Vesicle transfer and cell fusion: Emerging concepts of cell-cell communication in the tumor microenvironment

Cancer Biology and Therapy

Volumn 12, Issue 3, 2011, Pages 159-164

  Howcroft, T Kevin ^a   Zhang, Huang Ge ^b   Dhodapkar, Madhav ^c   Mohla, Suresh ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b University of Louisville School of Medicine   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Cancer; Cell fusion; Exosome; Tumor microenvironment; Vesicle

Indexed keywords

CD200 ANTIGEN; CD47 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLSERINE; PHOSPHOLIPASE A2; PROSTAGLANDIN SYNTHASE; PROTEIN TYROSINE KINASE; THROMBOSPONDIN 1;

BONE MARROW CELL; CARCINOGENESIS; CELL COMMUNICATION; CELL FUSION; CELL VACUOLE; CONFERENCE PAPER; EXOSOME; HUMAN; IMMUNE SYSTEM; MULTIVESICULAR BODY; NONHUMAN; TRANSPORT VESICLE; TUMOR CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

CELL COMMUNICATION; CELL FUSION; HUMANS; TUMOR MICROENVIRONMENT;

EID: 79961234482     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.3.17032     Document Type: Conference Paper

References (11)

1. Duelli D, Lazebnik Y. Cell-to-cell fusion as a link between viruses and cancer. Nat Rev Cancer 2007; 7:968-76. PMID: 18034186; DOI: 10.1038/nrc2272.
2. Cui W, Cuartas E, Ke J, Zhang Q, Einarsson HB, Sedgwick JD, et al. CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts. Proc Natl Acad Sci USA 2007; 104:14436-41. PMID: 17726108; DOI: 10.1073/pnas.0702811104.
3. Kukreja A, Radfar S, Sun BH, Insogna K, Dhodapkar MV. Dominant role of CD47-thrombospondin 1 interactions in myeloma induced fusion of human dendritic cells: implications for bone disease. Blood 2009; 114:3413-21. PMID: 19661269; DOI: 10.1182/blood-2009-03-211920.
4. Powell AE, Anderson EC, Davies PS, Silk AD, Pelz C, Impey S, et al. Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming. Cancer Res 2011; 71:1497-505. PMID: 21303980; DOI: 10.1158/0008-5472. CAN-10-3223.
5. Lu X, Lu X, Kang Y. Organ-specific enhancement of metastasis by spontaneous ploidy duplication and cell size enlargement. Cell Res 2010; 20:1012-22. PMID: 20603645; DOI: 10.1038/cr.2010.93.
6. Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008; 10:1470-6. PMID: 19011622; DOI: 10.1038/ncb1800.
7. Muralidharan-Chari V, Clancy J, Plou C, Romao M, Chavrier P, Raposo G, et al. ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. Curr Biol 2009; 19:1875-85. PMID: 19896381 DOI: 10.1016/j.cub.2009.09.059.
8. Ghosh AK, Secreto CR, Knox TR, Ding W, Mukhopadhyay D, Kay NE. Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression. Blood 2010; 115:1755-64. PMID: 20018914; DOI: 10.1182/blood-2009-09-242719.
9. Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, et al. Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J Lipid Res 2010; 51:2105-20. PMID: 20424270; DOI: 10.1194/jlr.M003657.
10. Szajnik M, Czystowska M, Szczepanski MJ, Mandapathil M, Whiteside TL. Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS ONE 2010; 5:e11469. PMID: 20661468; DOI: 10.1371/journal.pone.0011469.
11. Zhang H-G, Grizzle WE. Exosomes and cancer: A newly described pathway of immune suppression. Clin Cancer Res 2011; 17:959-64. PMID: 21224375; DOI: 10.1158/1078-0432.CCR-10-1489.