11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: Potent general anesthetics and photolabeling reagents for GABAA receptors

Psychopharmacology

Volumn 231, Issue 17, 2014, Pages 3479-3491

  Chen, Zi Wei ^a   Wang, Cunde ^a   Krishnan, Kathiresan ^a   Manion, Brad D ^a   Hastings, Randy ^a   Bracamontes, John ^a   Taylor, Amanda ^a   Eaton, Megan M ^a   Zorumski, Charles F ^a   Steinbach, Joseph H ^a   Akk, Gustav ^a   Mennerick, Steven ^a   Covey, Douglas F ^a   Evers, Alex S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

GABAA receptors; Neurosteroids; Photolabeling

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; CW 12; CW 14; CYCLOHEXANE; ELTANOLONE; NEUROSTEROID; REAGENT; TERT BUTYLBICYCLOPHOSPHOROTHIOATE S 35; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANESTHETIC AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; GABAERGIC RECEPTOR AFFECTING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN MEMBRANE; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; FEMALE; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; NONHUMAN; OOCYTE; PHOTOAFFINITY LABELING; PHOTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; STEREOSPECIFICITY; SYNTHESIS; TADPOLE; XENOPUS LAEVIS; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; LARVA; METABOLISM; REFLEX;

ANESTHETICS, GENERAL; ANIMALS; CELL LINE; GABA AGENTS; HUMANS; INDICATORS AND REAGENTS; LARVA; NEUROTRANSMITTER AGENTS; OOCYTES; PREGNANOLONE; RATS; RECEPTORS, GABA-A; REFLEX; XENOPUS LAEVIS;

EID: 84939823941     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3568-4     Document Type: Article

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