메뉴 건너뛰기




Volumn 127, Issue 22, 2013, Pages 2222-2230

Evolution and emergence of therapeutic monoclonal antibodies what cardiologists need to know

Author keywords

Antibodies; Heart diseases; Hypercholesterolemia; Monoclonal; Pcsk9 protein

Indexed keywords

ABCIXIMAB; ADALIMUMAB; ALEMTUZUMAB; ALIROCUMAB; BASILIXIMAB; BELIMUMAB; BEVACIZUMAB; BRENTUXIMAB VEDOTIN; CANAKINUMAB; CERTOLIZUMAB PEGOL; CETUXIMAB; DENOSUMAB; ECULIZUMAB; GOLIMUMAB; IBRITUMOMAB TIUXETAN; INFLIXIMAB; IPILIMUMAB; MONOCLONAL ANTIBODY; NATALIZUMAB; OFATUMUMAB; OKT 3; OMALIZUMAB; PANITUMUMAB; PERTUZUMAB; RITUXIMAB; TOCILIZUMAB; TOSITUMOMAB; TOSITUMOMAB I 131; TRASTUZUMAB; UNINDEXED DRUG; USTEKINUMAB;

EID: 84878550146     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.002033     Document Type: Article
Times cited : (81)

References (76)
  • 1
    • 33745192259 scopus 로고    scopus 로고
    • Recombinant polyclonal antibodies: The next generation of antibody therapeutics?
    • Haurum JS. Recombinant polyclonal antibodies: the next generation of antibody therapeutics? Drug Discov Today. 2006;11:655-660.
    • (2006) Drug Discov Today , vol.11 , pp. 655-660
    • Haurum, J.S.1
  • 3
    • 0038668192 scopus 로고
    • Chemical structure of gamma-globulin and antibodies
    • Porter RR. Chemical Structure Of Gamma-Globulin And Antibodies. Br Med Bull. 1963;19:197-201.
    • (1963) Br Med Bull , vol.19 , pp. 197-201
    • Porter, R.R.1
  • 4
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256:495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 5
    • 77951586447 scopus 로고    scopus 로고
    • Strategies and challenges for the next generation of therapeutic antibodies
    • Beck A, Wurch T, Bailly C, Corvaia N. Strategies and challenges for the next generation of therapeutic antibodies. Nat Rev Immunol. 2010;10:345-352.
    • (2010) Nat Rev Immunol , vol.10 , pp. 345-352
    • Beck, A.1    Wurch, T.2    Bailly, C.3    Corvaia, N.4
  • 6
    • 77957361348 scopus 로고    scopus 로고
    • Development trends for human monoclonal antibody therapeutics
    • Nelson AL, Dhimolea E, Reichert JM. Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov. 2010;9:767-774.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 767-774
    • Nelson, A.L.1    Dhimolea, E.2    Reichert, J.M.3
  • 7
    • 79952001750 scopus 로고    scopus 로고
    • Mechanisms of monoclonal antibody-drug interactions
    • Zhou H, Mascelli MA. Mechanisms of monoclonal antibody-drug interactions. Annu Rev Pharmacol Toxicol. 2011;51:359-372.
    • (2011) Annu Rev Pharmacol Toxicol , vol.51 , pp. 359-372
    • Zhou, H.1    Mascelli, M.A.2
  • 8
    • 14044253107 scopus 로고    scopus 로고
    • Immunoglobulins: Structure and function
    • Paul WE, ed, 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins
    • Kolar GR, Capra DJ. Immunoglobulins: structure and function. In: Paul WE, ed. Fundamental Immunology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2003.
    • (2003) Fundamental Immunology
    • Kolar, G.R.1    Capra, D.J.2
  • 10
    • 33644819090 scopus 로고    scopus 로고
    • Fully human therapeutic monoclonal antibodies
    • Weiner LM. Fully human therapeutic monoclonal antibodies. J Immunother. 2006;29:1-9.
    • (2006) J Immunother , vol.29 , pp. 1-9
    • Weiner, L.M.1
  • 11
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • DOI 10.1016/S1040-8428(00)00134-7, PII S1040842800001347
    • Yang XD, Jia XC, Corvalan JR, Wang P, Davis CG. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol. 2001;38:17-23. (Pubitemid 32194591)
    • (2001) Critical Reviews in Oncology/Hematology , vol.38 , Issue.1 , pp. 17-23
    • Yang, X.-D.1    Jia, X.-C.2    Corvalan, J.R.F.3    Wang, P.4    Davis, C.G.5
  • 12
    • 27144532832 scopus 로고    scopus 로고
    • Human antibodies from transgenic animals
    • DOI 10.1038/nbt1135, PII N1135
    • Lonberg N. Human antibodies from transgenic animals. Nat Biotechnol. 2005;23:1117-1125. (Pubitemid 41486393)
    • (2005) Nature Biotechnology , vol.23 , Issue.9 , pp. 1117-1125
    • Lonberg, N.1
  • 13
    • 48649094750 scopus 로고    scopus 로고
    • Fully human antibodies from transgenic mouse and phage display platforms
    • Lonberg N. Fully human antibodies from transgenic mouse and phage display platforms. Curr Opin Immunol 2008;20:450-459.
    • (2008) Curr Opin Immunol , vol.20 , pp. 450-459
    • Lonberg, N.1
  • 14
    • 30344484440 scopus 로고    scopus 로고
    • Antibody engineering for the development of therapeutic antibodies
    • Kim SJ, Park Y, Hong HJ. Antibody engineering for the development of therapeutic antibodies. Mol Cells. 2005;20:17-29.
    • (2005) Mol Cells , vol.20 , pp. 17-29
    • Kim, S.J.1    Park, Y.2    Hong, H.J.3
  • 16
    • 43749108590 scopus 로고    scopus 로고
    • Submitting antibodies to binding arbitration
    • DOI 10.1038/nchembio0608-326, PII NCHEMBIO0608326
    • Michnick SW, Sidhu SS. Submitting antibodies to binding arbitration. Nat Chem Biol. 2008;4:326-329. (Pubitemid 351693997)
    • (2008) Nature Chemical Biology , vol.4 , Issue.6 , pp. 326-329
    • Michnick, S.W.1    Sidhu, S.S.2
  • 18
    • 84971263917 scopus 로고    scopus 로고
    • Monoclonal antibodies
    • DeVita VT, Lawrence TS, Rosenberg SA, eds, Philadelphia, PA: Lippincott Williams & Wilkins
    • Robinson MK, Borghaei H, Adams GP, Weiner LM. Monoclonal antibodies. In: DeVita VT, Lawrence TS, Rosenberg SA, eds. Cancer Principles and Practice of Oncology. Vol 1. Philadelphia, PA: Lippincott Williams & Wilkins; 2008:537-548.
    • (2008) Cancer Principles and Practice of Oncology , vol.1 , pp. 537-548
    • Robinson, M.K.1    Borghaei, H.2    Adams, G.P.3    Weiner, L.M.4
  • 23
    • 84863930293 scopus 로고    scopus 로고
    • Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges
    • Vugmeyster Y, Xu X, Theil FP, Khawli LA, Leach MW. Pharmacokinetics and toxicology of therapeutic proteins: advances and challenges. World J Biol Chem. 2012;3:73-92.
    • (2012) World J Biol Chem , vol.3 , pp. 73-92
    • Vugmeyster, Y.1    Xu, X.2    Theil, F.P.3    Khawli, L.A.4    Leach, M.W.5
  • 24
    • 77449119116 scopus 로고    scopus 로고
    • Biodistribution mechanisms of therapeutic monoclonal antibodies in health and disease
    • Tabrizi M, Bornstein GG, Suria H. Biodistribution mechanisms of therapeutic monoclonal antibodies in health and disease. AAPS J. 2010;12:33-43.
    • (2010) AAPS J , vol.12 , pp. 33-43
    • Tabrizi, M.1    Bornstein, G.G.2    Suria, H.3
  • 25
    • 32444438731 scopus 로고    scopus 로고
    • Elimination mechanisms of therapeutic monoclonal antibodies
    • DOI 10.1016/S1359-6446(05)03638-X, PII S135964460503638X
    • Tabrizi MA, Tseng CM, Roskos LK. Elimination mechanisms of therapeutic monoclonal antibodies. Drug Discov Today. 2006;11:81-88. (Pubitemid 43227856)
    • (2006) Drug Discovery Today , vol.11 , Issue.1-2 , pp. 81-88
    • Tabrizi, M.A.1    Tseng, C.-M.L.2    Roskos, L.K.3
  • 26
    • 70449529637 scopus 로고    scopus 로고
    • Approaches to transport therapeutic drugs across the bloodbrain barrier to treat brain diseases
    • Gabathuler R. Approaches to transport therapeutic drugs across the bloodbrain barrier to treat brain diseases. Neurobiol Dis. 2010;37:48-57.
    • (2010) Neurobiol Dis , vol.37 , pp. 48-57
    • Gabathuler, R.1
  • 27
    • 34447091994 scopus 로고    scopus 로고
    • Preclinical and clinical safety of monoclonal antibodies
    • DOI 10.1016/j.drudis.2007.05.010, PII S1359644607002279
    • Tabrizi MA, Roskos LK. Preclinical and clinical safety of monoclonal antibodies. Drug Discov Today. 2007;12:540-547. (Pubitemid 47031663)
    • (2007) Drug Discovery Today , vol.12 , Issue.13-14 , pp. 540-547
    • Tabrizi, M.A.1    Roskos, L.K.2
  • 32
    • 43849094005 scopus 로고    scopus 로고
    • Cardiotoxicity profile of trastuzumab
    • DOI 10.2165/00002018-200831060-00002
    • Ewer SM, Ewer MS. Cardiotoxicity profile of trastuzumab. Drug Saf. 2008;31:459-467. (Pubitemid 351695459)
    • (2008) Drug Safety , vol.31 , Issue.6 , pp. 459-467
    • Ewer, S.M.1    Ewer, M.S.2
  • 33
    • 34248531422 scopus 로고    scopus 로고
    • Cytokine-release syndrome: Overview and nursing implications
    • Breslin S. Cytokine-release syndrome: overview and nursing implications. Clin J Oncol Nurs. 2007;11(suppl):37-42.
    • (2007) Clin J Oncol Nurs , vol.11 , Issue.SUPPL. , pp. 37-42
    • Breslin, S.1
  • 34
    • 79955573063 scopus 로고    scopus 로고
    • Immediate adverse reactions to biologicals: From pathogenic mechanisms to prophylactic management
    • Vultaggio A, Maggi E, Matucci A. Immediate adverse reactions to biologicals: from pathogenic mechanisms to prophylactic management. Curr Opin Allergy Clin Immunol. 2011;11:262-268.
    • (2011) Curr Opin Allergy Clin Immunol , vol.11 , pp. 262-268
    • Vultaggio, A.1    Maggi, E.2    Matucci, A.3
  • 36
    • 17644378667 scopus 로고    scopus 로고
    • Immunogenicity of engineered antibodies
    • DOI 10.1016/j.ymeth.2005.01.001, Humanized Antibodies and their Applications
    • Hwang WY, Foote J. Immunogenicity of engineered antibodies. Methods. 2005;36:3-10. (Pubitemid 40558811)
    • (2005) Methods , vol.36 , Issue.1 , pp. 3-10
    • Hwang, W.Y.K.1    Foote, J.2
  • 39
    • 38849152398 scopus 로고    scopus 로고
    • Targeted therapies: A new generation of cancer treatments
    • Gerber DE. Targeted therapies: a new generation of cancer treatments. Am Fam Physician. 2008;77:311-319. (Pubitemid 351206593)
    • (2008) American Family Physician , vol.77 , Issue.3 , pp. 311-319
    • Gerber, D.E.1
  • 40
    • 54249138516 scopus 로고    scopus 로고
    • Monoclonal antibody pharmacokinetics and pharmacodynamics
    • Wang W, Wang EQ, Balthasar JP. Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 2008;84:548-558.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 548-558
    • Wang, W.1    Wang, E.Q.2    Balthasar, J.P.3
  • 41
    • 3042780397 scopus 로고    scopus 로고
    • Current and future considerations for the new classes of biologicals
    • quiz 709
    • Kleinberg M, Mosdell KW. Current and future considerations for the new classes of biologicals. Am J Health Syst Pharm. 2004;61:695-708; quiz 709.
    • (2004) Am J Health Syst Pharm , vol.61 , pp. 695-708
    • Kleinberg, M.1    Mosdell, K.W.2
  • 42
    • 84863218474 scopus 로고    scopus 로고
    • Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars
    • Berkowitz SA, Engen JR, Mazzeo JR, Jones GB. Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars. Nat Rev Drug Discov. 2012;11:527-540.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 527-540
    • Berkowitz, S.A.1    Engen, J.R.2    Mazzeo, J.R.3    Jones, G.B.4
  • 43
    • 0026733110 scopus 로고
    • The use of antibodies in clinical cardiology
    • Azrin MA. The use of antibodies in clinical cardiology. Am Heart J. 1992;124:753-768.
    • (1992) Am Heart J , vol.124 , pp. 753-768
    • Azrin, M.A.1
  • 44
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab - Mechanism of action and use in clinical practice
    • DOI 10.1056/NEJMra043186
    • Hudis CA. Trastuzumab: mechanism of action and use in clinical practice. N Engl J Med. 2007;357:39-51. (Pubitemid 47026733)
    • (2007) New England Journal of Medicine , vol.357 , Issue.1 , pp. 39-51
    • Hudis, C.A.1
  • 48
    • 70349556405 scopus 로고    scopus 로고
    • In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION acute myocardial infarction treatment optimization program
    • Hassan AK, Liem SS, van der Kley F, Bergheanu SC, Wolterbeek R, Bosch J, Bootsma M, Zeppenfeld K, van der Laarse A, Atsma DE, Jukema JW, Schalij MJ. In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: results from the Leiden MISSION acute myocardial infarction treatment optimization program. Catheter Cardiovasc Interv. 2009;74:335-343.
    • (2009) Catheter Cardiovasc Interv , vol.74 , pp. 335-343
    • Hassan, A.K.1    Liem, S.S.2    Van Der Kley, F.3    Bergheanu, S.C.4    Wolterbeek, R.5    Bosch, J.6    Bootsma, M.7    Zeppenfeld, K.8    Van Der Laarse, A.9    Atsma, D.E.10    Jukema, J.W.11    Schalij, M.J.12
  • 50
    • 65249091961 scopus 로고    scopus 로고
    • Benefits from small molecule administration as compared with abciximab among patients with ST-segment elevation myocardial infarction treated with primary angioplasty: A meta-analysis
    • De Luca G, Ucci G, Cassetti E, Marino P. Benefits from small molecule administration as compared with abciximab among patients with ST-segment elevation myocardial infarction treated with primary angioplasty: a meta-analysis. J Am Coll Cardiol. 2009;53:1668-1673.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1668-1673
    • De Luca, G.1    Ucci, G.2    Cassetti, E.3    Marino, P.4
  • 52
    • 70449732531 scopus 로고    scopus 로고
    • Plasma proprotein convertase subtilisin/kexin type 9: A marker of LDL apolipoprotein B-100 catabolism?
    • Chan DC, Lambert G, Barrett PH, Rye KA, Ooi EM, Watts GF. Plasma proprotein convertase subtilisin/kexin type 9: a marker of LDL apolipoprotein B-100 catabolism? Clin Chem. 2009;55:2049-2052.
    • (2009) Clin Chem , vol.55 , pp. 2049-2052
    • Chan, D.C.1    Lambert, G.2    Barrett, P.H.3    Rye, K.A.4    Ooi, E.M.5    Watts, G.F.6
  • 54
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 2006;354:1264-1272.
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr., T.H.3    Hobbs, H.H.4
  • 55
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet. 2005;37:161-165.
    • (2005) Nat Genet , vol.37 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5    Hobbs, H.H.6
  • 57
    • 84870494510 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, doubleblind, placebo-controlled, phase 2 study
    • Koren MJ, Scott R, Kim JB, Knusel B, Liu T, Lei L, Bolognese M, Wasserman SM. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, doubleblind, placebo-controlled, phase 2 study. Lancet. 2012;380:1995-2006.
    • (2012) Lancet , vol.380 , pp. 1995-2006
    • Koren, M.J.1    Scott, R.2    Kim, J.B.3    Knusel, B.4    Liu, T.5    Lei, L.6    Bolognese, M.7    Wasserman, S.M.8
  • 58
    • 84870478439 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): A randomised, placebo-controlled, dose-ranging, phase 2 study
    • Giugliano RP, Desai NR, Kohli P, Rogers WJ, Somaratne R, Huang F, Liu T, Mohanavelu S, Hoffman EB, McDonald ST, Abrahamsen TE, Wasserman SM, Scott R, Sabatine MS. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study. Lancet. 2012;380:2007-2017.
    • (2012) Lancet , vol.380 , pp. 2007-2017
    • Giugliano, R.P.1    Desai, N.R.2    Kohli, P.3    Rogers, W.J.4    Somaratne, R.5    Huang, F.6    Liu, T.7    Mohanavelu, S.8    Hoffman, E.B.9    McDonald, S.T.10    Abrahamsen, T.E.11    Wasserman, S.M.12    Scott, R.13    Sabatine, M.S.14
  • 59
    • 84869220345 scopus 로고    scopus 로고
    • Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial
    • Raal F, Scott R, Somaratne R, Bridges I, Li G, Wasserman SM, Stein EA. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial. Circulation. 2012;126:2408-2417.
    • (2012) Circulation , vol.126 , pp. 2408-2417
    • Raal, F.1    Scott, R.2    Somaratne, R.3    Bridges, I.4    Li, G.5    Wasserman, S.M.6    Stein, E.A.7
  • 60
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: The GAUSS randomized trial
    • Sullivan D, Olsson AG, Scott R, Kim JB, Xue A, Gebski V, Wasserman SM, Stein EA. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA. 2012;308:2497-2506.
    • (2012) JAMA , vol.308 , pp. 2497-2506
    • Sullivan, D.1    Olsson, A.G.2    Scott, R.3    Kim, J.B.4    Xue, A.5    Gebski, V.6    Wasserman, S.M.7    Stein, E.A.8
  • 61
    • 84862219022 scopus 로고    scopus 로고
    • Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    • McKenney JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol. 2012;59:2344-2353.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 2344-2353
    • McKenney, J.M.1    Koren, M.J.2    Kereiakes, D.J.3    Hanotin, C.4    Ferrand, A.C.5    Stein, E.A.6
  • 63
    • 84863494422 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
    • Stein EA, Gipe D, Bergeron J, Gaudet D, Weiss R, Dufour R, Wu R, Pordy R. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet. 2012;380:29-36.
    • (2012) Lancet , vol.380 , pp. 29-36
    • Stein, E.A.1    Gipe, D.2    Bergeron, J.3    Gaudet, D.4    Weiss, R.5    Dufour, R.6    Wu, R.7    Pordy, R.8
  • 64
    • 84868689211 scopus 로고    scopus 로고
    • Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
    • Roth EM, McKenney JM, Hanotin C, Asset G, Stein EA. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med. 2012;367:1891-1900.
    • (2012) N Engl J Med , vol.367 , pp. 1891-1900
    • Roth, E.M.1    McKenney, J.M.2    Hanotin, C.3    Asset, G.4    Stein, E.A.5
  • 65
    • 84878535101 scopus 로고    scopus 로고
    • The effects of single dose administration of RN316 (PF-04950615), a humanized IgG2a monoclonal antibody binding proprotein convertase subtilisin kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin [abstract 13322]
    • November 3-7, 2012; Los Angeles, CA
    • Gumbiner B, Udata C, Joh T, Liang H, Wan H, Shelton D, Forgues P, Billotte S, Pons J, Baum C, Garzone P. The effects of single dose administration of RN316 (PF-04950615), a humanized IgG2a monoclonal antibody binding proprotein convertase subtilisin kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin [abstract 13322]. Presented at: American Heart Association Scientific Sessions 2012; November 3-7, 2012; Los Angeles, CA.
    • (2012) American Heart Association Scientific Sessions
    • Gumbiner, B.1    Udata, C.2    Joh, T.3    Liang, H.4    Wan, H.5    Shelton, D.6    Forgues, P.7    Billotte, S.8    Pons, J.9    Baum, C.10    Garzone, P.11
  • 66
    • 84878535101 scopus 로고    scopus 로고
    • The effects of multiple dose administration of RN316 (PF-04950615), a humanized IgG2a monoclonal antibody binding proprotein convertase subtilisin kexin type 9, in hypercholesterolemic subjects [abstract 13524]
    • November 3-7, 2012; Los Angeles, CA
    • Gumbiner B, Udata C, Joh T, Liang H, Wan H, Shelton D, Forgues P, Billotte S, Pons J, Baum C, Garzone P. The effects of multiple dose administration of RN316 (PF-04950615), a humanized IgG2a monoclonal antibody binding proprotein convertase subtilisin kexin type 9, in hypercholesterolemic subjects [abstract 13524]. Presented at: American Heart Association Scientific Sessions 2012; November 3-7, 2012; Los Angeles, CA.
    • (2012) American Heart Association Scientific Sessions
    • Gumbiner, B.1    Udata, C.2    Joh, T.3    Liang, H.4    Wan, H.5    Shelton, D.6    Forgues, P.7    Billotte, S.8    Pons, J.9    Baum, C.10    Garzone, P.11
  • 68
    • 84863459500 scopus 로고    scopus 로고
    • Blocking interleukin-1 as a novel therapeutic strategy for secondary prevention of cardiovascular events
    • Abbate A, Van Tassell BW, Biondi-Zoccai GG. Blocking interleukin-1 as a novel therapeutic strategy for secondary prevention of cardiovascular events. BioDrugs. 2012;26:217-233.
    • (2012) BioDrugs , vol.26 , pp. 217-233
    • Abbate, A.1    Van Tassell, B.W.2    Biondi-Zoccai, G.G.3
  • 71
    • 33746395904 scopus 로고    scopus 로고
    • Relation between proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome
    • DOI 10.1136/hrt.2005.080382
    • Kilic T, Ural D, Ural E, Yumuk Z, Agacdiken A, Sahin T, Kahraman G, Kozdag G, Vural A, Komsuoglu B. Relation between proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-ST elevation acute coronary syndrome. Heart. 2006;92:1041-1046. (Pubitemid 44125212)
    • (2006) Heart , vol.92 , Issue.8 , pp. 1041-1046
    • Kilic, T.1    Ural, D.2    Ural, E.3    Yumuk, Z.4    Agacdiken, A.5    Sahin, T.6    Kahraman, G.7    Kozdag, G.8    Vural, A.9    Komsuoglu, B.10
  • 72
    • 80053644777 scopus 로고    scopus 로고
    • Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
    • Ridker PM, Thuren T, Zalewski A, Libby P. Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J. 2011;162:597-605.
    • (2011) Am Heart J , vol.162 , pp. 597-605
    • Ridker, P.M.1    Thuren, T.2    Zalewski, A.3    Libby, P.4
  • 74
    • 84878592708 scopus 로고    scopus 로고
    • Accessed January 21, 2013
    • Clinical development pipeline. Lilly Web site. http://lilly.com/ SiteCollectionDocuments/Pipeline/Clinical%20Development%20Pipeline/index. html#PhaseI. Accessed January 21, 2013.
    • Clinical Development Pipeline. Lilly Web Site
  • 76
    • 84878610866 scopus 로고    scopus 로고
    • press release, Lund, Sweden: BioInvent, Accessed January 21, 2013
    • Announcement of topline results from the GLACIER study [press release]. Lund, Sweden: BioInvent. http://www.bioinvent.se/media-centre/pressreleases/ release.aspx?releaseid=682959. Accessed January 21, 2013.
    • Announcement of Topline Results from the GLACIER Study


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.