-
1
-
-
67651046995
-
SCF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII
-
Aerbajinai W., Zhu J, Kumkhaek C, Chin K, Rodgers GP. 2009. SCF induces γ-globin gene expression by regulating downstream transcription factor COUP-TFII. Blood 114: 187-194.
-
(2009)
Blood
, vol.114
, pp. 187-194
-
-
Aerbajinai, W.1
Zhu, J.2
Kumkhaek, C.3
Chin, K.4
Rodgers, G.P.5
-
2
-
-
78249264453
-
A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia
-
Arnaud L., Saison C, Helias V, Lucien N, Steschenko D, Giarratana M.C., Prehu C, Foliguet B, Montout L, de Brevern A.G., et al. 2010. A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia. Am J Hum Genet 87: 721-727.
-
(2010)
Am J Hum Genet
, vol.87
, pp. 721-727
-
-
Arnaud, L.1
Saison, C.2
Helias, V.3
Lucien, N.4
Steschenko, D.5
Giarratana, M.C.6
Prehu, C.7
Foliguet, B.8
Montout, L.9
de Brevern, A.G.10
-
3
-
-
78249266598
-
Pharmacologic induction of fetal hemoglobin production
-
Atweh G., Fathallah H. 2010. Pharmacologic induction of fetal hemoglobin production. Hematol Oncol Clin North Am 24: 1131-1144.
-
(2010)
Hematol Oncol Clin North Am
, vol.24
, pp. 1131-1144
-
-
Atweh, G.1
Fathallah, H.2
-
4
-
-
78650181399
-
siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures
-
Banzon V., Ibanez V, Vaitkus K, Ruiz MA, Peterson K, DeSimone J, Lavelle D. 2011. siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures. Exp Hematol 39: 26-36 e21.
-
(2011)
Exp Hematol
, vol.39
-
-
Banzon, V.1
Ibanez, V.2
Vaitkus, K.3
Ruiz, M.A.4
Peterson, K.5
DeSimone, J.6
Lavelle, D.7
-
5
-
-
0021846532
-
Relative rates of fetal hemoglobin and adult hemoglobin synthesis in cord blood of infants of insulin-dependent diabetic mothers
-
Bard H., Prosmanne J. 1985. Relative rates of fetal hemoglobin and adult hemoglobin synthesis in cord blood of infants of insulin-dependent diabetic mothers. Pediatrics 75: 1143-1147.
-
(1985)
Pediatrics
, vol.75
, pp. 1143-1147
-
-
Bard, H.1
Prosmanne, J.2
-
6
-
-
0020451351
-
Clinical management of gene expression
-
Benz Jr. EJ. 1982. Clinical management of gene expression. N Engl J Med 307: 1515-1516.
-
(1982)
N Engl J Med
, vol.307
, pp. 1515-1516
-
-
Benz Jr., E.J.1
-
7
-
-
77956622584
-
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
-
Borg J., Papadopoulos P, Georgitsi M, Gutierrez L, Grech G, Fanis P., Phylactides M, Verkerk AJ, van der Spek PJ, Scerri CA, et al. 2010. Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Nat Genet 42: 801-805.
-
(2010)
Nat Genet
, vol.42
, pp. 801-805
-
-
Borg, J.1
Papadopoulos, P.2
Georgitsi, M.3
Gutierrez, L.4
Grech, G.5
Fanis, P.6
Phylactides, M.7
Verkerk, A.J.8
van der Spek, P.J.9
Scerri, C.A.10
-
8
-
-
77955463320
-
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease
-
Bradner J.E., Mak R, Tanguturi SK, Mazitschek R, Haggarty S.J., Ross K, Chang CY, Bosco J, West N, Morse E., et al. 2010. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci 107: 12617-12622.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 12617-12622
-
-
Bradner, J.E.1
Mak, R.2
Tanguturi, S.K.3
Mazitschek, R.4
Haggarty, S.J.5
Ross, K.6
Chang, C.Y.7
Bosco, J.8
West, N.9
Morse, E.10
-
9
-
-
81755163577
-
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes
-
Campbell A.D., Cui S, Shi L, Urbonya R, Mathias A, Bradley K., Bonsu KO, Douglas RR, Halford B, Schmidt L., et al. 2011. Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. ProcNatl Acad Sci 108: 18808-18813.
-
(2011)
ProcNatl Acad Sci
, vol.108
, pp. 18808-18813
-
-
Campbell, A.D.1
Cui, S.2
Shi, L.3
Urbonya, R.4
Mathias, A.5
Bradley, K.6
Bonsu, K.O.7
Douglas, R.R.8
Halford, B.9
Schmidt, L.10
-
10
-
-
0037071383
-
Transcriptional regulation of erythropoiesis: An affair involving multiple partners
-
Cantor A.B., Orkin SH. 2002. Transcriptional regulation of erythropoiesis: An affair involving multiple partners. Oncogene 21: 3368-3376.
-
(2002)
Oncogene
, vol.21
, pp. 3368-3376
-
-
Cantor, A.B.1
Orkin, S.H.2
-
11
-
-
0942266022
-
Induction of human γ globin gene expression by histone deacetylase inhibitors
-
Cao H., Stamatoyannopoulos G, Jung M. 2004. Induction of human γ globin gene expression by histone deacetylase inhibitors. Blood 103: 701-709.
-
(2004)
Blood
, vol.103
, pp. 701-709
-
-
Cao, H.1
Stamatoyannopoulos, G.2
Jung, M.3
-
12
-
-
2342578680
-
Suppressor screen in Mpl2/2 mice: C-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
-
Carpinelli M.R., Hilton DJ, Metcalf D, Antonchuk JL, Hyland C.D., Mifsud SL, Di Rago L, Hilton AA, Willson T.A., Roberts AW, et al. 2004. Suppressor screen in Mpl2/2 mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci 101: 6553-6558.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 6553-6558
-
-
Carpinelli, M.R.1
Hilton, D.J.2
Metcalf, D.3
Antonchuk, J.L.4
Hyland, C.D.5
Mifsud, S.L.6
di Rago, L.7
Hilton, A.A.8
Willson, T.A.9
Roberts, A.W.10
-
13
-
-
0028234283
-
The acute chest syndrome in sickle cell disease: Incidence and risk factors. The Cooperative Study of Sickle Cell Disease
-
Castro O., Brambilla DJ, Thorington B, Reindorf CA, Scott R.B., Gillette P, Vera JC, Levy PS. 1994. The acute chest syndrome in sickle cell disease: Incidence and risk factors. The Cooperative Study of Sickle Cell Disease. Blood 84: 643-649.
-
(1994)
Blood
, vol.84
, pp. 643-649
-
-
Castro, O.1
Brambilla, D.J.2
Thorington, B.3
Reindorf, C.A.4
Scott, R.B.5
Gillette, P.6
Vera, J.C.7
Levy, P.S.8
-
14
-
-
77956928344
-
Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia
-
Cavazzana-Calvo M, Payen E, Negre O, Wang G, Hehir K, Fusil F., Down J, Denaro M, Brady T, Westerman K, et al. 2010. Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia. Nature 467: 318-322.
-
(2010)
Nature
, vol.467
, pp. 318-322
-
-
Cavazzana-Calvo, M.1
Payen, E.2
Negre, O.3
Wang, G.4
Hehir, K.5
Fusil, F.6
Down, J.7
Denaro, M.8
Brady, T.9
Westerman, K.10
-
15
-
-
14944379039
-
The Corfu dβ thalassemia deletion disrupts γ-globin gene silencing and reveals post-transcriptional regulation of HbF expression
-
Chakalova L., Osborne CS, Dai YF, Goyenechea B, Metaxotou-Mavromati A., Kattamis A, Kattamis C, Fraser P. 2005. The Corfu dβ thalassemia deletion disrupts γ-globin gene silencing and reveals post-transcriptional regulation of HbF expression. Blood 105: 2154-2160.
-
(2005)
Blood
, vol.105
, pp. 2154-2160
-
-
Chakalova, L.1
Osborne, C.S.2
Dai, Y.F.3
Goyenechea, B.4
Metaxotou-Mavromati, A.5
Kattamis, A.6
Kattamis, C.7
Fraser, P.8
-
16
-
-
0029025475
-
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia
-
Charache S., Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert S.V., McMahon RP, Bonds DR. 1995. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med 332: 1317-1322.
-
(1995)
N Engl J Med
, vol.332
, pp. 1317-1322
-
-
Charache, S.1
Terrin, M.L.2
Moore, R.D.3
Dover, G.J.4
Barton, F.B.5
Eckert, S.V.6
McMahon, R.P.7
Bonds, D.R.8
-
17
-
-
79961145533
-
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells
-
Cui S., Kolodziej KE, Obara N, Amaral-Psarris A, Demmers J, Shi L., Engel JD, Grosveld F, Strouboulis J, TanabeO. 2011. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol 31: 3298-3311.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3298-3311
-
-
Cui, S.1
Kolodziej, K.E.2
Obara, N.3
Amaral-Psarris, A.4
Demmers, J.5
Shi, L.6
Engel, J.D.7
Grosveld, F.8
Strouboulis, J.9
Tanabe, O.10
-
18
-
-
77952542911
-
Current strategies for diversity-oriented synthesis
-
Dandapani S., Marcaurelle LA. 2010. Current strategies for diversity-oriented synthesis. Curr Opin Chem Biol 14: 362-370.
-
(2010)
Curr Opin Chem Biol
, vol.14
, pp. 362-370
-
-
Dandapani, S.1
Marcaurelle, L.A.2
-
19
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore J.E., Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs H.M., Kastritis E, Gilpatrick T, Paranal RM, Qi J, et al. 2011. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146: 904-917.
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
Kastritis, E.7
Gilpatrick, T.8
Paranal, R.M.9
Qi, J.10
-
20
-
-
0000206049
-
5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons
-
DeSimone J, Heller P, Hall L, Zwiers D. 1982. 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. Proc Natl Acad Sci 79: 4428-4431.
-
(1982)
Proc Natl Acad Sci
, vol.79
, pp. 4428-4431
-
-
DeSimone, J.1
Heller, P.2
Hall, L.3
Zwiers, D.4
-
21
-
-
33745022988
-
Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development
-
Dumitriu B., Patrick MR, Petschek JP, Cherukuri S, Klingmuller U., Fox PL, Lefebvre V. 2006. Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development. Blood 108: 1198-1207.
-
(2006)
Blood
, vol.108
, pp. 1198-1207
-
-
Dumitriu, B.1
Patrick, M.R.2
Petschek, J.P.3
Cherukuri, S.4
Klingmuller, U.5
Fox, P.L.6
Lefebvre, V.7
-
22
-
-
0043239343
-
Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb
-
Emambokus N., Vegiopoulos A, Harman B, Jenkinson E, Anderson G., Frampton J. 2003. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. Embo J 22: 4478-4488.
-
(2003)
Embo J
, vol.22
, pp. 4478-4488
-
-
Emambokus, N.1
Vegiopoulos, A.2
Harman, B.3
Jenkinson, E.4
Anderson, G.5
Frampton, J.6
-
23
-
-
35548970109
-
Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin
-
Fathallah H., Weinberg RS, Galperin Y, Sutton M, Atweh GF. 2007. Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin. Blood 110: 3391-3397.
-
(2007)
Blood
, vol.110
, pp. 3391-3397
-
-
Fathallah, H.1
Weinberg, R.S.2
Galperin, Y.3
Sutton, M.4
Atweh, G.F.5
-
24
-
-
0033081098
-
Regulation of embryonic/ fetal globin genes by nuclear hormone receptors: A novel perspective on hemoglobin switching
-
Filipe A., Li Q, Deveaux S, Godin I, Romeo PH, Stamatoyannopoulos G, Mignotte V. 1999. Regulation of embryonic/ fetal globin genes by nuclear hormone receptors: A novel perspective on hemoglobin switching. EMBO J 18: 687-697.
-
(1999)
EMBO J
, vol.18
, pp. 687-697
-
-
Filipe, A.1
Li, Q.2
Deveaux, S.3
Godin, I.4
Romeo, P.H.5
Stamatoyannopoulos, G.6
Mignotte, V.7
-
25
-
-
0019000363
-
Molecular cloning and characterization of the human β-like globin gene cluster
-
Fritsch E.F., Lawn RM, Maniatis T. 1980. Molecular cloning and characterization of the human β-like globin gene cluster. Cell 19: 959-972.
-
(1980)
Cell
, vol.19
, pp. 959-972
-
-
Fritsch, E.F.1
Lawn, R.M.2
Maniatis, T.3
-
26
-
-
70449719115
-
Amelioration of Sardinian β0 thalassemia by genetic modifiers
-
Galanello R., Sanna S, Perseu L, Sollaino MC, Satta S, Lai M.E., Barella S, Uda M, Usala G, Abecasis GR, et al. 2009. Amelioration of Sardinian β0 thalassemia by genetic modifiers. Blood 114: 3935-3937.
-
(2009)
Blood
, vol.114
, pp. 3935-3937
-
-
Galanello, R.1
Sanna, S.2
Perseu, L.3
Sollaino, M.C.4
Satta, S.5
Lai, M.E.6
Barella, S.7
Uda, M.8
Usala, G.9
Abecasis, G.R.10
-
27
-
-
78649469071
-
Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation
-
Galarneau G., Palmer CD, Sankaran VG, Orkin SH, Hirschhorn J.N., Lettre G. 2010. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. Nat Genet 42: 1049-1051.
-
(2010)
Nat Genet
, vol.42
, pp. 1049-1051
-
-
Galarneau, G.1
Palmer, C.D.2
Sankaran, V.G.3
Orkin, S.H.4
Hirschhorn, J.N.5
Lettre, G.6
-
28
-
-
84857776735
-
Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults
-
Gallienne A.E., Dreau HM, Schuh A, Old J, Henderson S. 2012. Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults. Haematol 97: 340-343.
-
(2012)
Haematol
, vol.97
, pp. 340-343
-
-
Gallienne, A.E.1
Dreau, H.M.2
Schuh, A.3
Old, J.4
Henderson, S.5
-
29
-
-
0019827634
-
Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation
-
Groudine M., Eisenman R, Weintraub H. 1981. Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation. Nature 292: 311-317.
-
(1981)
Nature
, vol.292
, pp. 311-317
-
-
Groudine, M.1
Eisenman, R.2
Weintraub, H.3
-
30
-
-
50149085709
-
Genetic complexity in sickle cell disease
-
Higgs D.R., WoodWG. 2008. Genetic complexity in sickle cell disease. Proc Natl Acad Sci 105: 11595-11596.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 11595-11596
-
-
Higgs, D.R.1
Wood, W.G.2
-
31
-
-
71849118976
-
Allogeneic hematopoietic stem-cell transplantation for sickle cell disease
-
Hsieh M.M., Kang EM, Fitzhugh CD, Link MB, Bolan CD, Kurlander R., Childs RW, Rodgers GP, Powell JD, Tisdale JF. 2009. Allogeneic hematopoietic stem-cell transplantation for sickle cell disease. N Engl JMed 361: 2309-2317.
-
(2009)
N Engl JMed
, vol.361
, pp. 2309-2317
-
-
Hsieh, M.M.1
Kang, E.M.2
Fitzhugh, C.D.3
Link, M.B.4
Bolan, C.D.5
Kurlander, R.6
Childs, R.W.7
Rodgers, G.P.8
Powell, J.D.9
Tisdale, J.F.10
-
32
-
-
0002650772
-
Developmental hemoglobin anomalies in a chromosomal triplication: D1 trisomy syndrome
-
Huehns E.R., Hecht F, Keil JV, Motulsky AG. 1964. Developmental hemoglobin anomalies in a chromosomal triplication: D1 trisomy syndrome. Proc Natl Acad Sci 51: 89-97.
-
(1964)
Proc Natl Acad Sci
, vol.51
, pp. 89-97
-
-
Huehns, E.R.1
Hecht, F.2
Keil, J.V.3
Motulsky, A.G.4
-
33
-
-
0028804404
-
Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein
-
Jane S.M., Nienhuis AW, Cunningham JM. 1995. Hemoglobin switching in man and chicken is mediated by a heteromeric complex between the ubiquitous transcription factor CP2 and a developmentally specific protein. EMBO J 14: 97-105.
-
(1995)
EMBO J
, vol.14
, pp. 97-105
-
-
Jane, S.M.1
Nienhuis, A.W.2
Cunningham, J.M.3
-
34
-
-
33746632097
-
cMYB is involved in the regulation of fetal hemoglobin production in adults
-
Jiang J., Best S, Menzel S, Silver N, Lai MI, Surdulescu GL, Spector T.D., Thein SL. 2006. cMYB is involved in the regulation of fetal hemoglobin production in adults. Blood 108: 1077-1083.
-
(2006)
Blood
, vol.108
, pp. 1077-1083
-
-
Jiang, J.1
Best, S.2
Menzel, S.3
Silver, N.4
Lai, M.I.5
Surdulescu, G.L.6
Spector, T.D.7
Thein, S.L.8
-
35
-
-
0018860957
-
Cellular differentiation, cytidine analogs and DNA methylation
-
Jones P.A., Taylor SM. 1980. Cellular differentiation, cytidine analogs and DNA methylation. Cell 20: 85-93.
-
(1980)
Cell
, vol.20
, pp. 85-93
-
-
Jones, P.A.1
Taylor, S.M.2
-
36
-
-
0022977959
-
Sickle cell disease in Orissa State, India
-
Kar B.C., Satapathy RK, Kulozik AE, Kulozik M, Sirr S, Serjeant B.E., Serjeant GR. 1986. Sickle cell disease in Orissa State, India. Lancet 2: 1198-1201.
-
(1986)
Lancet
, vol.2
, pp. 1198-1201
-
-
Kar, B.C.1
Satapathy, R.K.2
Kulozik, A.E.3
Kulozik, M.4
Sirr, S.5
Serjeant, B.E.6
Serjeant, G.R.7
-
37
-
-
77952545553
-
A complex task? Direct modulation of transcription factors with small molecules
-
Koehler AN. 2010. A complex task? Direct modulation of transcription factors with small molecules. Curr Opin Chem Biol 14: 331-340.
-
(2010)
Curr Opin Chem Biol
, vol.14
, pp. 331-340
-
-
Koehler, A.N.1
-
38
-
-
50149117726
-
DNA polymorphisms at the BCL11A, HBS1LMYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
-
Lettre G., Sankaran VG, Bezerra MA, Araujo AS, Uda M, Sanna S., Cao A, SchlessingerD, Costa FF, Hirschhorn JN, et al. 2008. DNA polymorphisms at the BCL11A, HBS1LMYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci 105: 11869-11874.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 11869-11874
-
-
Lettre, G.1
Sankaran, V.G.2
Bezerra, M.A.3
Araujo, A.S.4
Uda, M.5
Sanna, S.6
Cao, A.7
Schlessinger, D.8
Costa, F.F.9
Hirschhorn, J.N.10
-
39
-
-
0021330872
-
Augmentation of fetal-hemoglobin pro-duction in anemicmonkeys by hydroxyurea
-
Letvin N.L., Linch DC, Beardsley GP, McIntyre KW, Nathan DG. 1984. Augmentation of fetal-hemoglobin pro-duction in anemicmonkeys by hydroxyurea. NEngl JMed 310: 869-873.
-
(1984)
NEngl JMed
, vol.310
, pp. 869-873
-
-
Letvin, N.L.1
Linch, D.C.2
Beardsley, G.P.3
McIntyre, K.W.4
Nathan, D.G.5
-
40
-
-
0022390335
-
Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis
-
Letvin N.L., Linch DC, Beardsley GP, McIntyre KW, Miller B.A., Nathan DG. 1985. Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis. J Clin Invest 75: 1999-2005.
-
(1985)
J Clin Invest
, vol.75
, pp. 1999-2005
-
-
Letvin, N.L.1
Linch, D.C.2
Beardsley, G.P.3
McIntyre, K.W.4
Miller, B.A.5
Nathan, D.G.6
-
41
-
-
80155200721
-
Therapeutic siRNA silencing in inflammatory monocytes in mice
-
Leuschner F., Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B., et al. 2011. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 29: 1005-1010.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 1005-1010
-
-
Leuschner, F.1
Dutta, P.2
Gorbatov, R.3
Novobrantseva, T.I.4
Donahoe, J.S.5
Courties, G.6
Lee, K.M.7
Kim, J.I.8
Markmann, J.F.9
Marinelli, B.10
-
42
-
-
0020466344
-
+thalassemia
-
+thalassemia. NEngl JMed307:1469-1475.
-
(1982)
NEngl JMed
, vol.307
, pp. 1469-1475
-
-
Ley, T.J.1
DeSimone, J.2
Anagnou, N.P.3
Keller, G.H.4
Humphries, R.K.5
Turner, P.H.6
Young, N.S.7
Keller, P.8
Nienhuis, A.W.9
-
43
-
-
0020563258
-
5-Azacytidine increases γglobin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia
-
Ley T.J., DeSimone J, Noguchi CT, Turner PH, Schechter AN, Heller P., Nienhuis AW. 1983. 5-Azacytidine increases γglobin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia. Blood 62: 370-380.
-
(1983)
Blood
, vol.62
, pp. 370-380
-
-
Ley, T.J.1
DeSimone, J.2
Noguchi, C.T.3
Turner, P.H.4
Schechter, A.N.5
Heller, P.6
Nienhuis, A.W.7
-
44
-
-
39049103889
-
Ontogeny of erythropoiesis in the mammalian embryo
-
McGrath K, Palis J. 2008. Ontogeny of erythropoiesis in the mammalian embryo. Curr Top Dev Biol 82: 1-22.
-
(2008)
Curr Top Dev Biol
, vol.82
, pp. 1-22
-
-
McGrath, K.1
Palis, J.2
-
45
-
-
79955945782
-
A transient definitive erythroid lineagewith unique regulation of the βglobin locus in the mammalian embryo
-
McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. 2011. A transient definitive erythroid lineagewith unique regulation of the βglobin locus in the mammalian embryo. Blood 117: 4600-4608.
-
(2011)
Blood
, vol.117
, pp. 4600-4608
-
-
McGrath, K.E.1
Frame, J.M.2
Fromm, G.J.3
Koniski, A.D.4
Kingsley, P.D.5
Little, J.6
Bulger, M.7
Palis, J.8
-
46
-
-
34748864128
-
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
-
Menzel S., Garner C, Gut I, Matsuda F, Yamaguchi M, Heath S., Foglio M, Zelenika D, Boland A, Rooks H, et al. 2007. A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat Genet 39: 1197-1199.
-
(2007)
Nat Genet
, vol.39
, pp. 1197-1199
-
-
Menzel, S.1
Garner, C.2
Gut, I.3
Matsuda, F.4
Yamaguchi, M.5
Heath, S.6
Foglio, M.7
Zelenika, D.8
Boland, A.9
Rooks, H.10
-
47
-
-
59249104210
-
Recent advances in bone marrow transplantation in hemoglobinopathies
-
Michlitsch J.G., Walters MC. 2008. Recent advances in bone marrow transplantation in hemoglobinopathies. Curr Mol Med 8: 675-689.
-
(2008)
Curr Mol Med
, vol.8
, pp. 675-689
-
-
Michlitsch, J.G.1
Walters, M.C.2
-
48
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
MoelleringRE, CornejoM, DavisTN, DelBiancoC, Aster JC, Blacklow S.C., Kung AL, Gilliland DG, Verdine GL, Bradner JE. 2009. Direct inhibition of the NOTCH transcription factor complex. Nature 462: 182-188.
-
(2009)
Nature
, vol.462
, pp. 182-188
-
-
Moellering, R.E.1
Cornejo, M.2
Davis, T.N.3
DelBianco, C.4
Aster, J.C.5
Blacklow, S.C.6
Kung, A.L.7
Gilliland, D.G.8
Verdine, G.L.9
Bradner, J.E.10
-
49
-
-
33750291889
-
Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation
-
Mukai H.Y., Motohashi H, Ohneda O, Suzuki N, Nagano M, Yamamoto M. 2006. Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Mol Cell Biol 26: 7953-7965.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 7953-7965
-
-
Mukai, H.Y.1
Motohashi, H.2
Ohneda, O.3
Suzuki, N.4
Nagano, M.5
Yamamoto, M.6
-
50
-
-
84855848552
-
Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia
-
Musallam K.M., Sankaran VG, Cappellini MD, Duca L, Nathan D.G., Taher AT. 2011. Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia. Blood 119: 364-367.
-
(2011)
Blood
, vol.119
, pp. 364-367
-
-
Musallam, K.M.1
Sankaran, V.G.2
Cappellini, M.D.3
Duca, L.4
Nathan, D.G.5
Taher, A.T.6
-
51
-
-
77949274495
-
A genome-wide association identified the common genetic variants influence disease severity in β0-thalassemia/hemoglobin E
-
Nuinoon M., Makarasara W, Mushiroda T, Setianingsih I, Wahidiyat P.A., Sripichai O, Kumasaka N, Takahashi A, Svasti S., Munkongdee T, et al. 2010. A genome-wide association identified the common genetic variants influence disease severity in β0-thalassemia/hemoglobin E. Hum Genet 127: 303-314.
-
(2010)
Hum Genet
, vol.127
, pp. 303-314
-
-
Nuinoon, M.1
Makarasara, W.2
Mushiroda, T.3
Setianingsih, I.4
Wahidiyat, P.A.5
Sripichai, O.6
Kumasaka, N.7
Takahashi, A.8
Svasti, S.9
Munkongdee, T.10
-
52
-
-
0028170523
-
α-Amino butyric acid cannot reactivate the silencedγ gene of the β locus YAC transgenic mouse
-
Pace B., Li Q, Peterson K, Stamatoyannopoulos G. 1994. α-Amino butyric acid cannot reactivate the silencedγ gene of the β locus YAC transgenic mouse. Blood 84: 4344-4353.
-
(1994)
Blood
, vol.84
, pp. 4344-4353
-
-
Pace, B.1
Li, Q.2
Peterson, K.3
Stamatoyannopoulos, G.4
-
53
-
-
0021362464
-
Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics
-
Papayannopoulou T., Torrealba de Ron A, Veith R, Knitter G, Stamatoyannopoulos G. 1984. Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics. Science 224: 617-619.
-
(1984)
Science
, vol.224
, pp. 617-619
-
-
Papayannopoulou, T.1
Torrealba de Ron, A.2
Veith, R.3
Knitter, G.4
Stamatoyannopoulos, G.5
-
54
-
-
0015492354
-
Benign sickle-cell anaemia
-
Perrine R.P., Brown MJ, Clegg JB, Weatherall DJ, May A. 1972. Benign sickle-cell anaemia. Lancet 2: 1163-1167.
-
(1972)
Lancet
, vol.2
, pp. 1163-1167
-
-
Perrine, R.P.1
Brown, M.J.2
Clegg, J.B.3
Weatherall, D.J.4
May, A.5
-
55
-
-
0021956121
-
Delay in the fetal globin switch in infants of diabetic mothers
-
Perrine S.P., Greene MF, Faller DV. 1985. Delay in the fetal globin switch in infants of diabetic mothers. NEngl J Med 312: 334-338.
-
(1985)
NEngl J Med
, vol.312
, pp. 334-338
-
-
Perrine, S.P.1
Greene, M.F.2
Faller, D.V.3
-
56
-
-
0027078611
-
A short-term trial of butyrate to stimulate fetal-globingene expression in the β-globin disorders
-
Perrine S.P., Ginder GD, Faller DV, Dover GH, Ikuta T, Witkowska H.E., Cai SP, Vichinsky EP, Olivieri NF. 1993. A short-term trial of butyrate to stimulate fetal-globingene expression in the β-globin disorders. N Engl J Med 328: 81-86.
-
(1993)
N Engl J Med
, vol.328
, pp. 81-86
-
-
Perrine, S.P.1
Ginder, G.D.2
Faller, D.V.3
Dover, G.H.4
Ikuta, T.5
Witkowska, H.E.6
Cai, S.P.7
Vichinsky, E.P.8
Olivieri, N.F.9
-
57
-
-
0028156777
-
Butyrate derivatives. New agents for stimulating fetal globin production in the β-globin disorders
-
Perrine S.P., Olivieri NF, Faller DV, Vichinsky EP, Dover GJ, Ginder GD. 1994. Butyrate derivatives. New agents for stimulating fetal globin production in the β-globin disorders. Am J Pediatr Hematol Oncol 16: 67-71.
-
(1994)
Am J Pediatr Hematol Oncol
, vol.16
, pp. 67-71
-
-
Perrine, S.P.1
Olivieri, N.F.2
Faller, D.V.3
Vichinsky, E.P.4
Dover, G.J.5
Ginder, G.D.6
-
58
-
-
77949441974
-
Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders
-
Persons DA. 2009. Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders. Hematology 2009: 690-697.
-
(2009)
Hematology
, vol.2009
, pp. 690-697
-
-
Persons, D.A.1
-
59
-
-
0021931881
-
Haemoglobin switching in human embryos: Asynchrony of z → α and 1 → γ-globin switches in primitive and definite erythropoietic lineage
-
Peschle C., Mavilio F, Care A, Migliaccio G, Migliaccio AR, Salvo G., Samoggia P, Petti S, Guerriero R, Marinucci M, et al. 1985. Haemoglobin switching in human embryos: Asynchrony of z → α and 1 → γ-globin switches in primitive and definite erythropoietic lineage. Nature 313: 235-238.
-
(1985)
Nature
, vol.313
, pp. 235-238
-
-
Peschle, C.1
Mavilio, F.2
Care, A.3
Migliaccio, G.4
Migliaccio, A.R.5
Salvo, G.6
Samoggia, P.7
Petti, S.8
Guerriero, R.9
Marinucci, M.10
-
60
-
-
41449112582
-
Hydroxyurea for the treatment of sickle cell anemia
-
Platt OS. 2008. Hydroxyurea for the treatment of sickle cell anemia. N Engl J Med 358: 1362-1369.
-
(2008)
N Engl J Med
, vol.358
, pp. 1362-1369
-
-
Platt, O.S.1
-
61
-
-
0021286875
-
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia
-
Platt O.S., Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. 1984. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest 74: 652-656.
-
(1984)
J Clin Invest
, vol.74
, pp. 652-656
-
-
Platt, O.S.1
Orkin, S.H.2
Dover, G.3
Beardsley, G.P.4
Miller, B.5
Nathan, D.G.6
-
62
-
-
0025770390
-
Pain in sickle cell disease. Rates and risk factors
-
Platt O.S., ThoringtonBD, BrambillaDJ, MilnerPF, RosseWF, Vichinsky E., Kinney TR. 1991. Pain in sickle cell disease. Rates and risk factors. N Engl J Med 325: 11-16.
-
(1991)
N Engl J Med
, vol.325
, pp. 11-16
-
-
Platt, O.S.1
Thorington, B.D.2
Brambilla, D.J.3
Milner, P.F.4
Rosse, W.F.5
Vichinsky, E.6
Kinney, T.R.7
-
63
-
-
0028291736
-
Mortality in sickle cell disease. Life expectancy and risk factors for early death
-
Platt O.S., Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg M.H., Klug PP. 1994. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med 330: 1639-1644.
-
(1994)
N Engl J Med
, vol.330
, pp. 1639-1644
-
-
Platt, O.S.1
Brambilla, D.J.2
Rosse, W.F.3
Milner, P.F.4
Castro, O.5
Steinberg, M.H.6
Klug, P.P.7
-
64
-
-
78249231390
-
Iron overload in thalassemia and related conditions: Therapeutic goals and assessment of response to chelation therapies
-
Porter J.B., Shah FT. 2010. Iron overload in thalassemia and related conditions: Therapeutic goals and assessment of response to chelation therapies. Hematol Oncol Clin North Am 24: 1109-1130.
-
(2010)
Hematol Oncol Clin North Am
, vol.24
, pp. 1109-1130
-
-
Porter, J.B.1
Shah, F.T.2
-
65
-
-
26944485129
-
Haemoglobin E β thalassaemia in Sri Lanka
-
Premawardhena A., Fisher CA, Olivieri NF, de Silva S, Arambepola M., Perera W, O'Donnell A, Peto TE, Viprakasit V., Merson L, et al. 2005. Haemoglobin E β thalassaemia in Sri Lanka. Lancet 366: 1467-1470.
-
(2005)
Lancet
, vol.366
, pp. 1467-1470
-
-
Premawardhena, A.1
Fisher, C.A.2
Olivieri, N.F.3
de Silva, S.4
Arambepola, M.5
Perera, W.6
O'Donnell, A.7
Peto, T.E.8
Viprakasit, V.9
Merson, L.10
-
66
-
-
78649719826
-
Reversing the hemoglobin switch
-
SankaranVG, Nathan DG. 2010a. Reversing the hemoglobin switch. N Engl J Med 363: 2258-2260.
-
(2010)
N Engl J Med
, vol.363
, pp. 2258-2260
-
-
Sankaran, V.G.1
Nathan, D.G.2
-
67
-
-
78249272956
-
Thalassemia: An overview of 50 years of clinical research
-
Sankaran V.G., Nathan DG. 2010b. Thalassemia: An overview of 50 years of clinical research. Hematol Oncol Clin North Am 24: 1005-1020.
-
(2010)
Hematol Oncol Clin North Am
, vol.24
, pp. 1005-1020
-
-
Sankaran, V.G.1
Nathan, D.G.2
-
68
-
-
84855709901
-
Persistence of fetal hemoglobin expression in an older child with trisomy 13
-
Sankaran V.G., Sapp MV. 2012. Persistence of fetal hemoglobin expression in an older child with trisomy 13. J Pediatr 160: 352.
-
(2012)
J Pediatr
, vol.160
, pp. 352
-
-
Sankaran, V.G.1
Sapp, M.V.2
-
69
-
-
57849083996
-
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
-
Sankaran V.G., Menne TF, Xu J, Akie TE, Lettre G, Van Handel B., Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. 2008. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 322: 1839-1842.
-
(2008)
Science
, vol.322
, pp. 1839-1842
-
-
Sankaran, V.G.1
Menne, T.F.2
Xu, J.3
Akie, T.E.4
Lettre, G.5
van Handel, B.6
Mikkola, H.K.7
Hirschhorn, J.N.8
Cantor, A.B.9
Orkin, S.H.10
-
70
-
-
69349092063
-
Developmental and species-divergent globin switching are driven by BCL11A
-
Sankaran V.G., Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika S.D., Fujiwara Y, Ito M, Groudine M, Bender MA, et al. 2009. Developmental and species-divergent globin switching are driven by BCL11A. Nature 460: 1093-1097.
-
(2009)
Nature
, vol.460
, pp. 1093-1097
-
-
Sankaran, V.G.1
Xu, J.2
Ragoczy, T.3
Ippolito, G.C.4
Walkley, C.R.5
Maika, S.D.6
Fujiwara, Y.7
Ito, M.8
Groudine, M.9
Bender, M.A.10
-
71
-
-
77949846880
-
Advances in the understanding of haemoglobin switching
-
Sankaran V.G., Xu J, Orkin SH. 2010. Advances in the understanding of haemoglobin switching. Brit J Haematol 149: 181-194.
-
(2010)
Brit J Haematol
, vol.149
, pp. 181-194
-
-
Sankaran, V.G.1
Xu, J.2
Orkin, S.H.3
-
72
-
-
79955951989
-
Heterozygous disruption of human SOX6 is insufficient to impair erythropoiesis or silencing of fetal hemoglobin
-
Sankaran V.G., Menne J, Heller R. 2011a. Heterozygous disruption of human SOX6 is insufficient to impair erythropoiesis or silencing of fetal hemoglobin. Blood 117: 4396-4397.
-
(2011)
Blood
, vol.117
, pp. 4396-4397
-
-
Sankaran, V.G.1
Menne, J.2
Heller, R.3
-
73
-
-
79952169016
-
MicroRNA-15a and-16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13
-
Sankaran V.G., Menne TF, Scepanovic D, Vergilio JA, Ji P, Kim J., Thiru P, Orkin SH, Lander ES, Lodish HF. 2011b. MicroRNA-15a and-16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci 108: 1519-1524.
-
(2011)
Proc Natl Acad Sci
, vol.108
, pp. 1519-1524
-
-
Sankaran, V.G.1
Menne, T.F.2
Scepanovic, D.3
Vergilio, J.A.4
Ji, P.5
Kim, J.6
Thiru, P.7
Orkin, S.H.8
Lander, E.S.9
Lodish, H.F.10
-
74
-
-
80052439730
-
A functional element necessary for fetal hemoglobin silencing
-
Sankaran V.G., Xu J, Byron R, Greisman HA, Fisher C, Weatherall D.J., Sabath DE, Groudine M, Orkin SH, Premawardhena A., et al. 2011c. A functional element necessary for fetal hemoglobin silencing. N Engl J Med 365: 807-814.
-
(2011)
N Engl J Med
, vol.365
, pp. 807-814
-
-
Sankaran, V.G.1
Xu, J.2
Byron, R.3
Greisman, H.A.4
Fisher, C.5
Weatherall, D.J.6
Sabath, D.E.7
Groudine, M.8
Orkin, S.H.9
Premawardhena, A.10
-
75
-
-
79955738088
-
Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin
-
Satta S., Perseu L, Moi P, Asunis I, Cabriolu A, Maccioni L, Demartis F.R., Manunza L, Cao A, Galanello R. 2011. Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin. Haematologica 96: 767-770.
-
(2011)
Haematologica
, vol.96
, pp. 767-770
-
-
Satta, S.1
Perseu, L.2
Moi, P.3
Asunis, I.4
Cabriolu, A.5
McCioni, L.6
Demartis, F.R.7
Manunza, L.8
Cao, A.9
Galanello, R.10
-
76
-
-
0029032965
-
Extended therapy with intravenous arginine butyrate in patients with β-hemoglobinopathies
-
Sher G.D., Ginder GD, Little J, Yang S, Dover GJ, Olivieri NF. 1995. Extended therapy with intravenous arginine butyrate in patients with β-hemoglobinopathies. N Engl J Med 332: 1606-1610.
-
(1995)
N Engl J Med
, vol.332
, pp. 1606-1610
-
-
Sher, G.D.1
Ginder, G.D.2
Little, J.3
Yang, S.4
Dover, G.J.5
Olivieri, N.F.6
-
77
-
-
84857051019
-
Dynamic longrange chromatin interactions control Myb proto-oncogene transcription during erythroid development
-
Stadhouders R., Thongjuea S, Andrieu-Soler C, Palstra RJ, Bryne J.C., van den Heuvel A, Stevens M, de Boer E, Kockx C., van der Sloot A, et al. 2011. Dynamic longrange chromatin interactions control Myb proto-oncogene transcription during erythroid development. EMBO J 31: 986-999.
-
(2011)
EMBO J
, vol.31
, pp. 986-999
-
-
Stadhouders, R.1
Thongjuea, S.2
Andrieu-Soler, C.3
Palstra, R.J.4
Bryne, J.C.5
van den Heuvel, A.6
Stevens, M.7
de Boer, E.8
Kockx, C.9
van der Sloot, A.10
-
78
-
-
0037414164
-
Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: Risks and benefits up to 9 years of treatment
-
Steinberg M.H., Barton F, Castro O, Pegelow CH, Ballas SK, Kutlar A., Orringer E, Bellevue R, Olivieri N, Eckman J, et al. 2003. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: Risks and benefits up to 9 years of treatment. JAMA 289: 1645-1651.
-
(2003)
JAMA
, vol.289
, pp. 1645-1651
-
-
Steinberg, M.H.1
Barton, F.2
Castro, O.3
Pegelow, C.H.4
Ballas, S.K.5
Kutlar, A.6
Orringer, E.7
Bellevue, R.8
Olivieri, N.9
Eckman, J.10
-
79
-
-
0036646514
-
An embryonic/fetal β-type globin gene repressor contains a nuclear receptor TR2/ TR4 heterodimer
-
TanabeO, Katsuoka F, CampbellAD, SongW, Yamamoto M, Tanimoto K., Engel JD. 2002. An embryonic/fetal β-type globin gene repressor contains a nuclear receptor TR2/ TR4 heterodimer. EMBO J 21: 3434-3442.
-
(2002)
EMBO J
, vol.21
, pp. 3434-3442
-
-
Tanabe, O.1
Katsuoka, F.2
Campbell, A.D.3
Song, W.4
Yamamoto, M.5
Tanimoto, K.6
Engel, J.D.7
-
80
-
-
34247569022
-
Embryonic and fetal β-globin gene repression by the orphan nuclear receptors, TR2 and TR4
-
Tanabe O., McPhee D, Kobayashi S, Shen Y, Brandt W, Jiang X., Campbell AD, Chen YT, Chang C, Yamamoto M, et al. 2007. Embryonic and fetal β-globin gene repression by the orphan nuclear receptors, TR2 and TR4. EMBO J 26: 2295-2306.
-
(2007)
EMBO J
, vol.26
, pp. 2295-2306
-
-
Tanabe, O.1
McPhee, D.2
Kobayashi, S.3
Shen, Y.4
Brandt, W.5
Jiang, X.6
Campbell, A.D.7
Chen, Y.T.8
Chang, C.9
Yamamoto, M.10
-
81
-
-
34547450531
-
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
-
Thein S.L., Menzel S, Peng X, Best S, Jiang J, Close J, Silver N, Gerovasilli A., Ping C, Yamaguchi M, et al. 2007. Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults. Proc Natl Acad Sci 104: 11346-11351.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 11346-11351
-
-
Thein, S.L.1
Menzel, S.2
Peng, X.3
Best, S.4
Jiang, J.5
Close, J.6
Silver, N.7
Gerovasilli, A.8
Ping, C.9
Yamaguchi, M.10
-
82
-
-
40349092939
-
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia
-
Uda M., Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W., Usala G, Busonero F, Maschio A, Albai G, et al. 2008. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia. Proc Natl Acad Sci 105: 1620-1625.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 1620-1625
-
-
Uda, M.1
Galanello, R.2
Sanna, S.3
Lettre, G.4
Sankaran, V.G.5
Chen, W.6
Usala, G.7
Busonero, F.8
Maschio, A.9
Albai, G.10
-
83
-
-
0018905582
-
DNA methylation in the human γdβ-globin locus in erythroid and nonerythroid tissues
-
van der Ploeg LH, Flavell RA. 1980. DNA methylation in the human γdβ-globin locus in erythroid and nonerythroid tissues. Cell 19: 947-958.
-
(1980)
Cell
, vol.19
, pp. 947-958
-
-
-
84
-
-
78549244494
-
Fetal globin expression is regulated by Friend of Prmt1
-
van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M., Grosveld F, Philipsen S. 2010. Fetal globin expression is regulated by Friend of Prmt1. Blood 116: 4349-4352.
-
(2010)
Blood
, vol.116
, pp. 4349-4352
-
-
van Dijk, T.B.1
Gillemans, N.2
Pourfarzad, F.3
van Lom, K.4
von Lindern, M.5
Grosveld, F.6
Philipsen, S.7
-
85
-
-
69849101637
-
The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells
-
Wahlberg K., Jiang J, Rooks H, Jawaid K, Matsuda F, Yamaguchi M., Lathrop M, Thein SL, Best S. 2009. The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells. Blood 114: 1254-1262.
-
(2009)
Blood
, vol.114
, pp. 1254-1262
-
-
Wahlberg, K.1
Jiang, J.2
Rooks, H.3
Jawaid, K.4
Matsuda, F.5
Yamaguchi, M.6
Lathrop, M.7
Thein, S.L.8
Best, S.9
-
86
-
-
0000343671
-
The significance of the paucity of sickle cells in newborn Negro infants
-
Watson J. 1948. The significance of the paucity of sickle cells in newborn Negro infants. Am J Med Sci 215: 419-423.
-
(1948)
Am J Med Sci
, vol.215
, pp. 419-423
-
-
Watson, J.1
-
87
-
-
0035320886
-
Phenotype-genotype relationships in monogenic disease: Lessons from the thalassaemias
-
Weatherall DJ. 2001. Phenotype-genotype relationships in monogenic disease: Lessons from the thalassaemias. Nat Rev 2: 245-255.
-
(2001)
Nat Rev
, vol.2
, pp. 245-255
-
-
Weatherall, D.J.1
-
89
-
-
34247143171
-
Inherited disorders of hemoglobin
-
In, 2nd ed., Oxford University Press, New York
-
Weatherall D., Akinyanju O, Fucharoen S, Olivieri N, Musgrove P. 2006. Inherited disorders of hemoglobin. In Disease control priorities in developing countries, 2nd ed., pp. 663-680. Oxford University Press, New York.
-
(2006)
Disease control priorities in developing countries
, pp. 663-680
-
-
Weatherall, D.1
Akinyanju, O.2
Fucharoen, S.3
Olivieri, N.4
Musgrove, P.5
-
90
-
-
79953117530
-
+ cells after lentiviral vector-mediated gene transfer
-
+ cells after lentiviral vector-mediated gene transfer. Blood 117: 2817-2826.
-
(2011)
Blood
, vol.117
, pp. 2817-2826
-
-
Wilber, A.1
Hargrove, P.W.2
Kim, Y.S.3
Riberdy, J.M.4
Sankaran, V.G.5
Papanikolaou, E.6
Georgomanoli, M.7
Anagnou, N.P.8
Orkin, S.H.9
Nienhuis, A.W.10
-
91
-
-
77950930726
-
Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6
-
Xu J., Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. 2010. Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev 24: 783-798.
-
(2010)
Genes Dev
, vol.24
, pp. 783-798
-
-
Xu, J.1
Sankaran, V.G.2
Ni, M.3
Menne, T.F.4
Puram, R.V.5
Kim, W.6
Orkin, S.H.7
-
92
-
-
81555205756
-
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing
-
Xu J., Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito G.C., Fujiwara Y, Ebert BL, TuckerPW, et al. 2011. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science 334: 993-996.
-
(2011)
Science
, vol.334
, pp. 993-996
-
-
Xu, J.1
Peng, C.2
Sankaran, V.G.3
Shao, Z.4
Esrick, E.B.5
Chong, B.G.6
Ippolito, G.C.7
Fujiwara, Y.8
Ebert, B.L.9
Tucker, P.W.10
-
93
-
-
33644515327
-
Repression of human γ-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter
-
Zhao Q., ZhouW, Rank G, Sutton R, Wang X, Cumming H, Cerruti L., Cunningham JM, Jane SM. 2006. Repression of human γ-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Blood 107: 2138-2145.
-
(2006)
Blood
, vol.107
, pp. 2138-2145
-
-
Zhao, Q.1
Zhou, W.2
Rank, G.3
Sutton, R.4
Wang, X.5
Cumming, H.6
Cerruti, L.7
Cunningham, J.M.8
Jane, S.M.9
-
94
-
-
2942735215
-
The role of p22 NF-E4 in human globin gene switching
-
Zhou W., Zhao Q, Sutton R, Cumming H, Wang X, Cerruti L., Hall M, Wu R, Cunningham JM, Jane SM. 2004. The role of p22 NF-E4 in human globin gene switching. J Biol Chem 279: 26227-26232.
-
(2004)
J Biol Chem
, vol.279
, pp. 26227-26232
-
-
Zhou, W.1
Zhao, Q.2
Sutton, R.3
Cumming, H.4
Wang, X.5
Cerruti, L.6
Hall, M.7
Wu, R.8
Cunningham, J.M.9
Jane, S.M.10
-
95
-
-
77956630402
-
KLF1 regulates BCL11A expression and γ-to β-globin gene switching
-
Zhou D., Liu K, Sun CW, Pawlik KM, Townes TM. 2010. KLF1 regulates BCL11A expression and γ-to β-globin gene switching. Nat Genet 42: 742-744.
-
(2010)
Nat Genet
, vol.42
, pp. 742-744
-
-
Zhou, D.1
Liu, K.2
Sun, C.W.3
Pawlik, K.M.4
Townes, T.M.5
-
96
-
-
80051513341
-
An integrated approach to dissecting oncogene addiction implicates aMyb-coordinated self-renewal program as essential for leukemia maintenance
-
Zuber J., Rappaport AR, LuoW, Wang E, Chen C, Vaseva AV, Shi J., Weissmueller S, Fellmann C, Taylor MJ, et al. 2011a. An integrated approach to dissecting oncogene addiction implicates aMyb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev 25: 1628-1640.
-
(2011)
Genes Dev
, vol.25
, pp. 1628-1640
-
-
Zuber, J.1
Rappaport, A.R.2
Luo, W.3
Wang, E.4
Chen, C.5
Vaseva, A.V.6
Shi, J.7
Weissmueller, S.8
Fellmann, C.9
Taylor, M.J.10
-
97
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
Zuber J., Shi J, Wang E, Rappaport AR, Herrmann H, Sison E.A., Magoon D, Qi J, Blatt K, Wunderlich M, et al. 2011b. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 478: 524-528.
-
(2011)
Nature
, vol.478
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
Magoon, D.7
Qi, J.8
Blatt, K.9
Wunderlich, M.10
-
98
-
-
84856405512
-
The mystery of missing heritability: Genetic interactions create phantom heritability
-
Zuk O., Hechter E, Sunyaev SR, Lander ES. 2012. The mystery of missing heritability: Genetic interactions create phantom heritability. ProcNatl Acad Sci 109: 1193-1198.
-
(2012)
ProcNatl Acad Sci
, vol.109
, pp. 1193-1198
-
-
Zuk, O.1
Hechter, E.2
Sunyaev, S.R.3
Lander, E.S.4
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