Prophylactic plasma and platelet transfusion in the critically Ill patient: Just useless and expensive or even harmful?

BMC Anesthesiology

Volumn 15, Issue 1, 2015, Pages

  Görlinger, Klaus ^a,b   Saner, Fuat H ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b Lahmeyer International GmbH   (Germany)

Author keywords

Critically ill; INR; Patient blood management; Prophylactic plasma transfusion; Thromboelastometry; Tracheostomy

Indexed keywords

FRESH FROZEN PLASMA;

BLOOD TRANSFUSION REACTION; CLINICAL PROTOCOL; COST BENEFIT ANALYSIS; CRITICALLY ILL PATIENT; EVIDENCE BASED MEDICINE; HEMATOLOGIC DISEASE; HEMATOLOGICAL PROCEDURE; HUMAN; INTERNATIONAL NORMALIZED RATIO; LUNG INJURY; MEDICAL LITERATURE; NORMAL THROMBOELASTOMETRY; NOTE; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; PATIENT SAFETY; PLASMA TRANSFUSION; PREOPERATIVE CARE; PROPHYLAXIS; PROTHROMBIN TIME; RISK BENEFIT ANALYSIS; RISK REDUCTION; SENSITIVITY AND SPECIFICITY; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TRACHEOSTOMY; TRANSFUSION ASSOCIATED CIRCULATORY OVERLOAD; TRANSFUSION RELATED IMMUNOMODULATION; TRANSFUSION RELATED LUNG INJURY; UNNECESSARY PROCEDURE; ADVERSE EFFECTS; CRITICAL ILLNESS; ECONOMICS; PLASMA; PRE-EXPOSURE PROPHYLAXIS; PROCEDURES; THROMBOELASTOGRAPHY;

CRITICAL ILLNESS; HUMANS; PLASMA; PLATELET TRANSFUSION; PRE-EXPOSURE PROPHYLAXIS; THROMBELASTOGRAPHY;

EID: 84940554737     PISSN: None     EISSN: 14712253     Source Type: Journal    
DOI: 10.1186/s12871-015-0074-0     Document Type: Note

References (55)

1. Arnold DM, Lauzier F, Whittingham H, Zhou Q, Crowther MA, McDonald E, et al. A multifaceted strategy to reduce inappropriate use of frozen plasma transfusions in the intensive care unit. J Crit Care. 2011;26:636.e7-636.e13.
2. Stanworth SJ, Grant-Casey J, Lowe D, Laffan M, New H, Murphy MF, et al. The use of fresh-frozen plasma in England: high levels of inappropriate use in adults and children. Transfusion. 2011;51:62-70.
3. Tinmouth AT, McIntyre L. The conundrum of persistent inappropriate use of frozen plasma. Crit Care. 2011;15:160.
4. Pybus S, MacCormac A, Houghton A, Martlew V, Thachil J. Inappropriateness of fresh frozen plasma for abnormal coagulation tests. J R Coll Physicians Edinb. 2012;42:294-300.
5. Visser A, Geldenhuys A, Du Preez S, Van de Vyver A. Fresh-frozen plasma use in a South African tertiary hospital. S Afr Med J. 2012;102:366-7.
6. Tinmouth A, Thompson T, Arnold DM, Callum JL, Gagliardi K, Lauzon D, et al. Utilization of frozen plasma in Ontario: a provincewide audit reveals a high rate of inappropriate transfusions. Transfusion. 2013;53:2222-9.
7. Stanworth SJ, Walsh TS, Prescott RJ, Lee RJ, Watson DM, Wyncoll D. Intensive Care Study of Coagulopathy (ISOC) investigators. A national study of plasma use in critical care: clinical indications, dose and effect on prothrombin time. Crit Care. 2011;15:R108.
8. Dara SI, Rana R, Afessa B, Moore SB, Gajic O. Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Crit Care Med. 2005;33:2667-71.
9. Abdel-Wahab OI, Healy B, Dzik WH. Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities. Transfusion. 2006;46:1279-85.
10. Holland LL, Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126:133-9.
11. Yang L, Stanworth S, Hopewell S, Doree C, Murphy M. Is fresh-frozen plasma clinically effective? An update of a systematic review of randomized controlled trials. Transfusion. 2012;52:1673-86.
12. Müller MC, Arbous MS, Spoelstra-de Man AM, Vink R, Karakus A, Straat M, et al. Transfusion of fresh-frozen plasma in critically ill patients with a coagulopathy before invasive procedures: a randomized clinical trial (CME). Transfusion. 2015;55:26-35.
13. Gonzalez EA, Moore FA, Holcomb JB, Miller CC, Kozar RA, Todd SR, et al. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma. 2007;62:112-9.
14. Sarani B, Dunkman WJ, Dean L, Sonnad S, Rohrbach JI, Gracias VH. Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Crit Care Med. 2008;36:1114-8.
15. Clifford L, Jia Q, Subramanian A, Yadav H, Wilson GA, Murphy SP, et al. Characterizing the epidemiology of postoperative transfusion-related acute lung injury. Anesthesiology. 2015;122:12-20.
16. Clifford L, Jia Q, Yadav H, Subramanian A, Wilson GA, Murphy SP, et al. Characterizing the epidemiology of perioperative transfusion-associated circulatory overload. Anesthesiology. 2015;122:21-8.
17. Bolton-Maggs PH. Bullet points from SHOT: key messages and recommendations from the Annual SHOT Report 2013. Transfus Med. 2014;24:197-203.
18. Bjursten H, Dardashti A, Ederoth P, Brondén B, Algotsson L. Increased long-term mortality with plasma transfusion after coronary artery bypass surgery. Intensive Care Med. 2013;39:437-44.
19. Inaba K, Branco BC, Rhee P, Blackbourne LH, Holcomb JB, Teixeira PG, et al. Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg. 2010;210:957-65.
20. Inaba K, Branco BC, Rhee P, Holcomb JB, Blackbourne LH, Shulman I, et al. Impact of ABO-identical vs ABO-compatible nonidentical plasma transfusion in trauma patients. Arch Surg. 2010;145:899-906.
21. Shanwell A, Andersson TM, Rostgaard K, Edgren G, Hjalgrim H, Norda R, et al. Post-transfusion mortality among recipients of ABO-compatible but non-identical plasma. Vox Sang. 2009;96:316-23.
22. Durila M, Lukas P, Astraverkhava M, Berousek J, Zabrodsky M, Vymazal T. Tracheostomy in intensive care unit patients can be performed without bleeding complications in case of normal thromboelastometry results (EXTEM CT) despite increased PT-INR: a prospective pilot study. BMC Anesthesiology. 2015; in press.
23. Haas T, Fries D, Tanaka KA, Asmis L, Curry NS, Schöchl H. Usefulness of standard plasma coagulation tests in the management of perioperative coagulopathic bleeding: is there any evidence? Br J Anaesth. 2015;114:217-24.
24. Haas T, Spielmann N, Mauch J, Madjdpour C, Speer O, Schmugge M, et al. Comparison of thromboelastometry (ROTEM®) with standard plasmatic coagulation testing in paediatric surgery. Br J Anaesth. 2012;108:36-41.
25. Schmidt DE, Holmström M, Majeed A, Näslin D, Wallén H, Ågren A. Detection of elevated INR by thromboelastometry and thromboelastography in warfarin treated patients and healthy controls. Thromb Res. 2015;135:1007-11.
26. Saner FH, Gieseler RK, Akiz H, Canbay A, Görlinger K. Delicate balance of bleeding and thrombosis in end-stage liver disease and liver transplantation. Digestion. 2013;88:135-44.
27. Adamzik M, Eggmann M, Frey UH, Görlinger K, Bröcker-Preuss M, Marggraf G, et al. Comparison of thromboelastometry with procalcitonin, interleukin 6, and C-reactive protein as diagnostic tests for severe sepsis in critically ill adults. Crit Care. 2010;14:R178.
28. Görlinger K, Bergmann L, Dirkmann D. Coagulation management in patients undergoing mechanical circulatory support. Best Pract Res Clin Anaesthesiol. 2012;26:179-98.
29. Adamzik M, Schäfer S, Frey UH, Becker A, Kreuzer M, Winning S, et al. The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis. Anesthesiology. 2013;118:123-33.
30. Dunham CM, Rabel C, Hileman BM, Schiraldi J, Chance EA, Shima MT, et al. TEG® and RapidTEG® are unreliable for detecting warfarin-coagulopathy: a prospective cohort study. Thromb J. 2014;12:4.
31. Weigand K, Encke J, Meyer FJ, Hinkel UP, Munder M, Stremmel W, et al. Low levels of prothrombin time (INR) and platelets do not increase the risk of significant bleeding when placing central venous catheters. Med Klin (Munich). 2009;104:331-5.
32. Zeidler K, Arn K, Senn O, Schanz U, Stussi G. Optimal preprocedural platelet transfusion threshold for central venous catheter insertions in patients with thrombocytopenia. Transfusion. 2011;51:2269-76.
33. Greene LA, Chen S, Seery C, Imahiyerobo AM, Bussel JB. Beyond the platelet count: immature platelet fraction and thromboelastometry correlate with bleeding in patients with immune thrombocytopenia. Br J Haematol. 2014;166:592-600.
34. Estcourt LJ, Stanworth SJ, Harrison P, Powter G, McClure M, Murphy MF, et al. Prospective observational cohort study of the association between thromboelastometry, coagulation and platelet parameters and bleeding in patients with haematological malignancies- the ATHENA study. Br J Haematol. 2014;166:581-91.
35. Kander T, Tanaka KA, Norström E, Persson J, Schött U. The effect and duration of prophylactic platelet transfusions before insertion of a central venous catheter in patients with bone marrow failure evaluated with point-of-care methods and flow cytometry. Anesth Analg. 2014;119:882-90.
36. Ziegler B, Solomon C, Cadamuro J, Jones N. Thromboelastometric Monitoring of the Hemostatic Effect of Platelet Concentrates Transfusion in Thrombocytopenic Children Undergoing Chemotherapy. Clin Appl Thromb Hemost. 2014. [Epub ahead of print]
37. Fayed NA, Abdallah AR, Khalil MK, Marwan IK. Therapeutic rather than prophylactic platelet transfusion policy for severe thrombocytopenia during liver transplantation. Platelets. 2014;25:576-86.
38. Görlinger K, Jambor C, Hanke AA, Dirkmann D, Adamzik M, Hartmann M, et al. Perioperative coagulation management and control of platelet transfusion by point-of-care platelet function analysis. Transfus Med Hemother. 2007;34(6):396-411.
39. Solomon C, Traintinger S, Ziegler B, Hanke A, Rahe-Meyer N, Voelckel W, et al. Platelet function following trauma. A multiple electrode aggregometry study. Thromb Haemost. 2011;106:322-30.
40. Adamzik M, Görlinger K, Peters J, Hartmann M. Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis. Crit Care. 2012;16:R204.
41. Konkle BA. Acquired disorders of platelet function. Hematol Am Soc Hematol Educ Program. 2011;2011:391-6.
42. Scharf RE. Drugs that affect platelet function. Semin Thromb Hemost. 2012;38:865-83.
43. Van Cann EM, Koole R. An emergency tracheotomy in case of airway compromise after post-operative bleeding associated with the use of an antidepressant. Ned Tijdschr Tandheelkd. 2009;116(10):544-6.
44. Haas T, Görlinger K, Grassetto A, Agostini V, Simioni P, Nardi G, et al. Thromboelastometry for guiding bleeding management of the critically ill patient: a systematic review of the literature. Minerva Anestesiol. 2014;80:1320-35.
45. Corredor C, Wasowicz M, Karkouti K, Sharma V. The role of point-of-care platelet function testing in predicting postoperative bleeding following cardiac surgery: a systematic review and meta-analysis. Anaesthesia. 2015;70:715-31.
46. Kirchner C, Dirkmann D, Treckmann JW, Paul A, Hartmann M, Saner FH, et al. Coagulation management with factor concentrates in liver transplantation: a single-center experience. Transfusion. 2014;54:2760-8.
47. Karkouti K, McCluskey SA, Callum J, Freedman J, Selby R, Timoumi T, et al. Evaluation of a novel transfusion algorithm employing point-of-care coagulation assays in cardiac surgery: a retrospective cohort study with interrupted time-series analysis. Anesthesiology. 2015;122:560-70.
48. Pearse BL, Smith I, Faulke D, Wall D, Fraser JF, Ryan EG, et al. Protocol guided bleeding management improves cardiac surgery patient outcomes. Vox Sang. 2015. doi: 10.1111/vox.12279 . [Epub ahead of print]
49. Görlinger K, Fries D, Dirkmann D, Weber CF, Hanke AA, Schöchl H. Reduction of Fresh Frozen Plasma Requirements by Perioperative Point-of-Care Coagulation Management with Early Calculated Goal-Directed Therapy. Transfus Med Hemother. 2012;39:104-13.
50. Görlinger K, Dirkmann D, Hanke AA, Kamler M, Kottenberg E, Thielmann M, et al. First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology. 2011;115:1179-91.
51. Weber CF, Görlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology. 2012;117:531-47.
52. Nienaber U, Innerhofer P, Westermann I, Schöchl H, Attal R, Breitkopf R, et al. The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion. Injury. 2011;42:697-701.
53. Mallaiah S, Barclay P, Harrod I, Chevannes C, Bhalla A. Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage. Anaesthesia. 2015;70:166-75.
54. Hincker A, Feit J, Sladen RN, Wagener G. Rotational thromboelastometry predicts thromboembolic complications after major non-cardiac surgery. Crit Care. 2014;18:549.
55. Dimitrova-Karamfilova A, Patokova Y, Solarova T, Petrova I, Natchev G. Rotational thromboelastography for assessment of hypercoagulation and thrombosis in patients with cardiovascular disease. J Life Sci. 2012;6:28-35.