메뉴 건너뛰기




Volumn 15, Issue 2, 2015, Pages 267-275

The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response

Author keywords

chemotherapy; circulating DNA; circulating miRNA; epigenetic alterations; genetic alterations; resistance; targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; MICRORNA; NUCLEIC ACID; TUMOR MARKER;

EID: 84921358315     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2015.980817     Document Type: Review
Times cited : (10)

References (68)
  • 1
    • 34247391164 scopus 로고    scopus 로고
    • Role of tumor markers in patients with solid cancers: A critical review
    • Duffy MJ. Role of tumor markers in patients with solid cancers: a critical review. Eur J Intern Med 2007;18(3):175-84
    • (2007) Eur J Intern Med , vol.18 , Issue.3 , pp. 175-184
    • Duffy, M.J.1
  • 2
    • 79952015320 scopus 로고    scopus 로고
    • Us fda perspective on challenges in co-developing in vitro companion diagnostics and targeted cancer therapeutics
    • Philip R, Carrington L, Chan M. US FDA perspective on challenges in co-developing in vitro companion diagnostics and targeted cancer therapeutics. Bioanalysis 2011;3(4):383-9
    • (2011) Bioanalysis , vol.3 , Issue.4 , pp. 383-389
    • Philip, R.1    Carrington, L.2    Chan, M.3
  • 3
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011; 11(6):426-37
    • (2011) Nat Rev Cancer , vol.11 , Issue.6 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.S.2    Pantel, K.3
  • 4
    • 0034020197 scopus 로고    scopus 로고
    • The origin and mechanism of circulating dna
    • Stroun M, Maurice P, Vasioukhin V, et al. The origin and mechanism of circulating DNA. Ann N Y Acad Sci 2000;906:161-8
    • (2000) Ann N y Acad Sci , vol.906 , pp. 161-168
    • Stroun, M.1    Maurice, P.2    Vasioukhin, V.3
  • 5
    • 79953202200 scopus 로고    scopus 로고
    • Argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma
    • Arroyo JD, Chevillet JR, Kroh EM, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 2011;108(12):5003-8
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.12 , pp. 5003-5008
    • Arroyo, J.D.1    Chevillet, J.R.2    Kroh, E.M.3
  • 6
    • 77952704204 scopus 로고    scopus 로고
    • Flow cytometric analysis of circulating microparticles in plasma
    • Orozco AF, Lewis DE. Flow cytometric analysis of circulating microparticles in plasma. Cytometry A 2010;77(6):502-14
    • (2010) Cytometry A , vol.77 , Issue.6 , pp. 502-514
    • Orozco, A.F.1    Lewis, D.E.2
  • 7
    • 84896703318 scopus 로고    scopus 로고
    • Clinical relevance of circulating cell-free micrornas in cancer
    • Schwarzenbach H, Nishida N, Calin GA, et al. Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol 2014;11(3):145-56
    • (2014) Nat Rev Clin Oncol , vol.11 , Issue.3 , pp. 145-156
    • Schwarzenbach, H.1    Nishida, N.2    Calin, G.A.3
  • 8
    • 58249088751 scopus 로고    scopus 로고
    • Micrornas: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;136(2): 215-33
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 9
    • 84901248831 scopus 로고    scopus 로고
    • A new generation of companion diagnostics: Cobas braf kras and egfr mutation detection tests
    • Angulo B, Lopez-Rios F, Gonzalez D. A new generation of companion diagnostics: cobas BRAF, KRAS and EGFR mutation detection tests. Expert Rev Mol Diagn 2014;14(5):517-24
    • (2014) Expert Rev Mol Diagn , vol.14 , Issue.5 , pp. 517-524
    • Angulo, B.1    Lopez-Rios, F.2    Gonzalez, D.3
  • 10
    • 28044468634 scopus 로고    scopus 로고
    • Detection and quantification of mutations in the plasma of patients with colorectal tumors
    • Diehl F, Li M, Dressman D, et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci USA 2005; 102(45):16368-73
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.45 , pp. 16368-16373
    • Diehl, F.1    Li, M.2    Dressman, D.3
  • 12
    • 84877579861 scopus 로고    scopus 로고
    • Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma dna
    • Murtaza M, Dawson SJ, Tsui DW, et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013;497(7447):108-12
    • (2013) Nature , vol.497 , Issue.7447 , pp. 108-112
    • Murtaza, M.1    Dawson, S.J.2    Tsui, D.W.3
  • 13
    • 77954149407 scopus 로고    scopus 로고
    • Systemic chemotherapy-induced microsatellite instability in the mononuclear cell fraction of women with breast cancer can be reproduced in vitro and abrogated by amifostine
    • Pinto JL, Fonseca FL, Marsicano SR, et al. Systemic chemotherapy-induced microsatellite instability in the mononuclear cell fraction of women with breast cancer can be reproduced in vitro and abrogated by amifostine. J Pharm Pharmacol 2010;62(7): 931-4
    • (2010) J Pharm Pharmacol , vol.62 , Issue.7 , pp. 931-934
    • Pinto, J.L.1    Fonseca, F.L.2    Marsicano, S.R.3
  • 14
    • 84883473901 scopus 로고    scopus 로고
    • Detection of mutant free circulating tumor dna in the plasma of patients with gastrointestinal stromal tumor harboring activating mutations of ckit or pdgfra
    • Maier J, Lange T, Kerle I, et al. Detection of mutant free circulating tumor DNA in the plasma of patients with gastrointestinal stromal tumor harboring activating mutations of CKIT or PDGFRA. Clin Cancer Res 2013;19(17):4854-67
    • (2013) Clin Cancer Res , vol.19 , Issue.17 , pp. 4854-4867
    • Maier, J.1    Lange, T.2    Kerle, I.3
  • 15
    • 84897097077 scopus 로고    scopus 로고
    • Gemcitabine and capecitabine for heavily pre-Treated metastatic colorectal cancer patients a phase ii and translational research study
    • Spindler KL, Pallisgaard N, Andersen RF, et al. Gemcitabine and capecitabine for heavily pre-Treated metastatic colorectal cancer patients a phase II and translational research study. Anticancer Res 2014;34(2): 845-50
    • (2014) Anticancer Res , vol.34 , Issue.2 , pp. 845-850
    • Spindler, K.L.1    Pallisgaard, N.2    Andersen, R.F.3
  • 16
    • 84906245875 scopus 로고    scopus 로고
    • Changes in mutational status during third-line treatment for metastatic colorectal cancer-results of consecutive measurement of cell free dna, kras and braf in the plasma
    • Spindler KL, Pallisgaard N, Andersen RF, et al. Changes in mutational status during third-line treatment for metastatic colorectal cancer-Results of consecutive measurement of cell free DNA, KRAS and BRAF in the plasma. Int J Cancer 2014;135(9):2215-22
    • (2014) Int J Cancer , vol.135 , Issue.9 , pp. 2215-2222
    • Spindler, K.L.1    Pallisgaard, N.2    Andersen, R.F.3
  • 17
    • 84883458149 scopus 로고    scopus 로고
    • Detection of epidermal growth factor receptor t790m mutation in plasma dna from patients refractory to epidermal growth factor receptor tyrosine kinase inhibitor
    • Sakai K, Horiike A, Irwin DL, et al. Detection of epidermal growth factor receptor T790M mutation in plasma DNA from patients refractory to epidermal growth factor receptor tyrosine kinase inhibitor. Cancer Sci 2013;104(9):1198-204
    • (2013) Cancer Sci , vol.104 , Issue.9 , pp. 1198-1204
    • Sakai, K.1    Horiike, A.2    Irwin, D.L.3
  • 18
    • 80053014135 scopus 로고    scopus 로고
    • A noninvasive system for monitoring resistance to epidermal growth factor receptor tyrosine kinase inhibitors with plasma dna
    • Nakamura T, Sueoka-Aragane N, Iwanaga K, et al. A noninvasive system for monitoring resistance to epidermal growth factor receptor tyrosine kinase inhibitors with plasma DNA. J Thorac Oncol 2011; 6(10):1639-48
    • (2011) J Thorac Oncol , vol.6 , Issue.10 , pp. 1639-1648
    • Nakamura, T.1    Sueoka-Aragane, N.2    Iwanaga, K.3
  • 19
    • 84862893803 scopus 로고    scopus 로고
    • Egfr array: Uses in the detection of plasma egfr mutations in non-small cell lung cancer patients
    • Yam I, Lam DC, Chan K, et al. EGFR array: uses in the detection of plasma EGFR mutations in non-small cell lung cancer patients. J Thorac Oncol 2012;7(7):1131-40
    • (2012) J Thorac Oncol , vol.7 , Issue.7 , pp. 1131-1140
    • Yam, I.1    Lam, D.C.2    Chan, K.3
  • 20
    • 74249106438 scopus 로고    scopus 로고
    • Egfr mutations detected in plasma are associated with patient outcomes in erlotinib plus docetaxel-Treated non-small cell lung cancer
    • Mack PC, Holland WS, Burich RA, et al. EGFR mutations detected in plasma are associated with patient outcomes in erlotinib plus docetaxel-Treated non-small cell lung cancer. J Thorac Oncol 2009;4(12):1466-72
    • (2009) J Thorac Oncol , vol.4 , Issue.12 , pp. 1466-1472
    • MacK, P.C.1    Holland, W.S.2    Burich, R.A.3
  • 21
    • 65249127504 scopus 로고    scopus 로고
    • Noninvasive detection of egfr t790m in gefitinib or erlotinib resistant non-small cell lung cancer
    • Kuang Y, Rogers A, Yeap BY, et al. Noninvasive detection of EGFR T790M in gefitinib or erlotinib resistant non-small cell lung cancer. Clin Cancer 2009;15(8):2630-6
    • (2009) Clin Cancer , vol.15 , Issue.8 , pp. 2630-2636
    • Kuang, Y.1    Rogers, A.2    Yeap, B.Y.3
  • 22
    • 84896539307 scopus 로고    scopus 로고
    • Noninvasive detection of response and resistance in egfr-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma dna
    • Oxnard GR, Paweletz CP, Kuang Y, et al. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA. Clin Cancer 2014;20(6):1698-705
    • (2014) Clin Cancer , vol.20 , Issue.6 , pp. 1698-1705
    • Oxnard, G.R.1    Paweletz, C.P.2    Kuang, Y.3
  • 23
    • 76749151984 scopus 로고    scopus 로고
    • Potential clinical significance of a plasma-based kras mutation analysis in patients with advanced non-small cell lung cancer
    • Wang S, An T, Wang J, et al. Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer. Clin Cancer Res 2010;16(4):1324-30
    • (2010) Clin Cancer Res , vol.16 , Issue.4 , pp. 1324-1330
    • Wang, S.1    An, T.2    Wang, J.3
  • 24
    • 84885477574 scopus 로고    scopus 로고
    • Detection of egfrviii mutant dna in the peripheral blood of brain tumor patients
    • Salkeni MA, Zarzour A, Ansay TY, et al. Detection of EGFRvIII mutant DNA in the peripheral blood of brain tumor patients. J Neurooncol 2013;115(1):27-35
    • (2013) J Neurooncol , vol.115 , Issue.1 , pp. 27-35
    • Salkeni, M.A.1    Zarzour, A.2    Ansay, T.Y.3
  • 25
    • 84901232920 scopus 로고    scopus 로고
    • Dna methylation of circulating dna: A marker for monitoring efficacy of neoadjuvant chemotherapy in breast cancer patients
    • Sharma G, Mirza S, Parshad R, et al. DNA methylation of circulating DNA: a marker for monitoring efficacy of neoadjuvant chemotherapy in breast cancer patients. Tumour Biol 2012;33(6):1837-43
    • (2012) Tumour Biol , vol.33 , Issue.6 , pp. 1837-1843
    • Sharma, G.1    Mirza, S.2    Parshad, R.3
  • 26
    • 84859376472 scopus 로고    scopus 로고
    • Molecular pathways: Regulation and therapeutic implications of multidrug resistance
    • Chen KG, Sikic BI. Molecular pathways: regulation and therapeutic implications of multidrug resistance. Clin Cancer Res 2012; 18(7):1863-9
    • (2012) Clin Cancer Res , vol.18 , Issue.7 , pp. 1863-1869
    • Chen, K.G.1    Sikic, B.I.2
  • 27
    • 76749116065 scopus 로고    scopus 로고
    • Cpg hypomethylation of mdr1 gene in tumor and serum of invasive ductal breast carcinoma patients
    • Sharma G, Mirza S, Parshad R, et al. CpG hypomethylation of MDR1 gene in tumor and serum of invasive ductal breast carcinoma patients. Clin Biochem 2010; 43(4-5):373-9
    • (2010) Clin Biochem , vol.43 , Issue.4-5 , pp. 373-379
    • Sharma, G.1    Mirza, S.2    Parshad, R.3
  • 28
    • 39049184409 scopus 로고    scopus 로고
    • Methylation patterns and chemosensitivity in nsclc
    • Ramirez JL, Salazar MF, Gupta J, et al. Methylation patterns and chemosensitivity in NSCLC. Adv Exp Med Biol 2006;587: 195-209
    • (2006) Adv Exp Med Biol , vol.587 , pp. 195-209
    • Ramirez, J.L.1    Salazar, M.F.2    Gupta, J.3
  • 29
    • 13944250245 scopus 로고    scopus 로고
    • Circulating tumor-specific dna: A marker for monitoring efficacy of adjuvant therapy in cancer patients
    • Fiegl H, Millinger S, Mueller-Holzner E, et al. Circulating tumor-specific DNA: a marker for monitoring efficacy of adjuvant therapy in cancer patients. Cancer Res 2005;65(4):1141-5
    • (2005) Cancer Res , vol.65 , Issue.4 , pp. 1141-1145
    • Fiegl, H.1    Millinger, S.2    Mueller-Holzner, E.3
  • 30
    • 3042774430 scopus 로고    scopus 로고
    • The acquisition of hmlh1 methylation in plasma dna after chemotherapy predicts poor survival for ovarian cancer patients
    • Gifford G, Paul J, Vasey PA, et al. The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin Cancer Res 2004;10(13):4420-6
    • (2004) Clin Cancer Res , vol.10 , Issue.13 , pp. 4420-4426
    • Gifford, G.1    Paul, J.2    Vasey, P.A.3
  • 31
    • 55849123946 scopus 로고    scopus 로고
    • Microrna-155 is regulated by the transforming growth factor beta/smad pathway and contributes to epithelial cell plasticity by targeting rhoa
    • Kong W, Yang H, He L, et al. MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 2008;28(22):6773-84
    • (2008) Mol Cell Biol , vol.28 , Issue.22 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3
  • 32
    • 84867353432 scopus 로고    scopus 로고
    • Serum microrna-155 as a potential biomarker to track disease in breast cancer
    • Sun Y, Wang M, Lin G, et al. Serum microRNA-155 as a potential biomarker to track disease in breast cancer. PLoS One 2012;7(10):e47003
    • (2012) PLoS One , vol.7 , Issue.10 , pp. e47003
    • Sun, Y.1    Wang, M.2    Lin, G.3
  • 33
    • 84888772543 scopus 로고    scopus 로고
    • Predicting distant metastasis and chemoresistance using plasma mirnas
    • Chen J, Wang W, Zhang Y, et al. Predicting distant metastasis and chemoresistance using plasma miRNAs. Med Oncol 2014;31(1):799
    • (2014) Med Oncol , vol.31 , Issue.1 , pp. 799
    • Chen, J.1    Wang, W.2    Zhang, Y.3
  • 34
    • 84906054474 scopus 로고    scopus 로고
    • Changes in serum levels of mir-21 mir-210 and mir-373 in her2-positive breast cancer patients undergoing neoadjuvant therapy: A translational research project within the geparquinto trial
    • Muller V, Gade S, Steinbach B, et al. Changes in serum levels of miR-21, miR-210, and miR-373 in HER2-positive breast cancer patients undergoing neoadjuvant therapy: a translational research project within the Geparquinto trial. Breast Cancer Res Treat 2014;147(1):61-8
    • (2014) Breast Cancer Res Treat , vol.147 , Issue.1 , pp. 61-68
    • Muller, V.1    Gade, S.2    Steinbach, B.3
  • 35
    • 84859810024 scopus 로고    scopus 로고
    • Circulating mir-125b as a marker predicting chemoresistance in breast cancer
    • Wang H, Tan G, Dong L, et al. Circulating MiR-125b as a marker predicting chemoresistance in breast cancer. PLoS One 2012;7(4):e34210
    • (2012) PLoS One , vol.7 , Issue.4 , pp. e34210
    • Wang, H.1    Tan, G.2    Dong, L.3
  • 36
    • 84873532679 scopus 로고    scopus 로고
    • Serum microrna 125b as a diagnostic or prognostic biomarker for advanced nsclc patients receiving cisplatin-based chemotherapy
    • Cui EH, Li HJ, Hua F, et al. Serum microRNA 125b as a diagnostic or prognostic biomarker for advanced NSCLC patients receiving cisplatin-based chemotherapy. Acta Pharmacol Sin 2013; 34(2):309-13
    • (2013) Acta Pharmacol Sin , vol.34 , Issue.2 , pp. 309-313
    • Cui, E.H.1    Li, H.J.2    Hua, F.3
  • 37
    • 84921410393 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy in breast cancer patients induces mir-34a and mir-122 expression
    • Epub ahead of print]
    • Freres P, Josse C, Bovy N, et al. Neoadjuvant chemotherapy in breast cancer patients induces miR-34a and miR-122 expression. J Cell Physiol 2014. [Epub ahead of print]
    • (2014) J Cell Physiol
    • Freres, P.1    Josse, C.2    Bovy, N.3
  • 38
    • 0027944206 scopus 로고
    • P53 status and the efficacy of cancer therapy in vivo
    • Lowe SW, Bodis S, McClatchey A, et al. p53 status and the efficacy of cancer therapy in vivo. Science 1994;266(5186):807-10
    • (1994) Science , vol.266 , Issue.5186 , pp. 807-810
    • Lowe, S.W.1    Bodis, S.2    McClatchey, A.3
  • 39
    • 34848868157 scopus 로고    scopus 로고
    • Tumor-suppressive mir-34a induces senescence-like growth arrest through modulation of the e2f pathway in human colon cancer cells
    • Tazawa H, Tsuchiya N, Izumiya M, et al. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 2007;104(39):15472-7
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.39 , pp. 15472-15477
    • Tazawa, H.1    Tsuchiya, N.2    Izumiya, M.3
  • 40
    • 84895075810 scopus 로고    scopus 로고
    • Circulating microrna expressions in colorectal cancer as predictors of response to chemotherapy
    • Zhang J, Zhang K, Bi M, et al. Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy. Anticancer Drugs 2014;25(3):346-52
    • (2014) Anticancer Drugs , vol.25 , Issue.3 , pp. 346-352
    • Zhang, J.1    Zhang, K.2    Bi, M.3
  • 41
    • 79952089256 scopus 로고    scopus 로고
    • Clinical impact of down-regulated plasma mir-92a levels in non-hodgkin's lymphoma
    • Ohyashiki K, Umezu T, Yoshizawa S, et al. Clinical impact of down-regulated plasma miR-92a levels in non-Hodgkin's lymphoma. PLoS One 2011;6(2):e16408
    • (2011) PLoS One , vol.6 , Issue.2 , pp. e16408
    • Ohyashiki, K.1    Umezu, T.2    Yoshizawa, S.3
  • 42
    • 84880634054 scopus 로고    scopus 로고
    • Microrna-21 gene and cancer
    • Huang Y, Yang YB, Zhang XH, et al. MicroRNA-21 gene and cancer. Med Oncol 2013;30(1):376
    • (2013) Med Oncol , vol.30 , Issue.1 , pp. 376
    • Huang, Y.1    Yang, Y.B.2    Zhang, X.H.3
  • 43
    • 84863229384 scopus 로고    scopus 로고
    • Serum microrna expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer
    • Liu R, Chen X, Du Y, et al. Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer. Clin Chem 2012;58(3):610-18
    • (2012) Clin Chem , vol.58 , Issue.3 , pp. 610-618
    • Liu, R.1    Chen, X.2    Du, Y.3
  • 44
    • 84878110643 scopus 로고    scopus 로고
    • The serum mir-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer and mir-21 expression confers chemoresistance by targeting fasl
    • Wang P, Zhuang L, Zhang J, et al. The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL. Mol Oncol 2013;7(3):334-45
    • (2013) Mol Oncol , vol.7 , Issue.3 , pp. 334-345
    • Wang, P.1    Zhuang, L.2    Zhang, J.3
  • 45
    • 84900548218 scopus 로고    scopus 로고
    • Circulating micrornas are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer
    • Lin HM, Castillo L, Mahon KL, et al. Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer. Br J Cancer 2014;110(10):2462-71
    • (2014) Br J Cancer , vol.110 , Issue.10 , pp. 2462-2471
    • Lin, H.M.1    Castillo, L.2    Mahon, K.L.3
  • 46
    • 84890967992 scopus 로고    scopus 로고
    • Changes in circulating micrornas after radiochemotherapy in head and neck cancer patients
    • Summerer I, Niyazi M, Unger K, et al. Changes in circulating microRNAs after radiochemotherapy in head and neck cancer patients. Radiat Oncol 2013;8:296
    • (2013) Radiat Oncol , vol.8 , pp. 296
    • Summerer, I.1    Niyazi, M.2    Unger, K.3
  • 47
    • 84892806594 scopus 로고    scopus 로고
    • Circulating mir-200c levels significantly predict response to chemotherapy and prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer
    • Tanaka K, Miyata H, Yamasaki M, et al. Circulating miR-200c levels significantly predict response to chemotherapy and prognosis of patients undergoing neoadjuvant chemotherapy for esophageal cancer. Ann Surg Oncol 2013;20(Suppl 3): S607-15
    • (2013) Ann Surg Oncol , vol.20 , pp. S607-S615
    • Tanaka, K.1    Miyata, H.2    Yamasaki, M.3
  • 48
    • 84875300687 scopus 로고    scopus 로고
    • Development of a mir-26 companion diagnostic test for adjuvant interferon-Alpha therapy in hepatocellular carcinoma
    • Ji J, Yu L, Yu Z, et al. Development of a miR-26 companion diagnostic test for adjuvant interferon-Alpha therapy in hepatocellular carcinoma. Int J Biol Sci 2013;9(3):303-12
    • (2013) Int J Biol Sci , vol.9 , Issue.3 , pp. 303-312
    • Ji, J.1    Yu, L.2    Yu, Z.3
  • 49
    • 0036397680 scopus 로고    scopus 로고
    • Technologies for individual genotyping: Detection of genetic polymorphisms in drug targets and disease genes
    • Shi MM. Technologies for individual genotyping: detection of genetic polymorphisms in drug targets and disease genes. Am J Pharmacogenomics 2002;2(3): 197-205
    • (2002) Am J Pharmacogenomics , vol.2 , Issue.3 , pp. 197-205
    • Shi, M.M.1
  • 50
    • 81255175501 scopus 로고    scopus 로고
    • High-Throughput droplet digital pcr system for absolute quantitation of dna copy number
    • Hindson BJ, Ness KD, Masquelier DA, et al. High-Throughput droplet digital PCR system for absolute quantitation of DNA copy number. Anal Chem 2011; 83(22):8604-10
    • (2011) Anal Chem , vol.83 , Issue.22 , pp. 8604-8610
    • Hindson, B.J.1    Ness, K.D.2    Masquelier, D.A.3
  • 51
    • 84905814375 scopus 로고    scopus 로고
    • Dna methylation markers for early detection of women's cancer: Promise and challenges
    • Wittenberger T, Sleigh S, Reisel D, et al. DNA methylation markers for early detection of women's cancer: promise and challenges. Epigenomics 2014;6(3):311-27
    • (2014) Epigenomics , vol.6 , Issue.3 , pp. 311-327
    • Wittenberger, T.1    Sleigh, S.2    Reisel, D.3
  • 52
    • 29144470346 scopus 로고    scopus 로고
    • Real-Time quantification of micrornas by stem-loop rt-pcr
    • Chen C, Ridzon DA, Broomer AJ, et al. Real-Time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005;33(20):e179
    • (2005) Nucleic Acids Res , vol.33 , Issue.20 , pp. e179
    • Chen, C.1    Ridzon, D.A.2    Broomer, A.J.3
  • 53
    • 84859892863 scopus 로고    scopus 로고
    • Microrna profiling: Approaches and considerations
    • Pritchard CC, Cheng HH, Tewari M. MicroRNA profiling: approaches and considerations. Nat Rev Genet 2012;13(5): 358-69
    • (2012) Nat Rev Genet , vol.13 , Issue.5 , pp. 358-369
    • Pritchard, C.C.1    Cheng, H.H.2    Tewari, M.3
  • 54
    • 84883856321 scopus 로고    scopus 로고
    • Microrna: Function, detection, and bioanalysis
    • Dong H, Lei J, Ding L, et al. MicroRNA: function, detection, and bioanalysis. Chem Rev
    • (2013) Chem Rev , pp. 2013
    • Dong, H.1    Lei, J.2    Ding, L.3
  • 55
    • 84896737232 scopus 로고    scopus 로고
    • Quantitative identification of mutant alleles derived from lung cancer in plasma cell-free dna via anomaly detection using deep sequencing data
    • Kukita Y, Uchida J, Oba S, et al. Quantitative identification of mutant alleles derived from lung cancer in plasma cell-free DNA via anomaly detection using deep sequencing data. PLoS One 2013;8(11): e81468
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e81468
    • Kukita, Y.1    Uchida, J.2    Oba, S.3
  • 56
    • 82955189198 scopus 로고    scopus 로고
    • How novel molecular diagnostic technologies and biomarkers are revolutionizing genetic testing and patient care
    • Baudhuin LM, Donato LJ, Uphoff TS. How novel molecular diagnostic technologies and biomarkers are revolutionizing genetic testing and patient care. Expert Rev Mol Diagn 2012;12(1): 25-37
    • (2012) Expert Rev Mol Diagn , vol.12 , Issue.1 , pp. 25-37
    • Baudhuin, L.M.1    Donato, L.J.2    Uphoff, T.S.3
  • 57
    • 53649106195 scopus 로고    scopus 로고
    • Next-generation dna sequencing
    • Shendure J, Ji H. Next-generation DNA sequencing. Nat Biotechnol 2008; 26(10):1135-45
    • (2008) Nat Biotechnol , vol.26 , Issue.10 , pp. 1135-1145
    • Shendure, J.1    Ji, H.2
  • 58
    • 84860389888 scopus 로고    scopus 로고
    • Rna-ligase-dependent biases in mirna representation in deep-sequenced small rna cdna libraries
    • Hafner M, Renwick N, Brown M, et al. RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries. RNA 2011; 17(9):1697-712
    • (2011) RNA , vol.17 , Issue.9 , pp. 1697-1712
    • Hafner, M.1    Renwick, N.2    Brown, M.3
  • 59
    • 84871990259 scopus 로고    scopus 로고
    • Biologic challenges in the detection of circulating tumor cells
    • Joosse SA, Pantel K. Biologic challenges in the detection of circulating tumor cells. Cancer Res 2013;73(1):8-11
    • (2013) Cancer Res , vol.73 , Issue.1 , pp. 8-11
    • Joosse, S.A.1    Pantel, K.2
  • 60
    • 84901705788 scopus 로고    scopus 로고
    • Circulating tumor cells: What is in it for the patient? A vision towards the future
    • van de Stolpe A, den Toonder JM. Circulating tumor cells: what is in it for the patient?. A vision towards the future. Cancers 2014;6(2):1195-207
    • (2014) Cancers , vol.6 , Issue.2 , pp. 1195-1207
    • Van De Stolpe, A.1    Den Toonder, J.M.2
  • 61
    • 0034748198 scopus 로고    scopus 로고
    • Functionality of circulating dna: The hypothesis of genometastasis
    • Garcia-Olmo D, Garcia-Olmo DC. Functionality of circulating DNA: the hypothesis of genometastasis. Ann N Y Acad Sci 2001;945:265-75
    • (2001) Ann N y Acad Sci , vol.945 , pp. 265-275
    • Garcia-Olmo, D.1    Garcia-Olmo, D.C.2
  • 62
    • 84861432560 scopus 로고    scopus 로고
    • Transformation of non-Tumor host cells during tumor progression: Theories and evidence
    • Garcia-Olmo DC, Picazo MG, Garcia-Olmo D. Transformation of non-Tumor host cells during tumor progression: theories and evidence. Expert Opin Biol Ther 2012;12(Suppl 1):S199-207
    • (2012) Expert Opin Biol Ther , vol.12 , pp. S199-S207
    • Garcia-Olmo, D.C.1    Picazo, M.G.2    Garcia-Olmo, D.3
  • 63
    • 84890313522 scopus 로고    scopus 로고
    • Exosomes in cancer development metastasis and drug resistance: A comprehensive review
    • Azmi AS, Bao B, Sarkar FH. Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Rev 2013;32(3-4):623-42
    • (2013) Cancer Metastasis Rev , vol.32 , Issue.3-4 , pp. 623-642
    • Azmi, A.S.1    Bao, B.2    Sarkar, F.H.3
  • 65
    • 33847129200 scopus 로고    scopus 로고
    • Circulating (cellfree) nucleic acids-A promising, non-invasive tool for early detection of several human diseases
    • Swarup V, Rajeswari MR. Circulating (cellfree) nucleic acids-A promising, non-invasive tool for early detection of several human diseases. FEBS Lett 2007;581(5):795-9
    • (2007) FEBS Lett , vol.581 , Issue.5 , pp. 795-799
    • Swarup, V.1    Rajeswari, M.R.2
  • 67
    • 84861441160 scopus 로고    scopus 로고
    • Circulating nucleic acids and protease activities in blood of tumor patients
    • Schwarzenbach H. Circulating nucleic acids and protease activities in blood of tumor patients. Expert Opin Biol Ther 2012; 12(Suppl 1):S163-9
    • (2012) Expert Opin Biol Ther , vol.12 , pp. S163-S169
    • Schwarzenbach, H.1
  • 68
    • 84872943055 scopus 로고    scopus 로고
    • Clinical applications of maternal plasma fetal dna analysis: Translating the fruits of 15 years of research
    • Chiu RW, Lo YM. Clinical applications of maternal plasma fetal DNA analysis: translating the fruits of 15 years of research. Clin Chem Lab Med 2013;51(1):197-204
    • (2013) Clin Chem Lab Med , vol.51 , Issue.1 , pp. 197-204
    • Chiu, R.W.1    Lo, Y.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.