Exercise-induced apoptosis of lymphocytes depends on training status

Medicine and Science in Sports and Exercise

Volumn 36, Issue 9, 2004, Pages 1476-1483

  Mooren, Frank C ^a,b   Lechtermann, Anja ^a   Völker, Klaus ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Annexin; Cell death; Fas ligand; Fas receptor; Marathon

Indexed keywords

FAS ANTIGEN; FAS LIGAND; LIPOCORTIN 5;

ADULT; ANTHROPOMETRY; APOPTOSIS; ARTICLE; BLOOD SAMPLING; EXERCISE; FLOW CYTOMETRY; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE COUNT; LYMPHOCYTE; MALE; MARATHON RUNNER; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NICK END LABELING; NORMAL HUMAN; STATISTICAL ANALYSIS; TRAINING; TREADMILL EXERCISE; VOLUNTEER;

ADULT; ANTIGENS, CD95; APOPTOSIS; EXERCISE; FAS LIGAND PROTEIN; GERMANY; HUMANS; LEUKOCYTE COUNT; LYMPHOCYTES; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED;

EID: 4444226673     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.MSS.0000139897.34521.E9     Document Type: Article

References (39)

1. ANSARI, B., P. J. COATES, B. D. GREENSTEIN, and P. A. HALL. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J. Pathol. 170:1-8, 1993.
2. BAUMANN, S., A. KRUEGER, S. KIRCHHOFF, and P. H. KRAMMER. Regulation of T cell apoptosis during the immune response. Curr. Mol. Med. 2:257-272, 2002.
3. CURTIN, J. F., and T. G. COTTER. Live and let die: regulatory mechanisms in Fas-mediated apoptosis. Cell. Signal. 15:983-992, 2003.
4. ELOSUA, R., L. MOLINA, M. FITO, et al. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis 167:327-334, 2003.
5. FRIDMAN, J. S., and S. W. LOWE. Control of apoptosis by p53. Oncogene 22:9030-9040, 2003.
6. GABRIEL, H., B. SCHMITT, A. URHAUSEN, and W. KINDERMANN. Increased CD45RA+CD45RO+ cells indicate activated T cells after endurance exercise. Med. Sci. Sports Exerc. 25:1352-1357, 1993.
7. GAMBELUNGHE, C., R. ROSSI, A. MICHELETTI, G. MARIUCCI, and S. RUFINI. Physical exercise intensity can be related to plasma glutathione levels. J. Physiol. Biochem. 57:9-14, 2001.
8. HARTMANN, A., S. PFUHLER, C. DENNOG, D. GERMADNIK, A. PILGER, and G. SPEIT. Exercise-induced DNA effects in human leukocytes are not accompanied by increased formation of 8-hydroxy-2′-deoxyguanosine or induction of micronuclei. Free Radic. Biol. Med. 24:245-245, 1998.
9. HARTMANN, A., U. PLAPPERT, K. RADDATZ, M. GRUNERT-FUCHS, and G. SPEIT. Does physical activity induce DNA damage? Mutagenesis 9:269-272, 1994.
10. HILEMAN, E. O., J. LIU, M. ALBITAR, M. J. KEATING, and P. HUANG, Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity. Cancer Chemother. Pharmacol. 53:209-219, 2004,
11. HOFFMAN-GOETZ, L., and J. QUADRILATERO. Treadmill exercise in mice increases intestinal lymphocyte loss via apoptosis. Acta Physiol. Scand. 179:289-297, 2003.
12. HSU, T. G., K. M. HSU, C. W. KONG, F. J. LU, H. CHENG, and K. TSAI. Leukocyte mitochondria alterations after aerobic exercise in trained human subjects. Med. Sci. Sports Exerc. 34:438-442, 2002.
13. KREBS, J. The role of calcium in apoptosis. Biometals 11:375-382, 1998.
14. LAGRANHA, C. J., S. M. SENNA, T. M. DE LIMA, et al. Beneficial effect of glutamine on exercise-induced apoptosis of rat neutrophils. Med. Sci. Sports Exerc. 36:210-27, 2004.
15. MADERNA, P., and C. GODSON. Phagocytosis of apoptotic cells and the resolution of inflammation. Biochim. Biophys. Acta 20:141-151, 2003.
16. MARS, M., S. GOVENDER, A. WESTON, V. NAICKER, and A. CHUTURGOON. High intensity exercise: a cause of lymphocyte apoptosis? Biochem. Biophys. Res. Commun. 19:366-370, 1998.
17. MASTALOUDIS, A., T. W. Yu, R. P. O'DONNELL, B. FREI, R. H. DASHWOOD, and M. G. TRABER. Endurance exercise results in DNA damage as detected by the comet assay. Free Radic. Biol. Med. 36:966-975, 2004.
18. MIYAZAKI, H., S. OH-ISHI, T. OOKAWARA, et al. Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur. J. Appl. Physiol. 84:1-6, 2001.
19. MOOREN, F. C., D. BLOMING, A. LECHTERMANN, M. M. LERCH, and K. VOLKER. Lymphocyte apoptosis after exhaustive and moderate exercise. J. Appl. Physiol. 93:147-145, 2002.
20. MOOREN, F. C., A. LECHTERMANN, A. FROMME, L. THORWESTEN, and K. VOLKER. Alterations in intracellular calcium signaling of lymphocytes after exhaustive exercise. Med. Sci. Sports Exerc. 33:242-248, 2001.
21. NEWELL, M. K., and J. DESBARATS. Fas ligand: receptor or ligand? Apoptosis 4:311-315, 1994.
22. NIEMAN, D. C. Upper respiratory tract infections and exercise. Thorax 50:1229-1231, 1995.
23. NIESS, A. M., A. HARTMANN, M. GRUNERT-FUCHS, B. POCH, and G. SPEIT. DNA damage after exhaustive treadmill running in trained and untrained men. Int. J. Sports Med. 17:397-403, 1996.
24. PEDERSEN, B. K., and H. B. NIELSEN. Acute exercise and the immune system. In: Exercise Immunology, B. K. Pedersen (Ed.). Austin, TX: Landes Company, 1997, pp. 5-38.
25. RADAK, Z., H. NAITO, T. KANEKO. Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflugers Arch. 445:273-278, 2002.
26. RADAK, Z., H. OGONOVSZKY, J. DUBECZ, et al. Super-marathon race increases serum and urinary nitrotyrosine and carbonyl levels. Eur. J. Clin. Invest. 33:726-730, 2003.
27. RADAK, Z., A. W. TAYLOR, H. OHNO, and S. GOTO. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc. Immunol. Rev. 7:90-107, 2001.
28. RUBARTELLI, A., A. POGGI, and M. R. ZOCCHI. The selective engulfment of apoptotic bodies by dendritic cells is mediated by the alpha(v)beta3 integrin and requires intracellular and extracellular calcium. Eur. J. Immunol. 27:1893-1900, 1997.
29. SCHINDOWSKI, K., S. LEUTNER, W. E. MULLER, and A. ECKERT. Age-related changes of apoptotic cell death in human lymphocytes. Neurobiol. Aging 21:661-670, 2000.
30. SEN, C. K., E. MARIN, M. KRETZSCHMAR, and O. HANNINEN. Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization. J. Appl. Physiol. 73:1265-1272, 1992.
31. TAYLOR, P. R., A. CARUGATI, V. A. FADOK, et al. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J. Exp. Med. 192:359-366, 2000.
32. TSAI, K., T. G. Hsu, K. M. Hsu, et al. Oxidative DNA damage in human peripheral leukocytes induced by massive aerobic exercise. Free Radic. Biol. Med. 31:1465-1472, 2001.
33. UEDA, S., H. MASUTANI, H. NAKAMURA, T. TANAKA, M. UENO, and J. YODOI. Redox control of cell death. Antioxid. Redox. Signal. 4:405-414, 2002.
34. UMEGAKI, K., M. HIGUCHI, K. INOUE, and T. ESASHI. Influence of one bout of intensive running on lymphocyte micronucleus frequencies in endurance-trained and untrained men. Int. J. Sports Med. 19:581-585, 1998.
35. VAN LIESHOUT, E. M., and W. H. PETERS. Age and gender dependent levels of glutathione and glutathione S-transferases in human lymphocytes. Carcinogenesis 19:1873-1875, 1998.
36. VOLL, R. E., M. HERRMANN, E. A. ROTH, C. STACH, J. R. KALDEN, and I. GIRKONTAITE. Immunosuppressive effects of apoptotic cells. Nature 390:350-351, 1997.
37. WASEM, C., D. ARNOLD, L. SAURER, et al. Sensitizing antigen-specific CD8+ T cells for accelerated suicide causes immune incompetence. J. Clin. Invest. 111:1191-1199, 2003.
38. YAMAMOTO, T., T. OHKUWA, H. ITOH, Y. SATO, and M. NAOI. Effect of gender differences and voluntary exercise on antioxidant capacity in rats. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 132:437-444, 2002.
39. YASUDA, M., S. UMEMURA, R. Y. OSAMURA, T. KENJO, and S. TSUTSUMI. Apoptotic cells in the human endometrium and placental villi: pitfalls in applying the TUNEL method. Arch. Histol. Cytol. 58:185-190, 1995.