New developments in atherosclerosis: Clinical potential of PCSK9 inhibition

Vascular Health and Risk Management

Volumn 11, Issue , 2015, Pages 493-501

  Giunzioni, Ilaria ^a   Tavori, Hagai ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cardiovascular risk; LDLR; Monoclonal antibodies; PCSK9; Pharmacokinetics

Indexed keywords

ALIROCUMAB; ATORVASTATIN; BOCOCIZUMAB; EVOLOCUMAB; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9; SERINE PROTEINASE; UNCLASSIFIED DRUG; ANTILIPEMIC AGENT; MONOCLONAL ANTIBODY; PCSK9 PROTEIN, HUMAN; PROPROTEIN CONVERTASE 9; SERINE PROTEINASE INHIBITOR;

ANTICHOLESTEROL ACTIVITY; ATHEROSCLEROSIS; BINDING AFFINITY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DRUG ACTIVITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HYPERCHOLESTEROLEMIA; INTERNALIZATION; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK REDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DYSLIPIDEMIAS; ENZYMOLOGY; METABOLISM; RISK FACTOR; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, MONOCLONAL; ATHEROSCLEROSIS; DYSLIPIDEMIAS; HUMANS; HYPOLIPIDEMIC AGENTS; PROPROTEIN CONVERTASE 9; PROPROTEIN CONVERTASES; RISK FACTORS; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; TREATMENT OUTCOME;

EID: 84940106915     PISSN: 11766344     EISSN: 11782048     Source Type: Journal    
DOI: 10.2147/VHRM.S74692     Document Type: Review

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