-
2
-
-
42949174616
-
Diagnosis and treatment of hepatocellular carcinoma
-
El-Serag HB, Marrero JA, Rudolph L et al. Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 134, 1752-1763 (2008).
-
(2008)
Gastroenterology
, vol.134
, pp. 1752-1763
-
-
El-Serag, H.B.1
Marrero, J.A.2
Rudolph, L.3
-
3
-
-
0035729049
-
Systemic treatment of hepatocellular carcinoma
-
Treiber G. Systemic treatment of hepatocellular carcinoma. Dig. Dis. 19, 311-323 (2001).
-
(2001)
Dig. Dis
, vol.19
, pp. 311-323
-
-
Treiber, G.1
-
4
-
-
40849124295
-
Novel advancements in the management of hepatocellular carcinoma in 2008
-
Llovet JM, Bruix J. Novel advancements in the management of hepatocellular carcinoma in 2008. J. Hepatol. 48(Suppl. 1), S20-S37 (2008).
-
(2008)
J. Hepatol
, vol.48
, Issue.SUPPL. 1
-
-
Llovet, J.M.1
Bruix, J.2
-
5
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
Abou-Alfa GK, Schwartz L, Ricci S et al. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 24, 4293-4300 (2006).
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
Schwartz, L.2
Ricci, S.3
-
6
-
-
34548720158
-
SHARP Investigators Study Group. Sorafenib improves survival in advanced Hepatocellular Carcinoma (HCC): Results of a Phase III randomized placebocontrolled trial (SHARP trial)
-
Llovet JM, Ricci S, Mazzaferro V et al.; SHARP Investigators Study Group. Sorafenib improves survival in advanced Hepatocellular Carcinoma (HCC): results of a Phase III randomized placebocontrolled trial (SHARP trial). J. Clin. Oncol. 25, LBA1 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
7
-
-
58049220774
-
Randomized Phase III trial of sorafenib versus placebo in Asian patients with advanced hepatocellular carcinoma
-
Abstract 4509
-
Cheng A, Kang Y, Chen Z et al. Randomized Phase III trial of sorafenib versus placebo in Asian patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 26, (2008) (Abstract 4509).
-
(2008)
J. Clin. Oncol
, pp. 26
-
-
Cheng, A.1
Kang, Y.2
Chen, Z.3
-
8
-
-
36349031829
-
Exploiting novel molecular targets in gastrointestinal cancers
-
Ma WW, Hidalgo M. Exploiting novel molecular targets in gastrointestinal cancers. World J. Gastroenterol. 13, 5845-5856 (2007).
-
(2007)
World J. Gastroenterol
, vol.13
, pp. 5845-5856
-
-
Ma, W.W.1
Hidalgo, M.2
-
9
-
-
37149004184
-
From molecular biology to targeted therapies for hepatocellular carcinoma: The future is now
-
Pang RW, Poon RT. From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now. Oncology 72(Suppl. 1), 30-44 (2007).
-
(2007)
Oncology
, vol.72
, Issue.SUPPL. 1
, pp. 30-44
-
-
Pang, R.W.1
Poon, R.T.2
-
10
-
-
34447530619
-
The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention
-
Kopelovich L, Fay JR, Sigman CC et al. The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention. Cancer Epidemiol. Biomarkers Prev. 16, 1330-1340 (2007).
-
(2007)
Cancer Epidemiol. Biomarkers Prev
, vol.16
, pp. 1330-1340
-
-
Kopelovich, L.1
Fay, J.R.2
Sigman, C.C.3
-
11
-
-
33750058023
-
Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
-
Corradetti MN, Guan KL. Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 25, 6347-6360 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 6347-6360
-
-
Corradetti, M.N.1
Guan, K.L.2
-
12
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat. Rev. Cancer 4, 335-348 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
13
-
-
33750072949
-
mTOR and cancer therapy
-
Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 25, 6436-6446 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
14
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat. Rev. Drug Discov. 5, 671-688 (2006).
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
15
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 12, 9-22 (2007)
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
17
-
-
36148962868
-
Role of mTOR in solid tumor systems: A therapeutical target against primary tumor growth, metastases, and angiogenesis
-
Seeliger H, Guba M, Kleespies A et al. Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis. Cancer Metastasis Rev. 26, 611-621 (2007).
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 611-621
-
-
Seeliger, H.1
Guba, M.2
Kleespies, A.3
-
18
-
-
33748194240
-
Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway
-
Smolewski P. Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs 17, 487-494 (2006).
-
(2006)
Anticancer Drugs
, vol.17
, pp. 487-494
-
-
Smolewski, P.1
-
20
-
-
11144236505
-
mTOR and P70 S6 kinase expression in primary liver neoplasms
-
Sahin F, Kannangai R, Adegbola O et al. mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin. Cancer Res. 10, 8421-8425 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 8421-8425
-
-
Sahin, F.1
Kannangai, R.2
Adegbola, O.3
-
21
-
-
33947501692
-
Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
-
Sieghart W, Fuereder T, Schmid K et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation 83, 425-432 (2007).
-
(2007)
Transplantation
, vol.83
, pp. 425-432
-
-
Sieghart, W.1
Fuereder, T.2
Schmid, K.3
-
22
-
-
59849095780
-
Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin-resected hepatocellular carcinoma
-
DOI: 10.1111/ j.1478-3231.2008.01798.x , Epub ahead of print
-
Baba HA, Wohlschlaeger J, Cicinnati VR et al. Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin-resected hepatocellular carcinoma. Liver Int. DOI: 10.1111/ j.1478-3231.2008.01798.x (2008) (Epub ahead of print).
-
(2008)
Liver Int
-
-
Baba, H.A.1
Wohlschlaeger, J.2
Cicinnati, V.R.3
-
23
-
-
57349087153
-
Pivotal role of mTOR signaling in hepatocellular carcinoma
-
Villanueva A, Chiang DY, Newell P et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 135(6), 1972-1983 (2008).
-
(2008)
Gastroenterology
, vol.135
, Issue.6
, pp. 1972-1983
-
-
Villanueva, A.1
Chiang, D.Y.2
Newell, P.3
-
24
-
-
36549013178
-
Activation of the ERK and AKT signaling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
-
Schmitz KJ, Wohlschlaeger J, Lang H et al. Activation of the ERK and AKT signaling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J. Hepatol. 48, 83-90 (2008).
-
(2008)
J. Hepatol
, vol.48
, pp. 83-90
-
-
Schmitz, K.J.1
Wohlschlaeger, J.2
Lang, H.3
-
25
-
-
17144373720
-
Inhibitors of the mammalian target of rapamycin
-
Dancey JE. Inhibitors of the mammalian target of rapamycin. Expert Opin. Investig. Drugs 14, 313-328 (2005).
-
(2005)
Expert Opin. Investig. Drugs
, vol.14
, pp. 313-328
-
-
Dancey, J.E.1
-
26
-
-
67651142420
-
RAD001 (everolimus) inhibits tumor growth in xenograft models of human hepatocellular carcinoma
-
DOI: 10.1111/j.1582-4934.2008.00364.x , Epub ahead of print
-
Huynh H, Chow KP, Soo KC et al. RAD001 (everolimus) inhibits tumor growth in xenograft models of human hepatocellular carcinoma. J. Cell. Mol. Med. DOI: 10.1111/j.1582-4934.2008.00364.x (2008) (Epub ahead of print).
-
(2008)
J. Cell. Mol. Med
-
-
Huynh, H.1
Chow, K.P.2
Soo, K.C.3
-
27
-
-
17444426124
-
Inhibition of mTOR suppresses experimental liver tumours
-
Rizell M, Lindner P. Inhibition of mTOR suppresses experimental liver tumours. Anticancer Res. 25, 789-793 (2005).
-
(2005)
Anticancer Res
, vol.25
, pp. 789-793
-
-
Rizell, M.1
Lindner, P.2
-
28
-
-
16344392137
-
Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth
-
Schumacher G, Oidtmann M, Rueggeberg A et al. Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth. World J. Gastroenterol. 11, 1420-1425 (2005).
-
(2005)
World J. Gastroenterol
, vol.11
, pp. 1420-1425
-
-
Schumacher, G.1
Oidtmann, M.2
Rueggeberg, A.3
-
29
-
-
34047118033
-
Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
-
Semela D, Piguet AC, Kolev M et al. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J. Hepatol. 46, 840-848 (2007).
-
(2007)
J. Hepatol
, vol.46
, pp. 840-848
-
-
Semela, D.1
Piguet, A.C.2
Kolev, M.3
-
30
-
-
44649105082
-
Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma
-
Piguet AC, Semela D, Keogh A et al. Inhibition of mTOR in combination with doxorubicin in an experimental model of hepatocellular carcinoma. J. Hepatol. 49, 78-87 (2008).
-
(2008)
J. Hepatol
, vol.49
, pp. 78-87
-
-
Piguet, A.C.1
Semela, D.2
Keogh, A.3
-
31
-
-
0033608450
-
Sirolimus: A potent new immunosuppressant for liver transplantation
-
Watson CJ, Friend PJ, Jamieson NV et al. Sirolimus: a potent new immunosuppressant for liver transplantation. Transplantation 67, 505-509 (1999).
-
(1999)
Transplantation
, vol.67
, pp. 505-509
-
-
Watson, C.J.1
Friend, P.J.2
Jamieson, N.V.3
-
32
-
-
0033743247
-
Experience with the use of sirolimus in liver transplantation - use in patients for whom calcineurin inhibitors are contraindicated
-
Chang GJ, Mahanty HD, Quan D et al. Experience with the use of sirolimus in liver transplantation - use in patients for whom calcineurin inhibitors are contraindicated. Liver Transpl. 6, 734-740 (2000).
-
(2000)
Liver Transpl
, vol.6
, pp. 734-740
-
-
Chang, G.J.1
Mahanty, H.D.2
Quan, D.3
-
33
-
-
34248327483
-
De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: Long-term outcomes and side effects
-
Toso C, Meeberg GA, Bigam DL et al. De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effects. Transplantation 83, 1162-1168 (2007).
-
(2007)
Transplantation
, vol.83
, pp. 1162-1168
-
-
Toso, C.1
Meeberg, G.A.2
Bigam, D.L.3
-
34
-
-
6444233347
-
Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma
-
Kneteman NM, Oberholzer J, Al Saghier M et al. Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma. Liver Transpl. 10, 1301-1311 (2004).
-
(2004)
Liver Transpl
, vol.10
, pp. 1301-1311
-
-
Kneteman, N.M.1
Oberholzer, J.2
Al Saghier, M.3
-
35
-
-
33744506402
-
Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma: Report of an initial experience
-
Zhou J, Fan J, Wang Z et al. Conversion to sirolimus immunosuppression in liver transplantation recipients with hepatocellular carcinoma: report of an initial experience. World J. Gastroenterol. 12, 3114-3118 (2006).
-
(2006)
World J. Gastroenterol
, vol.12
, pp. 3114-3118
-
-
Zhou, J.1
Fan, J.2
Wang, Z.3
-
36
-
-
34547653120
-
Predictors of long-term outcome following liver transplantation for hepatocellular carcinoma: A single-center experience
-
Zimmerman MA, Trotter JF, Wachs M et al. Predictors of long-term outcome following liver transplantation for hepatocellular carcinoma: a single-center experience. Transpl. Int. 20, 747-753 (2007).
-
(2007)
Transpl. Int
, vol.20
, pp. 747-753
-
-
Zimmerman, M.A.1
Trotter, J.F.2
Wachs, M.3
-
37
-
-
43849095466
-
Sirolimus-based immunosuppression following liver transplantation for hepatocellular carcinoma
-
Zimmerman MA, Trotter JF, Wachs M et al. Sirolimus-based immunosuppression following liver transplantation for hepatocellular carcinoma. Liver Transpl. 14, 633-638 (2008).
-
(2008)
Liver Transpl
, vol.14
, pp. 633-638
-
-
Zimmerman, M.A.1
Trotter, J.F.2
Wachs, M.3
-
39
-
-
40149098824
-
Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer
-
Rizell M, Andersson M, Cahlin C et al. Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer. Int J. Clin. Oncol. 13, 66-70 (2008).
-
(2008)
Int J. Clin. Oncol
, vol.13
, pp. 66-70
-
-
Rizell, M.1
Andersson, M.2
Cahlin, C.3
-
40
-
-
67349269258
-
Pilot study of sirolimus in cirrhotic patients with advanced hepatocellular carcinoma
-
Abstract 1453
-
Decaens T, Luciani A, Itti E et al. Pilot study of sirolimus in cirrhotic patients with advanced hepatocellular carcinoma. Hepatology 48(Suppl.), 953A (2008) (Abstract 1453).
-
(2008)
Hepatology
, vol.48
, Issue.SUPPL.
-
-
Decaens, T.1
Luciani, A.2
Itti, E.3
-
41
-
-
46449091500
-
Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
-
Siegel AB, Cohen EI, Ocean A et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J. Clin. Oncol. 26(18), 2992-2998 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, Issue.18
, pp. 2992-2998
-
-
Siegel, A.B.1
Cohen, E.I.2
Ocean, A.3
-
42
-
-
65749115668
-
Impact of different anticancer regimens on biomarkers of angiogenesis in patients with advanced hepatocellular cancer
-
Treiber G, Wex T, Malfertheiner P. Impact of different anticancer regimens on biomarkers of angiogenesis in patients with advanced hepatocellular cancer. J. Cancer Res. Clin. Oncol. 135(2), 271-281 (2009).
-
(2009)
J. Cancer Res. Clin. Oncol
, vol.135
, Issue.2
, pp. 271-281
-
-
Treiber, G.1
Wex, T.2
Malfertheiner, P.3
-
43
-
-
54449083925
-
Molecular targeted therapies in hepatocellular carcinoma
-
Llovet JM, Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48(4), 1312-1327 (2008).
-
(2008)
Hepatology
, vol.48
, Issue.4
, pp. 1312-1327
-
-
Llovet, J.M.1
Bruix, J.2
-
44
-
-
34548150925
-
Phase II study of erlotinib in patients with unresectable hepatocellular carcinoma
-
Thomas MB, Chadha R, Glover K et al. Phase II study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 110(5), 1059-1067 (2007).
-
(2007)
Cancer
, vol.110
, Issue.5
, pp. 1059-1067
-
-
Thomas, M.B.1
Chadha, R.2
Glover, K.3
-
45
-
-
33748351565
-
Impact of biomarkers on disease survival and progression in patients treated with octreotide for advanced hepatocellular carcinoma
-
Treiber G, Wex T, Rocken C et al. Impact of biomarkers on disease survival and progression in patients treated with octreotide for advanced hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 132, 699-708 (2006).
-
(2006)
J. Cancer Res. Clin. Oncol
, vol.132
, pp. 699-708
-
-
Treiber, G.1
Wex, T.2
Rocken, C.3
-
46
-
-
65749096363
-
Mechanisms of Ras pathway activation in HCC patients, and combination therapies blocking Ras (sorafenib) and mTOR pathways (rapamycin) in vivo
-
Abstract 1521
-
Newell P, Roayaie S, Schwartz M et al. Mechanisms of Ras pathway activation in HCC patients, and combination therapies blocking Ras (sorafenib) and mTOR pathways (rapamycin) in vivo. Hepatology 48(Suppl.), 983A (2008) (Abstract 1521).
-
(2008)
Hepatology
, vol.48
, Issue.SUPPL.
-
-
Newell, P.1
Roayaie, S.2
Schwartz, M.3
-
47
-
-
41449102603
-
Biologic study of the effects of octreotide-LAR on growth hormone in unresectable and metastatic hepatocellular carcinoma
-
Attia S, Holen KD, Thomas JP et al. Biologic study of the effects of octreotide-LAR on growth hormone in unresectable and metastatic hepatocellular carcinoma. Clin. Adv. Hematol. Oncol. 6, 44-54 (2008).
-
(2008)
Clin. Adv. Hematol. Oncol
, vol.6
, pp. 44-54
-
-
Attia, S.1
Holen, K.D.2
Thomas, J.P.3
-
48
-
-
44449085884
-
Design and endpoints of clinical trials in hepatocellular carcinoma
-
Llovet JM, Di Bisceglie AM, Bruix J et al. Design and endpoints of clinical trials in hepatocellular carcinoma. J. Natl Cancer Inst. 100, 698-711 (2008).
-
(2008)
J. Natl Cancer Inst
, vol.100
, pp. 698-711
-
-
Llovet, J.M.1
Di Bisceglie, A.M.2
Bruix, J.3
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