Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping

Blood

Volumn 126, Issue 5, 2015, Pages 665-672

  Krivega, Ivan ^a   Byrnes, Colleen ^a   De Vasconcellos, Jaira F ^a   Lee, Y Terry ^a   Kaushal, Megha ^a   Dean, Ann ^a   Miller, Jeffery L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEXYL N (1 ISOPROPYL 4 PIPERIDINYL) 6 METHOXY 7 [3 (1 PYRROLIDINYL)PROPOXY] 4 QUINAZOLINAMINE; CD34 ANTIGEN; G9A METHYLTRANSFERASE; HEMOGLOBIN F; HEMOGLOBIN GAMMA CHAIN; HISTONE METHYLTRANSFERASE; LDB1 PROTEIN; LMO2 PROTEIN; PEPTIDES AND PROTEINS; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR TAL1; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; EHMT2 PROTEIN, HUMAN; ENZYME INHIBITOR; HISTOCOMPATIBILITY ANTIGEN; HISTONE LYSINE METHYLTRANSFERASE; LDB1 PROTEIN, HUMAN; LIM PROTEIN; QUINAZOLINE DERIVATIVE; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG ACCUMULATION; ENZYME INHIBITION; EPIGENETICS; ERYTHROID PRECURSOR CELL; EX VIVO STUDY; FETUS; GENE ACTIVATION; GENE EXPRESSION; GENE LOCUS; GENE LOSS; GENE REPRESSION; GENETIC ASSOCIATION; HEMATOPOIETIC STEM CELL; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; REGULATOR GENE; ANEMIA, SICKLE CELL; ANTAGONISTS AND INHIBITORS; BETA-THALASSEMIA; BIOLOGICAL MODEL; BIOSYNTHESIS; BLOOD; CYTOLOGY; DRUG EFFECTS; ERYTHROPOIESIS; GENETIC EPIGENESIS; GENETICS; IN VITRO STUDY; METABOLISM; PROMOTER REGION;

ADULT; ANEMIA, SICKLE CELL; BETA-THALASSEMIA; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; ENZYME INHIBITORS; EPIGENESIS, GENETIC; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; FETAL HEMOGLOBIN; GAMMA-GLOBINS; HISTOCOMPATIBILITY ANTIGENS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; IN VITRO TECHNIQUES; LIM DOMAIN PROTEINS; LOCUS CONTROL REGION; MODELS, BIOLOGICAL; PROMOTER REGIONS, GENETIC; QUINAZOLINES; TRANSCRIPTION FACTORS;

EID: 84940055131     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-02-629972     Document Type: Article

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