Self-Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol-Free Drugs

Advanced Healthcare Materials

Volumn 4, Issue 12, 2015, Pages 1887-1890

  Riber, Camilla Frich ^a   Smith, Anton A A ^a   Zelikin, Alexander N ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Disulfide reshuffling; Drug delivery; Macromolecular prodrugs; Self immolative linkers

Indexed keywords

COVALENT BONDS; DRUG DELIVERY; MEDICAL NANOTECHNOLOGY; SULFUR COMPOUNDS; TARGETED DRUG DELIVERY;

CHEMICAL BARRIERS; DISULFIDE BONDS; DISULFIDE RESHUFFLING; MEDICINAL CHEMISTRY; ORGANIC CHEMISTRY; PRODRUGS; SELF-IMMOLATIVE; TARGET CELLS;

CONTROLLED DRUG DELIVERY;

CARBOXYLIC ACID; DRUG CARRIER; MERCAPTOETHANOL; MONOMER; POLYMER; POLY[N 2 (HYDROXYPROPYL METHACRYLAMIDE)]; RIBAVIRIN; UNCLASSIFIED DRUG; ZIDOVUDINE; DISULFIDE; PRODRUG; THIOL DERIVATIVE;

ARTICLE; DISULFIDE BOND; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG METABOLISM; DRUG RELEASE; NANOMEDICINE; NANOPHARMACEUTICS; NONHUMAN; ORGANIC CHEMISTRY; PRIORITY JOURNAL; SELF IMMOLATIVE LINKER; CHEMISTRY; DRUG EFFECTS; HIV INFECTIONS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; MEDICINAL CHEMISTRY;

CHEMISTRY, PHARMACEUTICAL; DISULFIDES; HIV; HIV INFECTIONS; HUMANS; NANOMEDICINE; PRODRUGS; SULFHYDRYL COMPOUNDS;

EID: 84940440594     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201500344     Document Type: Article

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