Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway

Free Radical Research

Volumn 49, Issue 10, 2015, Pages 1275-1284

  Chen, Y ^a   Qing, W ^b   Sun, M ^b   Lv, L ^a   Guo, D ^a   Jiang, Y ^a  

^a FUZHOU GENERAL HOSPITAL   (China)

^b 517Th Hospital of PLA   (China)

Author keywords

AMPK; GCDCA; hepatotoxicity; mitochondrial ROS; SIRT3; SOD2

Indexed keywords

BILE ACID; GLYCOCHENODEOXYCHOLIC ACID; MANGANESE SUPEROXIDE DISMUTASE; MELATONIN; REACTIVE OXYGEN METABOLITE; SIRTUIN 3; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; SIRT3 PROTEIN, HUMAN;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVE SITE; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; HUMAN; LIVER MITOCHONDRION; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING; RANDOMIZATION; RNA INTERFERENCE;

RATTUS;

ACETYLATION; ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; GLYCOCHENODEOXYCHOLIC ACID; HEPATOCYTES; HUMANS; MELATONIN; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RANDOM ALLOCATION; RATS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIRTUIN 3; SUPEROXIDE DISMUTASE;

EID: 84940020988     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2015.1067806     Document Type: Article

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