Multiplexed targeted quantitative proteomics predicts hepatic glucuronidation potential

Drug Metabolism and Disposition

Volumn 43, Issue 9, 2015, Pages 1331-1335

  Margaillan, Guillaume ^a   Rouleau, Michele ^a   Klein, Kathrin ^b   Fallon, John K ^c   Caron, Patrick ^a   Villeneuve, Lyne ^a   Smith, Philip C ^c   Zanger, Ulrich M ^b   Guillemette, Chantal ^a  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c University of North Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; PROTEIN UGT1A5; PROTEIN UGT2B10; PROTEIN UGT2B15; PROTEIN UGT2B17; PROTEIN UGT2B4; UNCLASSIFIED DRUG; GLUCURONIDE; ISOENZYME;

ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; GLUCURONIDATION; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER; LIVER LEVEL; MALE; MOLECULAR PROBE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RELIABILITY; TANDEM MASS SPECTROMETRY; ADULT; ENZYMOLOGY; METABOLISM;

ADULT; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; LIVER; PROTEOMICS;

EID: 84940382109     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.065391     Document Type: Article

References (20)

1. Achour B, Russell MR, Barber J, and Rostami-Hodjegan A (2014) Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics. Drug Metab Dispos 42:500-510.
2. Benoit-Biancamano M.O., Connelly J, Villeneuve L., Caron P, and Guillemette C (2009) Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants. Drug Metab Dispos 37:322-329.
3. Court MH, Zhang X, Ding X., Yee KK, Hesse LM, and Finel M (2012) Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues. Xenobiotica 42:266-277.
4. Fallon JK, Neubert H, Goosen T.C., and Smith PC (2013a) Targeted precise quantification of 12 human recombinant uridine-diphosphate glucuronosyl transferase 1A and 2B isoforms using nano-ultra-high-performance liquid chromatography/tandem mass spectrometry with selected reaction monitoring. Drug Metab Dispos 41:2076-2080.
5. Fallon JK, Neubert H, Hyland R., Goosen TC, and Smith PC (2013b) Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring. J Proteome Res 12:4402-4413.
6. Gomes AM, Winter S, Klein K., Turpeinen M, Schaeffeler E, Schwab M., and Zanger UM (2009) Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation. Pharmacogenomics 10:579-599.
7. Gröer C., Busch D, Patrzyk M., Beyer K, Busemann A, Heidecke C.D., Drozdzik M., Siegmund W, and Oswald S (2014) Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics. J Pharm Biomed Anal 100:393-401.
8. Guillemette C, Lévesque E, Harvey M., Bellemare J, and Menard V (2010) UGT genomic diversity: beyond gene duplication. Drug Metab Rev 42:24-44.
9. Guillemette C, Lévesque É, and Rouleau M (2014) Pharmacogenomics of human uridine diphospho-glucuronosyltransferases and clinical implications. Clin Pharmacol Ther 96: 324-339.
10. Harbourt DE, Fallon JK, Ito S, Baba T., Ritter JK, Glish GL, and Smith PC (2012) Quantification of human uridine-diphosphate glucuronosyl transferase 1A isoforms in liver, intestine, and kidney using nanobore liquid chromatography-tandem mass spectrometry. Anal Chem 84:98-105.
11. Hu DG, Meech R, McKinnon R.A., and Mackenzie PI (2014) Transcriptional regulation of human UDP-glucuronosyltransferase genes. Drug Metab Rev 46:421-458.
12. Innocenti F, Undevia SD, Iyer L, Chen P.X., Das S., Kocherginsky M, Karrison T, Janisch L., Ramírez J, and Rudin CM, et al. (2004) Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 22:1382-1388.
13. Lépine J., Bernard O, Plante M., Têtu B, Pelletier G., Labrie F, Bélanger A, and Guillemette C (2004) Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium. J Clin Endocrinol Metab 89:5222-5232.
14. Margaillan G, Rouleau M, Fallon J.K., Caron P., Villeneuve L, Turcotte V, Smith P.C., Joy MS, and Guillemette C (2015) Quantitative profiling of human renal UDP-glucuronosyltransferases and glucuronidation activity: a comparison of normal and tumoral kidney tissues. Drug Metab Dispos 43:611-619.
15. McCarroll SA, Hadnott TN, Perry G.H., Sabeti PC, Zody MC, Barrett JC, Dallaire S, Gabriel S.B., Lee C., and Daly MJ, et al.; International HapMap Consortium (2006) Common deletion polymorphisms in the human genome. Nat Genet 38:86-92.
16. Ohtsuki S, Schaefer O, Kawakami H., Inoue T, Liehner S, Saito A., Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, and Ebner T, et al. (2012) Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab Dispos 40:83-92.
17. Sato Y, Nagata M, Tetsuka K., Tamura K, Miyashita A, Kawamura A., and Usui T (2014) Optimized methods for targeted peptide-based quantification of human uridine 5'-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry. Drug Metab Dispos 42:885-889.
18. Sumida A, Kinoshita K, Fukuda T., Matsuda H, Yamamoto I, Inaba T., and Azuma J (1999) Relationship between mRNA levels quantified by reverse transcription-competitive PCR and metabolic activity of CYP3A4 and CYP2E1 in human liver. Biochem Biophys Res Commun 262:499-503.
19. Thibaudeau J, Lépine J, Tojcic J., Duguay Y, Pelletier G, Plante M., Brisson J, Têtu B, Jacob S., and Perusse L, et al. (2006) Characterization of common UGT1A8, UGT1A9, and UGT2B7 variants with different capacities to inactivate mutagenic 4-hydroxylated metabolites of estra-diol and estrone. Cancer Res 66:125-133.
20. Yan T, Gao S, Peng X., Shi J, Xie C, Li Q., Lu L, Wang Y, Zhou F., and Liu Z, et al. (2015) Significantly decreased and more variable expression of major CYPs and UGTs in liver microsomes prepared from HBV-positive human hepatocellular carcinoma and matched peri-carcinomatous tissues determined using an isotope label-free UPLC-MS/MS method. Pharm Res 32:1141-1157.