Passage of spermidine across the blood-brain barrier in short recirculation periods following global cerebral ischemia: Effects of mild hyperthermia

Neuroscience Research

Volumn 43, Issue 4, 2002, Pages 335-342

  Diler, A S ^a   Ziylan, Y Z ^a   Uzum, G ^a   Lefauconnier, J M ^a   Seylaz, J ^a   Pinard, E ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Blood brain barrier; Brain temperature; Cerebral ischemia; Polyamine; Spermidine

Indexed keywords

2 AMINO 2 METHYLPROPIONIC ACID; CARBON 14; POLYAMINE; SPERMIDINE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; BRAIN REGION; BRAIN TEMPERATURE; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; HYPERTHERMIA; MALE; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; RAT; TEMPORAL CORTEX;

AMINOISOBUTYRIC ACIDS; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN ISCHEMIA; HYPOTHERMIA, INDUCED; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPERMIDINE; TISSUE DISTRIBUTION;

EID: 0036316416     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(02)00059-7     Document Type: Article

References (55)

1. On the turnover of polyamines spermidine and spermine in mouse brain and other regions
2. Evolution and resolution of oedema following severe temporary cerebral ischemia in the gerbil
3. Regional brain polyamine levels in permanent focal cerebral ischemia
4. Transport of aminobutyric acid across brain capillary and cellular membranes
5. Selection of the experimental conditions for the accurate determination of theoretical analysis
6. Human heat shock gene expression and the modulation of plasma membrane Na-K ATPase activity
7. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury
8. The regulation of polyamine transport in mammalian cell model
9. Release of spermidine from parietal cortex following middle cerebral artery in rats
10. Exogenous spermine reduces ischemic damage in a model of focal cerebral ischemia in the rat
11. Management of polyamine pools and the regulation of ornithine decarboxylase
12. The importance of brain temperature in alterations of the blood brain barrier following cerebral ischemia
13. Interrelations between increased vascular permeability and acute neuronal damage following temperature controlled brain ischemia in rats
14. Transport of a polyamine: Spermidine across the blood brain barrier of adult and 6 day old rats
15. Effectsof ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia
16. Spermidine: A predictor for neurological outcome and infarct size in focal cerebral ischemia?
17. Early rapid and transient increase in ornithine decarboxylase activity with in sympathetic neurons after axonal injury
18. Polyamines can protect against ischemia induced nerve cell death in gerbil forebrain
19. Polyamines in neurotrauma - Ubiquitous molecules in search of a function
20. Novel polyamine derivatives as neuroprotective agents
21. Polyamines in rat brain extracellular space after ischemia
22. Accumulation of exogenous polyamines in gerbil brain after ischemia
23. Polyamines prevent apoptotic cell death in cultured cerebellar granule neurons
24. Brain edema during ischemia and after restoration of blood flow measurement of water, sodium, potassium content and plasma protein permeability
25. Selective gene expression in focal cerebral ischemia
26. Polyamines and cerebral ischemia
27. Regulation of receptor ionophore complex by polyamines and divalent cations
28. Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines
29. Brain polyamines are controlled by NMDA receptors during ischemia and recirculation
30. Metabolism of polyamines in the nervous system
31. Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue-culture cells
32. Spermidine/spermine N1-acetyltransferase activity in rat brain following transient focal cerebral ischemia and reperfusion
33. Differential expression of the immediately early genes c-fos, c-jun B and NGF-IB in the rat following transient forebrain ischemia
34. Synthesis of a stress protein following transient ischemia in the gerbil
35. Lower limits of cerebrovascular permeability to non electrolytes in the conscious rat
36. Polyamine metabolism in different pathological states of the brain
37. Polyamine metabolism in reversible cerebral ischemia
38. Polyamine metabolism in reversible cerebral ischemia of Mongolian gerbils
39. A new model of bilateral hemispheric ischemia in the unanaesthetized rat
40. Early changes is blood brain barrier permeability to small molecules after transient cerebral ischemia
41. Reduction of infarct size by the NO donors sodium nitroprusside and spermine/NO after transient focal cerebral ischemia in rats
42. Difluoromehyl ornithine decreases post ischemic brain edema and blood brain barrier breakdown
43. Disruption of the blood brain barrier in hyperammonemic coma and the pharmacologic effects of the dexamethasone and DFMO
44. Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach
45. Polyamine transport in mammalian cells
46. Limited blood brain barrier transport of polyamines
47. In vivo interaction of a polyamine with the NMDA receptor
48. Biosynthesis and metabolism of 1,4-diamineobutane, spermidine, spermine and related amines
49. Recirculation after cerebral ischemia. Simultaneous measurement of cerebral blood flow, brain edema, cerebrovascular permeability and cortical EEG in the rat
50. Polyamine inhibition of lipid peroxidation
51. Modulation of the NMDA receptor by polyamines
52. A new approach to the integrity of dual blood brain barrier functions of global ischemia rats
53. Changes in the permeability of the blood brain barrier in acute hyperammonemia effect of dexamethasone