Benefits of foods supplemented with vegetable oils rich in α-linolenic, stearidonic or docosahexaenoic acid in hypertriglyceridemic subjects: a double-blind, randomized, controlled trail

European Journal of Nutrition

Volumn 54, Issue 6, 2015, Pages 881-893

  Dittrich, Manja ^a   Jahreis, Gerhard ^a   Bothor, Kristin ^a   Drechsel, Carina ^a   Kiehntopf, Michael ^b   Blüher, Matthias ^c   Dawczynski, Christine ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

Echium oil; Human intervention study; Linseed oil; Microalgae oil; n 3 PUFA

Indexed keywords

ALPHA TOCOPHEROL; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSAPENTAENOIC ACID; ICOSATETRAENOIC ACID; LINOLENIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOUNSATURATED FATTY ACID; OXIDIZED LOW DENSITY LIPOPROTEIN; STEARIDONIC ACID; TOCOPHEROL; VEGETABLE OIL; CHOLESTEROL; FATTY ACID; LIPID; OMEGA 3 FATTY ACID; PLACEBO;

ARTICLE; CALORIC INTAKE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ECHIUM; ERYTHROCYTE; FAT CONTENT; FAT INTAKE; FATTY ACID BLOOD LEVEL; FEEDING BEHAVIOR; FOOD FREQUENCY QUESTIONNAIRE; HUMAN; HYPERTRIGLYCERIDEMIA; LINSEED; LIPID BLOOD LEVEL; MICROALGA; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; ADULT; AGED; BLOOD; CARDIOVASCULAR DISEASE; CHEMISTRY; COMPLICATION; DIET THERAPY; FEMALE; FORTIFIED FOOD; MALE; MEDICAL RECORD; MIDDLE AGED; RISK FACTOR;

ADULT; AGED; ALPHA-LINOLENIC ACID; CARDIOVASCULAR DISEASES; CHOLESTEROL; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DIET RECORDS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; ERYTHROCYTES; FATTY ACIDS; FATTY ACIDS, OMEGA-3; FEMALE; FOOD, FORTIFIED; HUMANS; HYPERTRIGLYCERIDEMIA; LIPIDS; MALE; MIDDLE AGED; PLACEBOS; PLANT OILS; RISK FACTORS; TOCOPHEROLS;

EID: 84940656574     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-014-0764-2     Document Type: Article

References (44)

1. Wang C, Harris WS et al (2006) n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr 84(1):5–17
2. Wei MY, Jacobson TA (2011) Effects of eicosapentaenoic acid versus docosahexaenoic acid on serum lipids: a systematic review and meta-analysis. Curr Atheroscler Rep 13(6):474–483
3. Simopoulos AP (2008) The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med 233:674–688
4. Deutsche Gesellschaft für Ernährung e.V. (DGE; 2012). 12. Ernährungsbericht 2012 (Nutrition Report 2012) Bonn, ISBN 978-3-88749-232-8
5. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2012) Scientific opinion on the tolerable upper intake level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA). EFSA J 10(7):2815. doi:10.2903/j.efsa.2012.2815
6. Hooper L, Summerbell CD et al (2011) Reduced or modified dietary fat for preventing cardiovascular disease. Cochrane Database Syst Rev 7:CD002137
7. Folch J, Lees M et al (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226(1):497–509
8. Dawczynski C, Massey KA et al (2012) Randomized placebo-controlled intervention with n-3 LC-PUFA-supplemented yoghurt: effects on circulating eicosanoids and cardiovascular risk factors. Clin Nutr 32(5):686–696
9. Kuhnt K, Wagner A, Kraft J et al (2006) Dietary supplementation with 11 trans- and 12 trans-18:1 and oxidative stress in humans. Am J Clin Nutr 84:981–988
10. Strobel C, Jahreis G et al (2012) Survey of n-3 and n-6 polyunsaturated fatty acids in fish and fish products. Lipids Health Dis 11:144
11. Bluher M, Rudich A et al (2012) Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention. Diabetes Care 35(2):342–349
12. Katan MB, Deslypere JP et al (1997) Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res 38(10):2012–2022
13. Sprecher H, Chen Q et al (1999) Regulation of the biosynthesis of 22:5n-6 and 22:6n-3: a complex intracellular process. Lipids 34:S153–S156
14. Deckelbaum RJ (2010) n-6 and n-3 Fatty acids and atherosclerosis: ratios or amounts? Arterioscler Thromb Vasc Biol 30(12):2325–2326
15. Goyens PL, Spilker ME et al (2006) Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. Am J Clin Nutr 84(1):44–53
16. James MJ, Ursin VM et al (2003) Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. Am J Clin Nutr 77(5):1140–1145
17. Voss A et al (1991) The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase. J Biol Chem 266(30):19995–20000
18. Brossard N et al (1996) Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols. Am J Clin Nutr 64(4):577–586
19. Kelley DS, Siegel D et al (2007) Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men. Am J Clin Nutr 86(2):324–333
20. Adam O, Wolfram G et al (2003) Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. Ann Nutr Metab 47(1):31–36
21. Young GS et al (2005) Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. Reprod Nutr Dev 45(5):549–558
22. Ramsden CE et al (2010) n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr 104(11):1586–1600
23. Harris WS, Von Schacky C (2004) The omega-3 index: a new risk factor for death from coronary heart disease? Prev Med 39(1):212–220
24. Harris WS (2007) Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor. Pharmacol Res 55(3):217–223
25. Lemke SL, Vicini JL et al (2010) Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety. Am J Clin Nutr 92(4):766–775
26. Jenkinson AM, Collins AR et al (1999) The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes. FASEB J 13(15):2138–2142
27. Koenig W et al (2011) Oxidized LDL and the risk of coronary heart disease: results from the MONICA/KORA Augsburg study. Clin Chem 57(8):1196–1200
28. Binkoski AE, Kris-Etherton PM et al (2005) Balance of unsaturated fatty acids is important to a cholesterol-lowering diet: comparison of mid-oleic sunflower oil and olive oil on cardiovascular disease risk factors. J Am Diet Assoc 105(7):1080–1086
29. Czernichow S et al (2010) n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations. Br J Nutr 104(6):788–796
30. Gillingham LG, Gustafson JA et al (2011) High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 105(3):417–427
31. Whelan J, Gouffon J et al (2012) Effects of dietary stearidonic acid on biomarkers of lipid metabolism. J Nutr 142(3):630S–634S
32. Surette ME, Edens M et al (2004) Dietary echium oil increases plasma and neutrophil long-chain (n-3) fatty acids and lowers serum triacylglycerols in hypertriglyceridemic humans. J Nutr 134(6):1406–1411
33. Egert S et al (2009) Dietary alpha-linolenic acid, EPA, and DHA have differential effects on LDL fatty acid composition but similar effects on serum lipid profiles in normolipidemic humans. J Nutr 139(5):861–868
34. Kamstrup PR, Tybjaerg-Hansen A et al (2013) Extreme lipoprotein(a) levels and improved cardiovascular risk prediction. J Am Coll Cardiol 61(11):1146–1156
35. Triffitt JT, Gebauer U et al (1976) Origin of plasma alpha2HS-glycoprotein and its accumulation in bone. Nature 262(5565):226–227
36. Jung CH, Kim BY et al (2013) Associations of serum fetuin-A levels with insulin resistance and vascular complications in patients with type 2 diabetes. Diab Vasc Dis Res 10(5):459–467
37. Ix JH, Shlipak MG et al (2006) Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation 113(14):1760–1767
38. Himmetoglu S, Teksoz S et al (2013) Serum levels of fetuin A and 8-hydroxydeoxyguanosine in morbidly obese subjects. Exp Clin Endocrinol Diabetes 121(8):505–508
39. Roos M, von Eynatten M et al (2010) Serum fetuin-A, cardiovascular risk factors, and six-year follow-up outcome in patients with coronary heart disease. Am J Cardiol 105(12):1666–1672
40. Reynolds JL, Skepper JN et al (2005) Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol 16(10):2920–2930
41. Stenvinkel P, Wang K et al (2005) Low fetuin-A levels are associated with cardiovascular death: impact of variations in the gene encoding fetuin. Kidney Int 67(6):2383–2392
42. Mori K et al (2007) Association of serum fetuin-A with carotid arterial stiffness. Clin Endocrinol (Oxf) 66(2):246–250
43. An WS, Lee SM et al (2012) Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. Nutr Res 32(7):495–502
44. Ozyazgan S, Karaoglu K et al (2013) Effects of omega-3 polyunsaturated fatty acid supplementation on serum fetuin-A levels in type 2 diabetic patients. Minerva Med 104(3):287–293