfate concentrations in normal subjects and men with cirrhosis Steroids 34 1979 563 573
15. C. Gómez-Santos, E. Larqué, E. Granero, J.J. Hernández-Morante, and M. Garaulet Dehydroepiandrosterone-sulphate replacement improves the human plasma fatty acid profile in plasma of obese women Steroids 76 2011 1425 1432
16. A.S. Hazell, and R.F. Butterworth Hepatic encephalopathy: an update of pathophysiologic mechanisms Proc. Soc. Exp. Biol. Med. 222 1999 99 112
17. P.J. Hunt, E.M. Gurnell, F.A. Huppert, C. Richards, A.T. Prevost, J.A. Wass, J. Herbert, and V.K. Chatterjee Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial J. Clin. Endocrinol. Metab. 85 2000 4650 4656
18. V. Lanthier, and V. Patwardhan Sex steroids and 5-en-3beta- hydroxysteroids in specific regions of the human brain and cranial nerves J. Steroid Biochem. 25 1986 445 449
19. A receptor Brain Res. 526 1990 143 146
20. M. Park-Chung, A. Malayev, R.H. Purdy, T.T. Gibbs, and D.H. Farb Sulfated and unsulfated steroids modulate gamma-aminobutyric acid A receptor function through distinct sites Brain Res. 29 830 1999 72 87
21. I. Pérez-Neri, S. Montes, C. Ojeda-López, J. Ramírez-Bermúdez, and C. Ríos Modulation of neurotransmitter systems by dehydroepiandrosterone and dehydroepiandrosterone sulfate: mechanism of action and relevance to psychiatric disorders Prog. Neuropsychopharmacol. Biol. Psychiatry 32 2008 1118 1130
22. R. Rupprecht, and F. Holsboer Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives Trends Neurosci. 22 1999 410 416
23. A receptor activity in rat hippocampus J. Neurosci. 24 2004 6521 6530
24. D.F. Schafer, S.C. Pappas, L.E. Brody, R. Jacobs, and E.A. Jones Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas Gastroenterology 86 1984 540 545
25. S. Weill-Engerer, J.P. David, V. Sazdovitch, P. Liere, B. Eychenne, A. Pianos, M. Schumacher, A. Delacourte, E.E. Baulieu, and Y. Akwa Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients J. Clin. Endocrinol. Metab. 87 2002 5138 5143
26. A receptor-mediated tonic inhibition in rat somatosensory cortex Cerebral Cortex 17 2007 1782 1787
27. P. Zheng Neuroactive steroid regulation of neurotransmitter release in the CNS: action, mechanism and possible significance Prog. Neurobiol. 89 2009 134 152
28. B. Zietz, G. Lock, B. Plach, W. Drobnik, J. Grossmann, J. Schölmerich, and R.H. Straub Dysfunction of the hypothalamic-pituitary- glandular axes and relation to child-pugh classification in male patients with alcoholic and virus-related cirrhosis Eur. J. Gastroenterol. Hepatol. 15 2003 495 501