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Volumn 58, Issue 4, 2015, Pages 352-358

Molecular mechanisms of dietary restriction in aging—insights from Caenorhabditis elegans research

Author keywords

aging; C. elegans; dietary restriction; insulin IGF 1 signaling; TOR pathway

Indexed keywords

AGING; ANIMAL; CAENORHABDITIS ELEGANS; DIET; GENETICS; GENOME; PHYSIOLOGY;

EID: 84940005412     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-015-4824-5     Document Type: Review
Times cited : (9)

References (43)
  • 2
    • 84880634531 scopus 로고    scopus 로고
    • Global aging and the allocation of health care across the life span
    • Daniels N. Global aging and the allocation of health care across the life span. Am J Bioethics, 2013, 13: 1–2
    • (2013) Am J Bioethics , vol.13 , pp. 1-2
    • Daniels, N.1
  • 3
    • 13944269223 scopus 로고    scopus 로고
    • The plasticity of aging: insights from long-lived mutants
    • COI: 1:CAS:528:DC%2BD2MXitVWntbc%3D, PID: 15734678
    • Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell, 2005, 120: 449–460
    • (2005) Cell , vol.120 , pp. 449-460
    • Kenyon, C.1
  • 4
    • 77955747346 scopus 로고    scopus 로고
    • With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging
    • COI: 1:CAS:528:DC%2BC3cXnsFyitro%3D, PID: 20519118
    • Kapahi P, Chen D, Rogers AN, Katewa SD, Li PW, Thomas EL, Kockel L. With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging. Cell Metab, 2010, 11: 453–465
    • (2010) Cell Metab , vol.11 , pp. 453-465
    • Kapahi, P.1    Chen, D.2    Rogers, A.N.3    Katewa, S.D.4    Li, P.W.5    Thomas, E.L.6    Kockel, L.7
  • 5
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span—from yeast to humans
    • COI: 1:CAS:528:DC%2BC3cXks1Snsro%3D, PID: 20395504
    • Fontana L, Partridge L, Longo VD. Extending healthy life span—from yeast to humans. Science, 2010, 328: 321
    • (2010) Science , vol.328 , pp. 321
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 6
    • 77950191067 scopus 로고    scopus 로고
    • Dietary restriction and aging, 2009
    • COI: 1:CAS:528:DC%2BC3cXktFOnsrY%3D, PID: 20096035
    • Katewa SD, Kapahi P. Dietary restriction and aging, 2009. Aging Cell, 2010, 9: 105–112
    • (2010) Aging Cell , vol.9 , pp. 105-112
    • Katewa, S.D.1    Kapahi, P.2
  • 7
    • 84901645732 scopus 로고    scopus 로고
    • GxGxE for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity
    • PID: 24832080
    • Zhu CT, Ingelmo P, Rand DM. GxGxE for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity. PLoS Genet, 2014, 10: e1004354
    • (2014) PLoS Genet , vol.10 , pp. e1004354
    • Zhu, C.T.1    Ingelmo, P.2    Rand, D.M.3
  • 8
    • 84908459586 scopus 로고    scopus 로고
    • Lifespan modulation in mice and the confounding effects of genetic background
    • PID: 25269675
    • Mulvey L, Sinclair A, Selman C. Lifespan modulation in mice and the confounding effects of genetic background. J Genet Genomics, 2014, 41: 497–503
    • (2014) J Genet Genomics , vol.41 , pp. 497-503
    • Mulvey, L.1    Sinclair, A.2    Selman, C.3
  • 9
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • COI: 1:CAS:528:DC%2BC3cXjvVGltLk%3D, PID: 20336132
    • Kenyon CJ. The genetics of ageing. Nature, 2010, 464: 504–512
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 10
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • COI: 1:STN:280:DyaE2c3ntFWlsw%3D%3D, PID: 4366476
    • Brenner S. The genetics of Caenorhabditis elegans. Genetics, 1974, 77: 71–94
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 11
    • 0032573178 scopus 로고    scopus 로고
    • The genetics of caloric restriction in Caenorhabditis elegans
    • COI: 1:CAS:528:DyaK1cXntFWkurc%3D, PID: 9789046
    • Lakowski B, Hekimi S. The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci USA, 1998, 95: 13091–13096
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13091-13096
    • Lakowski, B.1    Hekimi, S.2
  • 12
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • COI: 1:CAS:528:DC%2BD2sXlvVyktb4%3D, PID: 17476212
    • Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature, 2007, 447: 550–555
    • (2007) Nature , vol.447 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 13
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. elegans
    • COI: 1:CAS:528:DC%2BD2sXlvVyktbc%3D, PID: 17538612
    • Bishop NA, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature, 2007, 447: 545–549
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 14
    • 34848850156 scopus 로고    scopus 로고
    • An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
    • COI: 1:CAS:528:DC%2BD2sXhtFCjt7fJ, PID: 17900900
    • Greer EL, Dowlatshahi D, Banko MR, Villen J, Hoang K, Blanchard D, Gygi SP, Brunet A. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol, 2007, 17: 1646–1656
    • (2007) Curr Biol , vol.17 , pp. 1646-1656
    • Greer, E.L.1    Dowlatshahi, D.2    Banko, M.R.3    Villen, J.4    Hoang, K.5    Blanchard, D.6    Gygi, S.P.7    Brunet, A.8
  • 15
    • 0024385843 scopus 로고
    • Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions
    • COI: 1:STN:280:DyaL1M3ns1Ghtg%3D%3D, PID: 2731582
    • Hosono R, Nishimoto S, Kuno S. Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions. Exp Gerontol, 1989, 24: 251–264
    • (1989) Exp Gerontol , vol.24 , pp. 251-264
    • Hosono, R.1    Nishimoto, S.2    Kuno, S.3
  • 17
    • 33751203889 scopus 로고    scopus 로고
    • Dietary deprivation extends lifespan in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BD2sXhsF2gtQ%3D%3D, PID: 17096674
    • Lee GD, Wilson MA, Zhu M, Wolkow CA, de Cabo R, Ingram DK, Zou S. Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell, 2006, 5: 515–524
    • (2006) Aging Cell , vol.5 , pp. 515-524
    • Lee, G.D.1    Wilson, M.A.2    Zhu, M.3    Wolkow, C.A.4    de Cabo, R.5    Ingram, D.K.6    Zou, S.7
  • 18
    • 59649120539 scopus 로고    scopus 로고
    • Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans
    • PID: 19079239
    • Honjoh S, Yamamoto T, Uno M, Nishida E. Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature, 2008, 457: 726–730
    • (2008) Nature , vol.457 , pp. 726-730
    • Honjoh, S.1    Yamamoto, T.2    Uno, M.3    Nishida, E.4
  • 19
    • 33751090136 scopus 로고    scopus 로고
    • Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction
    • COI: 1:CAS:528:DC%2BD28XhtlWhur7O, PID: 17023606
    • Szewczyk NJ, Udranszky IA, Kozak E, Sunga J, Kim SK, Jacobson LA, Conley CA. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. J Exp Biol, 2006, 209: 4129–4139
    • (2006) J Exp Biol , vol.209 , pp. 4129-4139
    • Szewczyk, N.J.1    Udranszky, I.A.2    Kozak, E.3    Sunga, J.4    Kim, S.K.5    Jacobson, L.A.6    Conley, C.A.7
  • 20
    • 67149107430 scopus 로고    scopus 로고
    • HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans
    • PID: 19461873
    • Chen D, Thomas EL, Kapahi P. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet, 2009, 5: e1000486
    • (2009) PLoS Genet , vol.5 , pp. e1000486
    • Chen, D.1    Thomas, E.L.2    Kapahi, P.3
  • 21
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • PID: 21157483
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol, 2010, 12: 21–35
    • (2010) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 22
    • 4544311861 scopus 로고    scopus 로고
    • The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
    • COI: 1:CAS:528:DC%2BD2cXns1SntLc%3D, PID: 15253933
    • Jia K, Chen D, Riddle DL. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development, 2004, 131: 3897–3906
    • (2004) Development , vol.131 , pp. 3897-3906
    • Jia, K.1    Chen, D.2    Riddle, D.L.3
  • 23
    • 0037015269 scopus 로고    scopus 로고
    • TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation
    • COI: 1:CAS:528:DC%2BD38XntVaisLk%3D, PID: 12225660
    • Long X, Spycher C, Han ZS, Rose AM, Muller F, Avruch J. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol, 2002, 12: 1448–1461
    • (2002) Curr Biol , vol.12 , pp. 1448-1461
    • Long, X.1    Spycher, C.2    Han, Z.S.3    Rose, A.M.4    Muller, F.5    Avruch, J.6
  • 24
    • 0642367846 scopus 로고    scopus 로고
    • Genetics: influence of TOR kinase on lifespan in C. elegans
    • COI: 1:CAS:528:DC%2BD3sXps1Clur4%3D, PID: 14668850
    • Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature, 2003, 426: 620
    • (2003) Nature , vol.426 , pp. 620
    • Vellai, T.1    Takacs-Vellai, K.2    Zhang, Y.3    Kovacs, A.L.4    Orosz, L.5    Muller, F.6
  • 25
    • 33846418352 scopus 로고    scopus 로고
    • Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BD2sXisFCrsL0%3D, PID: 17266680
    • Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell, 2007, 6: 111–119
    • (2007) Aging Cell , vol.6 , pp. 111-119
    • Pan, K.Z.1    Palter, J.E.2    Rogers, A.N.3    Olsen, A.4    Chen, D.5    Lithgow, G.J.6    Kapahi, P.7
  • 26
    • 40149105890 scopus 로고    scopus 로고
    • A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    • PID: 18282106
    • Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet, 2008, 4: e24
    • (2008) PLoS Genet , vol.4 , pp. e24
    • Hansen, M.1    Chandra, A.2    Mitic, L.L.3    Onken, B.4    Driscoll, M.5    Kenyon, C.6
  • 27
    • 0038701745 scopus 로고    scopus 로고
    • Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    • COI: 1:CAS:528:DC%2BD3sXjslGqtr0%3D, PID: 12750521
    • Hsu AL, Murphy CT, Kenyon C. Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science, 2003, 300: 1142–1145
    • (2003) Science , vol.300 , pp. 1142-1145
    • Hsu, A.L.1    Murphy, C.T.2    Kenyon, C.3
  • 28
    • 43449138491 scopus 로고    scopus 로고
    • Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BD1cXntFWnt7w%3D, PID: 18331616
    • Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, Sutphin GL, Kennedy BK, Kaeberlein M. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell, 2008, 7: 394–404
    • (2008) Aging Cell , vol.7 , pp. 394-404
    • Steinkraus, K.A.1    Smith, E.D.2    Davis, C.3    Carr, D.4    Pendergrass, W.R.5    Sutphin, G.L.6    Kennedy, B.K.7    Kaeberlein, M.8
  • 29
    • 0028068018 scopus 로고
    • The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans
    • COI: 1:CAS:528:DyaK2MXhtl2mu74%3D, PID: 7607089
    • Mango SE, Lambie EJ, Kimble J. The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans. Development, 1994, 120: 3019–3031
    • (1994) Development , vol.120 , pp. 3019-3031
    • Mango, S.E.1    Lambie, E.J.2    Kimble, J.3
  • 30
    • 52049093450 scopus 로고    scopus 로고
    • The target of rapamycin pathway antagonizes pha-4/FoxA to control development and aging
    • COI: 1:CAS:528:DC%2BD1cXhtFCksb%2FM, PID: 18804378
    • Sheaffer KL, Updike DL, Mango SE. The target of rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Curr Biol, 2008, 18: 1355–1364
    • (2008) Curr Biol , vol.18 , pp. 1355-1364
    • Sheaffer, K.L.1    Updike, D.L.2    Mango, S.E.3
  • 31
    • 80053035284 scopus 로고    scopus 로고
    • AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function
    • COI: 1:CAS:528:DC%2BC3MXht1Oju7zO, PID: 21937710
    • Hardie DG. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev, 2011, 25: 1895–1908
    • (2011) Genes Dev , vol.25 , pp. 1895-1908
    • Hardie, D.G.1
  • 35
    • 30544447917 scopus 로고    scopus 로고
    • The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-alpha/Sima
    • COI: 1:CAS:528:DC%2BD28XjvFOitQ%3D%3D, PID: 16278294
    • Dekanty A, Lavista-Llanos S, Irisarri M, Oldham S, Wappner P. The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-alpha/Sima. J Cell Sci, 2005, 118: 5431–5441
    • (2005) J Cell Sci , vol.118 , pp. 5431-5441
    • Dekanty, A.1    Lavista-Llanos, S.2    Irisarri, M.3    Oldham, S.4    Wappner, P.5
  • 36
    • 40849118472 scopus 로고    scopus 로고
    • Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    • COI: 1:CAS:528:DC%2BD1cXkt1WqsLo%3D, PID: 18358814
    • Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell, 2008, 132: 1025–1038
    • (2008) Cell , vol.132 , pp. 1025-1038
    • Tullet, J.M.1    Hertweck, M.2    An, J.H.3    Baker, J.4    Hwang, J.Y.5    Liu, S.6    Oliveira, R.P.7    Baumeister, R.8    Blackwell, T.K.9
  • 38
    • 84880798936 scopus 로고    scopus 로고
    • Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BC3sXht1GisL%2FK, PID: 23935515
    • Heestand BN, Shen Y, Liu W, Magner DB, Storm N, Meharg C, Habermann B, Antebi A. Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. PLoS Genet, 2013, 9: e1003651
    • (2013) PLoS Genet , vol.9 , pp. e1003651
    • Heestand, B.N.1    Shen, Y.2    Liu, W.3    Magner, D.B.4    Storm, N.5    Meharg, C.6    Habermann, B.7    Antebi, A.8
  • 40
    • 79959981053 scopus 로고    scopus 로고
    • Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans
    • COI: 1:CAS:528:DC%2BC3MXosFeitb0%3D, PID: 21723504
    • Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P. Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab, 2011, 14: 55–66
    • (2011) Cell Metab , vol.14 , pp. 55-66
    • Rogers, A.N.1    Chen, D.2    McColl, G.3    Czerwieniec, G.4    Felkey, K.5    Gibson, B.W.6    Hubbard, A.7    Melov, S.8    Lithgow, G.J.9    Kapahi, P.10
  • 41
    • 84890973318 scopus 로고    scopus 로고
    • Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans
    • COI: 1:CAS:528:DC%2BC3sXhvFOhtbnK, PID: 24332851
    • Chen D, Li PW, Goldstein BA, Cai W, Thomas EL, Chen F, Hubbard AE, Melov S, Kapahi P. Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell reports, 2013, 5: 1600–1610
    • (2013) Cell reports , vol.5 , pp. 1600-1610
    • Chen, D.1    Li, P.W.2    Goldstein, B.A.3    Cai, W.4    Thomas, E.L.5    Chen, F.6    Hubbard, A.E.7    Melov, S.8    Kapahi, P.9
  • 42
    • 0030813398 scopus 로고    scopus 로고
    • daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • COI: 1:CAS:528:DyaK2sXltlCqsb0%3D, PID: 9252323
    • Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science, 1997, 277: 942–946
    • (1997) Science , vol.277 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 43
    • 84863514544 scopus 로고    scopus 로고
    • Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster
    • COI: 1:CAS:528:DC%2BC38XpvFGnurk%3D, PID: 22768842
    • Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab, 2012, 16: 97–103
    • (2012) Cell Metab , vol.16 , pp. 97-103
    • Katewa, S.D.1    Demontis, F.2    Kolipinski, M.3    Hubbard, A.4    Gill, M.S.5    Perrimon, N.6    Melov, S.7    Kapahi, P.8


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