MTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice

Gastroenterology

Volumn 149, Issue 3, 2015, Pages 741e14-752.e14

  Chen, Xinxin ^a   Wang, Yanan ^a   Tao, Jun ^a   Shi, Yuzhuo ^a   Gai, Xiaochen ^a   Huang, Fuqiang ^a   Ma, Qian ^b   Zhou, Zhenzhen ^b   Chen, Hongyu ^a   Zhang, Haihong ^a   Liu, Zhibo ^a   Sun, Qian ^a   Peng, Haiyong ^a   Chen, Rongrong ^a   Jing, Yanling ^a   Yang, Huayu ^c   Mao, Yilei ^c   Zhang, Hongbing ^a,b  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Drug; Liver Cancer; Mouse Model; Signal Transduction

Indexed keywords

DIETHYLNITROSAMINE; GOLGI PROTEIN 73; HERMES ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MATRILYSIN; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTEIN; RAPAMYCIN; RETROVIRUS VECTOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GOLM1 PROTEIN, HUMAN; GP73 PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; MTOR PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CELL MIGRATION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; ESCHERICHIA COLI; GENOTYPE; HEPG2 CELL LINE; LIVER CELL CARCINOMA; LIVER INJURY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; CELL MOTION; DEFICIENCY; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; KNOCKOUT MOUSE; LIVER NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; SECONDARY; SIGNAL TRANSDUCTION; TIME; TUMOR INVASION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MEMBRANE PROTEINS; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, NUDE; MULTIPROTEIN COMPLEXES; NEOPLASM INVASIVENESS; PHOSPHOPROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIROLIMUS; TIME FACTORS; TOR SERINE-THREONINE KINASES; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84939839539     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.05.005     Document Type: Article

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