Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 23, 2014, Pages 8512-8517

  Lindqvist, Lisa M ^a,b   Heinlein, Melanie ^a,b   Huang, David C S ^a,b   Vaux, David L ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

ABT 737; BH3 mimetic; Bim; LC3; LC3B

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; AMINO ACID; BH3 PROTEIN; BIM PROTEIN; ETOPOSIDE; INTERLEUKIN 3; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; SHORT HAIRPIN RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CELL VIABILITY ASSAY; EMBRYO; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION;

ABT-737; BH3 MIMETIC; BIM; LC3; LC3B;

ANIMALS; APOPTOSIS; AUTOPHAGY; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CELL LINE, TRANSFORMED; CELL SURVIVAL; CELLS, CULTURED; EMBRYO, MAMMALIAN; FIBROBLASTS; FLOW CYTOMETRY; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NITROPHENOLS; PHAGOSOMES; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; SULFONAMIDES;

EID: 84902125387     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406425111     Document Type: Article

References (31)

1. Baehrecke EH (2005) Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol 6(6):505-510.
2. Liang XH, et al. (1998) Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 72(11):8586-8596. (Pubitemid 28471796)
3. Oberstein A, Jeffrey PD, Shi Y (2007) Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 282(17):13123-13132. (Pubitemid 47100641)
4. Pattingre S, et al. (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122(6):927-939. (Pubitemid 41345209)
5. Shimizu S, et al. (2004) Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6(12):1221-1228. (Pubitemid 39625121)
6. Wei Y, Pattingre S, Sinha S, Bassik M, Levine B (2008) JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 30(6):678-688. (Pubitemid 351818252)
7. Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305(5684):626-629. (Pubitemid 39006738)
8. Youle RJ, Strasser A (2008) The BCL-2 protein family: Opposing activities that mediate cell death. Nat Rev Mol Cell Biol 9(1):47-59.
9. Lum JJ, et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120(2):237-248. (Pubitemid 40174766)
10. Maiuri MC, et al. (2007) BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy 3(4):374-376. (Pubitemid 46986348)
11. Maiuri MC, et al. (2007) Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 26(10):2527-2539. (Pubitemid 46788315)
12. Oltersdorf T, et al. (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435(7042):677-681. (Pubitemid 40825512)
13. van Delft MF, et al. (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 10(5):389-399. (Pubitemid 44711953)
14. Willis SN, et al. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19(11):1294-1305. (Pubitemid 41003019)
15. Lindqvist LM, et al. (2012) Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor. Cell Death Dis 3:e409.
16. Mizushima N, Yoshimori T, Levine B (2010) Methods in mammalian autophagy research. Cell 140(3):313-326.
17. Zalckvar E, et al. (2010) A systems level strategy for analyzing the cell death network: Implication in exploring the apoptosis/autophagy connection. Cell Death Differ 17(8):1244-1253.
18. Matsui Y, et al. (2007) Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 100(6):914-922. (Pubitemid 46555697)
19. Denton D, Nicolson S, Kumar S (2012) Cell death by autophagy: Facts and apparent artefacts. Cell Death Differ 19(1):87-95.
20. Gump JM, Thorburn A (2011) Autophagy and apoptosis: What is the connection? Trends Cell Biol 21(7):387-392.
21. Levine B, Sinha S, Kroemer G (2008) Bcl-2 family members: Dual regulators of apoptosis and autophagy. Autophagy 4(5):600-606.
22. Green DR, Levine B (2014) To be or not to be? How selective autophagy and cell death govern cell fate. Cell 157(1):65-75.
23. Malik SA, et al. (2011) BH3 mimetics activate multiple pro-autophagic pathways. Oncogene 30(37):3918-3929.
24. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15(3):1101-1111. (Pubitemid 38316219)
25. Xu Y, et al. (2007) Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27(1):135-144. (Pubitemid 47089027)
26. Bell BD, et al. (2008) FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci USA 105(43):16677-16682.
27. Denton D, et al. (2009) Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol 19(20):1741-1746.
28. Lee EF, et al. (2008) A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol 180(2):341-355. (Pubitemid 351185920)
29. Ekert PG, et al. (2006) Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma. Blood 108(5):1461-1468. (Pubitemid 44316109)
30. Zuber J, et al. (2011) Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol 29(1):79- 83.
31. Brumatti G, et al. (2013) HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia. Oncotarget 4(11):1933-1947.