Curcumin loaded solid lipid nanoparticles: An efficient formulation approach for cerebral ischemic reperfusion injury in rats

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 85, Issue 3 PART A, 2013, Pages 339-345

  Kakkar, Vandita ^a   Muppu, Sravan Kumar ^a   Chopra, Kanwaljit ^a   Kaur, Indu Pal ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Bioavailability; Cerebral ischemia; Curcumin; Oxidative nitosative stress; Solid lipid nanoparticles

Indexed keywords

ACETYLCHOLINESTERASE; CATALASE; CURCUMIN; GLUTATHIONE; MITOCHONDRIAL ENZYME; NITRITE; SOLID LIPID NANOPARTICLE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; BRAIN ISCHEMIA; COGNITION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; RAT; RECTUM TEMPERATURE; REPERFUSION INJURY;

25MG/KG AND 50MG/KG, CUR 25-I/R AND CUR 50-I/R, RESPECTIVELY; ACETYLCHOLINESTERASE; ACHE; BA; BBB; BCCAO; BILATERAL COMMON CAROTID ARTERY OCCLUSION; BIOAVAILABILITY; BLANK SLNS; BLOOD-BRAIN-BARRIER; BSLN-I/R; C-S; C-SLNS; CAT; CATALASE ACTIVITY; CEREBRAL ISCHEMIA; CURCUMIN; CURCUMIN LOADED SOLID LIPID NANOPARTICLES; CURCUMIN SOLUBILIZED IN TWEEN 80; CURCUMIN SUSPENDED IN 1% SODIUM CARBOXY METHYL CELLULOSE; CYTOSOLIC SUPEROXIDE DISMUTASE; ELEVALTED PLUS MAZE; EPM; FREE CURCUMIN; GCI; GLOBAL CEREBRAL ISCHEMIA; GSH; I/R; INDUCIBLE NITRIC OXIDE SYNTHASE; INITIAL TRANSFER LATENCY; INOS; ISCHEMIC REPERFUSION; ITL; LIPID PEROXIDATION; LPO; MALONDIALDEHYDE; MDA; MORRIS WATER MAZE; MWM; NITRIC OXIDE; NO; OXIDATIVE/NITOSATIVE STRESS; REACTIVE OXYGEN SPECIES; REDUCED GLUTATHIONE; RETENTION TRANSFER LATENCY; ROS; RTL; SLNS; SOD; SOLID LIPID NANOPARTICLES;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; AREA UNDER CURVE; BRAIN; BRAIN ISCHEMIA; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPID PEROXIDATION; LIPIDS; MALE; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; NANOPARTICLES; OXIDATIVE STRESS; RATS; RATS, WISTAR; REPERFUSION INJURY; TISSUE DISTRIBUTION;

EID: 84888362595     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.02.005     Document Type: Article

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