Mixing in microfluidic devices and enhancement methods

Journal of Micromechanics and Microengineering

Volumn 25, Issue 9, 2015, Pages

  Ward, Kevin ^a   Fan, Z Hugh ^a,b  

^a J Crayton Pruitt Family Department of Biomedical Engineering   (United States)

^b University of Florida   (United States)

Author keywords

flow controls; microfluidics; micromixers; mixing; review

Indexed keywords

FLOW CONTROL; FLOW VELOCITY; FLUIDIC DEVICES; LAMINAR FLOW; MICROCHANNELS; MIXERS (MACHINERY); MIXING; REVIEWS; REYNOLDS NUMBER;

CHANNEL SURFACE; EXTERNAL COMPONENTS; HYDRAULIC DIAMETER; KINETIC VISCOSITY; LOW REYNOLDS NUMBER; MICRO-FLUIDIC DEVICES; MICROMIXERS; MIXING ENHANCEMENT;

MICROFLUIDICS;

EID: 84940426120     PISSN: 09601317     EISSN: 13616439     Source Type: Journal    
DOI: 10.1088/0960-1317/25/9/094001     Document Type: Article

References (95)

1. Lo R 2013 Application of microfluidics in chemical engineering Chem. Eng. Process. Tech. 1 1002
2. Lee C, Chang C, Wang Y and Fu L 2011 Microfluidic mixing: a review Int. J. Mol. Sci. 12 3263
3. Hessel V, Löwe H and Schönfeld F 2005 Micromixers - a review on passive and active mixing principles Chem. Eng. Sci. 60 2479
4. Aubin J, Ferrando M and Jiricny V 2010 Current methods for characterising mixing and flow in microchannels Chem. Eng. Sci. 65 2065
5. Kockmann N 2008 Convective micromixers - design and industrial applications J. Mech. Eng. Sci. 222 807
6. Stone H and Kim S 2001 Microfluidics: basic issues, applications, and challenges AIChE J. 47 1250
7. Stroock A, Dertinger S K W, Ajdari A, Mezic I, Stone H and Whitesides G 2002 Chaotic mixer for microchannels Science 295 647
8. Kumar V, Paraschivoiu M and Nigam K D P 2011 Single-phase fluid flow and mixing in microchannels Chem. Eng. Sci. 66 1329
9. Wang H, Iovenitti P, Harvey E and Masood S 2003 Numerical investigation of mixing in microchannels with patterned grooves J. Micromech. Microeng. 13 801
10. Lu L, Ryu K and Liu C 2001 A novel microstirrer and arrays for microfluidic mixing Micro Total Analysis Systems ed J M Ramsey and A van den Berg (Berlin: Springer) pp 28-30
11. Nguyen N and Wu Z 2005 Micromixers - a review J. Micromech. Microeng. 15 R1
12. Mensing G, Pearce T, Graham M and Beebe D 2004 An externally driven magnetic microstirrer Phil. Trans. A 362 1059
13. Capretto L, Cheng W, Hill M and Zhang X 2011 Micromixing within microfluidic devices Top. Curr. Chem. 304 27
14. Lu L-H, Ryu K and Liu C 2002 A magnetic microstirrer and array for microfluidic mixing J. Microelectromech. Syst. 11 462
15. Barbic M, Mock J, Gray A and Schultz S 2001 Electromagnetic micromotor for microfluidics applications Appl. Phys. Lett. 79 1399
16. Campbell C and Grzybowski B 2004 Microfluidic mixers: from microfabricated to self-assembling devices Phil. Trans. R. Soc. Lond. A 362 1069
17. Mansur E, Mingxing Y, Yundong W and Youyuan D A I 2008 A state-of-the-art review of mixing in microfluidic mixers Chin. J. Chem. Eng. 16 503
18. Meijer H, Singh M, Kang T, den Toonder J and Anderson P 2009 Passive and active mixing in microfluidic devices Macromol. Symp. 279 201
19. Chang C and Yang R 2007 Electrokinetic mixing in microfluidic systems Microfluid. Nanofluidics 3 501
20. Jeong G, Chung S, Kim C and Lee S 2010 Applications of micromixing technology Analyst 135 460
21. Chen L, Wang G, Lim C, Hun Seong G, Choo J, Lee E, Kang S and Song J 2009 Evaluation of passive mixing behaviors in a pillar obstruction poly(dimethylsiloxane) microfluidic mixer using fluorescence microscopy Microfluid. Nanofluidics 7 267
22. Yasui T, Omoto Y, Osato K, Kaji N, Suzuki N, Naito T, Okamoto Y, Tokeshi M, Shamoto E and Baba Y 2012 Confocal microscopic evaluation of mixing performance for 3D microfluidic mixer Anal. Sci. 28 57
23. Fang W, Hsu M, Chen Y T and Yang J 2011 Characterization of microfluidic mixing and reaction in microchannels via analysis of cross-sectional patterns Biomicrofluidics 5 014111
24. Kockmann N, Karlen S, Girard C and Roberge D 2013 Liquid-liquid test reactions to characterize two-phase mixing in microchannels Heat Transfer Eng. 34 169
25. Schwesinger N, Frank T and Wurmus H 1996 A modular microfluid system with an integrated micromixer J. Micromech. Microeng. 6 99
26. Bessoth F, deMello A and Manz A 1999 Microstructure for efficient continuous flow mixing Anal. Commun 36 213
27. You J, Kang K, Tran T, Park H, Hwang W, Kim J and I S G 2015 PDMS-based turbulent microfluidic mixer Lab Chip 15 1727
28. Haverkamp V et al 1999 The potential of micromixers for contacting of disperse liquid phases Fresenius J. Anal. Chem. 364 617
29. Kim D, Lee S, Kwon T and Ahn C 2005 A serpentine laminating micromixer combining splitting/recombination and advection Lab Chip 5 739
30. Hessel V, Hardt S, Löwe H and Schönfeld F 2003 Laminar mixing in different interdigital micromixers: I. Experimental characterization AIChE J. 49 566
31. Lim C, Lam Y and Yang C 2010 Mixing enhancement in microfluidic channel with a constriction under periodic electro-osmotic flow Biomicrofluidics 4 014101
32. Lin Y, Chung Y and Wu C 2007 Mixing enhancement of the passive microfluidic mixer with J-shaped baffles in the tee channel Biomed. Microdevices 9 215
33. Su Y, Chen G and Kenig E 2015 An experimental study on the numbering-up of microchannels for liquid mixing Lab Chip 15 179
34. Lim T et al 2011 Three-dimensionally crossing manifold micro-mixer for fast mixing in a short channel length Lab Chip 11 100
35. Dreher S, Kockmann N and Woias P 2009 Characterization of laminar transient flow regimes and mixing in T-shaped micromixers Heat Transfer Eng. 30 91
36. Li Y, Liu C, Feng X, Xu Y and Liu B 2014 Ultrafast microfluidic mixer for tracking the early folding kinetics of human telomere G-quadruplex Anal. Chem. 86 4333
37. Johnson T, Ross D and Locascio L 2002 Rapid microfluidic mixing Anal. Chem. 74 45
38. Aref H 1984 Stirring by chaotic advection J. Fluid Mech. 143 1
39. Stroock A and Whitesides G 2003 Controlling flows in microchannels with patterned surface charge and topography Acc. Chem. Res. 36 597
40. Sugioka H 2010 Chaotic mixer using electro-osmosis at finite péclet number Phys. Rev. E 81 036306
41. Stremler M, Haselton F and Aref H 2004 Designing for chaos: applications of chaotic advection at the microscale Phil. Trans. R. Soc. Lond. A 362 1019
42. Xia Z, Cattafesta L and Fan Z H 2007 Deconvolution microscopy for flow visualization in microchannels Anal. Chem. 79 2576
43. Mei Q, Xia Z, Xu F, Soper S and Fan Z H 2008 Fabrication of microfluidic reactors and mixing studies for luciferase detection Anal. Chem. 80 6045
44. Marschewski J et al 2015 Mixing with herringbone-inspired microstructures: Overcoming the diffusion limit in co-laminar microfluidic devices Lab Chip 15 1923
45. Howell J et al 2005 A microfluidic mixer with grooves placed on the top and bottom of the channel Lab Chip 5 524
46. Yang Y-J et al 2006 Novel designs of herringbone chaotic mixers 1st IEEE Int. Conf. on Nano/Micro Engineered and Molecular Systems, 2006 NEMS, '06 pp 1307-10
47. Lin D et al 2013 3D staggered herringbone mixer fabricated by femtosecond laser direct writing J. Opt. 15 025601
48. Forbes T and Kralj J 2012 Engineering and analysis of surface interactions in a microfluidic herringbone micromixer Lab Chip 12 2634
49. Lynn N Jr et al 2014 Biosensing enhancement using passive mixing structures for microarray-based sensors Biosensors Bioelectron. 54 506
50. Lynn N and Dandy D 2007 Geometrical optimization of helical flow in grooved micromixers Lab Chip 7 580
51. Zhang Z, Yim C, Lin M and Cao X 2008 Quantitative characterization of micromixing simulation Biomicrofluidics 2 034104
52. Williams M, Longmuir K and Yager P 2008 A practical guide to the staggered herringbone mixer Lab Chip 8 1121
53. Xia Z, Mei R, Sheplak M and Fan Z H 2009 Electroosmotically driven creeping flows in a wavy microchannel Microfluid. Nanofluidics 6 37
54. Song H, Bringer M, Tice J, Gerdts C and Ismagilov R 2003 Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels Appl. Phys. Lett. 83 4664
55. Tice J, Song H, Lyon A and Ismagilov R 2003 Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers Langmuir 19 9127
56. Gunther A, Jhunjhunwala M, Thalmann M, Schmidt M and Jensen K 2005 Micromixing of miscible liquids in segmented gas-liquid flow Langmuir 21 1547
57. Garstecki P, Fuerstman M, Fischbach M, Sia S and Whitesides G 2006 Mixing with bubbles: a practical technology for use with portable microfluidic devices Lab Chip 6 207
58. Tangen U, Sharma A, Wagler P and McCaskill J 2015 On demand nanoliter-scale microfluidic droplet generation, injection, and mixing using a passive microfluidic device Biomicrofluidics 9 014119
59. Dogan H, Nas S and Muradoglu M 2009 Mixing of miscible liquids in gas-segmented serpentine channels Int. J. Multiphase Flow 35 1149
60. Che Z, Nguyen N and Wong T 2011 Analysis of chaotic mixing in plugs moving in meandering microchannels Phys. Rev. E 84 066309
61. Ou J, Moss G and Rothstein J 2007 Enhanced mixing in laminar flows using ultrahydrophobic surfaces Phys. Rev. E 76 016304
62. Ou J, Perot B and Rothstein J 2004 Laminar drag reduction in microchannels using ultrahydrophobic surfaces Phys. Fluids 16 4635
63. Chen C and Cho C 2007 Electrokinetically-driven flow mixing in microchannels with wavy surface J. Colloid Interface Sci. 312 470
64. Wang J, Liu Y and Xu Y 2009 The golden-mean surface pattern to enhance flow mixing in micro-channel Biomed. Microdevices 11 351
65. Kamio E, Ono T and Yoshizawa H 2009 Design of a new static micromixer having simple structure and excellent mixing performance Lab Chip 9 1809
66. Kockmann N and Robergeb D 2011 Scale-up concept for modular microstructured reactors based on mixing, heat transfer, and reactor safety Chem. Eng. Process.: Process Intensification 50 1017
67. Tierno P, Johansen T and Fischer T 2007 Magnetically driven colloidal microstirrer J. Phys. Chem. B 111 3077
68. Lee S, van Noort D, Lee J, Zhang B and Park T 2009 Effective mixing in a microfluidic chip using magnetic particles Lab Chip 9 479
69. Wei Z and Lee C 2009 Magnetic fluid micromixer with tapered magnets J. Appl. Phys. 105 07B523
70. Chen C, Chen C, Lina C and Hua Y 2013 Magnetically actuated artificial cilia for optimum mixing performance in microfluidics Lab Chip 13 2834
71. Zhou B et al 2015 Design and fabrication of magnetically functionalized flexible micropillar arrays for rapid and controllable microfluidic mixing Lab Chip 15 2125
72. Frommelt T, Kostur M, Wenzel-Schafer M, Talkner P, Hanggi P and Wixforth A 2008 Microfluidic mixing via acoustically driven chaotic advection Phys. Rev. Lett. 100 034502
73. Ahmed D, Mao X, Shi J, Juluri B and Huang T 2009 A millisecond micromixer via single-bubble-based acoustic streaming Lab Chip 9 2738
74. Folch A 2012 Introduction to BioMEMS 1st edn (Boca Raton, FL: CRC Press)
75. Ozcelik A et al 2014 An acoustofluidic micromixer via bubble inception and cavitation from microchannel sidewalls Anal. Chem. 86 5083
76. Wang S, Huang X and Yang C 2011 Mixing enhancement for high viscous fluids in a microfluidic chamber Lab Chip 11 2081
77. Petkovic-Duran K, Manasseh R, Zhu Y and Ooi A 2009 Chaotic micromixing in open wells using audio-frequency acoustic microstreaming Biotechniques 47 827
78. Bezagu M et al 2015 A fast and switchable microfluidic mixer based on ultrasound-induced vaporization of perfluorocarbon Lab Chip 15 2025
79. Glasgow I and Aubry N 2003 Enhancement of microfluidic mixing using time pulsing Lab Chip 3 114
80. Glasgow I, Lieber S and Aubry N 2004 Parameters influencing pulsed flow mixing in microchannels Anal. Chem. 76 4825
81. Niu X and Lee Y 2003 Efficient spatial-temporal chaotic mixing in microchannels J. Micromech. Microeng. 13 454
82. Balasuriya S 2010 Optimal frequency for microfluidic mixing across a fluid interface Phys. Rev. Lett. 105 064501
83. Abolhasani M, Oskooei A, Klinkova A, Kumacheva E and Gunther A 2014 Shaken, and stirred: oscillatory segmented flow for controlled size-evolution of colloidal nanomaterials Lab Chip 14 2309
84. Mao H, Yang T and Cremer P 2002 A microfluidic device with a linear temperature gradient for parallel and combinatorial measurements J. Am. Chem. Soc. 124 4432
85. Tsai J and Lin L 2002 Active microfluidic mixer and gas bubble filter driven by thermal bubble micropump Sensors Actuators A 97-98 665
86. Kim S, Wang F, Burns M and Kurabayashi K 2009 Temperature-programmed natural convection for micromixing and biochemical reaction in a single microfluidic chamber Anal. Chem. 81 4510
87. Wang X, Cheng C, Wang S and Liu S 2009 Electroosmotic pumps and their applications in microfluidic systems Microfluid. Nanofluidics 6 145
88. Ng W, Goh S, Lam Y, Yang C and Rodríguez I 2009 DC-biased ac-electroosmotic and ac-electrothermal flow mixing in microchannels Lab Chip 9 802
89. Tang G, He Y and Tao W 2010 Numerical analysis of mixing enhancement for micro-electroosmotic flow J. Appl. Phys. 107 104906
90. Choi E, Kwon K, Lee S, Kim D and Park J 2015 Non-equilibrium electrokinetic micromixer with nanochannel networks Lab Chip 15 1794
91. Aeinehvand M M et al 2015 Biosensing enhancement of dengue virus using microballoon mixers on centrifugal microfluidic platforms Biosensors Bioelectron. 67 424
92. Bynum M and Gordon G 2004 Hybridization enhancement using microfluidic planetary centrifugal mixing Anal. Chem. 76 7039
93. Berenguel-Alonso M, Granados X, Faraudo J, Alonso-Chamarro J and Puyol M 2014 Magnetic actuator for the control and mixing of magnetic bead-based reactions on-chip Anal. Bioanal. Chem. 406 6607
94. Zhu G and Nguyen N 2012 Rapid magnetofluidic mixing in a uniform magnetic field Lab Chip 12 4772
95. Yan D, Yang C, Miao J, Lam Y and Huang X 2009 Enhancement of electrokinetically driven microfluidic T-mixer using frequency modulated electric field and channel geometry effects Electrophoresis 30 3144