Neither methionine nor nitrous oxide inactivation of methionine synthase affect the concentration of 5,10-methylenetetrahydrofolate in rat liver

Journal of Nutrition

Volumn 133, Issue 2, 2003, Pages 476-478

  Horne, Donald W ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Folic acid; Methionine administration; Nitrous oxide; One carbon metabolism 5,10 methylenetetrahydrofolate

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; FOLIC ACID; METHIONINE; METHIONINE SYNTHASE; METHYLENETETRAHYDROFOLIC ACID; NITROUS OXIDE;

ARTICLE; ATMOSPHERE; CARBON METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME INACTIVATION; ENZYME METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER METABOLISM; MALE; METHYLATION; NONHUMAN; PURINE SYNTHESIS; RAT; STATISTICAL SIGNIFICANCE;

EID: 0037315156     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.2.476     Document Type: Article

References (24)

1. Selhub, J. (1999) Homocysteine metabolism. Annu. Rev. Nutr. 19: 217-246.
2. Pietrzik, K. & Brönstrup, A. (1997) Folate in preventive medicine: a new role in cardiovascular disease, neural tube defects and cancer. Ann. Nutr. Metab. 41: 331-343.
3. Tyagi, S. C. (1999) Homocyst(e)ine and heart disease: pathophysiology of extracellular matrix. Clin. Exp. Hypertens. 21: 181-198.
4. Rozen, R. (1996) Molecular genetic aspects of hyperhomocysteinemia and its relation to folic acid. Clin. Investig. Med. 19: 171-178.
5. Makar, A. B. & Tephly, T. R. (1987) The role of formate and S-adenosylmethionine in the reversal of nitrous oxide inhibition of formate oxidation in the rat. Mol. Pharmacol. 32: 309-314.
6. 12 and of methionine on folate coenzyme metabolism in rat liver, kidney, brain, small intestine and bone marrow. BioFactors. 2: 65-68.
7. Lumb, M., Bottiglieri, T., Deacon, R., Perry, J. & Chanarin, I. (1989) Regulation of 5-methyltetrahydrofolate synthesis. Biochem. J. 258: 611-612.
8. Kutzbach, C. & Stokstad, E.L.R. (1967) Feedback inhibition of methylene tetrahydrofolate reductase in rat liver by S-adenosylmethionine. Biochim. Biophys. Acta 139: 217-220.
9. 12-folate interrelationships. Annu. Rev. Nutr. 5: 115-141.
10. Green, J. M., Ballou, D. P. & Matthews, R. G. (1988) Examination of the role of methylenetetrahydrofolate reductase in incorporation of methyltetrahydrofolate into cellular metabolism. FASEB J. 2: 42-47.
11. Horne, D. W. (2001) High-performance liquid chromatographic measurement of 5,10-methylenetetrahydrofolate in liver. Anal. Biochem. 297: 154-159.
12. Blakley R. L. (1969) The Biochemistry of Folic Acid and Related Pteridines. North-Holland, Amsterdam, The Netherlands.
13. Harlan Teklad Standard Diets. Available at: http://www.teklad.com/standard/index.htm (accessed October 23, 2002).
14. Wilson, S. D. & Horne, D. W. (1984) High-performance liquid chromatographic determination of the distribution of naturally occurring folic acid derivatives in rat liver. Anal. Biochem. 142: 529-535.
15. Eloranta, T.O. (1977) Tissue distribution of S-adenosylmethionine and S-adenosylhomocysteine in the rat. Effect of age, sex and methionine administration on the metabolism of S-adenosylmethionine, S-adenosylhomocysteine and polyamines. Biochem. J. 166: 521-529.
16. Makar, A. B. & Tephly, T. R. (1983) Effect of nitrous oxide and methionine treatments on hepatic S-adenosylmethionine and methylation reactions in the rat. Mol. Pharmacol. 24: 124-128.
17. Cook, R. J. (2001) Folate metabolism. In: Homocysteine in Health and Disease (Carmel, R. & Jacobsen, D. W., eds.), pp. 113-134. Cambridge University Press, New York, NY.
18. Shin, M., Iwamoto, N., Yamashita, M., Sano, K. & Umezawa, C. (1998) Pyridine nucleotide levels in liver of rats fed clofibrate- or pyrazinamide-containing diets. Biochem. Pharmacol. 55: 367-371.
19. Herbig, K., Chiang, E. P., Lee, L. R., Hills, J., Shane, B. & Stover, P. J. (2002) Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J. Biol. Chem. 277: 38381-38389.
20. 12 and Intrinsic Factor, 2nd European Symposium (Heinrich, H. C., ed.), pp.728-736. Ferdinand Enke, Stuttgart, Germany.
21. 12 and folic acid metabolism: folic acid clearance studies. J. Clin. Investig. 41: 1263-1276.
22. 12-dependent methionine synthetase on the subcellular distribution of folate coenzymes in rat liver. Arch. Biochem. Biophys. 270: 729-733.
23. 12 on the levels of folate coenzymes in rat bone marrow, kidney, brain, and liver. Arch. Biochem. Biophys. 244: 248-253.
24. 10-methylene tetrahydrofolic acid). J. Am. Chem. Soc. 82: 4921-4927.