High glucose up-regulates ADAM17 through HIF-1β in mesangial cells

Journal of Biological Chemistry

Volumn 290, Issue 35, 2015, Pages 21603-21614

  Li, Renzhong ^a   Uttarwar, Lalita ^a   Gao, Bo ^a   Charbonneau, Martine ^b   Shi, Yixuan ^c   Chan, John S D ^c   Dubois, Claire M ^b   Krepinsky, Joan C ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; PROTEINS; RAT CONTROL; TRANSCRIPTION;

DIABETIC NEPHROPATHY; EPIDERMAL GROWTH FACTOR RECEPTORS; HYPOXIA RESPONSE ELEMENTS; HYPOXIA-INDUCIBLE FACTOR 1; NUCLEAR TRANSLOCATIONS; PROMOTER ACTIVITIES; RAT MESANGIAL CELL; THERAPEUTIC STRATEGY;

GLUCOSE;

EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METALLOPROTEINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ADAM17; PROTEIN KINASE B; UNCLASSIFIED DRUG; ADAM PROTEIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR-ALPHA CONVERTASE;

ADAM17 GENE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE; GENE DELETION; GENETIC TRANSCRIPTION; KIDNEY; MALE; MESANGIUM CELL; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL HYPOXIA; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; FEEDBACK SYSTEM; GENETICS; METABOLISM; PATHOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ADAM PROTEINS; ANIMALS; CELL HYPOXIA; DIABETES MELLITUS, EXPERIMENTAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; GLUCOSE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY; LIGANDS; MALE; MESANGIAL CELLS; MICE, INBRED C57BL; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84940676090     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.651604     Document Type: Article

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