Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [11C](R)-PK11195

Annals of Nuclear Medicine

Volumn 29, Issue 4, 2015, Pages 325-335

  Hatano, Kentaro ^a,h   Sekimata, Katsuhiko ^a   Yamada, Takashi ^a   Abe, Junichiro ^a   Ito, Kengo ^a   Ogawa, Mikako ^b   Magata, Yasuhiro ^b   Toyohara, Jun ^c   Ishiwata, Kiichi ^c   Biggio, Giovanni ^d   Serra, Mariangela ^d   Laquintana, Valentino ^e   Denora, Nunzio ^e   Latrofa, Andrea ^e   Trapani, Giuseppe ^e   Liso, Gaetano ^e   Suzuki, Hiromi ^f   Sawada, Makoto ^f   Nomura, Masahiko ^g   Toyama, Hiroshi ^g  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^d UNIVERSITY OF CAGLIARI   (Italy)

^e UNIVERSITY OF BARI   (Italy)

^f NAGOYA UNIVERSITY   (Japan)

^g FUJITA HEALTH UNIVERSITY   (Japan)

^h UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Alzheimer s disease; Neuroinflammation; PBR; Positron emission tomography; TSPO

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; BENZYLIDENE DERIVATIVE; BZRP PROTEIN, MOUSE; CARBON; CARRIER PROTEIN; CB 182; CB190 COMPOUND; IMIDAZOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; MESYLIC ACID DERIVATIVE; METHYL TRIFLATE; MORPHINAN DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; OCTANOL; PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TSPO PROTEIN, RAT; WATER;

ANIMAL; BRAIN; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; MOUSE; OUTBRED STRAIN; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; SYNTHESIS; VALIDATION STUDY; WISTAR RAT;

ANIMALS; ANIMALS, OUTBRED STRAINS; BENZYLIDENE COMPOUNDS; BRAIN; CARBON RADIOISOTOPES; CARRIER PROTEINS; IMIDAZOLES; INJECTIONS, INTRAVENOUS; ISOQUINOLINES; MALE; MESYLATES; MICE; MOLECULAR STRUCTURE; MORPHINANS; OCTANOLS; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIOPHARMACEUTICALS; RATS, WISTAR; RECEPTORS, GABA; RECEPTORS, GABA-A; WATER;

EID: 84940003915     PISSN: 09147187     EISSN: 18646433     Source Type: Journal    
DOI: 10.1007/s12149-015-0948-8     Document Type: Article

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