Reduction and pH dual-bioresponsive crosslinked polymersomes for efficient intracellular delivery of proteins and potent induction of cancer cell apoptosis

Acta Biomaterialia

Volumn 10, Issue 5, 2014, Pages 2159-2168

  Sun, Huanli ^a   Meng, Fenghua ^a   Cheng, Ru ^a   Deng, Chao ^a   Zhong, Zhiyuan ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Cancer therapy; Crosslinking; Dual sensitive; Polymersomes; Protein delivery

Indexed keywords

BODY FLUIDS; CELL DEATH; CONTROLLED DRUG DELIVERY; CROSSLINKING; DISEASES; FREE RADICAL POLYMERIZATION; HYDROGELS; LANTHANUM COMPOUNDS; PH; PH SENSORS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYETHYLENES; SULFUR COMPOUNDS; TARGETED DRUG DELIVERY;

% REDUCTIONS; CANCER CELL APOPTOSIS; CANCER THERAPY; CROSSLINKED; DIETHYL AMINO ETHYL METHACRYLATES; DUAL-SENSITIVE; INTRACELLULAR DELIVERY; POLY(ACRYLIC ACID); POLYMERSOMES; PROTEIN DELIVERY;

PROTEINS;

BOVINE SERUM ALBUMIN; CARRIER PROTEIN; CELL PROTEIN; COPOLYMER; CYTOCHROME C; DISULFIDE; FLUORESCEIN ISOTHIOCYANATE; POLY(ETHYLENE GLYCOL) POLY(ACRYLIC ACID) POLY[2 (DIETHYL AMINO)ETHYL METHACRYLATE]; POLYMER; POLYMERSOME; PROTEIN; THIOL DERIVATIVE; THIOL GROUP; UNCLASSIFIED DRUG; ACRYLIC ACID RESIN; CARBOPOL 940; COLLOID; CROSS LINKING REAGENT; DIETHYLAMINOETHYL METHACRYLATE; MACROGOL DERIVATIVE; METHACRYLIC ACID DERIVATIVE; NANOPARTICLE; WATER;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN MCF 7; CONFOCAL MICROSCOPY; DISSOCIATION; DRUG DELIVERY SYSTEM; ENCAPSULATION; FLOW RATE; FREEZE DRYING; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN SECRETION; PROTEIN TRANSPORT; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BOVINAE; CHEMISTRY; COLLOID; DRUG EFFECTS; HELA CELL LINE; HORSE; INTRACELLULAR SPACE; MCF 7 CELL LINE; METABOLISM; NEOPLASM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION; PATHOLOGY; PH; SOLUBILITY; ULTRASTRUCTURE;

BOVINAE;

ACRYLIC RESINS; ANIMALS; APOPTOSIS; CATTLE; COLLOIDS; CROSS-LINKING REAGENTS; CYTOCHROMES C; FLUORESCEIN-5-ISOTHIOCYANATE; HELA CELLS; HORSES; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; MAGNETIC RESONANCE SPECTROSCOPY; MCF-7 CELLS; METHACRYLATES; NANOPARTICLES; NEOPLASMS; OXIDATION-REDUCTION; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYMERS; SERUM ALBUMIN, BOVINE; SOLUBILITY; WATER;

EID: 84898058454     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2014.01.010     Document Type: Article

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