Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells

Xenobiotica

Volumn 45, Issue 10, 2015, Pages 921-929

  Xie, Yuchao ^a   McGill, Mitchell R ^a   Cook, Sarah F ^b   Sharpe, Matthew R ^c   Winefield, Robert D ^a   Wilkins, Diana G ^b   Rollins, Douglas E ^b   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Biomarkers; glucuronidation; hepatotoxicity; protein binding; sulfation

Indexed keywords

DRUG METABOLITE; PARACETAMOL; ANALGESIC AGENT; PLASMA PROTEIN;

ADULT; ARTICLE; CIRCULATION; CLINICAL ARTICLE; CULTURE MEDIUM; DRUG OVERDOSE; FEMALE; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; LIVER INJURY; MALE; NONHUMAN; PLASMA; ADOLESCENT; BLOOD; CELL LINE; CYTOLOGY; DRUG EFFECTS; LIVER; METABOLISM; MIDDLE AGED; TIME FACTOR; YOUNG ADULT;

ACETAMINOPHEN; ADOLESCENT; ADULT; ANALGESICS, NON-NARCOTIC; BLOOD PROTEINS; CELL LINE; DRUG OVERDOSE; FEMALE; HUMANS; LIVER; MALE; MIDDLE AGED; TIME FACTORS; YOUNG ADULT;

EID: 84940542371     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2015.1026426     Document Type: Article

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