Selective p38α mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma

Journal of Asthma and Allergy

Volumn , Issue 1, 2008, Pages 31-44

  Ma, Jing Ying ^a   Medicherla, Satyanarayana ^a   Kerr, Irene ^b   Mangadu, Ruban ^b   Protter, Andrew A ^b   Higgins, Linda S ^b  

^a SCIOS INC   (United States)

^b NONE

Author keywords

Asthma; Fibrosis; Inflammation; p38 selective MAPK inhibitor; Phosphorylated p38 MAPK; Phosphorylated SMAD2 3; SD 208; SD 282; TGF inhibitor

Indexed keywords

INTERLEUKIN 13; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SD 208; SD 282; UNCLASSIFIED DRUG;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; ATTENUATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG POTENCY; EOSINOPHIL; EPITHELIUM CELL; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; FEMALE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG FIBROSIS; LUNG INJURY; LYMPHOCYTE; MALE; METAPLASIA; MONONUCLEAR CELL; MORPHOMETRICS; MOUSE; MUCUS; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; TRANSGENIC MOUSE; TREATMENT DURATION;

EID: 77953373695     PISSN: None     EISSN: 11786965     Source Type: Journal    
DOI: 10.2147/jaa.s4199     Document Type: Article

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