Effect of Dietary ω -3 Polyunsaturated Fatty Acid DHA on Glycolytic Enzymes and Warburg Phenotypes in Cancer

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Manzi, Laura ^a   Costantini, Lara ^a   Molinari, Romina ^a   Merendino, Nicolò ^a  

^a UNIVERSITY OF TUSCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; GLYCOLYTIC ENZYME; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HIF1A PROTEIN, HUMAN; OMEGA 3 FATTY ACID;

CANCER CELL; CANCER GROWTH; CELL METABOLISM; CELL SURVIVAL; FOOD INTAKE; GLYCOLYSIS; METABOLIC REGULATION; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION; APOPTOSIS; BIOSYNTHESIS; CELL MOTION; CELL PROLIFERATION; DIET; DIET THERAPY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; NEOPLASM; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DIET; DOCOSAHEXAENOIC ACIDS; FATTY ACIDS, OMEGA-3; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASMS;

EID: 84939833197     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/137097     Document Type: Review

References (58)

1. W. Xin W. Wei and X. Li "Effects of fish oil supplementation on cardiac function in chronic heart failure: a meta-analysis of randomised controlled trials " Heart vol. 98 no. 22 pp. 1620-1625 2012.
2. S. Kar and R. Webel "Fish oil supplementation & coronary artery disease: does it help?" Missouri medicine vol. 109 no. 2 pp. 142-145 2012.
3. E.A. Miles and P.C. Calder "Influence ofmarine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis " British Journal of Nutrition vol. 107 supplement 2 pp. S171-S184 2012.
4. I. Rudkowska "Fish oils for cardiovascular disease: impact on diabetes " Maturitas vol. 67 no. 1 pp. 25-28 2010.
5. R. S. Chapkin W. Kim J. R. Lupton and D. N. McMurray "Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation " Prostaglandins Leukotrienes and Essential Fatty Acids vol. 81 no. 2-3 pp. 187-191 2009.
6. P. C. Calder "Immunomodulation by omega-3 fatty acids " Prostaglandins Leukotrienes and Essential Fatty Acids vol. 77 no. 5-6 pp. 327-335 2007.
7. V. C. Vaughan M.-R. Hassing and P. A. Lewandowski "Marine polyunsaturated fatty acids and cancer therapy " British Journal of Cancer vol. 108 no. 3 pp. 486-492 2013.
8. A. J. Cockbain G. J. Toogood and M. A. Hull "Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer " Gut vol. 61 no. 1 pp. 135-149 2012.
9. J. F. C. Glatz and G. J. Van Der Vusse "Cellular fatty acidbinding proteins: their function and physiological significance " Progress in Lipid Research vol. 35 no. 3 pp. 243-282 1996.
10. W. Stillwell and S. R. Wassall "Docosahexaenoic acid: membrane properties of a unique fatty acid " Chemistry and Physics of Lipids vol. 126 no. 1 pp. 1-27 2003.
11. H. Tapiero G. Nguyen Ba P. Couvreur and K. D. Tew "Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies " Biomedicine and Pharmacotherapy vol. 56 no. 5 pp. 215-222 2002.
12. H. Chamras A. Ardashian D. Heber and J. A. Glaspy "Fatty acid modulation of MCF-7 human breast cancer cell proliferation apoptosis and differentiation " Journal of Nutritional Biochemistry vol. 13 no. 12 pp. 711-716 2002.
13. S. Serini E. Piccioni N. Merendino and G. Calviello "Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer " Apoptosis vol. 14 no. 2 pp. 135-152 2009.
14. L. Spencer C. Mann M. Metcalfe et al. "The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential " European Journal of Cancer vol. 45 no. 12 pp. 2077-2086 2009.
15. D. D'Eliseo L. Manzi N. Merendino and F. Velotti "Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression " Journal of Nutritional Biochemistry vol. 23 no. 5 pp. 452-457 2012.
16. E. Horia and B. A. Watkins "Complementary actions of docosahexaenoicacid and genistein on COX-2 PGE2 and invasiveness inMDA-MB-231 breast cancer cells " Carcinogenesis vol. 28 no. 4 pp. 809-815 2007.
17. N. Merendino L. Costantini L. Manzi R. Molinari D.D'Eliseo and F. Velotti "Dietary ω-3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer " BioMed Research International vol. 2013 Article ID 310186 11 pages 2013.
18. J.-Q. Chen and J. Russo "Dysregulation of glucose transport glycolysis TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells " Biochimica et Biophysica Acta vol. 1826 no. 2 pp. 370-384 2012.
19. A.D'Alessandro G.M.D'Amici A. M. Timperio N. Merendino and L. Zolla "Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic metabolomic and interactomic overview " Journal of Proteomics vol. 74 no. 10 pp. 2138-2158 2011.
20. M. Mouradian K. D. Kikawa B. P. Dranka S. M. Komas B. Kalyanaraman and R. S. Pardini "Docosahexaenoic acid attenuates breast cancer cell metabolism and theWarburg phenotype by targeting bioenergetic function " Molecular Carcinogenesis 2014.
21. R. Andrade-Vieira J. H. Han and P. A. Marignani "Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes andmTOR signaling by regulating the tumor suppressor LKB1 " Cancer Biology and Therapy vol. 14 no. 11 pp. 1050-1058 2013.
22. O. Warburg "On respiratory impairment in cancer cells " Science vol. 124 no. 3215 pp. 269-270 1956.
23. R. J. Shaw "Glucose metabolism and cancer " Current Opinion in Cell Biology vol. 18 no. 6 pp. 598-608 2006.
24. H. Jadvar A. Alavi and S. S. Gambhir "18F-FDG uptake in lung breast and colon cancers: molecular biology correlates and disease characterization " Journal of Nuclear Medicine vol. 50 no. 11 pp. 1820-1827 2009.
25. V. R. Fantin J. St-Pierre and P. Leder "Attenuation of LDH-A expression uncovers a link between glycolysis mitochondrial physiology and tumor maintenance " Cancer Cell vol. 9 no. 6 pp. 425-434 2006.
26. R. A. Gatenby and R. J. Gillies "Why do cancers have high aerobic glycolysis?" Nature Reviews Cancer vol. 4 no. 11 pp. 891-899 2004.
27. A. M. Weljie and F. R. Jirik "Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect " International Journal of Biochemistry and Cell Biology vol. 43 no. 7 pp. 981-989 2011.
28. M. G. V. Heiden L. C. Cantley and C. B. Thompson "Understanding theWarburg effect: the metabolic requirements of cell proliferation " Science vol. 324 no. 5930 pp. 1029-1033 2009.
29. P. Icard and H. Lincet "A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells " Biochimica et Biophysica Acta vol. 1826 no. 2 pp. 423-433 2012.
30. S. Y. C. Choi C. C. Collins P. W. Gout and Y. Wang "Cancer-generated lactic acid: a regulatory immunosuppressive metabolite?" Journal of Pathology vol. 230 no. 4 pp. 350-355 2013.
31. P. R. Pandey W. Liu F. Xing K. Fukuda and K. Watabe "Anticancer drugs targeting fatty acid synthase (FAS) " Recent Patents on Anti-Cancer Drug Discovery vol. 7 no. 2 pp. 185-197 2012.
32. R. J. Deberardinis and T. Cheng "Q's next: the diverse functions of glutamine inmetabolism cell biology and cancer " Oncogene vol. 29 no. 3 pp. 313-324 2010.
33. S. J. Yeung J. Pan andM.-H. Lee "Roles of p53 MYC and HIF-1 in regulating glycolysis-the seventh hallmark of cancer " Cellular andMolecular Life Sciences vol. 65 no. 24 pp. 3981-3999 2008.
34. J.-J. Briere J. Favier A.-P. Gimenez-Roqueplo and P. Rustin "Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation " The American Journal of Physiology-Cell Physiology vol. 291 no. 6 pp. C1114-C1120 2006.
35. A. J. Levine and A. M. Puzio-Kuter "The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes " Science vol. 330 no. 6009 pp. 1340-1344 2010.
36. M. Stubbs and J. R. Griffiths "The alteredmetabolismof tumors: HIF-1 and its role in the Warburg effect " Advances in Enzyme Regulation vol. 50 no. 1 pp. 44-55 2010.
37. R. Wittig and J. F. Coy "The role of glucose metabolism and glucose-associated signalling in cancer " Perspectives in Medicinal Chemistry vol. 18 no. 1 pp. 64-82 2008.
38. K. Duvel J. L. Yecies S. Menon et al. "Activation of a metabolic gene regulatory network downstream of mTOR complex 1 " Science vol. 39 no. 2 pp. 171-183 2010.
39. R. M. Young D. Ackerman Z. L. Quinn et al. "Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress " Genes and Development vol. 27 no. 10 pp. 1115-1131 2013.
40. S. G. Kennedy A. J. Wagner S. D. Conzen et al. "The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal " Genes and Development vol. 11 no. 6 pp. 701-713 1997.
41. M. Laplante and D. M. Sabatini "MTOR signaling in growth control and disease " Cell vol. 149 no. 2 pp. 274-293 2012.
42. J. E. Thompson and C. B. Thompson "Putting the rap on Akt " Journal of ClinicalOncology vol. 22 no. 20 pp. 4217-4226 2004.
43. W. Wang and K.-L. Guan "AMP-activated protein kinase and cancer " Acta Physiologica vol. 196 no. 1 pp. 55-63 2009.
44. R. J. Shaw N. Bardeesy B. D. Manning et al. "The LKB1 tumor suppressor negatively regulates mTOR signaling " Cancer Cell vol. 6 no. 1 pp. 91-99 2004.
45. K. H. Vousden and C. Prives "Blinded by the light: the growing complexity of p53 " Cell vol. 137 no. 3 pp. 413-431 2009.
46. P. C. Calder "Mechanisms of action of (n-3) fatty acids " Journal of Nutrition vol. 142 no. 3 pp. 592S-599S 2012.
47. S. Ikemoto M. Takahashi N. Tsunoda K. Maruyama H. Itakura and O. Ezaki "High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils " Metabolism: Clinical and Experimental vol. 45 no. 12 pp. 1539-1546 1996.
48. C. H. S. Ruxton S. C. Reed M. J. A. Simpson and K. J. Millington "The health benefits of omega-3 polyunsaturated fatty acids: a review of the evidence " Journal of Human Nutrition and Dietetics vol. 17 no. 5 pp. 449-459 2004.
49. D. B. Jump S. D. Clarke A. Thelen and M. Liimatta "Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids " Journal of Lipid Research vol. 35 no. 6 pp. 1076-1084 1994.
50. R. Dentin F. Benhamed J.-P. Pégorier et al. "Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation " Journal of Clinical Investigation vol. 115 no. 10 pp. 2843-2854 2005.
51. P. Flachs O. Horakova P. Brauner et al. "Polyunsaturated fatty acids of marine origin upregulatemitochondrial biogenesis and induce β-oxidation in white fat " Diabetologia vol. 48 no. 11 pp. 2365-2375 2005.
52. W. C. Stanley R. J. Khairallah and E. R. Dabkowski "Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids " Current Opinion in Clinical Nutrition and Metabolic Care vol. 15 no. 2 pp. 122-126 2012.
53. M. T. Suchorolski T. G. Paulson C. A. Sanchez D. Hockenbery and B. J. Reid "Warburg and crabtree effects in premalignant barrett's esophagus cell lines with active mitochondria " PLoS ONE vol. 8 no. 2 Article ID e56884 2013.
54. H. Miwa M. Shikami M. Goto et al. "Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose " Oncology Reports vol. 29 no. 5 pp. 2053-2057 2013.
55. S. D. Clarke P. Thuillier R. A. Baillie and X. Sha "Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors " The American Journal of Clinical Nutrition vol. 70 no. 4 pp. 566-571 1999.
56. O. A. B. S. M. Gani "Are fish oil omega-3 long-chain fatty acids and their derivatives peroxisome proliferator-activated receptor agonists?" Cardiovascular Diabetology vol. 7 article 6 2008.
57. J. Zhou S. Zhang J. Xue et al. "Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxiainducible factor-1α (HIF-1α) signaling in cancer cells " Journal of Biological Chemistry vol. 287 no. 42 pp. 35161-35169 2012.
58. D. J. Stravopodis L. H. Margaritis and G. E. Voutsinas "Drugmediated targeted disruption of multiple protein activities through functional inhibition of the HSP90 chaperone complex " Current Medicinal Chemistry vol. 14 no. 29 pp. 3122-3138 2007.