Highly active macromolecular prodrugs inhibit expression of the hepatitis c virus genome in the host cells

Advanced Healthcare Materials

Volumn 4, Issue 1, 2015, Pages 65-68

  Ruiz Sanchis, Pau ^a   Wohl, Benjamin M ^a   Smith, Anton A A ^a   Zuwala, Kaja ^a,b   Melchjorsen, Jesper ^b   Tolstrup, Martin ^b   Zelikin, Alexander N ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Drug delivery; Hepatitis c virus; Polymers; Prodrugs

Indexed keywords

AMIDES; DRUG DELIVERY; GENES; MACROMOLECULES; POLYMERS;

HEPATITIS C VIRUS; HOST CELLS; INFLAMMATORY RESPONSE; PRODRUG ACTIVATION; PRODRUGS; RIBAVIRIN; VIRAL INFECTIONS;

VIRUSES;

ALPHA INTERFERON; METHACRYLIC ACID; MONOMER; POLYMER; PRODRUG; RIBAVIRIN; ANTIVIRUS AGENT; POLYMETHACRYLIC ACID; POLYMETHACRYLIC ACID DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; DRUG CONJUGATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RELEASE; GENE EXPRESSION; HEPATITIS C; HEPATITIS C VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOST CELL; HUMAN; IC50; MACROPHAGE; MONOTHERAPY; NONHUMAN; PHARMACODYNAMICS; POLYMERIZATION; VIRUS GENOME; VIRUS HEPATITIS; ANALOGS AND DERIVATIVES; CELL LINE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEPACIVIRUS; METABOLISM; PATHOLOGY; SYNTHESIS;

ANTIVIRAL AGENTS; CELL LINE; GENE EXPRESSION REGULATION, VIRAL; GENOME, VIRAL; HEPACIVIRUS; HEPATITIS C; HUMANS; POLYMETHACRYLIC ACIDS; PRODRUGS; RIBAVIRIN;

EID: 84920695226     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201400307     Document Type: Article

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