Efficacy and safety profile of evolocumab (AMG145), an injectable inhibitor of the proprotein convertase subtilisin/kexin type 9: The available clinical evidence

Expert Opinion on Biological Therapy

Volumn 14, Issue 6, 2014, Pages 863-868

  Cicero, Arrigo F G ^a   Tartagni, Elisa ^a   Ertek, Sibel ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Koru Hospital   (Turkey)

Author keywords

AMG145; Hypercholesterolemia; Lipid lowering drugs; Proprotein convertase subtilisin kexin type 9

Indexed keywords

APOLIPOPROTEIN B100; EVOLOCUMAB; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; UNCLASSIFIED DRUG; ANTILIPEMIC AGENT; BIOLOGICAL MARKER; ENZYME INHIBITOR; MONOCLONAL ANTIBODY; PCSK9 PROTEIN, HUMAN;

AMINOTRANSFERASE BLOOD LEVEL; ARTHRALGIA; ARTICLE; BACKACHE; COUGHING; CREATINE KINASE BLOOD LEVEL; DIARRHEA; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ENZYME INHIBITION; FAMILIAL HYPERCHOLESTEROLEMIA; HIGH RISK PATIENT; HUMAN; INCIDENCE; INJECTION SITE PAIN; INJECTION SITE REACTION; MYALGIA; MYOPATHY; MYOSITIS; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); RHABDOMYOLYSIS; RHINOPHARYNGITIS; SIDE EFFECT; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; DRUG EFFECTS; DYSLIPIDEMIAS; ENZYMOLOGY; LIVER; METABOLISM; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; CHOLESTEROL, LDL; DYSLIPIDEMIAS; ENZYME INHIBITORS; HUMANS; HYPOLIPIDEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; LIVER; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES; TREATMENT OUTCOME;

EID: 84900814036     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2014.902929     Document Type: Article

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